Enzyme

This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.

DFR

Enzyme

Dihydroflavonol 4-reductase

Enzyme name

EC:1.1.1.219

Entry

Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor

Class

(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase

Sysname

a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]

Reaction

(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]

Product

Species information

Pinus lambertiana

Species name

Sugar pine (Pinus lambertiana) is a species of seed plant in the family Pinaceae (pine family).

Species info

Gene sequence info

Pinus_lambertiana.DFR.fa

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>PILA_00588
MRKGSLLVTSLSTSQDGLPSISLEFYCLAKTLAEKAAIEYGLNTSEMEVVTIGPGYVGGPCMVSTLPFSCEQILGLITGNYEGLKMAMSFMGSIPLVHIDDVCEAHIFLMERPNVEGRHICCVCSLTLSQMADFIHKRYPHFTLKFNHGEDDNGISTSTCSRKLLDMGFSYKYNLEDIFDETIKCAQLYGLLKYIS
>PILA_05583
MEIMDEARRNCRVCITGGGGYIGSWLVRDLLHKGYYVNATHRDPANENKTRHILSLPGARERLMLFKADINEQGSFDSAVHGCDFVVHMATPMDYTKDPESGIIQAAVNGTLDILRACKKAKSVRRVIYTSSIVGASPLKDKGEYRDFVDESCWTSVDLIRREKPLFWMYYVAKTLTEQAVLQYGSEHGIDVVTIVPSLVAGPSLTPTIPLSIAQILTPITGNEQFYGYIKELQWLMGSVVLVHIEDLCSALIFLMEHPSAKGRYICSSEALSLQEMGDFCRKRYPQFSRPDNFLDDEALTGVPVSSKKLLDLGFSYQYGLSHIFDESIEFAEKFGILQ
>PILA_06749
MVLGEDNAQVREQLPSIHNFHRERTVCVTGAAGFIGSWLVMRLLERGYTVRATVRDTEDPVKTKHLLDLPGANERLILYKADMDDEGSFDAAIDGCEGVFHLATRTVFESRDPENEVIRPTVNGLLNVMRACAKAKSVKRVVFTSSVGAMKFTDDYGNPGKIYDETCWTNVELCTRLKITGWIYFASKTLAERAAWEFAEKNNIDLISIIPPLVVGPFISQTMPPSMKTALALLTRNEPHYAILRQVHLVHLDDLCMSHIFLYEHPEAKGRYISSSDETTIVQLAQMLAEKYPEYNIPTKFKDADESLQAVPFSTKKLLDLGFKFKYTKEEMFDGAIQCCRENGLLP
>PILA_09720
MNVLNTCSRDKSVRRVIYTSSIAAAAPLNEEGELLSGCSLDESRWTPVDFMRRKHQHPLGFYFVAKTLAEQAAIEYGSNSEMEVVTIGPSAVCGPCITSTFPVSC
>PILA_12467
MLGSSTKPYNTVLQRHRFTYSSAMVLCDKSLETRYKTPLPSVSLRSRAEKTSSRRFGNLARRLIQCTAMAFGEEQTLLPQETPVNPQVHRGTVCVTGAAGFIGSWLIMRLLERGYSVRATVRDTGNPVKTRHLLDLPGANERLTLWKADLDDEGSFDAAIDGCEGVFHVATPMDFESEDPENDIIKPTVNGVLNVMRSCAKAKTVKRVVFTSSAGTVNFTDDFQTPGKVFDESCWTNVELCRKVKMTGWMYFVSKTLAEKSAWDFAEENKIDLITVIPTLVVGPFIMQTMPPSMITALALLTRNEPHYMILRQVQLVHLDDLCMSHIFVYEHPEAKGRYISSTCDATIVQVAKMLAKKYPEYNVPTTFKDADESLPAVPFSSKKLLDLGFKFNYTMEEMFDGAIQCCREKGLLPEKASF
>PILA_14836
