Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Rosmarinus officinalis
Species name
Rosemary (Salvia rosmarinus) is a species of eudicot in the family Lamiaceae (mint family).
Species info
Gene sequence info
Rosmarinus_officinalis.4CL.fa
Download
>1023.g139.t1
MIFLFFESTKSTIDQDGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLSNPYISDAAVVSMQDEQAGEVPVAFVVRSNGSTITEDEIKQFISKQVIFYKRVYRVFFIDAIPKSPSGKILRKDLRARLAAAV
>1052.g14.t1.1.5db21123
MEVPTRPEEIIFRSKLPDIYIPKHLPLHSYCFENISKFSSRPCLINGATGDVYTYEEVEMTARKVASGLSQLGIQQGQTIMLLLPNTPEYIFAFLGASYIGAVSTMANPFFTPAEVIKQAKASAAKLIITQACYVDKVWDYAVEAGVKVMCIDAPPAGCLPFSELTSADEREMPAVKIHPEDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELMQRYKVTIGPFVPPIVLAIAKSPLVAKYDISSVRMVMSGAAPLGKELEDSVRTKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETNASLGRNQSGEICIRGDQIMKGYLNDPESTKSTIDQDGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNNPYISDAAVVSMQDEQAGEVPVAFVVRSNGSAITEDEIKQFISKQVIYYSYHIFQPFLKFVEIYFPTNRNTLLIHEQVIFYKRINRVFFIDAIPKSPSGKILRKDLRARLAAAV
>1067.g2.t1
MELKEEKEHIFRSKLPDIDIPTHLPLHTYCFQNLSNHRAWPYLINAATGETFTHAEFELTARRVAAGLHNLGIRKSDVVMLLLHNSPEFAFAFLGSSFIGAISTTANPLYTASEIALQARISRPKLIITHSCHVEKVRHYAAEAGAEIATIDIPPSPEIIHFSELRRSDEKLLPPVEIHADDTAALPFSSGTTGLPKGVMLTHKNLVACVSQQVDGENPAVHTEREDRMLCVLPLFHVYSMISVMLCCLRVGAAVVIMPKFEINELMEILEKYSVTIAPFVPPILLAIAKSPAAAKFDFSSVRRVVCGAAPMDRELELALKAKLPNAVIGQGYGMTEAGLLSMCLGFAKRPFKFKAGACGTVIRNARMKIVDPSTAASLPRNQTGEICIKGHAVMKGYYNDPEATRRTIDEEGWLHTGDQGRIDDDDEVFIVDRLKELIKYKGFHIAPAEIEALLVAHPSISEAAVVPMSDEAAGEVPVAFVVRANGANTTELEIKSYIAKQVAPYKRINRVFFTDTIPKAPTGFVASWLIKRLLQHGYSVNATVRPQRSGVKKDLSFLTNLPNARDRLHIFEADFENPDSFGGAIEGCVGVFHVAHPINFKEKESVESISQKCVDATLGILRACLSSKTVKRVVYTSSLSTVAAKEKLPDVLDEDVWSDVDFARNLNSTGASYFVSKTATERAALEFAEKHCIELVSVIPSWIHGPFVCPFLPGSVWSSLALFLGNENQIKYGMVTPMVHTDDVATAHIHLFEHPEAKGRYLCSSVEVKYDYLCDFLSRRYPQFQMLSPESLCDPAMQFTSISSKKLLDTGFRYKYGLEEMYDDAIECCKQKGFLYPKSISS
>1195.g6.t1
METLDDERWLHTGDVGYFDEEGMLYVVDRIKELIKCKGFQVAPAELEELLLAHIEIEDAAVVGFPDDEAGEVPIAYVVRSSVSSLTGEEIKQFIAKQVAPFKRLRNVVFTDAIPRSASGKILRRELRDNNFISKL
>1255.g109.t1
