Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Rubus corchorifolius
Species name
Rubus corchorifolius is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Rubus_corchorifolius.4CL.fa
Download
>Rf060219570
MWHQQSLKGCYFLNLKYWMQLFPDVKAGEVPIAFVVLAPNSLLTEQDILKFVEKQVAPCKRLRSITFASSVPKSASGKILRRELIQKPGAESSSLKRERSETPKLKEEEEKVFVCRSRFVGLEIEVEKEKDEIYYFLRRGYG
>Rf060207250
MAVQTPQHDIVYRSKLPDIHIPNHLPLHSYIFQNKSHLSSKPCIINGTTGDIHTYADVELTSRKVASGFNKLGIKQGDVIMLLLPNTPEFVFAFLGASFCGAMTTAANPFFTPAEIAKQAKASKAKLIITLACYYDKVKDLSCDEVKLMCIDSPPPDSSCLHFSELTQSDENDVPDVDISPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYYSSDDVVLCVLPLFHIYSLNSVLLCGLRAGAAILVMQKFEIVSLLELMQKHRVSVAPIVPPIVLAIAKFPDLDKYDLGSIRVLKSGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEPFEVKPGGCGTVVRNAELKIVDPETGASLPRNHPGEICIRGHQIMKGYLNDPEATRTTIDKQGWLHTGDIGFVDDDEELFIVDRLKELIKYKGFQVAPAELEALLVTHPNISDAAVVPMKDDAAGEVPVAFVVRSKGSQITEDEIKQFISKQVVFYKRINRVFFIEAIPKSPSGKILRKELRAKLAAGFAN
>Rf030083180
MAIDENGWLRTGDLGFFDGEGRLFVVDRIKELIKRKGFQVAPAELEGLLASHPEILDAVVIPFPDAEAGEVPAAYVVRALNSSLTEEDVKKFTANQLTSNDTNKAHLGSDLIDFLYLDLATKIAIHAIRCNLFSFPITGCTFQKTTNCNIHKHCPKISNRKNPQKRAD
>Rf030083170
MEKSGYGRDGIFRSLRPPLVLPRDPNLTMVSFLFRNSSSYPHKPALIDNDSSETLSFSQLKLMVIKVAHGLLHLGIKKNDVVLIFAPNSIQFPICFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPAVMLGPKTSSSQTESSSRIVGFHDLVESSGPVSDFPSVNVKQTDIAALLYSSGTTGMSKGVILTHRNFIASSLMITMDQELAGEMHHLRKGNAVISMARFNLEKILMAVEKYKVTHLWVVPPIILALSKDSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVSQGYGMTETCAIVSVENTLVGPRHSGSAGSLASGVEAQIVSVDTLKPLPPKQLGEIWVRGPNMMLGYFNNPEATKLTLDKNGWVHTGDLGYFDESGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIKSFIASQVASFKRLRRVTFINTVPKSASGKILRRELIAKVRSKI
>Rf030082770
MEKSGYGRDGIFRSLRPPLVLPRDPNLTMVSFLFRNSSSYPHKPALIDDDSSETLSFSQLKLMVIKVAHGLLHLGIKKNDVVLIFAPNSIQFPICFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPAVMLGPKTSSSQTESSSRIVGFHDLVESSGPVSDFPSVNVKQTDTAALLYSSGTTGMSKGVILTHRNFIASSLMITMDQELAGEMHHVFLCVLPMFHVFGLAVITYSQLRKGNAVISMARFNLEKILMAVEKYKVTHLWVVPPIILALSKDSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVSQGYGMTETCAIVSVENTLVGPRHSGSAGSLASGVEAQIVSVDTLKPLPPKQLGEIWVRGPNMMLGYFNNPEATKLTLDKNGWVHTGDLGYFDESGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIKSFIASQVASFKRLRRVTFINTVPKSASGKILRRELIEKVRSKI
>Rf030082780
MEKSGYGSDGIFRSLRPPLVLPGDPSLSLVSFLFRNTSSYPHQPALVEAESSETLSFSQLKSIVIKVSHGLLHLTIKKNDVVLIFAPNSIQFPICFLGIAAIGAITTTSNPLYTVSELSKQMKDCNPKLVITIPQLWEKVKGFNLPVVMLGSNASSFFPCCICIEFILLHLTHRNFITSSVMNTMDQDLIEDAINVSLCVLPMFHVYGMACIAYSQLQKGNAIVSMATFNFEKLLIALEKYKVKCLWVVPPIVLALSKSGLVEKYDISSLHYIVSSGAPLGKELMKECTEVIPQAQVFQKPVQLASTMEHPLIGTRNSGSAGSLVSGVEAKITSVDTGKSLRPNELGEICFRGPSIMKGYFNNPQATKMAINENGWLRTGDLGYFDGEGRLFVVDRIKELIKRKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPAANVVRALNSSLTEEDVKKFIANQVAPFKRLRIVTFINTVPKSATGKILRRELIEKVRSKI
