Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Roridula gorgonias
Species name
Roridula gorgonias is a species of eudicot in the family Roridulaceae.
Species info
Gene sequence info
Roridula_gorgonias.COMT.fa
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>rgor_00127-RA
MGSPSEPQPTPTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFQSPHELAAQLPTRNPNAAVMLDRVLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSMAPLLLMNQDKVLMESWYHFKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTMTMKKILETYQGFEGITTIVDVGGGTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYDALPDNGKVILAECILPVAPDTSLATKNVVHIDVIMLAHNPGGKERTEGEFEALAKGAGFEGFSVTMGSPSEPQPTPTEPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRMLRLLASYEVVKCALRTCPDGGVERLYGLAPVTRFLTKNEDGVSMAPLLLIIQDKVVIESWHHLKDAVLHGGIPFNKAYGMTPFEFQGTDPRFNKVFNQGMFNHSTMTMKKILETYQGFEGLTTIVDVGGGTGTMLNMILSKFPTIKGINFDLPHVLEDAPSYPGIAQSFSPIIVKMKQGVKHVGGDMFVSVPKGDAIFMKWICHNWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVHLDVIMLAHFQGGKERTKGEFEALAKGVGFEGFSIMCCAFNIIIPLHDAISQRLGRTHGRPNAFLSPHELAAQLPTRNPNTVAMLDRLRMCSPDPPDGGVERLYWLATVTRFLTKNEDGVSMAPLLLIIQDKVLMESWYHLKDAILDGGIPINKAYGMTPFEFQGTDPRFNEVFNQGMSNHSAMTMKKILETYQGFEGLTTIVDVGGGTGTMLNLIVSKFPTIKGINFGLPHYVGGEMFVSVLKGGAIFMKWICHDWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVHHDLLMLTHSPSGKQRTEGEFKALAKGVGFEGFSIMCCDTSLATKNVVHLDNLILAYNPGGKERTEGEFEALAKGLDLTGSASCAALSIRTSWSSSRRFDEPQPPPTNPTQEESFLFAMQLANASVVPMVLKSAIELDLLETLAKAGPDAFLSPQELAAQLPTRNPNAAVILDRVLRLLASYEVVKCALRTRPDGGVERLYGLSPVTRFLTKNEDGVSMAPLLLINQDKVLMESWYHLKDAILDGGIPFNKAYGMTAFEFQGTDPRFNEVFNQGMSNHSAMTMKKILETYQGLRASLLDVGGGTGTMLNMIVSKFPTIKGINFDLPYVIEDAPSYPGVKHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVSLDVIVLAHYQGGKERTEGEFEALAKGVGFEGFSIMCCAFNIMGSPSEPQPTPTEPTQEESFLFAMQLASASLVAQLLTRNPNAAVILDRVLRLLASYEVVKCALRTRPDGGVERLYGFAPVTRFLTKNEDGISIAPFLLLQQDKVFMESWYHFKDAVLDGGIPFNKAYGMTAFE
>rgor_13332-RA
MSSLESQTIRLSSFDEEDSHAQYALQLATSSVLPMVLKAAIELGVLRVIEKAGPAALLSSSEIAYQLLKSSNNPQAPVMLDRMLRLLASYSVLTCSLVTDHYSQHVNRLYDAVVEGGLPFNRAYGMNALDYVGKDARCRELFKAFMGDYNPMFLKKILETYKGFQARPEFDTCGGRSVSEHRERRRHFHEDIEKLLRVNTRQRQSDIVVETVVPETPETNVAVKCGFQLLLFLMNMNPGGKERTNAEFESL
>rgor_13370-RA
MGPTIENQITPTQADDMEEAFLFAKQLASACVLPMVLKTAIELDLLETIAKAGPGAYLSPSELASQLPTTNQDAAVMLDRILRLLATYSVLNCTLRDLPGGGVERLYGLAPVCNFLTRNADGVSLAPLLIMNQDKVLMESW
>rgor_13596-RA
YHLKDAVLDGGIPFNKAYGMSAFEYPGTDPRFNNVFNQGMSNHSTIFMKKILETYHGFEGLTTVVDVGGGTGATLNMIVSKYHTIKGINFDLPHVIDHAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFFKNCYDALPENGKVIVADCIMPVAPDTRLATKIAVHVDVIMLAHNPGGKERTENEFKALAKGAGFKGFRVACCAFGTYVMEFLK
>rgor_14185-RA
MSSSKNDQTNSTKSHEEEEEEEHSRAIQLVSTSIFPRILRVAVELNLFEIISTRGDYLSASEISSHLPTTNPEAIAMIERLLRFLASFDILKCKFGEDGDKKLYGLAPVCKYFVTDQNGISIAPLLLLLQDKVVQGCEFNDVFNKAMHGQTSMGMKILLDKYEGFASLKEIVDVGGGFGATLGSIVAKYPHIKGINYDLPFVLEKAPTWPGVQHVGGDMFESVPKGEAIIMKWILHDWSDEKCLKLLKNCWNALPDSGGKVIVVDAVLPENPEGSDPLSRIAFAADMIMLTLNPGGKERTEKEFDNLAKMAGFAATKLIFHTPSEWLMEFYKKI
