Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Perilla citriodora
Species name
Perilla frutescens var. hirtella is a varietas of beefsteak-mint (Perilla frutescens)
Species info
Gene sequence info
Perilla_citriodora.COMT.fa
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>rna-gnl|WGS:QIYW|chr09_45596216_45599025.mrna1
MEFLSISELLVEISDDLSSAVLLLNFVPWRRVHILHDLQGLIESFSITCACVGIIKQILCQSSKPNDVTGLITRIRNTTICNGSEMAYVTDNNRYNSRLFTAHSVLTCTLHTLPNGTVEHRYSATPICEFLTPNEDGFFIAPAPIMLQDRVLMESWYHMKDAILEGGISFNRAYRKNVFEYSGTDPRFNKIFNEAMHQQSTIFFKRILDIYNGFEGLNSLLDVGYGTGASSELIVSKYPSIKAINFDLPHIIQQATPHRGVEHVGGDMFIALPKADAIFMSWICHDWSDAHA
>rna-gnl|WGS:QIYW|chr09_45465619_45467135.mrna1
MELSTGSVLPMVVKSAIDLNLLQLIKKSGGEGASASQLVAQLPATNPDAADMIDRILRLLTAHSVLTCTLHTLPDGGVERRYSAAPVCEFLTPNEDGVSVAPASIMLQDRVLMESWYHMKDAILEGGIPFNRAYGKSVFEYSGTDPRFNKIFNEAMYQQSTIFMKRILDIYNGFEGLNSLLDVGGGTGASSKLIVSKYPSIKAINFDLPHVIQQATTHPGVEHVGGDMFVALPKADAIFMKWICHDWSDAHCVKVLKNCYDSLPENGKVIVAESILPEDPQSWSKALLAINGDVIMLNANLGGKERTEVEFQALAQQAGFKQLIKVCAASHIWIMEFHKSN
>rna-gnl|WGS:QIYW|chr05_62224151_62225474.mrna1
MKNSSTDEDLSIFALQVATSSIVPRALKVVIELDLLEMMKKAGRPLSTSEMAAQIQATNPEAALMMDRILRVLVASNILECTTAASHGRAERLYSLAPDAIVEGGIPFNIAHGMSGFEYPSTNPRYNKIFNQAMSDESTMFMHKILEIYDGFEGLKYVVDVGGGIGASLKVIITQHPSIKAINFDLPHVIQNAPSHPGLEHRSGDMFVSVPTGDAILLKWIIHNWSDGHCLKLLKNCYEALPEKGKVIIVDRILPETENYKEALTSVDLAGDALMLTLFTGGKERTEAEFQALAKASGFKYFRKVCCAFSTWIMELYK
>rna-gnl|WGS:QIYW|chr06_13953023_13953920.mrna1
MSAAARGAMAKALVDTFSGLKCTVLDLPQVVAGLEGSNNLRFVSGDMFQFIPPTDAVFLKRIMHDWSDENCVKILGKCKEAIIPSKNNGGKFVHNMEHRTVKHLIITQVSYEEGS
>rna-gnl|WGS:QIYW|chr07_59296361_59297911.mrna1
MTGFEYPATDPRYNEIFNQAMCQQSTMFMHQILELYNGFEGVKSLVDVGGGIGASLKIIVAKYPSINAINFDLDHVIQHDPSHPGVEHVSGDMFVSVPKSDAIFMKWISHNWSDGHCLKLLKDCHEALPEKGKVIIVDRIISEIPKKDPLVSIDLAADVLMFTLFPAGRERTEAEFQALAKAFGFKHFRKLCCAFNTWIMELYK
>rna-gnl|WGS:QIYW|chr08_24471795_24473993.mrna1
MGSTTKNSQTTALNSDEEENFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPAAFVSPAELAAQLPTTNAAAAVMLDRILRLLASYAIVECRLKTLPDGGVERLYGLAPVCKFLTKNDDGVSMAPLALMNQDKVLMESWFHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNQGMSNHSTITMKKILETYKGFDGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLKNCYDALPENGKVLLAECVLPEAPDTGLATKNVVHIDVIMLAHNPGGKERTEKEFYSLAIAAGFKRFNKACCAYNTWIIELLK