MRHLLDILGVAERLKLFRAELSENGSFDAAVTGCHKVFHLAIPMDSTTKDTENDVIKPAVEGTLSVLKVCTKAQTVKRGGLRLRLSLTSQWSRLRPLTNPAGLTLILSRLTSPLPGWVYA
>PILA_17819
MQGHEGGVGVKVCVTGAGGYIGSWLVKKLLLRGYTVNSTLRNPKNDAKTGPLLSLPGAAERLKLFQADLCEEGSFDSAVEGCSGVFHVASPMDFSKCSEDDFAQPALKGVLNVLKSCSRAKSVKRVVYTSSTAAACPLNEEGQLVGDVTLDESRWTPLDFLRILLFGQDFGGESSY
>PILA_19094
MQSRVGRMGIKVCVTGAGGYIGSWLVKNLLQRGYTVNATLRNPNNKAQTGPLLSLPGAAERLKLFQADLSEEHAFDSAVEGCQGVFHVASPMDFSNNSDDDSVELASKGVLNVLKSCSRAKSVRRLVYTSSVAAACPLNEEGQLITGSTLDESTWTPLDFMRRRARRLNFYYLSKTLAEKAAFEYGLKVGQMEVVTIAPAFVCGPGIISTFPQSCGAILGPIKGNYEALKLSESFLGSIPLVHIDDICEAHIFLMEQPNVQGRHICSLCSFTVSQLAHFIHKCYPHFTVPFKVDGEDESGVPVPTSCKKLLDMGFSFKHGAKDIIDDTIKWAHSYGLLK
>PILA_19096
MCRASLAAGPDGAWLEGTVKTPSGRGGRYSIQLDKIGQLLGLAKTKMLQLLGRCCDSILDDSVELASKGVLNLLKSCSRVNSVRRVVYTYSVAAACPLNEGRQLITGSTLDESTWTPLGFMRRRARRLDFYYLSKTLAEKAAIEYGLKGGQMEVVPIAPAFVCGAGIISTFPQSCGAILGPIKGNYEALKLSEPFLGSIALVHIDDVCEAHIFLMEQPNVQGRHICSLCSFTVSHLAHYIHKRYQHFTVPFKMDGEDESGVLVPTSCKKLLDMGFSFKHGAEDIVDETIKWAHSYGLLK
>PILA_19097
MRRRARRLNVSRYCVDSMIEFVCQIWQSIKVVLITRVVLLPVQDFAEKAAIEYGLKGGQMEVVTIAPAFVCGAGIISTFPQSCGAILGPIKGNYEALKLSESFLGSIPLVHIDDVCEAHIFLMEQPNVQGRHICSLCSFTVSQLAHYIHKRYQHFTVPFKMDGEDESGVLVPTSCKKLLDMGFSFKHGAEDIVDETIKWAHSYGLLK
>PILA_20583
MLGDHGKNCRVCVTGAGGYIASWLVKNLLAKGYNVNATFRDPENESKTRHILSLPGATERLTLFKADITKEGSFDSALSDCDFVVHLATPMDFTVDAEAQTSVVEAEVKGTLVRRVIYTSSINAASPLNDNGEFRDCVDESCWTPEDLIRREKPLFWMYYVSKTSSEQAALQYGSDHGIEVVTIAPSLVAGPSLTPTLPTSVEETLGIITGSQEGYEWLKEFQWLMGSIALVHIDDLCDAYILLMEHPSAKGRYICSAQHLSLNELSDFCNKRYSQYCPPLQSPNEDAFLQNVSVSSKRLLDLGFSYKYGLPEIFDESIEFAKRIGILQ
>PILA_20901
MASRTENPQVSEELLNHEIHQGRTVCVTGAAGFIGSWLVMRLLERGYAVRATVRDTGNLVKTKHLLDLPGANERLTLWKADLDDEGSFDTAIDGCQGVFHVATPMDFESEDPENEVIKPTVNGMLNVLRSCGKTKSVKRVVFTSSAGTVFFTDDQGQPGKVYDETCWTNVEICRRVMMTGWMYFVSKTLAEKAAWEFAEKNNIDLITIIPTLVVGPFIMQAMPPSMITALALLTRNEPHYMILRQVQLVHLDDLCMSHIFLYEHPKAKGRYICSSHDITIIQLAELLAEKYPEYNIPTKFKDVDESLQPVPFSSKKLLDMGFKFKYTMEEMFDGAIQCCREKGLLPSIIV
>PILA_21075
MLLYLSQITLSPSSYFDINDIQGHSGLQANHCLSTRSYKFHGLPCLSLSKGYIVHVVVRHSENEEKVFHLLEIPGATERVNLFIAKLLEDDNFNAAIAGCHGVFHLITPINFAPKDPENVSINKTLNVVKSCMKAMKVKLMVVTSSLPTISVNELAEENQYIDESCCRDVEFLQTKKPLTWPYPVSKTLAEQAVLYMRKSRGWMW
>PILA_24356
