Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Roridula gorgonias
Species name
Roridula gorgonias is a species of eudicot in the family Roridulaceae.
Species info
Gene sequence info
Roridula_gorgonias.HIDH.fa
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>rgor_04696-RA
MAFTNKEVATEFLPLLRVYTDGTVERLVGSPIVPPSLSGPANGVSSKDISISSDVSARLYLPKLTTISDRQKLPILVYFHGGGFCVESPFSALNHRYINLLASQAKINIHPSKLKSLAPEHPLPIAYEDSWAALQWVSSHSTGETSDKDPWLIEYGDFGRIFVGGDSTGANIAHNIAMRGGVEPLHGGVKLRGAFLSQPFFWGSNPIRSEPSIGHQQNMKCRVWKFVYPSAPNGIDNPMINPFAPGAPSLAGLGCSKLLVCVGEKDASKERGMHYCDAVRGSGWGGEVELYEVDGGGTYGFHINNPETEMAKNMMGRLASFIK
>rgor_05480-RA
MGSLPHLVEDCHGLLQLYSDGSVVRSDDINFNTQIHHDPTVTYKDCLFDKPHNLHLRLYKPLSSAASLPVLLFFHGGGFCFGSRTWPHTHNSCLRLASALRALVIAPDYRLAPEHRLPAALDDAMTAVKWVQAQAILEHGNTWLGEGVDFKRVFVVGDSSGGNIAHHLAVRLGSGSPELAPLSVRGYVLMAPFFGGVVRTKSEEDGVQESLLNVDILDRFWRLSIPIGGTADHPLANPFGPASPSLESVTLDPILVVVGGRELLKDRAVDYTRRLKEMRKKIEYVEFEGREHGFFTNEPYSDVANKVLQVIKTFMDENSD
>rgor_05686-RA
MSIIAEAPGFLQVFSDGSAKRFGREIAPASSELSSNGYRSKDVIIDPSKPITGRIFLPDSARTPASRLPVIVYFHGGGFCIGSTTWLGYHLFLGDLSVASQAIVLSVDYRLAPENRLPVAHDDCYSSLEWLSQQVSSLDSWLERAELSRVFLSGDSAGGNLSHQVAIMTTQRFNPLCGIELKGLLLIHPYFGSKKRTETEKAEGAAGDVAMNDLFWRLSLPEGLDRDHYGCNFETAVVSAEEWRRFPAVVVYVAGLDFLKERGVMYAEFLKKKGVRRVEMVEADGEPHVYHVYHPESEATKLLQKQMSDFIHSF
>rgor_05702-RA
MDSSKPEVSHEVPPYLRVYKDGTVERLFGNEIAPPGFDPQTGVESKDTLITAGTGVSARLYRPSLPPTSPKLPLVVYFHGGAFFISSISDPKYHHSLNVLVTKANVILVSVDYRRVPEHPLPAAYEDSWAALGWVASHVSGGGPEPWLRGKIDFSRVFLAGDSAGANIAHHLVIRARSNPLGGMKIPGIIMIHPYFWGKEPVGSEAHDPVRKAMVDGWWRFVCPSDRGNDDPLINPVADGAPSISGMACDRVIVCVAQKDILRDRGRLYYESLVKSEWHGEAEILEIEGEDHVFHIMDPTCDKAIMMMECLASFINQE
>rgor_05843-RA
MSDTTATTSPPYEVDECRGVLRVFSDGSIVRSSKSSFNVPVHDDGSVLWKDVTFDVPHDLQLRLYKPASPISSAAEPLPIFYYIHGGGFCIGSRAWPNCQNYCFRLALELQAVIVAPDYRLAPENRLPAAIEDGYAALKWLQAQATSDEPDPWLADVADFNRVFISGDSAGGNIAHNLAVRLGSGSTGLAPVRVRGYWRLSIPIGETTDYPLVNPFGPVSPPLEPLDLDPILAMVGGSDLLKDRVKDYTKKLKGWGKKVEYVEFEGQQHGFFTIDPNSQASNDLMLVIKKFIVENSN
>rgor_06326-RA
