Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Perilla citriodora
Species name
Perilla frutescens var. hirtella is a varietas of beefsteak-mint (Perilla frutescens)
Species info
Gene sequence info
Perilla_citriodora.HIDH.fa
Download
>rna-gnl|WGS:QIYW|chr01_11273524_11274504.mrna1
MAANENELEFEFLPYIRVYKNGNIVRLKGEDTIPAGTDPRTGVSSKDVTNIIPETEVYVRIYVPKISTNNQKFPLLVYYHGGAFLVQTPSSPTYHNYLNALVAKSQVIAVSVHYRRAPEHHLPAAYEDSWAALHWVASHCNGDGPEAMLNHHADFCRVFLGGDSAGGNIVHNLAMAAGNPDGGLNVGILGIALVDPFFWGSDPIEAEELDSGKKAYVDRLWGAVCPSCPLDDPWINPLAEGGPSLVGLGCWRVLVTVAEKDLLKDRGWLYFQVLSRSGWLGAVEIDETEGEEHCFHLDNLESEKAKERMRKMADFFNRDLPPMAFQ
>rna-gnl|WGS:QIYW|chr09_06082050_06082997.mrna1
MSLIAEAPGFLQVFSDGAVVRTSHKTAACSTISATFISKDVTIDPSKPITARIFLPSSSAPQSPLPLLLYFHGGGFCIGTTTWLGYHAFLGNLSATAGAIILSVDYRLAPENKLPTAYEDGYAALEWLSSNSEPWLEHADLYRVFLAGDSAGGNIAHHVAVKSIETNIANFTIRGLLPIHPYFGSEARTELEVAEGSASEVAMNDMFWKLSLPEGADRDFYGCNFENREAEWSLFPATTVFVAGKDFLRERGVMYANFLKKKGVENVSLVEAEEEKHVFHAWNPESEAAVLLQNQIKRFIKACDYKQAQSRICLI
>rna-gnl|WGS:QIYW|chr02_34972623_34973614.mrna1
MRVHECSRSSSEQDRGKAEPLGDGVDELHYIIIDIERIPPPQYTPPSDDPNGVVRSKDVVIDTEIGLSIRIFAPRRHDPPQKLPIVMYVHGGAFCVGPASNPVFHNFVSNLVEKGNVIAVFIDDKLALENPMPIPFDDAWAVFQ
>rna-gnl|WGS:QIYW|chr02_34921296_34922360.mrna1
MSGNKSSPVLLLFIIFHLLVIPSFAANSSDILYEIEPYIKVYKNGSVERLIGAETVPPSLDPRSRVLSKDIIIQPTLNISARLFLPNTAAAKLPLLVYFHGGAFLTESPFSPTYHNYLNSVVAKANLIAVSVNYRLAPEHPLPIGYEDSWLALKWVFSHCKNGSGSETWLRSYVDFEHVYIGGDSAGGNIAHNVAIRVGLEKTGRDEGVVIQGMFLNCPHFWGKHRIGKEASYPKMVELEEKTWIHAYPNSTGLDDPASNPGLDPNLWRLGCKKVLVYVAENDVLRDRGLYYKKALEKSKWDGIVKAVEVKGVTHVFNLQSPNTTKAKQMLKHVALFLNGRDWRSRDYNLINLQ
>rna-gnl|WGS:QIYW|chr02_38207972_38208973.mrna1
MSQAKKVVDHVAGWLTVFDDGSVDRTWTGPPEVKFVMDAVPPHTHFIDGVAVADTITDDGLKLRIYLPEKQETEPKKLPVLLHFHGGGFCLSDADWFMYYAVYTRLAREARAIVVSPYLRQAPEHRLPAACDDGFAALLWLRSFAQGKSHHEWLDAAADFNRVFLIGDSSGGNIVHQVAARAGEEDLSPLKLVGAIPIHTDFCRTQRSKSEMEKAETPFLTPEMMDKLFSMALPEGATKDHPITCPMGEAAPPLETLKLPPYLYCMADHDLVRDRELEFYEAMKKANKEVELFMSHDVGHSFYLNKIAVDSDAKAAEETRKLFQGIIQFVNNH
>rna-gnl|WGS:QIYW|chr02_34946544_34947482.mrna1