>Rf070266120
MISIASNNNHNNNSVVVETPTKPEISPNIISDVISTSQTKPEQEQQPPTTTNHHVFKSKLPDLPNISNHLPLHTYCFENISNFSERPCLIVGSTGKSYTFSETRFLSQKTGAGLSKLGIHKGDVVMILLQNCAEFVFSFMGASMIGAVTTTANPFYTASEIFKQLEASNAKLIITQSQYVDKLRQPGQHFQVVTIDDPPENCLHFSVLSDANENELPQVSIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKGDDVVLCVLPLFHIFSLNSVLLCSLRAGAAVLVMLKFEIATLLELIQRYRVSVAAVVPPLVIALTKNPMVADYDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGSVVRNAELKVVEPETGRSVGYNQPGEICIRGSQIMKGYLNDSEATATTVDVEGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLVSHQSIADAAVVPQKDDAAGEVPVAFVVRSNGGNELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAAATPNPRHPI
>Rf040116730
MKGYLNDPDATENTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPNLSDAAVVSMKDEAAGEVPVAFVVRSNGSKISEDDIKQYISKQVVFYKRISRVFFTDKIPKAPSGKILRKDLRARLAAGVPN
>Rf040116720
MENKRQDNHEFIFRSKLPDIYIPNHLPLHTYCFENLSQFHDRPCLINGNTGETFTYAEVELTSRRVAAGLDKLGIQQNDVVMLLLQNCPEFAFAFLGASYIGAMSTTANPFYTPAEVAKQAKASNAKLIITQSPYVDKVKDFAKLNDVKVMCVDETSSEDVLHFSELTSADESEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVEGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEINKLLELVEKEKVTIAPFVPPIVLSIAKCPDLHRYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQVINSF
>Rf040115930
MENKRQDNHEFIFRSKLPDIYIPNHLPLHTYCFENLSQFHDRPCLINGNTGETFTYAEVELTSRRVAAGLDKLGIQQNDVVMLLLQNCPEFAFAFLGASYIGAMSTTANPFYTPAEVAKQAKASNAKLIITQSPYVDKVKDFAKLNDVKVMCVDETSSEDVLHFSELTSADESEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVEGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEINKLLELVEKEKVTIAPFVPPIVLSIAKCPDLHRYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPYEIKSGACGTVVRNAEMKIIDPDTNESLPRNQSGEICIRGSQIMKGYLNDPDATENTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPNLSDAAVVSMKDEAAGEVPVAFVVRSNGSKISEDDIKQYISKQVVFYKRISRVFFTDKIPKAPSGKILRKDLRARLAAGVPN
>Rf040136710
MGTFVQSSDQDLQEHIFRSRVPAVQVPDNITLPEFVLQDAELYADNVAFVEAVTGKKITYGEVVRDTRRFAKALGSLGLRKGHVVIVVLPNVAEYAIIALGIMAAGGVFSGANPAGHASEIKKQVAAADAKIIVTNGASYDKVKAFGVPVIVLGDETIEGAMNWNKLLEAGDRAGANTNQEKIHQSDLCALPFSSGTTGLSKGVMLTHRNLVANLSSTLFGVTPEMIGNVTVLGLIPFFHIYGTVGICCATLRNKGKVVVMGRYELRTFLNALISQEVTFAPIVPPIILNLVKHPILDEFDLSKLKLQAVMTAAAPLAPDLLKAFESKFPGVQVQEAYGLTEHSCITLTHAGQGFKAKKNSVGFILPNMEVKFIDPETGRSLPRKTPGEICVLSQCTMQGYYNNEEETMRTIDKNGWLHTGDIGYIDEDDNVFIVDRIKELIKFKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVKAAGAKESEEDIISYVASNVARYKKVRVVHFVDTIPKSPSGKIMRRLVKETMIENIKASKLSSN
