Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Phtheirospermum japonicum
Species name
Phtheirospermum japonicum is a species of eudicot in the family Orobanchaceae.
Species info
Gene sequence info
Phtheirospermum_japonicum.4CL.fa
Download
>Pjv1_00000982
MELREEKHQIFRSKLPDIDIPNHLPIHTYCFQNLPNHRSRPALINAATGESFTHADIDLTARRVASGLHNLGIRKRQVIMLLLHNSPEFVFVFLAASFIGATATTANPNYTAAEIASQANISRPKLIVTHACYAEKVNRLVEELGAKIVVIDDGPLPPSPETIRLSELMRSDEKSLPAVEIHASDTAALLFSSGTTGLPKGVMLSHKNIVTCIAQKVDGENPNFHVDGQDVTLCVLPLFHVFSLAMVLVNLRAGAAVLIVPKFEINALLELIQRYRVTIAPFVPPILLAVAKSPAAAAKFDLSSVRKVYCGAAPMDRKLEAVVRAKLPNATIGQGYGMTEAGVISICLGFAKKPLKYKSGSCGTVIRNTEMKIVDPLSGASLSRNQTGEICVRGDSIMIGYYNDPEATKKTIDNDGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFHVAPAELEALLIAHPSICDAAVVPMMDEDSGEVPVAFVVPSNGSIISEYEIKQYISEQVVSYKRINRVFFTDEIPKAPSGKILRKNLRSRI
>Pjv1_00011355
MPVFILQNDQPSFLGSTPAKLIKVDTSFFLSPLSKSIPMEPTTKPEEIIFRSKLPDIYIPKHLPLHSYCFENISKFGTRPCLINGATNEIYTYEEVELTSRKVASGLSKLGIRQGDTIMLLLPNSPEFVYAFLGASYIGAVSTMANPYFTPAEVIKQAKASQAKLIVTQACYVDKVSDYASVNAVKVMCIDEPPPNPEILRFSDLTSADEREMPAVKVNPDDVVALPYSSGTTGMPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQKYRVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGRELEDAVRLKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDTETGASLGRNQAGEICIRGDQIMKGYLKDPDSTERTIDKDGWLHTGDIGFIDGDEELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPNISDAAVVPLMDEQAGEVPVAFVVKSNGSTISEDEIKQFVSKQVVFYKRINRVFFVDAIPKSPSGKILRKDLRARLAAGLPN
>Pjv1_00010873
MLTHRNLVANLCSTLFSVGPELIGQVTILGLIPFFHIYGLVGICCATIRNKGKVVVMHRYEFRLFLSALISHEITFAPIVPPIILGLVKNPTVDEFDLSKLKLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGNPNNGHGIAKKNSVGFILPNLEVKFIDPETGRSLPENTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVGLPDEEAGEIPGACVVINKKAKESEEDILNYVSSNVASYKKLRLLQFVDAIPKSPSGKIMRRFIKENMMKN
>Pjv1_00020240
MEKSGYGRDGIYRSLRPPLFAPKDPNLSMVSFLFRNASSFLDKPALIDSYTGETLNFAQLKSTVSRVSHGLLQLGIQKNDVVLIFSPNSIQFPLCFFGITAIGAIVTTVNPMYTVSELSKQIQDSTSKLIITVEELLPKAKDFGLPVVLLNASEKPGSPIGKIPSITLFLELVNNDGSVNFNKIKQDDVAALLYSSGTMGTSKGVVLTHRNLIAASLMVTADQEFAGETHNVFLYLLPMFHVFGLSVIMYAQLQRGNAVVSMLKFNPEMVLRTGEKYRITQLWAVPPIILGLAKSDVEKCLLIKYHLLYYLLIVFLFL
>Pjv1_00017345