MEFLSISELLVEISDDLSSAVLLLNFVPWRRVHILHDLQGLIESFSITCACVGIIKQILCQSSKPNDVTGLITRIRNTTICNGSEMAYVTDNNRYNSRLFTAHSVLTCTLHTLPNGTVEHRYSATPICEFLTPNEDGFFIAPAPIMLQDRVLMESWYHMKDAILEGGISFNRAYRKNVFEYSGTDPRFNKIFNEAMHQQSTIFFKRILDIYNGFEGLNSLLDVGYGTGASSELIVSKYPSIKAINFDLPHIIQQATPHRGVEHVGGDMFIALPKADAIFMSWICHDWSDAHA
>rna-gnl|WGS:QIYW|chr09_45465619_45467135.mrna1
MELSTGSVLPMVVKSAIDLNLLQLIKKSGGEGASASQLVAQLPATNPDAADMIDRILRLLTAHSVLTCTLHTLPDGGVERRYSAAPVCEFLTPNEDGVSVAPASIMLQDRVLMESWYHMKDAILEGGIPFNRAYGKSVFEYSGTDPRFNKIFNEAMYQQSTIFMKRILDIYNGFEGLNSLLDVGGGTGASSKLIVSKYPSIKAINFDLPHVIQQATTHPGVEHVGGDMFVALPKADAIFMKWICHDWSDAHCVKVLKNCYDSLPENGKVIVAESILPEDPQSWSKALLAINGDVIMLNANLGGKERTEVEFQALAQQAGFKQLIKVCAASHIWIMEFHKSN
>rna-gnl|WGS:QIYW|chr05_62224151_62225474.mrna1
MKNSSTDEDLSIFALQVATSSIVPRALKVVIELDLLEMMKKAGRPLSTSEMAAQIQATNPEAALMMDRILRVLVASNILECTTAASHGRAERLYSLAPDAIVEGGIPFNIAHGMSGFEYPSTNPRYNKIFNQAMSDESTMFMHKILEIYDGFEGLKYVVDVGGGIGASLKVIITQHPSIKAINFDLPHVIQNAPSHPGLEHRSGDMFVSVPTGDAILLKWIIHNWSDGHCLKLLKNCYEALPEKGKVIIVDRILPETENYKEALTSVDLAGDALMLTLFTGGKERTEAEFQALAKASGFKYFRKVCCAFSTWIMELYK
>rna-gnl|WGS:QIYW|chr06_13953023_13953920.mrna1
MSAAARGAMAKALVDTFSGLKCTVLDLPQVVAGLEGSNNLRFVSGDMFQFIPPTDAVFLKRIMHDWSDENCVKILGKCKEAIIPSKNNGGKFVHNMEHRTVKHLIITQVSYEEGS
>rna-gnl|WGS:QIYW|chr07_59296361_59297911.mrna1
MTGFEYPATDPRYNEIFNQAMCQQSTMFMHQILELYNGFEGVKSLVDVGGGIGASLKIIVAKYPSINAINFDLDHVIQHDPSHPGVEHVSGDMFVSVPKSDAIFMKWISHNWSDGHCLKLLKDCHEALPEKGKVIIVDRIISEIPKKDPLVSIDLAADVLMFTLFPAGRERTEAEFQALAKAFGFKHFRKLCCAFNTWIMELYK
>rna-gnl|WGS:QIYW|chr08_24471795_24473993.mrna1
MGSTTKNSQTTALNSDEEENFLFAMQLASASVLPMVLKSAIELDLLELIKKAGPAAFVSPAELAAQLPTTNAAAAVMLDRILRLLASYAIVECRLKTLPDGGVERLYGLAPVCKFLTKNDDGVSMAPLALMNQDKVLMESWFHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNQGMSNHSTITMKKILETYKGFDGLKTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIQDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLKNCYDALPENGKVLLAECVLPEAPDTGLATKNVVHIDVIMLAHNPGGKERTEKEFYSLAIAAGFKRFNKACCAYNTWIIELLK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University