MAANSDELLHDFLPMLRVHKNGRIERLTGTEFVPPSLDPATAVNSKDVEISPEINLSARIYLPGNADRSKKLPLLVYFHGGGFIIESAFSPLYQKHLNHVVAEANVVAVSVNYRLAPEFPLPIAFEDSWRALKWATAGNDEWINEFADRNRLYLGGDSAGGTIAHNIAMRVGSENPVGFNLRGVFLNCPFFWGVDPIGCETEEQFKFWKEFSDRLLPFACPIVSNHDEPWINPGKDLNVSSLGCKKVLIYVGGKDFLKERGWYYKEVLSKSGWNGEVECVEIAGEEHVFSVFFPDGETGMAMIKKVASFINE
>rna-gnl|WGS:QIYW|chr02_34953598_34954533.mrna1
MESDPTQITHDFPPFFRVHTTGHIHRYQQHDFLPPSHDPQTDVVSRDVVLSPENPLSVRIYLPKTTKTDPKLPLIFYTHGGGFSIESAFSSTYHRYINILASRSRSVVVSVEYRLAPEHPIPACYDDSYAALKWVDSHSHPGQGPDPWLNDHADLRRVFLAGDSAGANIAHNTLVRAKKEGGFGIHFSGLILVHPFFGTGKPDRVWDYVCPETSGPDDFRLHPMAHPELLSGLGCARVLVCVAEKDFLKNRGLNYYQSLKKSDWNGVVEIFETAGEPHVFHLFDPTRDNAVSLMTRIVEFVTSGVHVVSHV
>rna-gnl|WGS:QIYW|chr02_34955923_34956834.mrna1
MASPTKEIAVNMSPYFRLFTDGTIERLPPPLKTPPSDDPDLAVRSKDVVIDAETGVSVRIYVPRHRDPPRKFPLVVYIHGGAFCMGSASSPAFHNFITNLVEKGDVVAVSVSYRLAPENPLPIPFDDSWAAFQWIVAHADGRGADPWLNECADFRRVFIGGESAGATIANDVAIRAGVERFLGVDILGVFLVHPFFGSKEEDKLYKLLCPTSSGRDDDPRLNPAVDPRIREMAGRRVVFFVAEKDFLRDRGRAYYEGLKKSEWNGEVEIVESEGEGHCFHLFNPKTEKAAAITDRLVALFNAA
>rna-gnl|WGS:QIYW|chr02_34943386_34944333.mrna1
MAANSDEILHDFTPMLRAYKNGRIERLAGQDFVPPSLDPATAVNSKDVQIAPEINLSARLYLPGNADRRKKLPLLVYFHGGGFVIESAFSPQYQKHLNRLVAEANVVAVSVNYRLAPEFPLPIAFDDSWVALKWAAAEGSDEWITEFADLNRLYLGGDSAGANIAHNITMRVGSDYPERFNLRGIFMNCPFFGGVDPVGSESVEQFKPWKEFADKLWQFVCPTASDCDEPWINPGKDPNISRLVCKKVLIYVAEKDLLKERGWYYKEVLSKSGWNGKVECVEIAGEEHVFSVFFPDGENGMAMFKKLASFINDNE
>rna-gnl|WGS:QIYW|chr02_01874449_01876897.mrna1
MSCTNEGNTAASVATATPPPPHEVEECRGVLRVYSDGSIWRSSEPSFSVPVEDDGSVLWKDVVFDHTHNLQLRLYKPAKPSSSKLPVFYYIHGGGFCIGSRAWPNCQNYCFKLASQLQAVIVAPDYRLAPENRLPAAVEDGYASVKWLQAQATAEEPDAWLADVADFGRVFISGDSAGGNMAHHLAVWLGSGSAGLAPVRVRGYVYLAPFFGGTVRTEFEAHGPKEAFLNIDLIDRFWRLSIPLGETTDHPIVNPFGPKSPNLENMDLGPILVIVGGCDLLRDRALDYANKLKKWGKKIEYVEFDGQQHGFFTIDPNSHPSQQLMLLINKFIAENSL
>rna-gnl|WGS:QIYW|chr03_65844510_65845475.mrna1
MAAVATATDLSPLIKVYTDGTVQRLIGSSYVPPSPEDPTTAVASKDITISPSISARLYLPKLASAATPQKLPILVYFHGGGFCLESAFSLLHHRYTNLLSAASNALIISVEYRLAPEHPLPAAYDDSDAALKWVCSHALDQTGFDKESWIANHGNFGRVFIGGDASGANIAHNMAMRAGSDPLPGNVKIEGVILAHPFFGGSNPVGNQSKEDLERSFVYRVWSFVYPNAGGGIDNPMINPLAGGAPSLSELGCSKMIVFLAEKDPMAARGRLYTEMVRRSGWGGEMEVVEFEGENHCFQILDTRTQNAKNLINRFVVFISG
>rna-gnl|WGS:QIYW|chr04_03068804_03069184.mrna1
MTWRFESEWTDSSAWRFWGVFLVHHFFGSKEEDKLYKLLCPRIRGRDDLSRLNPAVDPRIREIAGRGVVFFVAEKDFLRDRGRAYYEGLKKSEWNGEVEILEIEGEGHCFHLFNPKTEKAIVAITD