MEKSGYGRDGIYRSLRPPLFAPKDPNLSMVSFLFRNASSFPDKPALIDSHTGETLNFAQLESTISRVSHGLLQLGIKKNDVVLIFSPNSIQFPLCFFGITAIGAIATTVNPMYTVSELSKQVQDSTSKLIITVEELLPKVKDFGLPVVLLNASAKPGSPVGKIPSITLFSELVNNDGSVNFNKIKQDDVAALLYSSGTTGTSKGVVLTHRNFIAASLMVTADQEFAGETHNVFLCLLPMFHVFGLSVIMYAQLQRGNAVVSMSKFDLEMILWTVEKYRITQLWVVPPIILGLAKSDVIKKYNLSTLKLIGSGAAPLGKELMQECAKKFPQAVVLQGYGMTETCSIISYENAYAGPRHSGSAGILVPGIESQIVSVDKSKPLPPGQLGEIWARGPNIMQGYFNNPQATKLTIDKQGWVHTGDLGYFDDAGHLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVTSFPDAEAGEVPAAYVVRAPNSSLTEEEIKKFIADQVAPFKRLRRVKFINTVPKSASGKILRRELIDKVRPKL
>Pjv1_00017344
MPQRNPVRQSGKIPSITLFSELVNNDGSVNYNKIKQDDVAALLYSSGTTGTSKGVVLTHRNFIAASLMVTTDQEFAGEAHNVFLCFLPLFHVFGLVAIMYAQLQRGNAVVSMSKFDLELILKTVEQYGVTHMWVVPPVVLGLAKSPVVKKYNLSTLKQIGSGAAPLGRELMQDCAKNFPQAVVVQGYGMTETCAIVSIENPHVGPRNSGSAGMLVPGVESQIVSVDKSKPLPPGQLGEIWVRGPNMMRGYFNNPQATKITIDKQGWVHTGDLGYFNDEGYLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRAPNSSLTEEDVKKFIADQVAPFKRLRGVTFINAVPKSASGKILRRELIDKVRSKL
>Pjv1_00023386
MANPFFTPAEVAKQAKASNAKLIITLACYVEKVNESGLKVVTVDAPPPNCLSFSVLTSADENEIPAVEIDPDDVVALPYSSGTTGLPKGVMLTHKGMVTSVAQQVDGSNPNNYVHSEDVMLCVLPLFHIYSLNSVLLCGLRVGSAIVIMQKFDIVPFLEVMQRYRVTIGPLVPPIVLAIVKSPEVAKYDLSAVRTVMSGAAPLGKELEDALRSKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFKIKSGACGTVVRNAEMKIVDAESGVSLERNQYGEICIKGDQLMKGYLNDPKATGKTIDKEGWLHTGDIGFIDDDDELFIVDRIKEIIKYKGFQVAPAELEALLLKHPNISDAAVISIKDEQAGEVPAAFVVKSNGSTVTEDEIKQFVSKQVIFYKRINRVCFVDVIPKSQSGKIMRKDLRAILAAGPLSNQLNSYKLYEAKLL
>Pjv1_00021758
MLSVATVEAQNPELSPSSLVLPHNNQTTASDGKTHVFVSKLPSIPIPNHLPLHAYCFQNISQYPDRTCLFVGNTGKSYTFAETHLACRRVAAGLSRLGIGKGDVVMALLQNCAEFVFTFMGASMVGAVTTTANPFCTTNEIFKQFHASKSRLIVTQSQYVDKLRDPGDNSAVFGEDFTVITIDGPPEGCLHFSVLSEADEAAPAAEVDPDDAVALPFSSGTTGLPKGVILTHRSLITSVAQQVDGENPNLHLKPDDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFDIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGRRRLEGAGGAAAQPFAAGVFGAGYLNDDEATARTIDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLVSHPNIADAAVVPQIDEAAGEVPVAFVVPSNGFELTEEVVKEFISKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLTAPLVP
>Pjv1_00024418
MNPLSSLLEIKRQVLDSNASLVFSAFNRVDELVSELKRCRVIGVPEILDNDGSVFHKLVSSDPNLAPRPKITQHDVAAILYSSGTTGRAKGVMLTHRNFISVVELFARFEASLYDYPPSESVYLAVVPMFHVYGLSLFVMGLLSLGCTIVTMRKFDVDEMVRAIGRFGVTHLHAVPPLLTALTRRVKRDGNKNNSFRSLKQVSCGAAPLSEKIINEFNEMLPHVDFIQGYGMTESTAVGTRGYNTAEVCKYSSVGLLSPNVEAKVVDWVTGSHLPPGSVGELWLRSPGNMKGYLNNIEETMAALDKDGWLHTGDIVYFDQEGYLYVIDRLKEVIKYKGFQVAPADLEAVLMSHPKVLDAAVTGVRDEEAGEIPVAFVVLKNGSSISQAALMDYVAKQVAPYKKVRKVYFRDSIPRSAAGKILRRELRSLLASRL
>Pjv1_00027323
