Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Rhodiola crenulata
Species name
Da hua hong jing tian (Rhodiola crenulata) is a species of eudicot in the family Crassulaceae (stonecrop family).
Species info
Gene sequence info
Rhodiola_crenulata.4CL.fa
Download
>CCG001863.1
MRYITSTTTQLKSGKVRENTLTTSHLIPPSFSIITIVICFSVFFFITAMAIAGKETEEYIFRSKLPDIYIPNHLPLHTYCFENIAQFNDRPCVINGSTGEEFTYAEVELKSRRVASGLNKLGIKQGDVIMLLLQNCPEFVFAFIGASYRGAVSTTANPFYTPAEVAKQAKAAGAKLIITTSSFVEKVKEFGQQNEVKIMTVDSLHDGCLHFSELLNADENEIPAVKINADDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHHEDVIMCVLPMFHIYSLNSILLCGLRAGAAILIMNKFEIVSLMELVQKYKVTIAPFVPPIVLAIAKSPLVDQYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPLEIKSGACGTVVRNAEMKIVDPDTGTSLPRNQAGEICIRGSQIMKGYLNDPAATENTIDKQGWLHTGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLINHSDISDAAVVSMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKRISRVFFIESIPKAPSGKILRKDLRAQVAAVAAN
>CCG023545.1
MDTTQLNLGQEDEHVFRSRFPPAPIPSDISLPDFVLQDAEGRFAKALRSLGLRKGNVVIVVLPNVAEYAIVALGIMAAGGIFSGANPASLAVEIKKQVEAADAKLIVTSGSIYGKVKNLNLPVIILGEERIEGTIYWDELLEAGERASVIHETISQNDLCALPFSSGTTGLSNGVMLTHRNLIANLCSTLFSVPPEMIGQVTTLGLVPFFHIYGITGICCATLRNKGKVVAMSRFDLRIFMDALISQEVTFAPIVPPIILQLVKNPTVDEFDLSKLKLRAIMTAAAPLAPDLLAAFEKKFPNVQVQEAYGLTEHSCITLTHGDPTKENGVAKKNSVGFVLPNLEVKFIDPEKGRSLPCNSPGELCIRSECVMLGYYNNKEETEKTIDNEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILVSHPSVNDAAVIPLPDEEAGEVPAACVVKQPNATESEEEIMEYVASNVAHYKKIRVLYFVDSIPKSTSGKIMRRYLKDTLMDKLKLAKPAT
>CCG027837.1
MISIESQLLPDQLDQQQLLIKDNAEVQPELEALDNAEENHVFRSKLPDIDISNNMPLHSYCFERVSDFSNQTCLVVGSTGKTYSYSETHLLCKRTAAGLAKLGIRKGDVVMILLQNCAEFAFTFFGASMIGAVTTTANPFYTSAEIYKQMVAAGAKLIVTQAQYVEKLKKDDQGGDDELPKIHEDFKVVTIDDPPEDKCLHFSTLSEANEAEIPEVAIDADDPVALPFSSGTTGLPKGVILTHKNLITSVAQQVDGENPNLYLSHSDMVLCVLPLFHIYSLNSVLLCSMRAGSGVLLMHKFEIGTLLQQIEKHRVSVAAVVPPLVIALAKNTKVAEFDLSSIRVVLSGAAPLGKELEDALRSRVPQATFGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVIDPLTGSSLPHNKPGEICIRGAQIMKGYLNDAEATARTIDADGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQACSHNYIHVPPAELEALLISHPHIADAAVVPQKDVNAGEVPVAFVVKSNGLELTEDAVKEFIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDLRAKLALQADAPLPQ
>CCG026858.1