MNTPQSSEGKSLPVCVTGAGGYIGSWLVKFLLENGYTVHATLRDPENPSKNSCLLALPGAHERLRLFKADLCEEGSFDSAIHGCHGVFHVATPTDFGSQDPEREVIEAAVRGTLNVLKSCAAIKTVRRVVYTSSSSAASFVEKPVEIIDESCWSSVDLIRQNKPPGWMYYVSKTLADQAAIQFAKENKMELVSIVPVTVAGPWLTTGVPSSVDVTISLITGNTQSQGILKSIATSFAHIEDVCRAHLFLMEQLVVGERYICSAHSTTLSKLTDFIYKHYPKYKETIKLEKVESNNNVIPMSSKKLIDLGFTYKYDMGDIIEQTLQHFSKLNIQII
>PILA_26198
MAAAAINGNDRGPTIVCVTGGTGFLASWLVKRLLEKGYTVHATVRDPENNPKVRHLLDIPEAREKLKLFRADLLEEGSFQAAIDGCDGVFHVASPVAFAPKDPENDVIKPAVEGTLNTWISSGLKSLLPGHIWLPRRLQNKQRCNMGKKIQGWMW
>PILA_26312
MASGKENSQVPEEQLNHHEVQQGNSTVCVTGAAGFIGSWLAMRLLERGYSVRATVRDTGNPVKTKHLLDLPGATERLTLWKADLDDEGSFDAAIDGCEGVFHAATPMDFESDDPENEIIKPTVNGVLNVLRSCAKAKSVKRVVFTSSAGAVYFTEDFQTPGKIFDESCWTNVELCKKVKMTGWMYFVSKTLAERSAWDFAEENTIDLITVIPTLVVGPFIMQTMPPSMITALALFTRNEAHYMILRQINLVHLDDVCMSLIFVYEQPEAKGRYICSTCDVTIVQLAKMLAEKYPEYNIPTKFKDADESLQALPFSSKKLLDLGFRFKYTKEEMFDGAIQCCREKGILPEKA
>PILA_29715
MLLNIPYPAPYLTRFQSNVPNLFTHYSSLLLYPLLDIPCSQRYPVRFHSNFPNSLICNPIILLKRGTKIMMCEERRECTVCVTGAGGFIASWLIKDLLLQGYNVNGTVMDPGDEHETAHILSLPGAKERLRLFRANLLEKGSFDAAVQGCEFAILLATPMDFAIDAETQSSVVEAEVNGTLDILKACVKAKTIKRVIYTSSISAASPLNDKGEFGDCIDESCWSNADIFKRKGPLFWMYYLAKVSGEQTARQFGLENGIEVVTIAASLVAGPFLTPTLPASIEEALAVVTGNAQCYEWLRELQHLIGSIALLHTEDVCRAHIFLMEHPSAQGRYICSAHSLTLRELDDFCLKRYPQFNLPVRFYEEEDLISSVPISSKKLLDMGFSFKYGLAEIFDDSIEFAKKLGFLPCHECMEGE
>PILA_30451
MEIQEGKAGVKVCVTGAGGYIGSWLVKNLLQRGYTVNATLRDPKNEAKFGPLLSLPGAAERLKLFQADLCGEHAFDSAVEGCQGVFHVASPMDFTKLSGEDFVEPAVKGVMNLLNACSRAKSVRRVIYTSSIAAAAPLNEEGGLLSGCSLDESRWTPVDFMRRKHQHPLGFYFVAKTLAEQAAIEYGLNSEMEVVTISPSNVCGPCITSTFPVSCRVVVDMAELGNSELFGFIALLGSIACNDEVDGSVFVPTSSKKLLDMGFSYKYGLEDMLDETLKSAKSFGILK
>PILA_34121
MHRYIYFIFSTYNISSLSYFNAENEEKIGPLLSLPGAAERLKLFQADLSGEHAFDSAVEGCQGVFHVATPMDFSKHSEDDYVQPTVKGVLNVLNACSRSKSVRRVVYTSSIAAAIPFNEEGEVINSCSVDESIWTPVEFLRRRHQHNLGFYFVAKTLAEQAAIEYGSNSEMEVVTISPSTVCGPCITSKFPVSCLAIIGIPPESPEFTEIGNFTQFKFESISLVHIDDVCEAHIFLMEQPNAEGRHICSAFTLSFPALANMIHKLHPHCTLPFEYGKEDDGIVFKGLSSKKLLDIGFIYKYGLEDIINETIKSAQIYGLLK
>PILA_34855
MNIHGGLPVCVTGAGGYIGSWLVKALLQNGYTVHATLRDPDNPSKNSCLVSLPGAEERLRLFRADLCEEGSFDSAIHGCRGVFHVATPTDFGSQDPEREVIEAAVRGTLNVLKSCAATKSVRRVVYTSSASAASFVEKAVEMIDESCWSSVDFIRQNKPPGWMYCVSKTLADQAALQFAKENKMEVVSIVPVTVVGPWLTTTIPSSVDVTMSLITGNTHWQGLLKSIVTSFVHIEDVCRAHLFLMEQPIVGERYICSAHSTTLSEFANFICKRYPKYKIDFQLDSAECDGGVITMSSKKLLDLGFTYKYDIGDMIDQTLQHLYKLDIPIK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University