MYTVSELSKQVQDSTSKLIITVEELLPKVKDFGLPVVLLNASEKPGSPIGKIPSITLFSELVNNDGSVNFNKIKQDDVAALLYSSGTTGTSIGVVLTHRNFIAASLMVTADQEFTGETHNVFLCLLPMFHVFGLSVIMYVQLQRGNAVVSMSKFDLEMVLRTVEKYRITQLWVVPPIILGLAKSGFGEKWVWRKVTLKNAF
MELREEKHQIFRSKLPDIDIPNHLPIHTYCFQNLPNHRSRPALINAATGESFTHADIDLTARRVASGLHNLGIRKRQVIMLLLHNSPEFVFVFLAASFIGATATTANPNYTAAEIASQANISRPKLIVTHACYAEKVNRLVEELGAKIVVIDDGPLPPSPETIRLSELMRSDEKSLPAVEIHASDTAALLFSSGTTGLPKGVMLSHKNIVTCIAQKVDGENPNFHVDGQDVTLCVLPLFHVFSLAMVLVNLRAGAAVLIVPKFEINALLELIQRYRVTIAPFVPPILLAVAKSPAAAAKFDLSSVRKVYCGAAPMDRKLEAVVRAKLPNATIGQGYGMTEAGVISICLGFAKKPLKYKSGSCGTVIRNTEMKIVDPLSGASLSRNQTGEICVRGDSIMIGYYNDPEATKKTIDNDGWLHTGDIGYVDDDDELFIVDRLKELIKYKGFHVAPAELEALLIAHPSICDAAVVPMMDEDSGEVPVAFVVPSNGSIISEYEIKQYISEQVVSYKRINRVFFTDEIPKAPSGKILRKNLRSRI
>Pjv1_00011355
MPVFILQNDQPSFLGSTPAKLIKVDTSFFLSPLSKSIPMEPTTKPEEIIFRSKLPDIYIPKHLPLHSYCFENISKFGTRPCLINGATNEIYTYEEVELTSRKVASGLSKLGIRQGDTIMLLLPNSPEFVYAFLGASYIGAVSTMANPYFTPAEVIKQAKASQAKLIVTQACYVDKVSDYASVNAVKVMCIDEPPPNPEILRFSDLTSADEREMPAVKVNPDDVVALPYSSGTTGMPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQKYRVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGRELEDAVRLKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDTETGASLGRNQAGEICIRGDQIMKGYLKDPDSTERTIDKDGWLHTGDIGFIDGDEELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPNISDAAVVPLMDEQAGEVPVAFVVKSNGSTISEDEIKQFVSKQVVFYKRINRVFFVDAIPKSPSGKILRKDLRARLAAGLPN
>Pjv1_00010873
MLTHRNLVANLCSTLFSVGPELIGQVTILGLIPFFHIYGLVGICCATIRNKGKVVVMHRYEFRLFLSALISHEITFAPIVPPIILGLVKNPTVDEFDLSKLKLRSIMTAAAPLAPEILNEFEKKFPGVEVQEAYGMTEHSCITLTHGNPNNGHGIAKKNSVGFILPNLEVKFIDPETGRSLPENTPGEICVRSQCVMKGYYKNEYETNLTIDKDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVGLPDEEAGEIPGACVVINKKAKESEEDILNYVSSNVASYKKLRLLQFVDAIPKSPSGKIMRRFIKENMMKN
>Pjv1_00020240
MEKSGYGRDGIYRSLRPPLFAPKDPNLSMVSFLFRNASSFLDKPALIDSYTGETLNFAQLKSTVSRVSHGLLQLGIQKNDVVLIFSPNSIQFPLCFFGITAIGAIVTTVNPMYTVSELSKQIQDSTSKLIITVEELLPKAKDFGLPVVLLNASEKPGSPIGKIPSITLFLELVNNDGSVNFNKIKQDDVAALLYSSGTMGTSKGVVLTHRNLIAASLMVTADQEFAGETHNVFLYLLPMFHVFGLSVIMYAQLQRGNAVVSMLKFNPEMVLRTGEKYRITQLWAVPPIILGLAKSDVEKCLLIKYHLLYYLLIVFLFL
>Pjv1_00017345
MEKSGYGRDGIYRSLRPPLFAPKDPNLSMVSFLFRNASSFPDKPALIDSHTGETLNFAQLESTISRVSHGLLQLGIKKNDVVLIFSPNSIQFPLCFFGITAIGAIATTVNPMYTVSELSKQVQDSTSKLIITVEELLPKVKDFGLPVVLLNASAKPGSPVGKIPSITLFSELVNNDGSVNFNKIKQDDVAALLYSSGTTGTSKGVVLTHRNFIAASLMVTADQEFAGETHNVFLCLLPMFHVFGLSVIMYAQLQRGNAVVSMSKFDLEMILWTVEKYRITQLWVVPPIILGLAKSDVIKKYNLSTLKLIGSGAAPLGKELMQECAKKFPQAVVLQGYGMTETCSIISYENAYAGPRHSGSAGILVPGIESQIVSVDKSKPLPPGQLGEIWARGPNIMQGYFNNPQATKLTIDKQGWVHTGDLGYFDDAGHLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVTSFPDAEAGEVPAAYVVRAPNSSLTEEEIKKFIADQVAPFKRLRRVKFINTVPKSASGKILRRELIDKVRPKL
