Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Aquilaria sinensis
Species name
Aquilaria sinensis is a species of eudicot in the family Thymelaeaceae (mezereum family).
Species info
Gene sequence info
Aquilaria_sinensis.4CL.fa
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>evm.model.Scaffold36.169
MEKSGFGRDGVYRSLRPPLAFPKDPNLSMTSFLFRNASSYPDAPALIDADSGEALSFSQFKSAVIKVAHSFLHLGIRKNDVVMIFAPNSIRFPICFLAVTAVGGIATTVNPIYTVGELSKQIEDSKPKLLVTVSQLLGKLESFKLPVVLLGSEQKHEFPSKIYSFHEFLNMSGNSTEFPEVTIKQSDTAALLYSSGTTGTSKGVILTHGNFIAASQMVVVDQDAAGDVHNRFICVLPMFHVFGLSVLLYSQLQRGNAIISMAKFDFEELLKNVEKYKVTHLWVVPPIILALAKQSVIKKFDLSSLRQIGSGAAPLGKDLMLECAKNFPHAVVMQGYGMTETCGIICLENLNHGLRHSGSAGLLVSGVESQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNPKATKETIDKKGWVHTGDLGYFDDNGFLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPYPDAEAGEVPIGYVVRKPSSSLTEEDVINFIAKQVASFKRLRRVTFVNAVPKSASGKILRRELIAKVRAKM
>evm.model.Scaffold23.7
MTVDSPPEGCLHFSALIEADEREMPEAKIEPEDVVALPYSSGTTGLPKGVAQQVDGENPNLYFHQEDVILCVLPLFHIYSLSSVLMASLRVGAAMLIVPKFEMVRLMELVEKHKVTVAALVPPILLAVSKSTELEKYDLSSIRIVLSGAAPMGKELEESVRAKLPNARLGQGYGMTEAGPVISMCLAFAKEPMEIKPGASGTVVRNAEMKIGYLNDPESTRRTIDKQGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQVAPLSLRLSCLLIPPSLTPLLFRAMKDEAAGEVPVAFVVRSNASNISEDDIKLYISKQVVFYKRLNRVFFTDMIPRAVSGKILRKQLRAKLAA
>evm.model.Scaffold23.6
MSPFRDPKRHGEKIENWILDRLVCVNGEVEDEFRNRPCLINGPDGRVYTYADVELTARKVAAGLNNLGIRQGDVIMILLHNSPEFVFAFLGASFRGAVNTTANPFCTPAEIAKQATASNTKLIITQSAYVEK
>evm.model.Scaffold123.11
MSTPVQASSQDDDDHIFRSRFPPIPVPDNVSLPEFVLQDAELYADKVAFVEAVTGKAYTYQEVTRDTYRFAKALRSLGLKKGNVVIVVLPNIAEYGIVALGIMAAGGVFSGANPRAHQSEIKKQVEAANAALIVTDSPSYERVKGIELPVIVVGDEKIEGAVNWNELLQAANRAGTRSCNEKVLQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSSLFSVSKEMIGHVTTLGLIPFFHIYGITGICCATLRNKGKVVTMTRFDLRTFLSTLITHEVSFAPIVPPIILDLVKNPIMKEFDVSKIKLRAVLTAAAPLAPDILTAFEHKFPGVQVQEAYGLTEHSCITLTHGDPNTKHGTAKKNSVGFILPNLEVKFIDPDTGKSLPKNTPGELCVRSQCVMKGYYNSEEETARTIDKHGWLHTGDIGYIDEDGDIFIVDRIKELIKYKGFQVAPAELEAVLLAHPSVEDAAVVPLPDEEAGEIPAAFVVKNSNSKEKEEDIMEFVASNVASYKKVRLVYFVDAIPKSPSGKIMRRLLKDKLMEKMTNSNSTISK
>evm.model.Scaffold3.711
MGEINYHREEEFLFRSKLPDIYIPNHLPLHTYCFQNISQFRNRPCLINGPDGRVYTYADVELTAGKVAAGLNNLGIRQGDVIMILLHNSPEFVFAFLGASFRGAVNTTANPFCTPAEIAKQATASNTKLIITQSAYVEKIKNLPGIKVMTVDSPPEGCLHFSALIEADEREMPEAKIEPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHQEDVILCVLPLFHIYSLSSVLMASLRVGAAMLIVPKFEMVRLMELVEKHKVTVAALVPPILLAVSKSTELEKYDLSSIRIVLSGAAPMGKELEESVRAKLPNARLGQGYGMTEAGPVISMCLAFAKEPMEIKPGASGTVVRNAELKIVDPDTGASLPRNRPGEICIRGSQLMKGYLNDPESTRRTIDKQGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQVAPAELEAILLAHPSISDAAVVPMKDEAAGEVPVAFVVRSNASNISEDDIKLYISKQVVFYKRLNRVFFTDMIPRAVSGKILRKQLRAKLAA
