Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Piper nigrum
Species name
Piper nigrum is a species of flowering plant in the family Piperaceae (pepper family).
Species info
Gene sequence info
Piper_nigrum.HIDH.fa
Download
>evm.model.Pn28.377
MGALPLSDQSLEATMGKKHKTQHQHGAVLDEVKGLVKLYKDGHIERYPVVPHVTCRSNPDPSVTSGDVVIDSCHGVWARFYVPKRQTRLPLLIYFHGGGFCVGSAAWKCYHEFLLRLAGVVGCVVMSVNYRLAPENRLPAAFDDGVAAVKWVRQKAIAFRSEEQSWWGAMCDFSKVFIVGDSAGGCLAHNVMLQLTSINGANLSNALSPVCIRGLILIQPFFGGEARTWSEKNMTQPPNSALTLSAADSYWRLSLPAGATRDHPWCNPLSTTAKAAAKRAESLCLPPVLVCISELDILKDRNMEFCSFMKMAGKKVEHVVHVGVGHAFQILHKSPTAQARTKEMISQISSFVNTL
>evm.model.Pn19.1229
MDQISPSTLPKQVENCRNVLFVYSDGSIVRSAQPSFNATVHDDGSVLYKDVDFDTNHHLSLRLYKPSATTAVSGKLPVFFYFHGGGYCIGSRTWPNCQNYCLNLARSLPAVIVAPDYRLAPENRLPASIEDSVAAVEWLKGQAVGEEPDEWLVGVADFRRVFISGDSAGGNIAHHLAVRLGIGSPGLEPVMVRGYVFLAPFFGGTTRTRSESECPKDAFFPLELNDRFWRLSLPLGADTDHSFSNPFGPASTSLESVSLDPILVVIGGADLLRDRAREYTEKLKAWGKRVELAEFEGEQHGFYTIDPFSKASDELMRLIQRFITDNSS
>evm.model.Pn15.2750
MGSDVPPTEVENIAGIVRYFSDGTVQRSDPTFDIAVADKGSVAWEDVEFNKVHRLSAHVYKPSAATGKLPLFIYLHGGGFCIGSCTWPHCHNYCHHLADRLQVIVVAPNYHLAPESRLPAAIDDGLAALSWLRDEAQASDGWLAGAADFGRVVVCGDSAGGNIAHHLAVKIAGGSADLDPIRVRGYILLGPFFGGAVRTRSELECPEDALFNLETNDRYV
>evm.model.Pn15.2746
MGSDVPPTEVENIAGIVRYFSDGTVQRSDPTFDIAVADKGSVAWEDVEFDKVHRLSAHVYKPSAATGKLPVFIYLHGGGFCIGSCTWPHCHNYCHHLADRLQVIVVAPNYRLAPESRLPAAIDDGLAALSWLRDEAQASDGWLAGAADFGRVVVCGDSAGGNIAHHLAVKIAGGSADLDPIRVRGYILLGPFFGGAVRTRSELECPEDALFNLETNDRFWRLSLPPGANRDHPFSNPFGRGSQDLESLSLDPILVVVGSDDLLRDRAEYYAKKLKEWRKHIEFIEFKGQKHGFSLTNPSSEESEKLNKIMEQFISQISDSN
>evm.model.Pn43.5
MGALHLSDQSLEARMGKKHKNQHQHGAVPDEVKGLVKLYKDGHVERYPDVPHVTCRSNPDPSVTSGDVVIDSCHRVWARFYVPKRQTKLPILIYFHGGGICVGSAA
>evm.model.Pn3.3230
MGAISGSDSRSWLRGVKANHNNGLVEEIEGLIRVCMDGKVERHPIMPIVACGYVSESDVASWDATIDANNGVWARFYLPKRQRKLPLLIYFHGGGFCVGSPAWKCYHNFLSKLASTAECIIMSVNYRLAPEHRLPAAFEDGAMAVKWAREQASKRQKEQSWWWAWCNFSNVFIGGDSAGACLAYNVVIGTSPSVLTPLCLKGMVLVQPFFGGEARTKSERSMDQPPNSVLTLKTSDCYWRMALPVGTNRDPSMVQPTVEGLE
>evm.model.Pn3.3842
MDAPPPLPISTPKDDDEVLHHIPPFGRIYKSGRVERFLGTAIVPAGHDPATAVSSKDVSLSPGVSARLFLPTSALEAGQSRRLPVLVYVHGGGFMIETAFSPTYTAFLNTLCSESGALAVSVDYRRAPEDPLPAAYDDSYAALQWVLSHSDPAGAADPWLAEHGDFEKVVLAGDSAGANIVHNMLLRHAEEESAGPIWKAVLIHPFFWGTTDVGPRSKEPQAMAGVEKNWKIMCPGTVGIDDPRVNPVAEAAAMARVRCEQVLVCVAGLDFLCEWGRAYYEALAGSGFGGRAEVVESEGEDHVFHLFKSGSAEALAFIRRLADFIRPGSGVGASL