MWHQQSLKGCYFLNLKYWMQLFPDVKAGEVPIAFVVLAPNSLLTEQDILKFVEKQVAPCKRLRSITFASSVPKSASGKILRRELIQKPGAESSSLKRERSETPKLKEEEEKVFVCRSRFVGLEIEVEKEKDEIYYFLRRGYG
>Rf060207250
MAVQTPQHDIVYRSKLPDIHIPNHLPLHSYIFQNKSHLSSKPCIINGTTGDIHTYADVELTSRKVASGFNKLGIKQGDVIMLLLPNTPEFVFAFLGASFCGAMTTAANPFFTPAEIAKQAKASKAKLIITLACYYDKVKDLSCDEVKLMCIDSPPPDSSCLHFSELTQSDENDVPDVDISPNDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYYSSDDVVLCVLPLFHIYSLNSVLLCGLRAGAAILVMQKFEIVSLLELMQKHRVSVAPIVPPIVLAIAKFPDLDKYDLGSIRVLKSGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEPFEVKPGGCGTVVRNAELKIVDPETGASLPRNHPGEICIRGHQIMKGYLNDPEATRTTIDKQGWLHTGDIGFVDDDEELFIVDRLKELIKYKGFQVAPAELEALLVTHPNISDAAVVPMKDDAAGEVPVAFVVRSKGSQITEDEIKQFISKQVVFYKRINRVFFIEAIPKSPSGKILRKELRAKLAAGFAN
>Rf030083180
MAIDENGWLRTGDLGFFDGEGRLFVVDRIKELIKRKGFQVAPAELEGLLASHPEILDAVVIPFPDAEAGEVPAAYVVRALNSSLTEEDVKKFTANQLTSNDTNKAHLGSDLIDFLYLDLATKIAIHAIRCNLFSFPITGCTFQKTTNCNIHKHCPKISNRKNPQKRAD
>Rf030083170
MEKSGYGRDGIFRSLRPPLVLPRDPNLTMVSFLFRNSSSYPHKPALIDNDSSETLSFSQLKLMVIKVAHGLLHLGIKKNDVVLIFAPNSIQFPICFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPAVMLGPKTSSSQTESSSRIVGFHDLVESSGPVSDFPSVNVKQTDIAALLYSSGTTGMSKGVILTHRNFIASSLMITMDQELAGEMHHLRKGNAVISMARFNLEKILMAVEKYKVTHLWVVPPIILALSKDSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVSQGYGMTETCAIVSVENTLVGPRHSGSAGSLASGVEAQIVSVDTLKPLPPKQLGEIWVRGPNMMLGYFNNPEATKLTLDKNGWVHTGDLGYFDESGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIKSFIASQVASFKRLRRVTFINTVPKSASGKILRRELIAKVRSKI
>Rf030082770
MEKSGYGRDGIFRSLRPPLVLPRDPNLTMVSFLFRNSSSYPHKPALIDDDSSETLSFSQLKLMVIKVAHGLLHLGIKKNDVVLIFAPNSIQFPICFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLVITVPELWEKVKGFNLPAVMLGPKTSSSQTESSSRIVGFHDLVESSGPVSDFPSVNVKQTDTAALLYSSGTTGMSKGVILTHRNFIASSLMITMDQELAGEMHHVFLCVLPMFHVFGLAVITYSQLRKGNAVISMARFNLEKILMAVEKYKVTHLWVVPPIILALSKDSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVSQGYGMTETCAIVSVENTLVGPRHSGSAGSLASGVEAQIVSVDTLKPLPPKQLGEIWVRGPNMMLGYFNNPEATKLTLDKNGWVHTGDLGYFDESGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIKSFIASQVASFKRLRRVTFINTVPKSASGKILRRELIEKVRSKI
>Rf030082780
MEKSGYGSDGIFRSLRPPLVLPGDPSLSLVSFLFRNTSSYPHQPALVEAESSETLSFSQLKSIVIKVSHGLLHLTIKKNDVVLIFAPNSIQFPICFLGIAAIGAITTTSNPLYTVSELSKQMKDCNPKLVITIPQLWEKVKGFNLPVVMLGSNASSFFPCCICIEFILLHLTHRNFITSSVMNTMDQDLIEDAINVSLCVLPMFHVYGMACIAYSQLQKGNAIVSMATFNFEKLLIALEKYKVKCLWVVPPIVLALSKSGLVEKYDISSLHYIVSSGAPLGKELMKECTEVIPQAQVFQKPVQLASTMEHPLIGTRNSGSAGSLVSGVEAKITSVDTGKSLRPNELGEICFRGPSIMKGYFNNPQATKMAINENGWLRTGDLGYFDGEGRLFVVDRIKELIKRKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPAANVVRALNSSLTEEDVKKFIANQVAPFKRLRIVTFINTVPKSATGKILRRELIEKVRSKI