MATVFRSPRPPVTLPADPNTSMLSFLFRDLSSVSTKLALVDADSLETLTFAQLKSTVAKLSHALRRIGIGKGDVVLIFSPNSIRFPVFFLAVLALGAVVTTVNPVYTVGEIAKQVADSKPRLVITVPELFEKVVEFGLPTVLMTSGNVGGLGLRLRVWEYSDLIEMCYGEDELPKAEVNQSDVAALLYSSGTTGLSKGVVLTHRNFIATAVAVTADQDRLSEEERNKVVFICFLPMFHIFGLSVITFAQLQKKNTVVSLGKFEIDKVLKAVQDYRVTHLFVVPPVMIALAKQSVVKNYDLSLLKQIGSGAAPLGKDLMGEVGKNIPGAQIIQGYGMTESCGIISLEDPDFRTRITGSTGHLVAGVESQITDVATMQPLPPNQLGEIWIRGENMMEGYFNNPEATKLTKDEQGWVHTGDLGYFDDEGQLYVVDRIKELIKYKGYQIAPAELEGLLLTHPDILDAVVIPFPDSEAGEVPAAYVVRSSGSSLNEQKVKDFIAKQNKARFAPFVNFINPSDPIAAMGAGFIVGALGGLVLAHAAYSTIHYRGLLKIMEEEFSGPPMNVVLEMIIGFVLCLWAAMTVSGKFLSINLDSEENRTVSLTANLDFMIFNHRGKLFPLETDLKLKH
>CCG006075.1
MDTTQLNIAQEDEHVFRSRFPPAPIPSDITLPDFVLQDAEGYAEKVAFVEAVTGKQYTYSQVVRDTRRFAKALRSLGLRKGNVVIVVLPNVAEYAIVALGIMAAGGIFSGANPASLAVEIKKQVEAADAKLIVTSGSIYGKVKNLNLPVIILGEERIEGTIYWDELLEAGERASVIHETISQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVPPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVAMSRFDLRIFMDALISQEVTFAPIVPPIILQLVKNPTVDEFDLSKLKLKAIMTAAAPLAPDLLAAFEKKFPNVQVQEAYGLTEHSCITLTHGDPTKENGVAKKNSVGFVLPNLEVKFIDPETGRSLPCNSPGELCVRSECVMLGYYNNKEETEKTIDNEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILVSHPSVNDAAVIPLPDEEAGEVPAACVVKQPNATESEEEIMEYVASNVAHYKKIRVLHFVDSIPKSTSGKIMRRFLKDTLMDKLKLAKPAN
>CCG006817.1
MGKELQDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEAWVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLINHPNISDAAVISMKDESAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKKNSRVFFIKSIPKAPSGKILRKDLRIKVAAIAASQLVRSPTFHSFLSLS
>CCG006818.1
MAIAGDKGEAKEYFIFRSKLPEPHLPLHTYCFENIANFSDRPCIINGSTGQQFTYSEVELTSRRIASGLNKLWIKQGDVIMLLLQNCPEFVFAFLGASFRGAVCTTANPFYTSAEVAKQAKAAGAKLIVTTSCVCRESQGVWSTNDVMVLTVDSSPEGCLNFTDLLNADEGETPPVEINENDVVALPYSSGTTGLPKGVMLTHKGLVTTHERSSASRWRESKYVLSPR
>CCG007768.1
MEKSGYGRDGVYRSLRRPRHFPTDPNLSLIPFLLRNVASYPHKPALIDADTGESLTFHILHDTLVKVAHGLKNLGIGKGDVVLIFAPNSIQFPLCFLGAAAIGAIATTANPLYTVSELSKQRKDSNPKLVVTVPELLDKVRGFNLPIVILGSRTVSIPDSINLNTKLILFSELLKSAGSETEFPRVSLKQTDTAALLYSSGTTGVSKGVVLTHRNFITASLMMTSEQDELGEMHNVFLCFLPMFHVYGLAVLTCSNLQRGNAVVSKAKFDLVEVLMAVEKYRVTHLWVVPPVILALAKQSIVKKYDLSTLKQIGSGAAPLGGELMEECSKNLPHVVIVQGYGMTETTGIVSVEESRYGKRHTGSAGTLVYGVEAQIVSVETMKPQPPNRMGEIWVRGPNMMKGYLNNPQATRETIDKNGWVHTGDLGYFDGEGRLFVVDRIKELIKVKGYQVAPAELEGILVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEESVKEYVATQVAPFKRLRRVEFIGNVPKSAAGKILRQELIAKVRSKI