MTATTLDPSLSLQINTRTHHHHGPLVEEIDGLIRVYKDGHVERPQIMPCTASSSATEPGVTSRDMVIDNFTNIWARFYLPKCHGSLLPLLVYFHGGGFCVGSAAWSCYHEFLGKLAARTSCVIMSVNYRLAPENTLPAAYDDGVKALTWVKQQALCGGGGSEWWSKKCNFSSIFLAGDSAGANIAYNVAIRLSGMAQNPLTIKGIILIQPFFGGERRTNSEKYMVEPPRSSLSLAASDTYWRLSLPPGANRDHPWCNPGAKGSIFPMMVCVAEMDILRDRILEMCDGLARAGKKVECVVHKGVGHAFQVLNKSQLSQTRTLEMISQIRSFISK
>rgor_07965-RA
MINPLDRNGPTLVGLGCSRLLVCVAAEDELREGGWCGDLELFEVEGEGHCFHILNLESESAKNMIKRLASFLLH
>rgor_10341-RA
MDKMESSKPEVSLELPPYLRVYKDGTIERIAGTQVTPANLDPQTGVVSKDMLILPETGVSARLYRPNLTPNHQKLPLVIYFHGGAFCIASVAEPFYHTSLNILAAKANSLVISVDYRLSPENPLPAAYEDSWGALQWLATQISSGGTEDWLKDKVDLGRVFLAGDSAGANISHHLAIRAGTTQIEGLKFRGIVMIHPYFWGKEAIGSEVTDPIRKAMVDSWWLFVCPSEKGNDDPLINPFTDGSPDLSGLACDRVIICVAEKDILRDRGRLYYDRLVKSGWPGTAEVVETEGEDHVFHIFNPSSEKAMDMIKQLASFINKE
>rgor_10951-RA
MASTSNEITREFPPFFRVYKDGRVERYMGSTYVPPSVDPQTGVETKDVLISPETDLKARIFMPKINGPDQKLPLVVHYHGGGFCIGSSFGSFTHGFLTSLSSEARVIAVSVDYRLAPEHPLPIAYDDSWSALQWIATHSSGQGPEPWLNQYADFGRVFLAGESAGANLAHHVAVRVGTASADGFRVNGLIAVHPFFANDEPDEMIRFLYPGSSGSDDDPRLSPKEDPDLAKMGCSRVVVHVAEKDWLKSRGLSYCEVLEKSGWGGKVELVEDEGEDHCFHLFNPSGEKAVILVKSLASFINQD
>rgor_10988-RA
MVICEKKIVEEVSGWLRVFEDGSVDRTWSGPREVEFMTLPVPSHEDFIEGVATRDVVIDAGSGLRARIYLPETNLNSKKLPILLHFHGGGFCISQPDWYMYYHVYTRLARSARAICVSVYLRLAPDHRLPAACHDGFSALLWLSSVAQATKPEPWLKAHADFNRVFLIGDSSGGNLVHEVAARAGKVDLGPVRLAGAIPIHPGFVRSERSKSELEQPESPFLTLDMVDKFLRLALPVGSTKDHPITCPMGEGAPPIFALKLPPMLLCVAEMDLIRDTEMEYYEAMKKANKDVELMINYGMGHSFYLNKIAVDMDPQTTEQTTKLIVGITDFINRH
>rgor_15330-RA
KFSFSLNYRLAPEHRYLIGAALKWVASHAGRSGPDPWINERVNFNRVLRGGRQCGCKHIPQHGNSGRVGNLVSGQTKEDCFDPPHPTPSLLAVKEYMSSNVTKQWSYVCPSCNGLRDPQFNPVSDPNLVTLGCKARGLHLSL
>rgor_15331-RA
MDSATVEVTHDLTPFIRVYKDGRVERLMGTEIVPPSPIDPKTGVESKDVVIVRETGVSARLYKPKTTSPPTQKFPLLIYFHGGAFFVQTAFSPTYQYFLNSLVAETKVIVVSVDYRRAPESPLPIGYEDSWAAVKWVASHSSGAGQEVWLKEHVDFDLVYFGGDSAGANIANNMAIRVGLEGLEGGKLVGVVMMHPYFWGKDPIGSEDTDTDRRGVVERFWLMACPSSTGSDDPLINPAKDPNLPSLGCKRVLVFVAERDLMRDRGRFYYEVLGKSGWGGEVEIEESEGEDHVFHLEKPNCEKAKDMVKRVASFINQHKAKAKA
>rgor_15332-RA
MADEVAQDFPPLGIRVYKDGKVERSKGTEIVPASTDPATGVQSNDVVIDPAIDLTARLYLPRSAAASGSQKLPLLIYLHGGGFCIETAFSPSYHNYLNSVAAEANVVVLSVNYRLAPEHHLPIAYDDSWATIQWAASHSTNHGPEAWLNEYADFNRVFFAGDSAGGNLAHNMAVRVGTARLDGFKLIGIILVHPYFWGKDPVGNEPTDPNTRGFVEGLWFFTFPSSSGCDDPLMNPGKDPKLSGLGCEKVLVFVAEQDILKHRGWFYKAELEKSGWGGAVEVVEDAGENHVFHLFKPSCDNAKAMLKRDPVGNKSTDPNMRGFVDGLWLFAFPSSSRV