>evm.model.Scaffold351.9
MAPQEEFIFRSKLPDIYIPNHLPLHSYCFQNLKDVASRPCLINGATGKVYTFAEVELTARRVAAGLHKLGIKQHDVIMLLLPNSPEFVLSFLGASFRGSVATMANPFFTAAEIAKQAKASNSKVIITQACYVDKLRDLATENDMKIICIDSAPDGCLHFSELSEVDETQLPAVEIDPDDVVALPYSSGTTGLPKGVMLSHKGLVTSVAQQVDGENPNLYLHSEDVILCVLPMFHVYALNSIMLCGLRVGAAILIMPKFEIGQLLGLIEKYKVTILPIVPPIVLAIAKSPETEKYDLSSVRMLKSGAAPMGKELEDAVRAKFPGARLGQGYGMTEAGPVLAMCLGFAKKPFEIKSGACGTVVRNAEMKIVDPETGDSLPRNQPGEICIRGDQIMKGYLNDPEATASTIDKEEWLHTGDIGFIDDADELFIVDRLKELIKYKGFQVAPAELEALLIAHPQIVDAAVVAVKDEAAGEVPVAFVVKSENSKLTEDEIKLYVSKQVIFYKRINRVFFIEAIPKAPSGKILRKELRTKLQTPGN
>evm.model.Scaffold272.14
MISVAEPQNAEIPNPTPAASVSSSNDMTSDHVFRSKLPDIPISSHLPLHTYCFENLRQFSDNPCLISGSTGRKFSYAETHVMCLKTAAGLSRLGVGKGDVIMILLQNCPEFVFSFMAASMIGAVSTTANPFYTSAEIFKQFAAAKPKLIVTQAQYVDKLRDNDKNLRLNEDFKVVTIDDPPENCLHFTVLSEGNEGEVPEAEIDPDDAVAMPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKEDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLFMHKFEIGALLELIQRHKVSVAAVVPPLVLALAKNPLVAQFDLSSIRVVLSGAAPLGKELEGALRSRLPQAIFGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPDTGCSHGYNQPGEICIRGAQIMKGYLNDPDATATTIDAHGWLHTGDIGYVDDDDEVFIIDRVKEIIKFKGFQVPPAELEALLLTHPLIADAAVVPQKDEVAGEVPVAFVVRSSNGIELTEEAVKEHIAKQVVFYKKLHKVQFVHAIPKSPSGKILRKDLRAKLVVATTTT
MEKSGFGRDGVYRSLRPPLAFPKDPNLSMTSFLFRNASSYPDAPALIDADSGEALSFSQFKSAVIKVAHSFLHLGIRKNDVVMIFAPNSIRFPICFLAVTAVGGIATTVNPIYTVGELSKQIEDSKPKLLVTVSQLLGKLESFKLPVVLLGSEQKHEFPSKIYSFHEFLNMSGNSTEFPEVTIKQSDTAALLYSSGTTGTSKGVILTHGNFIAASQMVVVDQDAAGDVHNRFICVLPMFHVFGLSVLLYSQLQRGNAIISMAKFDFEELLKNVEKYKVTHLWVVPPIILALAKQSVIKKFDLSSLRQIGSGAAPLGKDLMLECAKNFPHAVVMQGYGMTETCGIICLENLNHGLRHSGSAGLLVSGVESQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYFNNPKATKETIDKKGWVHTGDLGYFDDNGFLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPYPDAEAGEVPIGYVVRKPSSSLTEEDVINFIAKQVASFKRLRRVTFVNAVPKSASGKILRRELIAKVRAKM
>evm.model.Scaffold23.7
MTVDSPPEGCLHFSALIEADEREMPEAKIEPEDVVALPYSSGTTGLPKGVAQQVDGENPNLYFHQEDVILCVLPLFHIYSLSSVLMASLRVGAAMLIVPKFEMVRLMELVEKHKVTVAALVPPILLAVSKSTELEKYDLSSIRIVLSGAAPMGKELEESVRAKLPNARLGQGYGMTEAGPVISMCLAFAKEPMEIKPGASGTVVRNAEMKIGYLNDPESTRRTIDKQGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQVAPLSLRLSCLLIPPSLTPLLFRAMKDEAAGEVPVAFVVRSNASNISEDDIKLYISKQVVFYKRLNRVFFTDMIPRAVSGKILRKQLRAKLAA
>evm.model.Scaffold23.6
MSPFRDPKRHGEKIENWILDRLVCVNGEVEDEFRNRPCLINGPDGRVYTYADVELTARKVAAGLNNLGIRQGDVIMILLHNSPEFVFAFLGASFRGAVNTTANPFCTPAEIAKQATASNTKLIITQSAYVEK
