Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Piper nigrum
Species name
Piper nigrum is a species of flowering plant in the family Piperaceae (pepper family).
Species info
Gene sequence info
Piper_nigrum.C4H.fa
Download
>evm.model.Pn11.26
MAASSFLRRFATCSLILVALLSITRHLYPSLNQYAALTITLPLFFLSFLLSTTYKSSIKLPPGPGSIPIFGNWLQVGNDLTHRYLASMSKKYGKVFLLKLGARNLVVVSDPTLACQVLHSQGVEFGSRPRNVVFDIFTGDGQDMVFTAYGDHWRKMRKIMTVPFFTNKVVQQYRNMWEEEMELVVKDLCMDNEGAGLAGVVIRSRLQLMIYNILYRMMFDCRFESMDDPMFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLNGYLERCRELQSSRLKFFNNHYVEKRRKIMAENGAKHKISCAIDHILEAERKGEINDKNVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQTKLREEISTVLKGSKVRECELHKLPYLQAVVKETLRLHTPIPLLVPHMNLEEAELDGYTIPKGSKVVVNAWWLANNPEWWRNPQEFRPERFMEEEGETEAVVGGKVDFRFAPFGVGRRSCPGIILALPLLGMVIGKLVSEFELRPAEGMEKVDVSEQGGQFSLHIAYHSTVVFRPVHG
>evm.model.Pn9.1366
MALLYGGFTRLVTLYQLYTYFYNISIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIQRLPYLQAVIKETLRLRMAIPLPVPNMNLHEAKLVGYDIPAESKILVNAWWLANNPENWKKPEEFRTERFLEEIYCTFIYFFPCKSFVKESWLVGLYK
>evm.model.Pn9.1365
MDLLLLQKVLLTLFATSVVATVVSKLRGKRFRLPPGPLPVPVFGNWLQVGDDLNHKNLAELARKFGEILLLRMGQRNLVVVSSPDLAKEVLHTQGVVFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKNNPEASTSGIVLRRRLQLLMYNNMYRIMFDTRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLRICKQVKERRLQLFKDNFVDERKKMSSTKPADNNSLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIQRLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLVGYDIPAESKILVNAWWLANNPENWMKPEEFRPERFLEEEKHVEINGNDFRFLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRVF
>evm.model.Pn2.84
MDLLLLQKVLLTLFATSVVATVISKLRGKRFRLPPGPLPVPVFGNWLQVGDDLNHRNLAELARKFGEILLLRMGQRNLVVVSSPNLAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKNNPEASTTGIVLRRRLQLLMYNNMYRIMFDTRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLRICKQVKERRLQLFKDYFVDERKKMSSTKPADNNRLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIERLPYLQAVIKETIRLRMAIPLLVPHMNLHDAKLAGFDIPAESKILVNAWWLANNPENWKKPDEFRPERFLEEEKHVEINGNDFRFLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRMFLS
>evm.model.Pn9.345
MEWAIAELVNYPKIQTKRREEMSTLLKAARLGSVSCTSCLTCRQW*RRL*GYTHQSHCWCPT*ILRKQSLMGTPYPKGLHRLAWAGEAAR*SYLRCRCWGC*SENWSRSSN*DRRRGGEGGREGTRRAVHLAHCQSFYCCVSPSSSLITSHSNMVNTFIHMNMSG*LFG
MAASSFLRRFATCSLILVALLSITRHLYPSLNQYAALTITLPLFFLSFLLSTTYKSSIKLPPGPGSIPIFGNWLQVGNDLTHRYLASMSKKYGKVFLLKLGARNLVVVSDPTLACQVLHSQGVEFGSRPRNVVFDIFTGDGQDMVFTAYGDHWRKMRKIMTVPFFTNKVVQQYRNMWEEEMELVVKDLCMDNEGAGLAGVVIRSRLQLMIYNILYRMMFDCRFESMDDPMFIEATRFNSERSRLAQSFEYNYGDFIPLLRPFLNGYLERCRELQSSRLKFFNNHYVEKRRKIMAENGAKHKISCAIDHILEAERKGEINDKNVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQTKLREEISTVLKGSKVRECELHKLPYLQAVVKETLRLHTPIPLLVPHMNLEEAELDGYTIPKGSKVVVNAWWLANNPEWWRNPQEFRPERFMEEEGETEAVVGGKVDFRFAPFGVGRRSCPGIILALPLLGMVIGKLVSEFELRPAEGMEKVDVSEQGGQFSLHIAYHSTVVFRPVHG
>evm.model.Pn9.1366
MALLYGGFTRLVTLYQLYTYFYNISIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIQRLPYLQAVIKETLRLRMAIPLPVPNMNLHEAKLVGYDIPAESKILVNAWWLANNPENWKKPEEFRTERFLEEIYCTFIYFFPCKSFVKESWLVGLYK
>evm.model.Pn9.1365
MDLLLLQKVLLTLFATSVVATVVSKLRGKRFRLPPGPLPVPVFGNWLQVGDDLNHKNLAELARKFGEILLLRMGQRNLVVVSSPDLAKEVLHTQGVVFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKNNPEASTSGIVLRRRLQLLMYNNMYRIMFDTRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLRICKQVKERRLQLFKDNFVDERKKMSSTKPADNNSLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIQRLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLVGYDIPAESKILVNAWWLANNPENWMKPEEFRPERFLEEEKHVEINGNDFRFLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRVF
>evm.model.Pn2.84
MDLLLLQKVLLTLFATSVVATVISKLRGKRFRLPPGPLPVPVFGNWLQVGDDLNHRNLAELARKFGEILLLRMGQRNLVVVSSPNLAKEVLHTQGVEFGSRTRNVVFDIFTDKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKNNPEASTTGIVLRRRLQLLMYNNMYRIMFDTRFESEEDPLFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLRICKQVKERRLQLFKDYFVDERKKMSSTKPADNNRLKCAIDHILDAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGLAELVNHPEIQSKLRRELDDVLGVGVPVTEPDIERLPYLQAVIKETIRLRMAIPLLVPHMNLHDAKLAGFDIPAESKILVNAWWLANNPENWKKPDEFRPERFLEEEKHVEINGNDFRFLPFGVGRRSCPGIILALPILGITIGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRMFLS
>evm.model.Pn9.345
MEWAIAELVNYPKIQTKRREEMSTLLKAARLGSVSCTSCLTCRQW*RRL*GYTHQSHCWCPT*ILRKQSLMGTPYPKGLHRLAWAGEAAR*SYLRCRCWGC*SENWSRSSN*DRRRGGEGGREGTRRAVHLAHCQSFYCCVSPSSSLITSHSNMVNTFIHMNMSG*LFG
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University