MGTEAKSLVHEEIIFRSKFPPVEVPEDVTLPEFVLSGIEPYLDKVAVVDSITGKGYTYREVKRDVYRFSKALRSLGLRKGRVVVVLLPNVAEYATLALGIMAAGGVFSGANPNCHASEIKSQVEVADAKIIVTDGSTYHKVKDLGVPVIIQGEDRIEGTINCEELLEAADKASTNTVFIDQKVLQTDLCALPFSSGTTGLSKGVMLTHQNLVANLCSTLFSVGPELIGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLSALITHRVTFAPIVPPIMLGLVKNPIVDEFDLTKLSLRSVMTAAAPLAPEILNAFERKFPGVEVQEAYGMTEHSCITLSHGSVVAKRNSVGFILPNLEVKFVDPETGRSLPENAPGEICVRSKCVMKGYYKNDQETAITIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVVGLPHEEAGEIPAACVVIKTQAKESEEDIVKYVSSKSASYKRVRVVQFVSAIPKSPSGKILRRVIRENMLKDVHN
>1434.g71.t1
METATRKDDVIFRSKLPDIYIPKHLPLHSYCFENISKYRTKPCLINGGTGDVYSYEEVEAISRRVGAGLSRLGLRHGDTLMILLPNSPEFVFAFLGASYIGAVSTMANPYFTPAEVVKQAKASKAKLIITQACHVGKVNGYALDNGVRVMLVDSLPPPAAATDYLQFSELTSVDEKALPAVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTNVAQQVDGENPNLYIHSDDVMICVLPFFHIYSLNSILLCGLRAGAAILVMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIVKSPVVDKYDLSSVRTVMSGAAPLGKELEEAVRNKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDTESGASLGRNQPGEICIRGDQIMKGYLNDPEATERTIDKQGWLHTGDIGFIDEDDELFIIDRLKEIIKYKGYQVAPAEIEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVKSTGSTITEDDIKQFISKQVIFYKRISRVFFVDAIPKNPSGKILRKDLKAILAATTPAPN
>2496.g76.t1
MEKSGYGRDGVFRSLRPPLSLPTNPNLSMVNFLFRNASSFADKRALIDAHTGKTLTFSQFKSTVSRVAHGLLQLGIKKNDVVLIFSPNSIQFPLCFFAIIAIGAIATTVNPVYTAGEVSKQLKDSMAKMIVTVEELLPKVKDFDLPIVLLGDSEKQVSPIGKIPKITLFSKLVENEGSVDLEVNSFGIKQSDTAALLYSSGTTGASKGVILTHRNFIASSQMVTADQEMAGEVNCVFLCVLPMFHVFGLAVIMLAQLQRGSAVVSMSKFDFEMILRSVEKYGVTHLWVVPPIILALAKSSVVKKYDTSSLKQVGSGAAPLGKELMQECAKNFPQAVVMQGYGMTETCGIVSVESPYTGPRHTGSAGMLVPGVECQIVSVETLKPLLPTQLGEIWVRGQNMMQGYFRNPQATKLTIDKQGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGYQVAPAELEGLLVSHPEISDAVVIPYPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIANQVLTRQTVRHETNQKIKKSNGEQQQKNDGTESKKKVSGGSKGGNVTVVLKADLHCEGCVSKVLKCIRTVDGVDTANIGDGQITVVGKVDPVKLRERVEKKTHKKVEVISPQPNKNGEGKEKVKGRESGGGGDPKKEDKKKESHEKNMSNKSNEKKSKEKEPPITTAVLKVHLHCEGCIQKIRSIVVKTKGYRDMKIDKQKEMVTVTGALDMKALAEVLKKHLKREVQIVPQKKEAEKKENAGGGDKGKSSGGGGGGGGGGKGSDGEKMEGDNNKMEFQVAHPHQYPFPYPIVYESGVAMDQFHYNPYAFGPNHAPQLFSDENPNACSVM
>2509.g27.t1
MLTTQEIYGKDGIYRSRRPPISLPNDPKFSMLPFLLRNLSSISNSPALIDAQSAQTLTVSNLKTHVLRLSSALLNLNISKNDVVLILSPNSIHFPIGFLAVVAVGAVATTANPLYTSSELSKQMRDSNPKLIITVHELYDKIKEFNLPCIMLDHNGHTSTSPMLLSHSELIQSTPTTSLPTVMQSDAAAILYSSGTTGDSKGAVLTHKNFMASALMMTSDQEGKRESGNVFLCFLPMFHIFGLSALVYAQLQRGNTVVVMARYEMNTMLKAIEQYKVTNLFVVPPIVLELIKKQETVKEYNVSTLREILSGAAPLGKDMIEACANIFPQATVCQAYGMTEATGVISHENRRMGSPHPGSAGPLASSVEAQIVNSQTMQRLSYFETGYLNNHKATMETIDEQGWLHTGDVGYFDDEGRLYIVDRVKELIKYKCFQVAPAELEELLLTHPQILDAAVIGLADAEGDEIPIAYVVRSSITSLTAQEVQQFIAEQVAPFKRLRRVIFTEDIPRSPTGKILRKVLRQKVVAKL