MRYITSTTTQLKSGKVRENTLTTSHLIPPSFSIITIVICFSVFFFITAMAIAGKETEEYIFRSKLPDIYIPNHLPLHTYCFENIAQFNDRPCVINGSTGEEFTYAEVELKSRRVASGLNKLGIKQGDVIMLLLQNCPEFVFAFIGASYRGAVSTTANPFYTPAEVAKQAKAAGAKLIITTSSFVEKVKEFGQQNEVKIMTVDSLHDGCLHFSELLNADENEIPAVKINADDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHHEDVIMCVLPMFHIYSLNSILLCGLRAGAAILIMNKFEIVSLMELVQKYKVTIAPFVPPIVLAIAKSPLVDQYDLSSIRMVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPLEIKSGACGTVVRNAEMKIVDPDTGTSLPRNQAGEICIRGSQIMKGYLNDPAATENTIDKQGWLHTGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLINHSDISDAAVVSMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKRISRVFFIESIPKAPSGKILRKDLRAQVAAVAAN
>CCG023545.1
MDTTQLNLGQEDEHVFRSRFPPAPIPSDISLPDFVLQDAEGRFAKALRSLGLRKGNVVIVVLPNVAEYAIVALGIMAAGGIFSGANPASLAVEIKKQVEAADAKLIVTSGSIYGKVKNLNLPVIILGEERIEGTIYWDELLEAGERASVIHETISQNDLCALPFSSGTTGLSNGVMLTHRNLIANLCSTLFSVPPEMIGQVTTLGLVPFFHIYGITGICCATLRNKGKVVAMSRFDLRIFMDALISQEVTFAPIVPPIILQLVKNPTVDEFDLSKLKLRAIMTAAAPLAPDLLAAFEKKFPNVQVQEAYGLTEHSCITLTHGDPTKENGVAKKNSVGFVLPNLEVKFIDPEKGRSLPCNSPGELCIRSECVMLGYYNNKEETEKTIDNEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILVSHPSVNDAAVIPLPDEEAGEVPAACVVKQPNATESEEEIMEYVASNVAHYKKIRVLYFVDSIPKSTSGKIMRRYLKDTLMDKLKLAKPAT
>CCG027837.1
MISIESQLLPDQLDQQQLLIKDNAEVQPELEALDNAEENHVFRSKLPDIDISNNMPLHSYCFERVSDFSNQTCLVVGSTGKTYSYSETHLLCKRTAAGLAKLGIRKGDVVMILLQNCAEFAFTFFGASMIGAVTTTANPFYTSAEIYKQMVAAGAKLIVTQAQYVEKLKKDDQGGDDELPKIHEDFKVVTIDDPPEDKCLHFSTLSEANEAEIPEVAIDADDPVALPFSSGTTGLPKGVILTHKNLITSVAQQVDGENPNLYLSHSDMVLCVLPLFHIYSLNSVLLCSMRAGSGVLLMHKFEIGTLLQQIEKHRVSVAAVVPPLVIALAKNTKVAEFDLSSIRVVLSGAAPLGKELEDALRSRVPQATFGQGYGMTEAGPVLSMCLAFAKQPFPTKSGSCGTVVRNAELKVIDPLTGSSLPHNKPGEICIRGAQIMKGYLNDAEATARTIDADGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQACSHNYIHVPPAELEALLISHPHIADAAVVPQKDVNAGEVPVAFVVKSNGLELTEDAVKEFIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDLRAKLALQADAPLPQ
>CCG026858.1