>Rf070266120
MISIASNNNHNNNSVVVETPTKPEISPNIISDVISTSQTKPEQEQQPPTTTNHHVFKSKLPDLPNISNHLPLHTYCFENISNFSERPCLIVGSTGKSYTFSETRFLSQKTGAGLSKLGIHKGDVVMILLQNCAEFVFSFMGASMIGAVTTTANPFYTASEIFKQLEASNAKLIITQSQYVDKLRQPGQHFQVVTIDDPPENCLHFSVLSDANENELPQVSIDPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKGDDVVLCVLPLFHIFSLNSVLLCSLRAGAAVLVMLKFEIATLLELIQRYRVSVAAVVPPLVIALTKNPMVADYDLSSIRVVLSGAAPLGKELEEALRSRVPQAVLGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGSVVRNAELKVVEPETGRSVGYNQPGEICIRGSQIMKGYLNDSEATATTVDVEGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLVSHQSIADAAVVPQKDDAAGEVPVAFVVRSNGGNELTEEAVKEFIAKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLAAAATPNPRHPI
>Rf040116730
MKGYLNDPDATENTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPNLSDAAVVSMKDEAAGEVPVAFVVRSNGSKISEDDIKQYISKQVVFYKRISRVFFTDKIPKAPSGKILRKDLRARLAAGVPN
>Rf040116720
MENKRQDNHEFIFRSKLPDIYIPNHLPLHTYCFENLSQFHDRPCLINGNTGETFTYAEVELTSRRVAAGLDKLGIQQNDVVMLLLQNCPEFAFAFLGASYIGAMSTTANPFYTPAEVAKQAKASNAKLIITQSPYVDKVKDFAKLNDVKVMCVDETSSEDVLHFSELTSADESEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVEGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEINKLLELVEKEKVTIAPFVPPIVLSIAKCPDLHRYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQVINSF
>Rf040115930
MENKRQDNHEFIFRSKLPDIYIPNHLPLHTYCFENLSQFHDRPCLINGNTGETFTYAEVELTSRRVAAGLDKLGIQQNDVVMLLLQNCPEFAFAFLGASYIGAMSTTANPFYTPAEVAKQAKASNAKLIITQSPYVDKVKDFAKLNDVKVMCVDETSSEDVLHFSELTSADESEIPAVKINPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVEGENPNLYFHKEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEINKLLELVEKEKVTIAPFVPPIVLSIAKCPDLHRYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPYEIKSGACGTVVRNAEMKIIDPDTNESLPRNQSGEICIRGSQIMKGYLNDPDATENTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPNLSDAAVVSMKDEAAGEVPVAFVVRSNGSKISEDDIKQYISKQVVFYKRISRVFFTDKIPKAPSGKILRKDLRARLAAGVPN
>Rf040136710
MGTFVQSSDQDLQEHIFRSRVPAVQVPDNITLPEFVLQDAELYADNVAFVEAVTGKKITYGEVVRDTRRFAKALGSLGLRKGHVVIVVLPNVAEYAIIALGIMAAGGVFSGANPAGHASEIKKQVAAADAKIIVTNGASYDKVKAFGVPVIVLGDETIEGAMNWNKLLEAGDRAGANTNQEKIHQSDLCALPFSSGTTGLSKGVMLTHRNLVANLSSTLFGVTPEMIGNVTVLGLIPFFHIYGTVGICCATLRNKGKVVVMGRYELRTFLNALISQEVTFAPIVPPIILNLVKHPILDEFDLSKLKLQAVMTAAAPLAPDLLKAFESKFPGVQVQEAYGLTEHSCITLTHAGQGFKAKKNSVGFILPNMEVKFIDPETGRSLPRKTPGEICVLSQCTMQGYYNNEEETMRTIDKNGWLHTGDIGYIDEDDNVFIVDRIKELIKFKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPAACVVKAAGAKESEEDIISYVASNVARYKKVRVVHFVDTIPKSPSGKIMRRLVKETMIENIKASKLSSN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University