>2621.g1.t1
MGTEAKSLVHEEIIFRSKFPPVEVPEDVTLPEFVLSAQASSPLGLRKGRVVVVLIPNVAEYATLALGIMAAGGVFSGANPNCHASEIKSQVEAADARIIVTDGSTYREDRIEGTIYYEELLEAADKANTNNFFIDEKVLQIDLYALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELIGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYDPPLPQCPHHPPRHFRAHRPPHHARPRQEPRRRRVRPHQAQPQAYGMTEHSCIMVEKRNSVGFILPNLEVKFIDPETGGSLPKNSLGEICDIIRKTAITIDKDGWLHTGDIGCIDDDGDVFLVDRIKELIKYKGF
>349761.g1.t1
MLSVAAAEAQNPELSSHALPQTQSSKETHIFVSKLPTISISNDIPLHTYCFQNYEQYPDRPCLLVGTGAGKSYTFAETHLICRKVAAGLTNLGIKKGDVVMALLQNCAEFVFTFMGASMIGAVTTTANPFCTSNEIFKQFKASKSKMIVTQAMYVDKLRDTGDESIVLGEDFSVVTIDSPPEGCLHFSVLSEADEAAVPEVEIDPNDAVALPFSSGTTGLPKGVILTHKSLITSIAQQVDGENPNLYLKPDDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGALLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEAALLSRLPQAVFGQGYGMTEAGPVLSMSPCFAKQPLPTKSGSCGNVVRNAELKVVDPDTCCSLPRNQPGEICIRGPQIMKGYLNDAEATARTVDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHPQISDAAVVPQKDEAAGEVPVAFVVPSSGSELTEEAVKEFISKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAAASSAS
MIFLFFESTKSTIDQDGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLSNPYISDAAVVSMQDEQAGEVPVAFVVRSNGSTITEDEIKQFISKQVIFYKRVYRVFFIDAIPKSPSGKILRKDLRARLAAAV
>1052.g14.t1.1.5db21123
MEVPTRPEEIIFRSKLPDIYIPKHLPLHSYCFENISKFSSRPCLINGATGDVYTYEEVEMTARKVASGLSQLGIQQGQTIMLLLPNTPEYIFAFLGASYIGAVSTMANPFFTPAEVIKQAKASAAKLIITQACYVDKVWDYAVEAGVKVMCIDAPPAGCLPFSELTSADEREMPAVKIHPEDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELMQRYKVTIGPFVPPIVLAIAKSPLVAKYDISSVRMVMSGAAPLGKELEDSVRTKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETNASLGRNQSGEICIRGDQIMKGYLNDPESTKSTIDQDGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNNPYISDAAVVSMQDEQAGEVPVAFVVRSNGSAITEDEIKQFISKQVIYYSYHIFQPFLKFVEIYFPTNRNTLLIHEQVIFYKRINRVFFIDAIPKSPSGKILRKDLRARLAAAV
>1067.g2.t1