>evm.model.Pn10.1384
MESPLPTPTTNSHDDDELLLDHPPLFRVYKSGRVERLLGTSTVPAGDDPATGVSSKDVTLFPGVSARLFLPLHATIITDNDNKKKKKLPVLIYYHGGGFIIESASSPTYVTFLNALCSAAGVLAVSVDYRRAPEHPLPAAYDDSYAALQWALSPAGADPWLAEHGDLGAVLLGGDSAGANIAHHVLLRHAASGAPPLLGAILIHPFFWGTTEVGPRSAEARKQGLIEKLWRSTCPATSGLDDPLLNPLAVAAEALGRVGCGRVLVCVAEKDILMEWGWAYYKWFGGGVGWEGGDGGDEGGGPCLPPQKAQLQRGQGLHPPSRRLHQPACTPKVAAS
>evm.model.Pn12.342
MSNTDSPLPTPTTNSDDVDELLHDFPPLVRVHKSGRVERLLGTATVSAGHDPATGVSSKDVTLFPGKKKKLPVLIYYHGGGFIIESASSPTYVTFLNALCSAAGVLAVSVDYRRAPEHPLPAAYDDSYAALQWALSPAGADPWLADHCDLGAVVLGGDSAGANIVHHVLLRHAASAAPPLLGAVLIHPFFWGTTEVGPRSTEVQKQGWVEKLWKFVCPATSGVDDPRMNPLAAALGRMGCGRVLVCVAEKDMLMEWGWAYYKGLASTSGLEGRVEMVETKGEDHVFHLMKPNSDEAKDFVRRLADFSPPACTPN
>evm.model.Pn3.1169
MGSISVSDSRSWLSGVKANDDNGLVEEIEGLIRVYMDGKVERHPIMPIVACGNVSESDVASWDATIDANKGGWARFYLPKRQRKLPLLIYFHGGGFCVGSPAWKCYHDFLCKLASTAECIIMSVNYRLAPEHRLPAAFEDGATAVKWVREQDSKRKEEQSWWWAWCNFSNVFIGGDSAGACLAYNVVIGTSPSALTPLCLKGMVLVQPFFGGEARTKSERSMDQPPNSVLTLKASDCYWRMALPFGTNRDHPWCNPLWKGWSKKLQGLSLPPSLVCVAEKDILKERNLDFCAAMRRAGKSVEHFVYEGMGHAFQILNTSPSSRAQTYNMISHIRSFMNR
MGALPLSDQSLEATMGKKHKTQHQHGAVLDEVKGLVKLYKDGHIERYPVVPHVTCRSNPDPSVTSGDVVIDSCHGVWARFYVPKRQTRLPLLIYFHGGGFCVGSAAWKCYHEFLLRLAGVVGCVVMSVNYRLAPENRLPAAFDDGVAAVKWVRQKAIAFRSEEQSWWGAMCDFSKVFIVGDSAGGCLAHNVMLQLTSINGANLSNALSPVCIRGLILIQPFFGGEARTWSEKNMTQPPNSALTLSAADSYWRLSLPAGATRDHPWCNPLSTTAKAAAKRAESLCLPPVLVCISELDILKDRNMEFCSFMKMAGKKVEHVVHVGVGHAFQILHKSPTAQARTKEMISQISSFVNTL
>evm.model.Pn19.1229
MDQISPSTLPKQVENCRNVLFVYSDGSIVRSAQPSFNATVHDDGSVLYKDVDFDTNHHLSLRLYKPSATTAVSGKLPVFFYFHGGGYCIGSRTWPNCQNYCLNLARSLPAVIVAPDYRLAPENRLPASIEDSVAAVEWLKGQAVGEEPDEWLVGVADFRRVFISGDSAGGNIAHHLAVRLGIGSPGLEPVMVRGYVFLAPFFGGTTRTRSESECPKDAFFPLELNDRFWRLSLPLGADTDHSFSNPFGPASTSLESVSLDPILVVIGGADLLRDRAREYTEKLKAWGKRVELAEFEGEQHGFYTIDPFSKASDELMRLIQRFITDNSS
>evm.model.Pn15.2750
MGSDVPPTEVENIAGIVRYFSDGTVQRSDPTFDIAVADKGSVAWEDVEFNKVHRLSAHVYKPSAATGKLPLFIYLHGGGFCIGSCTWPHCHNYCHHLADRLQVIVVAPNYHLAPESRLPAAIDDGLAALSWLRDEAQASDGWLAGAADFGRVVVCGDSAGGNIAHHLAVKIAGGSADLDPIRVRGYILLGPFFGGAVRTRSELECPEDALFNLETNDRYV
>evm.model.Pn15.2746
