Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Apium graveolens
Species name
Apium graveolens is a species of eudicot in the family Apiaceae (carrot family).
Species info
Gene sequence info
Apium_graveolens.4CL.fa
Download
>Ag2G00994.1
MEKSGYGRDGIFRSLRPPLNLPKDPNLSMISFLFRNISSFSTKPALIDSNSGVTLTFSGLKTAVTNLSSNLHQMGIKKNDVVLIFAPNSIEFPVSFLGIIAAGAVATTANPAYTVTEVEKQVKDCGPKLIFTVPELLSKVKKFNLPVVLMGCQENLDGLMGNYKVTLFTDMVKNNGVVVNLPKVGGSDIAALLYSSGTTGMSKGVILSHRNFIASSLMLNSDEEMLGEVDSVYICVVPMFHVFGLALITFGQLQRGSTVVAMPKFDFEMILRTIEKYRVTHLWIVPPVVLALAKQSLVKKYDLSSLKQIGSGAAPLGRELMQECAKNFPWALVIQGYGMTETCGIVSVENQLGGPRHTGSAGLLAPGVESQIISIDTQKSLPPNQVGEIWVRGPNMMQGYFKNPQATKLTIDSQGWVHTGDLGYFDNEGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVKSFIAKQVAPFKRLRRINFVNSVPKSASGKILRRELIEKVRAKL
>Ag11G04319.1
MTSFLFRNISSYPHHPAVIDSNSNQTLTFSQLNSTVSKLSRGLQQLGVKKNDVVLIFSPNSLHFPVCFFGIINAGAIATTVNPSYTSQEVAKQVQDCNPKVIFTVFELFDKVKEFGLPVVIIGFDQNVNKMDSRIVLFDDLFRNDGSLLFPVDVSGDDTAALLYSSGTTGISKGVVLSHRNFIAAALMACSDWI
>Ag11G04320.1
MFHVFGLCVITYAQLQRGSTIVTMAKYDLEVLLRTVERYKVTHTWIVPPIVLALAKYNGVEKFDLSSLKQIGSGAAPLGRELMQECAKKFPQALVMQGYGMTETTAVVSVESQLGGPRHTGSAGMLVPGVECQIVSVDTLERLPPKQLGYFNNPQATELTIDKQGWLHTGDLGYFDEEGLLYVVDRIKELIKYKGFQVAPAELEGLLVSHPDILDAVVIPFPDAEAGEVPSAHVVRAPNSSLTEEDVKKFISEQVAPFKDCGGVTFIKSVPKSASGKFSEENS
>Ag11G04321.1
MEKSGYGLDGIYRSLRPPLNLPKNSNISMTSFLFRNISSYPHHPAVIDSNSNQTLTFSQLNSTVSKLSRGLQQLGVKKNDVVLIFSPNSLLFPVCFFGIINAGAIATTVNPSYTSQEVAKQVQDCNPKVIFTVFELFDKVKEFGLPVVIIGFDQNVNKMDSRIVLFDDLFRNDGSLLFPVDVSGDDTAALLYSSGTTGISKGVVLSHRNFIAAALMACSDLDLMGELSSVFLCIVPMFHVFGLCVITYAQLQRGSTIVTMAKYDLEVLLRTVERYKVTHTWIVPPIVLALAKYNGVEKFDLSSLKQIGSGAAPLGRELMQECAKKFPQALVMQGYGMTETTAVVSVESQLGGPRHTGSAGMLVPGVECQIVSVDTLERLPPKQLGEICVRGPNIMQGYFNNPQATELTIDKQGWLHTGDLGYFDEEGLLYVVDRIKELIKYKGFQVAPAELEGLLVSHPDILDAVVIPFPDAEAGEVPSAHVVRAPNSSLTEEDVKKFISEQVAPFKRLRRVTFIKSVPKSASGKILRRELVEQVRAKI
>Ag8G02302.1
MASNHEEHIFKSRYAPVPIPDDITLPEFVLQDVELYAEKVAFVDAFTGKEYTYGQVNRDVKRFAKALRSLGLRRGHVVMVVLPNIVEYPIVALGIMAAGGIVSGANPASHVSEIKKQAESADAKSVVTDAATYEKVKGLGLPHVIVGEKRVEGSIYWNDLLDAAERASDSIMNEKVQQSDICALPFSSGTTGLSKGVMISHRNLVANLCSTLFSVGPELVGNVTTLGLIPFFHIYGLTGICCAAMRNKGKVVVMGRYELRTFLNALIKYEVTFAPIVPPIILGLVKNPIVDEFDLSKLKLRSIMTAAAPLAPEILAEFEKKFPDVVVQEAYGMTEHSCITLTHGDPNKGHAIAKKHSVGFILPNLEVKFIDPDTNNSLPKNTPGEICVRSQCVMEGYYKNEYETAHAIDKEGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEGILLTHPSVEDAAVVGLPDEEAGEIPGACVVMNIEAKDNEEEVMNFVASNVAQYKKIRVLQFVDSIPKSSSGKIMRRLIKDKMIQTIKSCPKTACPRRIAI