MELKEEKEHIFRSKLPDIDIPTHLPLHTYCFQNLSNHRAWPYLINAATGETFTHAEFELTARRVAAGLHNLGIRKSDVVMLLLHNSPEFAFAFLGSSFIGAISTTANPLYTASEIALQARISRPKLIITHSCHVEKVRHYAAEAGAEIATIDIPPSPEIIHFSELRRSDEKLLPPVEIHADDTAALPFSSGTTGLPKGVMLTHKNLVACVSQQVDGENPAVHTEREDRMLCVLPLFHVYSMISVMLCCLRVGAAVVIMPKFEINELMEILEKYSVTIAPFVPPILLAIAKSPAAAKFDFSSVRRVVCGAAPMDRELELALKAKLPNAVIGQGYGMTEAGLLSMCLGFAKRPFKFKAGACGTVIRNARMKIVDPSTAASLPRNQTGEICIKGHAVMKGYYNDPEATRRTIDEEGWLHTGDQGRIDDDDEVFIVDRLKELIKYKGFHIAPAEIEALLVAHPSISEAAVVPMSDEAAGEVPVAFVVRANGANTTELEIKSYIAKQVAPYKRINRVFFTDTIPKAPTGFVASWLIKRLLQHGYSVNATVRPQRSGVKKDLSFLTNLPNARDRLHIFEADFENPDSFGGAIEGCVGVFHVAHPINFKEKESVESISQKCVDATLGILRACLSSKTVKRVVYTSSLSTVAAKEKLPDVLDEDVWSDVDFARNLNSTGASYFVSKTATERAALEFAEKHCIELVSVIPSWIHGPFVCPFLPGSVWSSLALFLGNENQIKYGMVTPMVHTDDVATAHIHLFEHPEAKGRYLCSSVEVKYDYLCDFLSRRYPQFQMLSPESLCDPAMQFTSISSKKLLDTGFRYKYGLEEMYDDAIECCKQKGFLYPKSISS
>1195.g6.t1
METLDDERWLHTGDVGYFDEEGMLYVVDRIKELIKCKGFQVAPAELEELLLAHIEIEDAAVVGFPDDEAGEVPIAYVVRSSVSSLTGEEIKQFIAKQVAPFKRLRNVVFTDAIPRSASGKILRRELRDNNFISKL
>1255.g109.t1
MGTEAKSLVHEEIIFRSKFPPVEVPEDVTLPEFVLSGIEPYLDKVAVVDSITGKGYTYREVKRDVYRFSKALRSLGLRKGRVVVVLLPNVAEYATLALGIMAAGGVFSGANPNCHASEIKSQVEVADAKIIVTDGSTYHKVKDLGVPVIIQGEDRIEGTINCEELLEAADKASTNTVFIDQKVLQTDLCALPFSSGTTGLSKGVMLTHQNLVANLCSTLFSVGPELIGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLSALITHRVTFAPIVPPIMLGLVKNPIVDEFDLTKLSLRSVMTAAAPLAPEILNAFERKFPGVEVQEAYGMTEHSCITLSHGSVVAKRNSVGFILPNLEVKFVDPETGRSLPENAPGEICVRSKCVMKGYYKNDQETAITIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVVGLPHEEAGEIPAACVVIKTQAKESEEDIVKYVSSKSASYKRVRVVQFVSAIPKSPSGKILRRVIRENMLKDVHN
>1434.g71.t1
METATRKDDVIFRSKLPDIYIPKHLPLHSYCFENISKYRTKPCLINGGTGDVYSYEEVEAISRRVGAGLSRLGLRHGDTLMILLPNSPEFVFAFLGASYIGAVSTMANPYFTPAEVVKQAKASKAKLIITQACHVGKVNGYALDNGVRVMLVDSLPPPAAATDYLQFSELTSVDEKALPAVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTNVAQQVDGENPNLYIHSDDVMICVLPFFHIYSLNSILLCGLRAGAAILVMQKFEIVPFLELIQKYKVTIGPFVPPIVLAIVKSPVVDKYDLSSVRTVMSGAAPLGKELEEAVRNKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDTESGASLGRNQPGEICIRGDQIMKGYLNDPEATERTIDKQGWLHTGDIGFIDEDDELFIIDRLKEIIKYKGYQVAPAEIEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVKSTGSTITEDDIKQFISKQVIFYKRISRVFFVDAIPKNPSGKILRKDLKAILAATTPAPN
>2496.g76.t1