MATVFRSPRPPVTLPADPNTSMLSFLFRDLSSVSTKLALVDADSLETLTFAQLKSTVAKLSHALRRIGIGKGDVVLIFSPNSIRFPVFFLAVLALGAVVTTVNPVYTVGEIAKQVADSKPRLVITVPELFEKVVEFGLPTVLMTSGNVGGLGLRLRVWEYSDLIEMCYGEDELPKAEVNQSDVAALLYSSGTTGLSKGVVLTHRNFIATAVAVTADQDRLSEEERNKVVFICFLPMFHIFGLSVITFAQLQKKNTVVSLGKFEIDKVLKAVQDYRVTHLFVVPPVMIALAKQSVVKNYDLSLLKQIGSGAAPLGKDLMGEVGKNIPGAQIIQGYGMTESCGIISLEDPDFRTRITGSTGHLVAGVESQITDVATMQPLPPNQLGEIWIRGENMMEGYFNNPEATKLTKDEQGWVHTGDLGYFDDEGQLYVVDRIKELIKYKGYQIAPAELEGLLLTHPDILDAVVIPFPDSEAGEVPAAYVVRSSGSSLNEQKVKDFIAKQNKARFAPFVNFINPSDPIAAMGAGFIVGALGGLVLAHAAYSTIHYRGLLKIMEEEFSGPPMNVVLEMIIGFVLCLWAAMTVSGKFLSINLDSEENRTVSLTANLDFMIFNHRGKLFPLETDLKLKH
>CCG006075.1
MDTTQLNIAQEDEHVFRSRFPPAPIPSDITLPDFVLQDAEGYAEKVAFVEAVTGKQYTYSQVVRDTRRFAKALRSLGLRKGNVVIVVLPNVAEYAIVALGIMAAGGIFSGANPASLAVEIKKQVEAADAKLIVTSGSIYGKVKNLNLPVIILGEERIEGTIYWDELLEAGERASVIHETISQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVPPEMIGQVTTLGLIPFFHIYGITGICCATLRNKGKVVAMSRFDLRIFMDALISQEVTFAPIVPPIILQLVKNPTVDEFDLSKLKLKAIMTAAAPLAPDLLAAFEKKFPNVQVQEAYGLTEHSCITLTHGDPTKENGVAKKNSVGFVLPNLEVKFIDPETGRSLPCNSPGELCVRSECVMLGYYNNKEETEKTIDNEGWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVAPAELEAILVSHPSVNDAAVIPLPDEEAGEVPAACVVKQPNATESEEEIMEYVASNVAHYKKIRVLHFVDSIPKSTSGKIMRRFLKDTLMDKLKLAKPAN
>CCG006817.1
MGKELQDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEAWVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLINHPNISDAAVISMKDESAGEVPVAFVVRSNGSKITEDEIKQYISKQVVFYKKNSRVFFIKSIPKAPSGKILRKDLRIKVAAIAASQLVRSPTFHSFLSLS
>CCG006818.1
MAIAGDKGEAKEYFIFRSKLPEPHLPLHTYCFENIANFSDRPCIINGSTGQQFTYSEVELTSRRIASGLNKLWIKQGDVIMLLLQNCPEFVFAFLGASFRGAVCTTANPFYTSAEVAKQAKAAGAKLIVTTSCVCRESQGVWSTNDVMVLTVDSSPEGCLNFTDLLNADEGETPPVEINENDVVALPYSSGTTGLPKGVMLTHKGLVTTHERSSASRWRESKYVLSPR
>CCG007768.1
MEKSGYGRDGVYRSLRRPRHFPTDPNLSLIPFLLRNVASYPHKPALIDADTGESLTFHILHDTLVKVAHGLKNLGIGKGDVVLIFAPNSIQFPLCFLGAAAIGAIATTANPLYTVSELSKQRKDSNPKLVVTVPELLDKVRGFNLPIVILGSRTVSIPDSINLNTKLILFSELLKSAGSETEFPRVSLKQTDTAALLYSSGTTGVSKGVVLTHRNFITASLMMTSEQDELGEMHNVFLCFLPMFHVYGLAVLTCSNLQRGNAVVSKAKFDLVEVLMAVEKYRVTHLWVVPPVILALAKQSIVKKYDLSTLKQIGSGAAPLGGELMEECSKNLPHVVIVQGYGMTETTGIVSVEESRYGKRHTGSAGTLVYGVEAQIVSVETMKPQPPNRMGEIWVRGPNMMKGYLNNPQATRETIDKNGWVHTGDLGYFDGEGRLFVVDRIKELIKVKGYQVAPAELEGILVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEESVKEYVATQVAPFKRLRRVEFIGNVPKSAAGKILRQELIAKVRSKI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University