>rgor_22085-RA
YHLKDVVLYGGTSFIKAYGMTPFEYTGTDPKFNKVFNQSMSNHSTMTMKQILETYQGFEGLTTIIDVGGGTGATLNMIVSKFPSIIKGINSDLPHVIEDAPSYPRVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKLLKNCYYALPDNGKVILAECILPVAPDTSLATKNVIHLDILMLAYTPGGKERTDGEFEALAKGAGFEGFSVIASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAHLPTRNPNAAVILDRMLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSIAPFLLLEQDKVFMESWYHLKDVVLDGGILFNKAYGMTAFEYNGTDPRCNKVFNQGMSNHSTMTMKKILETYQGFEGLTTIVDIGGSTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCHDWSDEHCSKFLKNCYKVLPDNGKVILAECILPMAPDTSLATKNAVHHDLLMLAHSPGGKERTAGEFEALAKGAGFEGFSIMCCAFNTYIMELIKKI
>rgor_22086-RA
YHLKDVVLYGGTSFIKAYGMTPFEYTGTDPKFNKVFNQSMSNHSTMTMKQILETYQGFEGLTTIIDVGGGTGATLNMIVSKFPSIIKGINFDLPHVIEDAPSYPRVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKLLKNCYYALPDNGKVILAECILPVAPDTSLATKNVIHLDILMLAYTPGGKERTDGEFEALAKGAGFEGFSVIASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAHLPTRNPNAAVILDRMLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSIAPFLLLEQDKVFMESWYHLKDVVLDGGILFNKAYGMTAFEYNGTDPRCNKVFNQGMSNHSTMTMKKILETYQGFEGLTTIVDIGGSTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCHDWSDEHCSKFLKNCYKVLPDNGKVILAECILPMAPDTSLATKNAVHHDLLMLAHSPGGKERTAGEFEALAKGAGFEGFSIMCCAFNTYIMELIKKI
>rgor_22087-RA
MGSPSEPQPTLTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRLLRLLASYEVVKCALRTRPDGGVEQLYGLAPVTRFLTKNEDGVSMAPFLLTNQDKVFMESW
>rgor_22088-RA
MGSPSEPQPTLTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRLLRLLASYEVVKCALRTRPDGGVEQLYGLAPVTRFLTKNEDGVSMAPFLLTNQDKVFMESW
MGSPSEPQPTPTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFQSPHELAAQLPTRNPNAAVMLDRVLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSMAPLLLMNQDKVLMESWYHFKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTMTMKKILETYQGFEGITTIVDVGGGTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYDALPDNGKVILAECILPVAPDTSLATKNVVHIDVIMLAHNPGGKERTEGEFEALAKGAGFEGFSVTMGSPSEPQPTPTEPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRMLRLLASYEVVKCALRTCPDGGVERLYGLAPVTRFLTKNEDGVSMAPLLLIIQDKVVIESWHHLKDAVLHGGIPFNKAYGMTPFEFQGTDPRFNKVFNQGMFNHSTMTMKKILETYQGFEGLTTIVDVGGGTGTMLNMILSKFPTIKGINFDLPHVLEDAPSYPGIAQSFSPIIVKMKQGVKHVGGDMFVSVPKGDAIFMKWICHNWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVHLDVIMLAHFQGGKERTKGEFEALAKGVGFEGFSIMCCAFNIIIPLHDAISQRLGRTHGRPNAFLSPHELAAQLPTRNPNTVAMLDRLRMCSPDPPDGGVERLYWLATVTRFLTKNEDGVSMAPLLLIIQDKVLMESWYHLKDAILDGGIPINKAYGMTPFEFQGTDPRFNEVFNQGMSNHSAMTMKKILETYQGFEGLTTIVDVGGGTGTMLNLIVSKFPTIKGINFGLPHYVGGEMFVSVLKGGAIFMKWICHDWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVHHDLLMLTHSPSGKQRTEGEFKALAKGVGFEGFSIMCCDTSLATKNVVHLDNLILAYNPGGKERTEGEFEALAKGLDLTGSASCAALSIRTSWSSSRRFDEPQPPPTNPTQEESFLFAMQLANASVVPMVLKSAIELDLLETLAKAGPDAFLSPQELAAQLPTRNPNAAVILDRVLRLLASYEVVKCALRTRPDGGVERLYGLSPVTRFLTKNEDGVSMAPLLLINQDKVLMESWYHLKDAILDGGIPFNKAYGMTAFEFQGTDPRFNEVFNQGMSNHSAMTMKKILETYQGLRASLLDVGGGTGTMLNMIVSKFPTIKGINFDLPYVIEDAPSYPGVKHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKFLKNCYDVLPDNGKVILAECILPVAPDTSLATKNVVSLDVIVLAHYQGGKERTEGEFEALAKGVGFEGFSIMCCAFNIMGSPSEPQPTPTEPTQEESFLFAMQLASASLVAQLLTRNPNAAVILDRVLRLLASYEVVKCALRTRPDGGVERLYGFAPVTRFLTKNEDGISIAPFLLLQQDKVFMESWYHFKDAVLDGGIPFNKAYGMTAFE
