Enzyme

Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.

COMT

Enzyme

Flavone 3'-O-methyltransferase

Enzyme name

EC:2.1.1.76

Entry

Transferases;Transferring one-carbon groups;Methyltransferases

Class

S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase

Sysname

S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]

Reaction

S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]

Product

Species information

Piper nigrum

Species name

Piper nigrum is a species of flowering plant in the family Piperaceae (pepper family).

Species info

Gene sequence info

Piper_nigrum.COMT.fa

Download
>evm.model.Pn1.1318
MFVLSKCRYHLKDAVLEGGISFNKAYGMTAFEYLGTDTRLNKMFNRGMSNHTTLVMNKILEVYNGFAELSSLTDVGGGLGVTTNLIVTKYPHIKAINFDLKHVIDDAPAYPGVEHAHGDYFTIGPRGDAIFMKWILHDWNDEHCVKILKNCLKALPDSGKVIIAEMVLPMTPIPTTDARRVFQVDMVMLAYIPGGKERTQREYESLAKAAGFSEIKAVCCAYNTWVMEIYKQDDGVAGYWIIERRYGLAPECKYLVKNEDGGCPRRPKSS
>evm.model.Pn1.1317
MDTPLNQQEGSDENTAAMYAMHLTSLSVLPMTLKAATELDVFEIIARAGPGAYLSSGEIAAQLPTNNPNAPAMLDRMLRLLASHSVLSCSLATLDDGRVERRYGLAPVCKFLVKNEDGVSMAALGLMNHDKVLMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSDHSALVMKKILETYNGFGSIGSLVDVGGGVGVATNLIVSQYPHIKAINFDLEHVIDVAPAYPGVQQVGGDMFESVPSADAIFMKWILHDWSDEHCLKLLKNCYKALPESGKVVIAEMLLSDAPKPTLEASSVFHVDMIMLAHNPGGKERTRREYENLAKAAGFSQLKAVCSAYNVWVMELYK
>evm.model.Pn1.1319
MELPCSKDDASDENTAHLMQLATLGTLPMTLKAAIELDVFEIIAKEGPGAYLSPADIVAHLPTQNTEPPAMLDRMLCLLASYSILSCSVDVLEGSGGRVERRYGLAPVSTYLVKNEGGVSVAPLALLSNHDKVFMESWQPKLLFPIHDKMKMKIP
>evm.model.Pn1.1321
MDTPLNQQEGSDENTAAMYAMHLTSLSVLPMTLKAATELDVFEIIARAGPGAYLSPGEIAAQLPTNNPNAPAMLDRMLRLLASHSVLSCSLATLDDGRVERRYGLAPVCKFLVKNEDGVSMAALGLMNHDKVLMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSDHSALVMKKILQTYNGFGSIGSLVDVGGGVGVATNLIVSQYPHIKAINFDLEHVIDVAPAYPGVQHVAGDMFESVPSADAIFMKLRQGLIGQMKGNWTQEQSFFETRIAQFFEDVEFRGGNEVRDFVFEEESDSLPMIVLDNNQDQGHISDVVQETIPELQDNVENLPNQVISKEETQQPQEQMPLRRSTREKRKAISDDYIIFLEEHEDNIGMWILHDWSDEHCLKLLKNCYKALPESGKVVIAEMLLSHAPKPTLEASYVFHEDVIMLANNPGGKERTQREYENLAKAAGFSQLKAVCSAYNVWVMELYK
>evm.model.Pn1.1320
MLVLVQNVVVCAERQGAAKALSITEIDDLRYWKHLPTDESRTSGNKIVRAYAKDHYFDVVTNVVGLAAAVLGDKFFLWIDPVGPIILAVYTISNWSGTVLENAGTNQICRLPRHLRLLITLPSSPSRPTSLLTDSSAQSAMDAPMDYQHNGDDVDQTTTMLGMQVASLSVLPMALKVAIELDVLKIIAKAQKPPSHRLRSPPSSPPRDARLA
>evm.model.Pn1.1313
MDPLPSLQEKASDENTPALLALQLTCLSVLPMTLKAAIELDVFGIIAKEGPGAYLSPADIVSQLRTQNPEAPTMLDRMLRLLASYCILSCSVDVVEAGSSRVKRRYGLAPVSKYLMKNEDGVSVAPLVLMNQDKVFMESCCGGPGVALIYKSGCVGRPAGEQHGQLWPCGCVGNNIMAVGRMYHLKDALLEGGIPFNKAYNMTPFEYQMTDPRFNKLFNGAMSDSSMLVMKKILETYNGFADLRSLVDVGGGTGVIANLIVSKYPHLKAINFDLKHVIDDAPPYPGVQHVSGDMFTSVPNADAIFMKWILHDWSDECCLKILENCYKALPDHSGKVIIAEQIVPEAAMPTIEAQRVFQVDMVMLAYNPGGKERTQREFESLVKAAGFSGLKSNGPENTLKLPPLRRSRSHPPRAPASHPPTSCPAAAIKKPRPTSHKTTPPPIPPPAAPCHRPLPYPPSRQPPACHPLPPHTPPPVLLPASPCPSPCHRPPAANPRPTAPFPPTRRPRPFPRRRPTPCSPPPPPHPPATKPRPAAPCPPTCCPLPLPLPCCPCHAPPPAPATPPAPPPPPPPIPHAAPLPLPLLPTPRPPTPLPPTPFRQPHATSPCCWPPAASPLPPAPYRRPPAAGPCRRPPTMAPCCRPPGCCHTTPYPFPCCHPPATNPPATNPLPPAPCHQPLLLTPCRRPPTDSPLLLAPAIGPLPRPLATGPLPLPPAPPDGLPSCHGLPPPLTCGTCCVGVEEA