>Ag9G01212.1
MGDCVAPAQDIIFRSKLPDIYIPKHLPLHTYCFENISKVGDKACLINGATGETFTYSQVELISRKVASGLNKLGIQQADTIMLLLPNSPEYFFAFLGASYRGAVSTMANPFFTSAEVIKQLKASQAKLIITQACYVDKVKDYAKENNIQIVCIDDAPQDCLHFSKLMEADESEMPEVVINSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYIHSEDVMICILPLFHIYSLNAVLCCGLRAGVTILIMQKFDIEPFLELIQKYKVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPYEIKSGACGTVVRNAEMKIVDPETNASLPRNERGEICIRGDQIMKGYLNDPESTKTTIDEEGWLHTGDIGFIDGDDELFIVDRLKEIIKYKGFQVAPAELEALLLTHPTISDAAVVSMIDEKAGEVPVAFVVRTNGFTTTEDEIKQFVSKQVVFYKRIFRVFFVDAIPKSPSGKILRKELRARIASGDLPK
>AgUnG01485.1
MDTNTNNNKQDIIFRSKLPDIYIPKHLPLHSYCFENISRFSSRPCLINGATGQTYTYYDVQLVSKKVSSGLKTLGIHQGDTIMLLLPNAPEFVFAFLGASYCGAISTMANPFFTSAEVIKQVKASNAKLIITQASYVDKIREYACENKLKIMCIDSPPEGCLHFSVLSQANEKYMPEVVISPDDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSEDVMLCVLPLFHIYSLNSVLLCGLRAGTAILIMQKFDIVPFLELIQKYKVTIGPFVPPIVLAIAKSPVVDNYDLSSVRTVMSGAAPLGKDLEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTSISLPRNQRGEICIRGDQIMKGYLNDPESTERTIDKEGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAELEAMLLTHPNISDAAVVPMIDEKAGEVPVAFVVRSNGSSTTEDEVKQFISKQVVFYKRVYRVFFVDSIPKSPSGKILRKDLRARLAAGDLPQN
MEKSGYGRDGIFRSLRPPLNLPKDPNLSMISFLFRNISSFSTKPALIDSNSGVTLTFSGLKTAVTNLSSNLHQMGIKKNDVVLIFAPNSIEFPVSFLGIIAAGAVATTANPAYTVTEVEKQVKDCGPKLIFTVPELLSKVKKFNLPVVLMGCQENLDGLMGNYKVTLFTDMVKNNGVVVNLPKVGGSDIAALLYSSGTTGMSKGVILSHRNFIASSLMLNSDEEMLGEVDSVYICVVPMFHVFGLALITFGQLQRGSTVVAMPKFDFEMILRTIEKYRVTHLWIVPPVVLALAKQSLVKKYDLSSLKQIGSGAAPLGRELMQECAKNFPWALVIQGYGMTETCGIVSVENQLGGPRHTGSAGLLAPGVESQIISIDTQKSLPPNQVGEIWVRGPNMMQGYFKNPQATKLTIDSQGWVHTGDLGYFDNEGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHSEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVKSFIAKQVAPFKRLRRINFVNSVPKSASGKILRRELIEKVRAKL
>Ag11G04319.1
MTSFLFRNISSYPHHPAVIDSNSNQTLTFSQLNSTVSKLSRGLQQLGVKKNDVVLIFSPNSLHFPVCFFGIINAGAIATTVNPSYTSQEVAKQVQDCNPKVIFTVFELFDKVKEFGLPVVIIGFDQNVNKMDSRIVLFDDLFRNDGSLLFPVDVSGDDTAALLYSSGTTGISKGVVLSHRNFIAAALMACSDWI
>Ag11G04320.1
MFHVFGLCVITYAQLQRGSTIVTMAKYDLEVLLRTVERYKVTHTWIVPPIVLALAKYNGVEKFDLSSLKQIGSGAAPLGRELMQECAKKFPQALVMQGYGMTETTAVVSVESQLGGPRHTGSAGMLVPGVECQIVSVDTLERLPPKQLGYFNNPQATELTIDKQGWLHTGDLGYFDEEGLLYVVDRIKELIKYKGFQVAPAELEGLLVSHPDILDAVVIPFPDAEAGEVPSAHVVRAPNSSLTEEDVKKFISEQVAPFKDCGGVTFIKSVPKSASGKFSEENS
>Ag11G04321.1