>rgor_13332-RA
MSSLESQTIRLSSFDEEDSHAQYALQLATSSVLPMVLKAAIELGVLRVIEKAGPAALLSSSEIAYQLLKSSNNPQAPVMLDRMLRLLASYSVLTCSLVTDHYSQHVNRLYDAVVEGGLPFNRAYGMNALDYVGKDARCRELFKAFMGDYNPMFLKKILETYKGFQARPEFDTCGGRSVSEHRERRRHFHEDIEKLLRVNTRQRQSDIVVETVVPETPETNVAVKCGFQLLLFLMNMNPGGKERTNAEFESL
>rgor_13370-RA
MGPTIENQITPTQADDMEEAFLFAKQLASACVLPMVLKTAIELDLLETIAKAGPGAYLSPSELASQLPTTNQDAAVMLDRILRLLATYSVLNCTLRDLPGGGVERLYGLAPVCNFLTRNADGVSLAPLLIMNQDKVLMESW
>rgor_13596-RA
YHLKDAVLDGGIPFNKAYGMSAFEYPGTDPRFNNVFNQGMSNHSTIFMKKILETYHGFEGLTTVVDVGGGTGATLNMIVSKYHTIKGINFDLPHVIDHAPAYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFFKNCYDALPENGKVIVADCIMPVAPDTRLATKIAVHVDVIMLAHNPGGKERTENEFKALAKGAGFKGFRVACCAFGTYVMEFLK
>rgor_14185-RA
MSSSKNDQTNSTKSHEEEEEEEHSRAIQLVSTSIFPRILRVAVELNLFEIISTRGDYLSASEISSHLPTTNPEAIAMIERLLRFLASFDILKCKFGEDGDKKLYGLAPVCKYFVTDQNGISIAPLLLLLQDKVVQGCEFNDVFNKAMHGQTSMGMKILLDKYEGFASLKEIVDVGGGFGATLGSIVAKYPHIKGINYDLPFVLEKAPTWPGVQHVGGDMFESVPKGEAIIMKWILHDWSDEKCLKLLKNCWNALPDSGGKVIVVDAVLPENPEGSDPLSRIAFAADMIMLTLNPGGKERTEKEFDNLAKMAGFAATKLIFHTPSEWLMEFYKKI
>rgor_22085-RA
YHLKDVVLYGGTSFIKAYGMTPFEYTGTDPKFNKVFNQSMSNHSTMTMKQILETYQGFEGLTTIIDVGGGTGATLNMIVSKFPSIIKGINSDLPHVIEDAPSYPRVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKLLKNCYYALPDNGKVILAECILPVAPDTSLATKNVIHLDILMLAYTPGGKERTDGEFEALAKGAGFEGFSVIASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAHLPTRNPNAAVILDRMLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSIAPFLLLEQDKVFMESWYHLKDVVLDGGILFNKAYGMTAFEYNGTDPRCNKVFNQGMSNHSTMTMKKILETYQGFEGLTTIVDIGGSTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCHDWSDEHCSKFLKNCYKVLPDNGKVILAECILPMAPDTSLATKNAVHHDLLMLAHSPGGKERTAGEFEALAKGAGFEGFSIMCCAFNTYIMELIKKI
>rgor_22086-RA
YHLKDVVLYGGTSFIKAYGMTPFEYTGTDPKFNKVFNQSMSNHSTMTMKQILETYQGFEGLTTIIDVGGGTGATLNMIVSKFPSIIKGINFDLPHVIEDAPSYPRVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCSKLLKNCYYALPDNGKVILAECILPVAPDTSLATKNVIHLDILMLAYTPGGKERTDGEFEALAKGAGFEGFSVIASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAHLPTRNPNAAVILDRMLRLLASYEVVKCALRTRPDGGVERLYGLAPVTRFLTKNEDGVSIAPFLLLEQDKVFMESWYHLKDVVLDGGILFNKAYGMTAFEYNGTDPRCNKVFNQGMSNHSTMTMKKILETYQGFEGLTTIVDIGGSTGATLNMIVSKFPTIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWMCHDWSDEHCSKFLKNCYKVLPDNGKVILAECILPMAPDTSLATKNAVHHDLLMLAHSPGGKERTAGEFEALAKGAGFEGFSIMCCAFNTYIMELIKKI
>rgor_22087-RA
MGSPSEPQPTLTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRLLRLLASYEVVKCALRTRPDGGVEQLYGLAPVTRFLTKNEDGVSMAPFLLTNQDKVFMESW
>rgor_22088-RA
MGSPSEPQPTLTDPTQEESFLFAMQLASASVVPMVLKSAIELDLLETMAKAGPDAFLSPHELAAQLPTRNPNAAVMLDRLLRLLASYEVVKCALRTRPDGGVEQLYGLAPVTRFLTKNEDGVSMAPFLLTNQDKVFMESW
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University