>Pjv1_00017344
MPQRNPVRQSGKIPSITLFSELVNNDGSVNYNKIKQDDVAALLYSSGTTGTSKGVVLTHRNFIAASLMVTTDQEFAGEAHNVFLCFLPLFHVFGLVAIMYAQLQRGNAVVSMSKFDLELILKTVEQYGVTHMWVVPPVVLGLAKSPVVKKYNLSTLKQIGSGAAPLGRELMQDCAKNFPQAVVVQGYGMTETCAIVSIENPHVGPRNSGSAGMLVPGVESQIVSVDKSKPLPPGQLGEIWVRGPNMMRGYFNNPQATKITIDKQGWVHTGDLGYFNDEGYLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRAPNSSLTEEDVKKFIADQVAPFKRLRGVTFINAVPKSASGKILRRELIDKVRSKL
>Pjv1_00023386
MANPFFTPAEVAKQAKASNAKLIITLACYVEKVNESGLKVVTVDAPPPNCLSFSVLTSADENEIPAVEIDPDDVVALPYSSGTTGLPKGVMLTHKGMVTSVAQQVDGSNPNNYVHSEDVMLCVLPLFHIYSLNSVLLCGLRVGSAIVIMQKFDIVPFLEVMQRYRVTIGPLVPPIVLAIVKSPEVAKYDLSAVRTVMSGAAPLGKELEDALRSKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFKIKSGACGTVVRNAEMKIVDAESGVSLERNQYGEICIKGDQLMKGYLNDPKATGKTIDKEGWLHTGDIGFIDDDDELFIVDRIKEIIKYKGFQVAPAELEALLLKHPNISDAAVISIKDEQAGEVPAAFVVKSNGSTVTEDEIKQFVSKQVIFYKRINRVCFVDVIPKSQSGKIMRKDLRAILAAGPLSNQLNSYKLYEAKLL
>Pjv1_00021758
MLSVATVEAQNPELSPSSLVLPHNNQTTASDGKTHVFVSKLPSIPIPNHLPLHAYCFQNISQYPDRTCLFVGNTGKSYTFAETHLACRRVAAGLSRLGIGKGDVVMALLQNCAEFVFTFMGASMVGAVTTTANPFCTTNEIFKQFHASKSRLIVTQSQYVDKLRDPGDNSAVFGEDFTVITIDGPPEGCLHFSVLSEADEAAPAAEVDPDDAVALPFSSGTTGLPKGVILTHRSLITSVAQQVDGENPNLHLKPDDVVLCVLPLFHIYSLNSVLLCSLRAGAGVLLMQKFDIGSLLELIQRHRVSVAAVVPPLVLALAKNPMVDNFDLSSIRMVLSGRRRLEGAGGAAAQPFAAGVFGAGYLNDDEATARTIDVDGWLHTGDIGYVDDDDDVFIVDRVKELIKFKGFQVPPAELEALLVSHPNIADAAVVPQIDEAAGEVPVAFVVPSNGFELTEEVVKEFISKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLRAKLTAPLVP
>Pjv1_00024418
MNPLSSLLEIKRQVLDSNASLVFSAFNRVDELVSELKRCRVIGVPEILDNDGSVFHKLVSSDPNLAPRPKITQHDVAAILYSSGTTGRAKGVMLTHRNFISVVELFARFEASLYDYPPSESVYLAVVPMFHVYGLSLFVMGLLSLGCTIVTMRKFDVDEMVRAIGRFGVTHLHAVPPLLTALTRRVKRDGNKNNSFRSLKQVSCGAAPLSEKIINEFNEMLPHVDFIQGYGMTESTAVGTRGYNTAEVCKYSSVGLLSPNVEAKVVDWVTGSHLPPGSVGELWLRSPGNMKGYLNNIEETMAALDKDGWLHTGDIVYFDQEGYLYVIDRLKEVIKYKGFQVAPADLEAVLMSHPKVLDAAVTGVRDEEAGEIPVAFVVLKNGSSISQAALMDYVAKQVAPYKKVRKVYFRDSIPRSAAGKILRRELRSLLASRL
>Pjv1_00027323
MYTVSELSKQVQDSTSKLIITVEELLPKVKDFGLPVVLLNASEKPGSPIGKIPSITLFSELVNNDGSVNFNKIKQDDVAALLYSSGTTGTSIGVVLTHRNFIAASLMVTADQEFTGETHNVFLCLLPMFHVFGLSVIMYVQLQRGNAVVSMSKFDLEMVLRTVEKYRITQLWVVPPIILGLAKSGFGEKWVWRKVTLKNAF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University