MEKSGYGLDGIYRSLRPPLNLPKNSNISMTSFLFRNISSYPHHPAVIDSNSNQTLTFSQLNSTVSKLSRGLQQLGVKKNDVVLIFSPNSLLFPVCFFGIINAGAIATTVNPSYTSQEVAKQVQDCNPKVIFTVFELFDKVKEFGLPVVIIGFDQNVNKMDSRIVLFDDLFRNDGSLLFPVDVSGDDTAALLYSSGTTGISKGVVLSHRNFIAAALMACSDLDLMGELSSVFLCIVPMFHVFGLCVITYAQLQRGSTIVTMAKYDLEVLLRTVERYKVTHTWIVPPIVLALAKYNGVEKFDLSSLKQIGSGAAPLGRELMQECAKKFPQALVMQGYGMTETTAVVSVESQLGGPRHTGSAGMLVPGVECQIVSVDTLERLPPKQLGEICVRGPNIMQGYFNNPQATELTIDKQGWLHTGDLGYFDEEGLLYVVDRIKELIKYKGFQVAPAELEGLLVSHPDILDAVVIPFPDAEAGEVPSAHVVRAPNSSLTEEDVKKFISEQVAPFKRLRRVTFIKSVPKSASGKILRRELVEQVRAKI
>Ag8G02302.1
MASNHEEHIFKSRYAPVPIPDDITLPEFVLQDVELYAEKVAFVDAFTGKEYTYGQVNRDVKRFAKALRSLGLRRGHVVMVVLPNIVEYPIVALGIMAAGGIVSGANPASHVSEIKKQAESADAKSVVTDAATYEKVKGLGLPHVIVGEKRVEGSIYWNDLLDAAERASDSIMNEKVQQSDICALPFSSGTTGLSKGVMISHRNLVANLCSTLFSVGPELVGNVTTLGLIPFFHIYGLTGICCAAMRNKGKVVVMGRYELRTFLNALIKYEVTFAPIVPPIILGLVKNPIVDEFDLSKLKLRSIMTAAAPLAPEILAEFEKKFPDVVVQEAYGMTEHSCITLTHGDPNKGHAIAKKHSVGFILPNLEVKFIDPDTNNSLPKNTPGEICVRSQCVMEGYYKNEYETAHAIDKEGWLHTGDIGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEGILLTHPSVEDAAVVGLPDEEAGEIPGACVVMNIEAKDNEEEVMNFVASNVAQYKKIRVLQFVDSIPKSSSGKIMRRLIKDKMIQTIKSCPKTACPRRIAI
>Ag9G01212.1
MGDCVAPAQDIIFRSKLPDIYIPKHLPLHTYCFENISKVGDKACLINGATGETFTYSQVELISRKVASGLNKLGIQQADTIMLLLPNSPEYFFAFLGASYRGAVSTMANPFFTSAEVIKQLKASQAKLIITQACYVDKVKDYAKENNIQIVCIDDAPQDCLHFSKLMEADESEMPEVVINSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYIHSEDVMICILPLFHIYSLNAVLCCGLRAGVTILIMQKFDIEPFLELIQKYKVTIGPFVPPIVLAIAKSPVVDKYDLSSVRTVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPYEIKSGACGTVVRNAEMKIVDPETNASLPRNERGEICIRGDQIMKGYLNDPESTKTTIDEEGWLHTGDIGFIDGDDELFIVDRLKEIIKYKGFQVAPAELEALLLTHPTISDAAVVSMIDEKAGEVPVAFVVRTNGFTTTEDEIKQFVSKQVVFYKRIFRVFFVDAIPKSPSGKILRKELRARIASGDLPK
>AgUnG01485.1
MDTNTNNNKQDIIFRSKLPDIYIPKHLPLHSYCFENISRFSSRPCLINGATGQTYTYYDVQLVSKKVSSGLKTLGIHQGDTIMLLLPNAPEFVFAFLGASYCGAISTMANPFFTSAEVIKQVKASNAKLIITQASYVDKIREYACENKLKIMCIDSPPEGCLHFSVLSQANEKYMPEVVISPDDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYMHSEDVMLCVLPLFHIYSLNSVLLCGLRAGTAILIMQKFDIVPFLELIQKYKVTIGPFVPPIVLAIAKSPVVDNYDLSSVRTVMSGAAPLGKDLEDAVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTSISLPRNQRGEICIRGDQIMKGYLNDPESTERTIDKEGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAELEAMLLTHPNISDAAVVPMIDEKAGEVPVAFVVRSNGSSTTEDEVKQFISKQVVFYKRVYRVFFVDSIPKSPSGKILRKDLRARLAAGDLPQN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University