>evm.model.Scaffold123.11
MSTPVQASSQDDDDHIFRSRFPPIPVPDNVSLPEFVLQDAELYADKVAFVEAVTGKAYTYQEVTRDTYRFAKALRSLGLKKGNVVIVVLPNIAEYGIVALGIMAAGGVFSGANPRAHQSEIKKQVEAANAALIVTDSPSYERVKGIELPVIVVGDEKIEGAVNWNELLQAANRAGTRSCNEKVLQTDLCALPFSSGTTGLSKGVMLTHRNLVANLCSSLFSVSKEMIGHVTTLGLIPFFHIYGITGICCATLRNKGKVVTMTRFDLRTFLSTLITHEVSFAPIVPPIILDLVKNPIMKEFDVSKIKLRAVLTAAAPLAPDILTAFEHKFPGVQVQEAYGLTEHSCITLTHGDPNTKHGTAKKNSVGFILPNLEVKFIDPDTGKSLPKNTPGELCVRSQCVMKGYYNSEEETARTIDKHGWLHTGDIGYIDEDGDIFIVDRIKELIKYKGFQVAPAELEAVLLAHPSVEDAAVVPLPDEEAGEIPAAFVVKNSNSKEKEEDIMEFVASNVASYKKVRLVYFVDAIPKSPSGKIMRRLLKDKLMEKMTNSNSTISK
>evm.model.Scaffold3.711
MGEINYHREEEFLFRSKLPDIYIPNHLPLHTYCFQNISQFRNRPCLINGPDGRVYTYADVELTAGKVAAGLNNLGIRQGDVIMILLHNSPEFVFAFLGASFRGAVNTTANPFCTPAEIAKQATASNTKLIITQSAYVEKIKNLPGIKVMTVDSPPEGCLHFSALIEADEREMPEAKIEPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHQEDVILCVLPLFHIYSLSSVLMASLRVGAAMLIVPKFEMVRLMELVEKHKVTVAALVPPILLAVSKSTELEKYDLSSIRIVLSGAAPMGKELEESVRAKLPNARLGQGYGMTEAGPVISMCLAFAKEPMEIKPGASGTVVRNAELKIVDPDTGASLPRNRPGEICIRGSQLMKGYLNDPESTRRTIDKQGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFQVAPAELEAILLAHPSISDAAVVPMKDEAAGEVPVAFVVRSNASNISEDDIKLYISKQVVFYKRLNRVFFTDMIPRAVSGKILRKQLRAKLAA
>evm.model.Scaffold351.9
MAPQEEFIFRSKLPDIYIPNHLPLHSYCFQNLKDVASRPCLINGATGKVYTFAEVELTARRVAAGLHKLGIKQHDVIMLLLPNSPEFVLSFLGASFRGSVATMANPFFTAAEIAKQAKASNSKVIITQACYVDKLRDLATENDMKIICIDSAPDGCLHFSELSEVDETQLPAVEIDPDDVVALPYSSGTTGLPKGVMLSHKGLVTSVAQQVDGENPNLYLHSEDVILCVLPMFHVYALNSIMLCGLRVGAAILIMPKFEIGQLLGLIEKYKVTILPIVPPIVLAIAKSPETEKYDLSSVRMLKSGAAPMGKELEDAVRAKFPGARLGQGYGMTEAGPVLAMCLGFAKKPFEIKSGACGTVVRNAEMKIVDPETGDSLPRNQPGEICIRGDQIMKGYLNDPEATASTIDKEEWLHTGDIGFIDDADELFIVDRLKELIKYKGFQVAPAELEALLIAHPQIVDAAVVAVKDEAAGEVPVAFVVKSENSKLTEDEIKLYVSKQVIFYKRINRVFFIEAIPKAPSGKILRKELRTKLQTPGN
>evm.model.Scaffold272.14
MISVAEPQNAEIPNPTPAASVSSSNDMTSDHVFRSKLPDIPISSHLPLHTYCFENLRQFSDNPCLISGSTGRKFSYAETHVMCLKTAAGLSRLGVGKGDVIMILLQNCPEFVFSFMAASMIGAVSTTANPFYTSAEIFKQFAAAKPKLIVTQAQYVDKLRDNDKNLRLNEDFKVVTIDDPPENCLHFTVLSEGNEGEVPEAEIDPDDAVAMPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKEDDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLFMHKFEIGALLELIQRHKVSVAAVVPPLVLALAKNPLVAQFDLSSIRVVLSGAAPLGKELEGALRSRLPQAIFGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPDTGCSHGYNQPGEICIRGAQIMKGYLNDPDATATTIDAHGWLHTGDIGYVDDDDEVFIIDRVKEIIKFKGFQVPPAELEALLLTHPLIADAAVVPQKDEVAGEVPVAFVVRSSNGIELTEEAVKEHIAKQVVFYKKLHKVQFVHAIPKSPSGKILRKDLRAKLVVATTTT
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University