MGSDVPPTEVENIAGIVRYFSDGTVQRSDPTFDIAVADKGSVAWEDVEFDKVHRLSAHVYKPSAATGKLPVFIYLHGGGFCIGSCTWPHCHNYCHHLADRLQVIVVAPNYRLAPESRLPAAIDDGLAALSWLRDEAQASDGWLAGAADFGRVVVCGDSAGGNIAHHLAVKIAGGSADLDPIRVRGYILLGPFFGGAVRTRSELECPEDALFNLETNDRFWRLSLPPGANRDHPFSNPFGRGSQDLESLSLDPILVVVGSDDLLRDRAEYYAKKLKEWRKHIEFIEFKGQKHGFSLTNPSSEESEKLNKIMEQFISQISDSN
>evm.model.Pn43.5
MGALHLSDQSLEARMGKKHKNQHQHGAVPDEVKGLVKLYKDGHVERYPDVPHVTCRSNPDPSVTSGDVVIDSCHRVWARFYVPKRQTKLPILIYFHGGGICVGSAA
>evm.model.Pn3.3230
MGAISGSDSRSWLRGVKANHNNGLVEEIEGLIRVCMDGKVERHPIMPIVACGYVSESDVASWDATIDANNGVWARFYLPKRQRKLPLLIYFHGGGFCVGSPAWKCYHNFLSKLASTAECIIMSVNYRLAPEHRLPAAFEDGAMAVKWAREQASKRQKEQSWWWAWCNFSNVFIGGDSAGACLAYNVVIGTSPSVLTPLCLKGMVLVQPFFGGEARTKSERSMDQPPNSVLTLKTSDCYWRMALPVGTNRDPSMVQPTVEGLE
>evm.model.Pn3.3842
MDAPPPLPISTPKDDDEVLHHIPPFGRIYKSGRVERFLGTAIVPAGHDPATAVSSKDVSLSPGVSARLFLPTSALEAGQSRRLPVLVYVHGGGFMIETAFSPTYTAFLNTLCSESGALAVSVDYRRAPEDPLPAAYDDSYAALQWVLSHSDPAGAADPWLAEHGDFEKVVLAGDSAGANIVHNMLLRHAEEESAGPIWKAVLIHPFFWGTTDVGPRSKEPQAMAGVEKNWKIMCPGTVGIDDPRVNPVAEAAAMARVRCEQVLVCVAGLDFLCEWGRAYYEALAGSGFGGRAEVVESEGEDHVFHLFKSGSAEALAFIRRLADFIRPGSGVGASL
>evm.model.Pn10.1384
MESPLPTPTTNSHDDDELLLDHPPLFRVYKSGRVERLLGTSTVPAGDDPATGVSSKDVTLFPGVSARLFLPLHATIITDNDNKKKKKLPVLIYYHGGGFIIESASSPTYVTFLNALCSAAGVLAVSVDYRRAPEHPLPAAYDDSYAALQWALSPAGADPWLAEHGDLGAVLLGGDSAGANIAHHVLLRHAASGAPPLLGAILIHPFFWGTTEVGPRSAEARKQGLIEKLWRSTCPATSGLDDPLLNPLAVAAEALGRVGCGRVLVCVAEKDILMEWGWAYYKWFGGGVGWEGGDGGDEGGGPCLPPQKAQLQRGQGLHPPSRRLHQPACTPKVAAS
>evm.model.Pn12.342
MSNTDSPLPTPTTNSDDVDELLHDFPPLVRVHKSGRVERLLGTATVSAGHDPATGVSSKDVTLFPGKKKKLPVLIYYHGGGFIIESASSPTYVTFLNALCSAAGVLAVSVDYRRAPEHPLPAAYDDSYAALQWALSPAGADPWLADHCDLGAVVLGGDSAGANIVHHVLLRHAASAAPPLLGAVLIHPFFWGTTEVGPRSTEVQKQGWVEKLWKFVCPATSGVDDPRMNPLAAALGRMGCGRVLVCVAEKDMLMEWGWAYYKGLASTSGLEGRVEMVETKGEDHVFHLMKPNSDEAKDFVRRLADFSPPACTPN
>evm.model.Pn3.1169
MGSISVSDSRSWLSGVKANDDNGLVEEIEGLIRVYMDGKVERHPIMPIVACGNVSESDVASWDATIDANKGGWARFYLPKRQRKLPLLIYFHGGGFCVGSPAWKCYHDFLCKLASTAECIIMSVNYRLAPEHRLPAAFEDGATAVKWVREQDSKRKEEQSWWWAWCNFSNVFIGGDSAGACLAYNVVIGTSPSALTPLCLKGMVLVQPFFGGEARTKSERSMDQPPNSVLTLKASDCYWRMALPFGTNRDHPWCNPLWKGWSKKLQGLSLPPSLVCVAEKDILKERNLDFCAAMRRAGKSVEHFVYEGMGHAFQILNTSPSSRAQTYNMISHIRSFMNR
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University