MEKSGYGRDGVFRSLRPPLSLPTNPNLSMVNFLFRNASSFADKRALIDAHTGKTLTFSQFKSTVSRVAHGLLQLGIKKNDVVLIFSPNSIQFPLCFFAIIAIGAIATTVNPVYTAGEVSKQLKDSMAKMIVTVEELLPKVKDFDLPIVLLGDSEKQVSPIGKIPKITLFSKLVENEGSVDLEVNSFGIKQSDTAALLYSSGTTGASKGVILTHRNFIASSQMVTADQEMAGEVNCVFLCVLPMFHVFGLAVIMLAQLQRGSAVVSMSKFDFEMILRSVEKYGVTHLWVVPPIILALAKSSVVKKYDTSSLKQVGSGAAPLGKELMQECAKNFPQAVVMQGYGMTETCGIVSVESPYTGPRHTGSAGMLVPGVECQIVSVETLKPLLPTQLGEIWVRGQNMMQGYFRNPQATKLTIDKQGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGYQVAPAELEGLLVSHPEISDAVVIPYPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIANQVLTRQTVRHETNQKIKKSNGEQQQKNDGTESKKKVSGGSKGGNVTVVLKADLHCEGCVSKVLKCIRTVDGVDTANIGDGQITVVGKVDPVKLRERVEKKTHKKVEVISPQPNKNGEGKEKVKGRESGGGGDPKKEDKKKESHEKNMSNKSNEKKSKEKEPPITTAVLKVHLHCEGCIQKIRSIVVKTKGYRDMKIDKQKEMVTVTGALDMKALAEVLKKHLKREVQIVPQKKEAEKKENAGGGDKGKSSGGGGGGGGGGKGSDGEKMEGDNNKMEFQVAHPHQYPFPYPIVYESGVAMDQFHYNPYAFGPNHAPQLFSDENPNACSVM
>2509.g27.t1
MLTTQEIYGKDGIYRSRRPPISLPNDPKFSMLPFLLRNLSSISNSPALIDAQSAQTLTVSNLKTHVLRLSSALLNLNISKNDVVLILSPNSIHFPIGFLAVVAVGAVATTANPLYTSSELSKQMRDSNPKLIITVHELYDKIKEFNLPCIMLDHNGHTSTSPMLLSHSELIQSTPTTSLPTVMQSDAAAILYSSGTTGDSKGAVLTHKNFMASALMMTSDQEGKRESGNVFLCFLPMFHIFGLSALVYAQLQRGNTVVVMARYEMNTMLKAIEQYKVTNLFVVPPIVLELIKKQETVKEYNVSTLREILSGAAPLGKDMIEACANIFPQATVCQAYGMTEATGVISHENRRMGSPHPGSAGPLASSVEAQIVNSQTMQRLSYFETGYLNNHKATMETIDEQGWLHTGDVGYFDDEGRLYIVDRVKELIKYKCFQVAPAELEELLLTHPQILDAAVIGLADAEGDEIPIAYVVRSSITSLTAQEVQQFIAEQVAPFKRLRRVIFTEDIPRSPTGKILRKVLRQKVVAKL
>2621.g1.t1
MGTEAKSLVHEEIIFRSKFPPVEVPEDVTLPEFVLSAQASSPLGLRKGRVVVVLIPNVAEYATLALGIMAAGGVFSGANPNCHASEIKSQVEAADARIIVTDGSTYREDRIEGTIYYEELLEAADKANTNNFFIDEKVLQIDLYALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVGPELIGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYDPPLPQCPHHPPRHFRAHRPPHHARPRQEPRRRRVRPHQAQPQAYGMTEHSCIMVEKRNSVGFILPNLEVKFIDPETGGSLPKNSLGEICDIIRKTAITIDKDGWLHTGDIGCIDDDGDVFLVDRIKELIKYKGF
>349761.g1.t1
MLSVAAAEAQNPELSSHALPQTQSSKETHIFVSKLPTISISNDIPLHTYCFQNYEQYPDRPCLLVGTGAGKSYTFAETHLICRKVAAGLTNLGIKKGDVVMALLQNCAEFVFTFMGASMIGAVTTTANPFCTSNEIFKQFKASKSKMIVTQAMYVDKLRDTGDESIVLGEDFSVVTIDSPPEGCLHFSVLSEADEAAVPEVEIDPNDAVALPFSSGTTGLPKGVILTHKSLITSIAQQVDGENPNLYLKPDDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFEIGALLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGAAPLGKELEAALLSRLPQAVFGQGYGMTEAGPVLSMSPCFAKQPLPTKSGSCGNVVRNAELKVVDPDTCCSLPRNQPGEICIRGPQIMKGYLNDAEATARTVDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLISHPQISDAAVVPQKDEAAGEVPVAFVVPSSGSELTEEAVKEFISKQVVFYKRLHKVYFVHAIPKSPSGKILRKDLRAKLAAASSAS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University