>evm.model.Pn1.1316
MLAPVCKVKNEDGVSTVALGLMNHAKQGLAAEDGSNTASASDAGTGAERGGLCRATGCGTGSDSLFLAHRRVPASGAELVRAEIWLAMNTGGICLLLSAKALSITEIDDLRYWKHLPTDESRTSGNKIVRAYAKDHYFDVVTNVVGLAAAVLGDKFFLWIDPVGPIILAVYTISNWSGTVLENAGTNQICRLPRHLRLLITLPSSPSCPTSLLNASSAQSAMDAPMDYQHNGDDVDQTTTMLGMQVASLSVLPMALKVAIELDVFKIIAKAQKPPSHRLRSPPSSPPRDARLA
>evm.model.Pn6.2812
SLRGYSTAAESKEANVKVPLSLFGVAGNYASALFIAASKANALQKVESEILDIVEASKNSPVFSQFIKDLSVPADTRVKAVQEIFSEAKFSDITKNFLCILAENGRLRHVETIAKNFTDLTMAHRGEVKATVTTVIPLPAEEEKQLKEILGTIIGQGKTVKLEQKIDQSILGGIVIEFSQKVFDMSIKTRAKNMEAFLRVPINFNDLQ
>evm.model.Pn16.1844
MKNGYNSLPKGGKLIACEPVVPETTDTSNRTRALLEGDILVMAIYRAEGKERTEEEFRQLGHSAGFSSFRAVYVDHFYTFLELQK
>evm.model.Pn16.1831
MTTLALLAQKRREVHSPMPLAPPVMIATFPSGLLEEFTTLASMETLQANVARQSLALNGNKSLPKGRKLIVCEPVVPETTDTSNRTRALLVSDIFVMPIYRAKGKERTEEEFRASGLSMLIISILFLSSRSDQ
>evm.model.Pn19.1109
MDGTDEELFQSAFYLCTSASILSTALVAAIELDVLQIIAGSGPGARLSPPEIAGHLPTHNPDAAERFTGYSEC
>evm.model.Pn19.1110
MDDADEELFQSAFYLCTSASILPAALVAAIELDVLQIIAGSGPGARLSPAEIVGHLPTRNPDAAAALHRILRVLASHSILECSLSCEGEAKYGLRPVCKFLVNDKDGLSLNAWPLLLQCKAYLDSWQYMKDAVLEGGVPFEKAHGMRFYQLQAVNPQFNETFAKAMAAHSTLAVKKMLDTYNGFEGLAELMDVGGGTGSTLNLIVFKYPQIKGTNFDLKHVIETAPNYPGVKHVSGDMFVSLPNAKNIFMKHVLHNWSDEHCVELLKNCYASLPETGKLIVVDGIVGEEVDAGLTATNICAMDLLMQQLLPNAKERTSKEFQDLARASGFSQFKPICPIYGLWVMEFHK
>evm.model.Pn15.1255
MATPISLLDLAAAIPIPVVKVPHLLRLLRLLIHLGVFTVDQTANNDLEPGYCLTPISELLLSTNAHAKMVLDPYLVNPCFYFGDWLKMEGSMPFELCHGGSMWEVAARKSDFNMGFNAAMASDSHFWMNTIVEKCPHVFQGLRTLIDVGGGIGVTARTIAKAFPHLDVKVLDLPHVVAQMPADAAGNVEAIGGDMFKYIPPADAIFLKWILHDWNDKVCVQILRKCKEAVP
>evm.model.Pn15.789
MESHLHLLNVSDEDSAAMLAMQLASLSVVPMTLKAAIELGVFEVIAEAGPKAYLSPADIAAELPTENPQATTMLDRMLRLLASYNVLSYLLVTGEDGQVERRYGLAPAGKFLVKNKDGVSVAPLGLMNQDEVLMKSWYHLKDAVLDGGIPFNKAYGMSAFEYHGTDRRFNKVFNRGMSDHSALVTNKLLETYTGFEGVESLVDVGGGVGVTTSLIVSKYPNIKGINFDLKHVIDDAPNFPGVQHVGGDMFDSVPSADAIFMKWILHDWSDEHCLTLLKNCYKALPATGKAIVVEMVILDDPKPSLESSGVYQVDMIMLAHNPGGKERTQREFESLAKAAGFSGLKSVCSVYNIWVMEFYK
>evm.model.Pn8.263
MASDPEDEYCLCYSCMGVLCSDFDQDYVKDAILEGRVPFDKAHGMVAVVCPGTDPRFKKWIPHDWGDEKCIQSLKNCYDSLPQNGKVIVIDSIAPVMPENNVSTRAVFLCDILMLSFNPGGKARTFDEFLALAKAAGFAGTRSVCNVNIYVVMEFYK
>evm.model.Pn23.375
MESISDNGLFEQAVQVCTMGWVPMALKAAIELDVLNIIARAGPNARLSAVEIVGQLPSKNPGMSAVMLNRVLQLLASHSILTCVVDDGEEQKYGLAILSKFLVGSEDDGSLAPLVVMCYDKVQMESWYYLKEGIFEGEVPFQRAFDNGPFEGLKELVDVGGGVGANLRLVLSKYPHIKGINYDLKHAIDTAPPLPGEEDDLTSSEAKYVLRADVLMMAVTHGKERTQKEFEALAMAAGFSTFKKLFTAYSTWVMEFHK
>evm.model.Pn23.369