MAFTNKEVATEFLPLLRVYTDGTVERLVGSPIVPPSLSGPANGVSSKDISISSDVSARLYLPKLTTISDRQKLPILVYFHGGGFCVESPFSALNHRYINLLASQAKINIHPSKLKSLAPEHPLPIAYEDSWAALQWVSSHSTGETSDKDPWLIEYGDFGRIFVGGDSTGANIAHNIAMRGGVEPLHGGVKLRGAFLSQPFFWGSNPIRSEPSIGHQQNMKCRVWKFVYPSAPNGIDNPMINPFAPGAPSLAGLGCSKLLVCVGEKDASKERGMHYCDAVRGSGWGGEVELYEVDGGGTYGFHINNPETEMAKNMMGRLASFIK
>rgor_05480-RA
MGSLPHLVEDCHGLLQLYSDGSVVRSDDINFNTQIHHDPTVTYKDCLFDKPHNLHLRLYKPLSSAASLPVLLFFHGGGFCFGSRTWPHTHNSCLRLASALRALVIAPDYRLAPEHRLPAALDDAMTAVKWVQAQAILEHGNTWLGEGVDFKRVFVVGDSSGGNIAHHLAVRLGSGSPELAPLSVRGYVLMAPFFGGVVRTKSEEDGVQESLLNVDILDRFWRLSIPIGGTADHPLANPFGPASPSLESVTLDPILVVVGGRELLKDRAVDYTRRLKEMRKKIEYVEFEGREHGFFTNEPYSDVANKVLQVIKTFMDENSD
>rgor_05686-RA
MSIIAEAPGFLQVFSDGSAKRFGREIAPASSELSSNGYRSKDVIIDPSKPITGRIFLPDSARTPASRLPVIVYFHGGGFCIGSTTWLGYHLFLGDLSVASQAIVLSVDYRLAPENRLPVAHDDCYSSLEWLSQQVSSLDSWLERAELSRVFLSGDSAGGNLSHQVAIMTTQRFNPLCGIELKGLLLIHPYFGSKKRTETEKAEGAAGDVAMNDLFWRLSLPEGLDRDHYGCNFETAVVSAEEWRRFPAVVVYVAGLDFLKERGVMYAEFLKKKGVRRVEMVEADGEPHVYHVYHPESEATKLLQKQMSDFIHSF
>rgor_05702-RA
MDSSKPEVSHEVPPYLRVYKDGTVERLFGNEIAPPGFDPQTGVESKDTLITAGTGVSARLYRPSLPPTSPKLPLVVYFHGGAFFISSISDPKYHHSLNVLVTKANVILVSVDYRRVPEHPLPAAYEDSWAALGWVASHVSGGGPEPWLRGKIDFSRVFLAGDSAGANIAHHLVIRARSNPLGGMKIPGIIMIHPYFWGKEPVGSEAHDPVRKAMVDGWWRFVCPSDRGNDDPLINPVADGAPSISGMACDRVIVCVAQKDILRDRGRLYYESLVKSEWHGEAEILEIEGEDHVFHIMDPTCDKAIMMMECLASFINQE
>rgor_05843-RA
MSDTTATTSPPYEVDECRGVLRVFSDGSIVRSSKSSFNVPVHDDGSVLWKDVTFDVPHDLQLRLYKPASPISSAAEPLPIFYYIHGGGFCIGSRAWPNCQNYCFRLALELQAVIVAPDYRLAPENRLPAAIEDGYAALKWLQAQATSDEPDPWLADVADFNRVFISGDSAGGNIAHNLAVRLGSGSTGLAPVRVRGYWRLSIPIGETTDYPLVNPFGPVSPPLEPLDLDPILAMVGGSDLLKDRVKDYTKKLKGWGKKVEYVEFEGQQHGFFTIDPNSQASNDLMLVIKKFIVENSN
>rgor_06326-RA
MTATTLDPSLSLQINTRTHHHHGPLVEEIDGLIRVYKDGHVERPQIMPCTASSSATEPGVTSRDMVIDNFTNIWARFYLPKCHGSLLPLLVYFHGGGFCVGSAAWSCYHEFLGKLAARTSCVIMSVNYRLAPENTLPAAYDDGVKALTWVKQQALCGGGGSEWWSKKCNFSSIFLAGDSAGANIAYNVAIRLSGMAQNPLTIKGIILIQPFFGGERRTNSEKYMVEPPRSSLSLAASDTYWRLSLPPGANRDHPWCNPGAKGSIFPMMVCVAEMDILRDRILEMCDGLARAGKKVECVVHKGVGHAFQVLNKSQLSQTRTLEMISQIRSFISK