MESISDNGLFEQAVQVCTMGWVPMALKAAIELDVLNIIARAGPNARLSAAEEIVGQLPSKNPGMSAVMLNRVLQLLASHSILTCVVDDGEEQRYGFAILSKFLVGRQDDGSLAPLVVMCYDKVQMESWYYLKEGIFEGEVPFERAFDNGPFEGLKELVDVGGGVGANLRLILSKYPHIKGIKYDLKHAIDTAPPLPVVKHVSGDLFESVPSGEAIFMKASEEDDLTSSDAKYVLRADVLMMAVTHGKERTQKEFEALAMAAGFSTSKKLFNAYSTWVMEFHK
>evm.model.Pn24.716
MDGYSDGFRGVRKLVDVGGSAGTSLRLIMDRFPNVSEGVNFDLPEVVARAPTLPGVTHVGGDMFKWIPSGDAIFMKWVLTTWTDDECLTIMKNCYNSLPEGGKLIACEPVVPETTDTSSRTRALLEGDIFVMAIYRAKGKERTEEEFRQLGHSVGFSSFRAVYVDHFYTVLEFQK
>evm.model.Pn25.170
MRLLTYSGIFAVDQNGAYTLTSFSRPLLPGPNGTSLAAISLLSLESGVVDLWNHLDEWYKVENAEMASFDVAHGMSTLDYLQCEPRLQGYFNEAMAADYELLMNTMVTIVARCSMGFVRWWTLAVAFAWRLSQGHTRPNFLPKRSPCDVFLS
>evm.model.Pn17.1668
MLERILQVLASHSVLLCEAGEGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFEYHGRDPRFNDVFNHGMSSHSTMVMKKVLSIYKGFEGLKELVDVGGGVGANLSLILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASVPSGDAIFMKWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTNNVAKDVLHEDLLMLALNHGGKERTQKELEALAMAAGFSAFNKLCNAYNTWVMEFHK
>evm.model.Pn17.1669
MDSRDNELCMEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLSTAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGEGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDRRFNNVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSIILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASVPSGDAIFMKWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKELEALAMTAGFSAFNKICNAYNTWVMEFHK
>evm.model.Pn17.1666
MDSRDNELCMEVMQVATMGFVPMALKAAIDLNVINIIARAGAKARLSAAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGDGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKGVLEGGVPFEKAHGMKAFDYHGRDPRFNDVSNHGM
>evm.model.Pn17.1667
MDSRDNELCMEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLSTAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGDGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDRRFNNVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSIILSQYPQIKGINYDLKHVIDVAPPHPGLDHISGDMFASVPSGDAIFMKASIKQWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLAVNHGGKERTQKELEALAMAAGFSAFDKLCNAYNTWVMEFHK
>evm.model.Pn17.1664
MALKAAIDLNVINIIARAGPKARLSAAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGDGERRYGLLPLCKFLESWYYFKEGVLEGAVPFEKAHGMKAFDYHGRDTRFNNVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSIILSKYPQIKGINYDLKHWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKSWKLWQ
>evm.model.Pn17.1665
MVMKKVLNIYKGFEGLKELVDVGGGVGANLSLILSKYPQIKGINYDLKHVTEVAPPHPGLDHISGDMFASVPSGDAIFMKWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKELEALAMAAGFSAFNKLCNAYNTWVMEFHK
>evm.model.Pn17.1662
MDSRDNELYVEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLSAAEIAEKLPSKNPDVAAAMLERILQVLASHSVLLCEAREGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDPRFNDVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSLILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASVPSGDAIFMKWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKELEALAMTAGFSAFNKICNAYNTWVMEFHK
>evm.model.Pn17.1663
MDSRDNELYVEVMQVATMGFVPMALKAAIDLNVINIIARAGPKAGLSAAEIAEKLPSKNPDVAAAMLERILQVLASHSVLLCEAGEGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDPRFNDVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSLILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASVPSGDAIFMKASIKQWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKELEALAMAAGFSAFNKLCNAYNTWVMEFHK
>evm.model.Pn17.1661
MDSRDNELCMEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLSAAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGDGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDPRFNNVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSIILSQYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASVPSGDAIFMKWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQRELEALAMTAGFSAFNKICNAYNTWVMEFHK
>evm.model.Pn17.1671
MDSRDNELCMEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLSAAEIAEKLPSKNPDVAAAMLERILRVLASHSVLLCEAGDGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDPRFNNVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSIILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASWILHDWSDKDCLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQKELEALAMTAGFSAFNKICNAYNTWVMEFHK
>evm.model.Pn17.1670
MDSRDNELYVEVMQVATMGFVPMALKAAIDLNVINIIARAGPKAGLSAAEIAEKLPSKNPDVAAAMLERILQVLASHSVLLCEAGEGERRYGLLPLCKFLVPNEDGLSLSPFVTLILDKVFQESWYYFKEGVLEGGVPFEKAHGMKAFDYHGRDPRFNDVFNHGMSSHSTMVMKKVLNIYKGFEGLKELVDVGGGVGANLSLILSKYPQIKGINYDLKHVIEVAPPHPGLDHISGDMFASWILHDWSDKECLKILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDLLMLALNHGGKERTQNELEALAMAAGFSAFNKLCNAYNT
>evm.model.Pn17.1725
MESISDNQLCELALQVCTMGFVSMALKAAIELDVLNFIARAGLDARFSAAEITGHVCHHAESSPSVAGQSLRP
>evm.model.Pn17.1723
MDSRDNELYVEVMQVATMGFVPMALKAAIDLNVINIIARAGPKARLWAAEIAEKLPSKNPDVAEAMPERILRMLVSHSSSFARPGTESGGMDFFPFASSWYYFKEGVLEGGVPFKKAYGMKAFEYHGRDPRFNNVFNHGMSSHSTMVMKKGLNIYKGFEGLKELVDVGGGILKNCYQALPEGGKIIVLESILPGEEDDLTSNVAKDVLHEDPHVGIKPWR
>evm.model.Pn17.1724
MKKILNIDNGPFEELKELVDVGGGIVVNLMLILYKYPHIKGINYDLKHVIDTAPPLPHEEDDLTRSDAKNVLRADVLMLAVSPGKERTQKEFEALAMAAGFSTFKKLFHAYNTWVLEFHK
>evm.model.Pn17.1051
MDTPLNQQKGSDENTAAMFAMHLTSLSVLPMTLKAATELDVFEIIARAGLGAYLSPAEIAAQLPTENRNAATMLDRMLRLLASYSVLRCSLTTLNDGRVERRYGLAPVCKFLVKNEDGVSMAPLGLMNHDKILMESWYHLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSDHSTLVMKKILETYNGFLSIGSLVDVGGGIGVTTNLIVSQYPHITAINFDLEHVIDVAPAYPGVQHVGGDMFESVPSADAIFMKWILHDWSDVHCLKLLENCYKALPESGKVIIAEMLLSDAPKPTLEVSSVFHVDMIMLAHNPGGKERTQREYENLAKAAGFSELKAVCSAYNVWVMELYK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University