>rgor_07965-RA
MINPLDRNGPTLVGLGCSRLLVCVAAEDELREGGWCGDLELFEVEGEGHCFHILNLESESAKNMIKRLASFLLH
>rgor_10341-RA
MDKMESSKPEVSLELPPYLRVYKDGTIERIAGTQVTPANLDPQTGVVSKDMLILPETGVSARLYRPNLTPNHQKLPLVIYFHGGAFCIASVAEPFYHTSLNILAAKANSLVISVDYRLSPENPLPAAYEDSWGALQWLATQISSGGTEDWLKDKVDLGRVFLAGDSAGANISHHLAIRAGTTQIEGLKFRGIVMIHPYFWGKEAIGSEVTDPIRKAMVDSWWLFVCPSEKGNDDPLINPFTDGSPDLSGLACDRVIICVAEKDILRDRGRLYYDRLVKSGWPGTAEVVETEGEDHVFHIFNPSSEKAMDMIKQLASFINKE
>rgor_10951-RA
MASTSNEITREFPPFFRVYKDGRVERYMGSTYVPPSVDPQTGVETKDVLISPETDLKARIFMPKINGPDQKLPLVVHYHGGGFCIGSSFGSFTHGFLTSLSSEARVIAVSVDYRLAPEHPLPIAYDDSWSALQWIATHSSGQGPEPWLNQYADFGRVFLAGESAGANLAHHVAVRVGTASADGFRVNGLIAVHPFFANDEPDEMIRFLYPGSSGSDDDPRLSPKEDPDLAKMGCSRVVVHVAEKDWLKSRGLSYCEVLEKSGWGGKVELVEDEGEDHCFHLFNPSGEKAVILVKSLASFINQD
>rgor_10988-RA
MVICEKKIVEEVSGWLRVFEDGSVDRTWSGPREVEFMTLPVPSHEDFIEGVATRDVVIDAGSGLRARIYLPETNLNSKKLPILLHFHGGGFCISQPDWYMYYHVYTRLARSARAICVSVYLRLAPDHRLPAACHDGFSALLWLSSVAQATKPEPWLKAHADFNRVFLIGDSSGGNLVHEVAARAGKVDLGPVRLAGAIPIHPGFVRSERSKSELEQPESPFLTLDMVDKFLRLALPVGSTKDHPITCPMGEGAPPIFALKLPPMLLCVAEMDLIRDTEMEYYEAMKKANKDVELMINYGMGHSFYLNKIAVDMDPQTTEQTTKLIVGITDFINRH
>rgor_15330-RA
KFSFSLNYRLAPEHRYLIGAALKWVASHAGRSGPDPWINERVNFNRVLRGGRQCGCKHIPQHGNSGRVGNLVSGQTKEDCFDPPHPTPSLLAVKEYMSSNVTKQWSYVCPSCNGLRDPQFNPVSDPNLVTLGCKARGLHLSL
>rgor_15331-RA
MDSATVEVTHDLTPFIRVYKDGRVERLMGTEIVPPSPIDPKTGVESKDVVIVRETGVSARLYKPKTTSPPTQKFPLLIYFHGGAFFVQTAFSPTYQYFLNSLVAETKVIVVSVDYRRAPESPLPIGYEDSWAAVKWVASHSSGAGQEVWLKEHVDFDLVYFGGDSAGANIANNMAIRVGLEGLEGGKLVGVVMMHPYFWGKDPIGSEDTDTDRRGVVERFWLMACPSSTGSDDPLINPAKDPNLPSLGCKRVLVFVAERDLMRDRGRFYYEVLGKSGWGGEVEIEESEGEDHVFHLEKPNCEKAKDMVKRVASFINQHKAKAKA
>rgor_15332-RA
MADEVAQDFPPLGIRVYKDGKVERSKGTEIVPASTDPATGVQSNDVVIDPAIDLTARLYLPRSAAASGSQKLPLLIYLHGGGFCIETAFSPSYHNYLNSVAAEANVVVLSVNYRLAPEHHLPIAYDDSWATIQWAASHSTNHGPEAWLNEYADFNRVFFAGDSAGGNLAHNMAVRVGTARLDGFKLIGIILVHPYFWGKDPVGNEPTDPNTRGFVEGLWFFTFPSSSGCDDPLMNPGKDPKLSGLGCEKVLVFVAEQDILKHRGWFYKAELEKSGWGGAVEVVEDAGENHVFHLFKPSCDNAKAMLKRDPVGNKSTDPNMRGFVDGLWLFAFPSSSRV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University