>rna-gnl|WGS:QIYW|chr05_05297069_05298046.mrna1
MEAKDSKIVIHDVPPYIRVYEDGTIERLVGVEFTPAALDDPETGVSSKDVVFQPETGVSARLYRPKRAAAHPNKLPLVVYFHGGAFCISSTGDPKYHAMLNILVNEAQIILVSIDYRRAPEHPLPAAYEDSWAALRWVADHASGGATATEVWLRDHVDFDKVFLAGDSAGANISHHLSIRAGSPDHGLGEMKIRGILMIQPYFWGEEPMGVEAENPVFKAVVDKWWRFVCPSEGGCDDPLINPFVSGAPSLDRIACGRVLVCVAGNDILRERGRFYYSVLRKSKWPGKAEFFETEGEDHVFHVMDPTSENSKILINRCAEFINRE
>rna-gnl|WGS:QIYW|chr06_44778127_44778546.mrna1
MSQEKKVINCVVGWLTVFDNGSVDWTWTGPPEVKFVMDVVPRHTHFIDGVAVTDTTIDDGLKLRIYLPQKQETDPEKLPVLLHFHGGSFCLSDADWFMYYAVYTCLAREARAIMVSPYLRQAPEHRLPAACNDGFAALL
>rna-gnl|WGS:QIYW|chr08_29271110_29272129.mrna1
MLPCKGLSLIFLPLIFTLHSIPTISTDPILYDIYPFIRVYKNGTIQRFIGQDFAPPSTDPSTAVRSKDVKFSPQLNLTARLYLPTNSAAGRKLPLLIYFHGGGFFTESAFSPTYHHHLTSLVARAQIVAVSVNYRLAPEHLLPTAYQDSWVALKWAFSHYGGKGSEPWLNSYANFEYLYLGGDSAGGNIAHRMAIRVGLEKPGGGIKLKGMFLNCPYFLGKKAIGNESANANVYAETQMQKLWEHAYPKSAGLDDPMVNPGMDPGLKMVGCKRVLVYVAGNDVLKWRGEYYAAALGRSGWKGEVKVVEVEGENHVFNLINPNSSKAIAMLRVLASFLNH
MAANENELEFEFLPYIRVYKNGNIVRLKGEDTIPAGTDPRTGVSSKDVTNIIPETEVYVRIYVPKISTNNQKFPLLVYYHGGAFLVQTPSSPTYHNYLNALVAKSQVIAVSVHYRRAPEHHLPAAYEDSWAALHWVASHCNGDGPEAMLNHHADFCRVFLGGDSAGGNIVHNLAMAAGNPDGGLNVGILGIALVDPFFWGSDPIEAEELDSGKKAYVDRLWGAVCPSCPLDDPWINPLAEGGPSLVGLGCWRVLVTVAEKDLLKDRGWLYFQVLSRSGWLGAVEIDETEGEEHCFHLDNLESEKAKERMRKMADFFNRDLPPMAFQ
>rna-gnl|WGS:QIYW|chr09_06082050_06082997.mrna1
MSLIAEAPGFLQVFSDGAVVRTSHKTAACSTISATFISKDVTIDPSKPITARIFLPSSSAPQSPLPLLLYFHGGGFCIGTTTWLGYHAFLGNLSATAGAIILSVDYRLAPENKLPTAYEDGYAALEWLSSNSEPWLEHADLYRVFLAGDSAGGNIAHHVAVKSIETNIANFTIRGLLPIHPYFGSEARTELEVAEGSASEVAMNDMFWKLSLPEGADRDFYGCNFENREAEWSLFPATTVFVAGKDFLRERGVMYANFLKKKGVENVSLVEAEEEKHVFHAWNPESEAAVLLQNQIKRFIKACDYKQAQSRICLI
>rna-gnl|WGS:QIYW|chr02_34972623_34973614.mrna1
MRVHECSRSSSEQDRGKAEPLGDGVDELHYIIIDIERIPPPQYTPPSDDPNGVVRSKDVVIDTEIGLSIRIFAPRRHDPPQKLPIVMYVHGGAFCVGPASNPVFHNFVSNLVEKGNVIAVFIDDKLALENPMPIPFDDAWAVFQ
>rna-gnl|WGS:QIYW|chr02_34921296_34922360.mrna1
MSGNKSSPVLLLFIIFHLLVIPSFAANSSDILYEIEPYIKVYKNGSVERLIGAETVPPSLDPRSRVLSKDIIIQPTLNISARLFLPNTAAAKLPLLVYFHGGAFLTESPFSPTYHNYLNSVVAKANLIAVSVNYRLAPEHPLPIGYEDSWLALKWVFSHCKNGSGSETWLRSYVDFEHVYIGGDSAGGNIAHNVAIRVGLEKTGRDEGVVIQGMFLNCPHFWGKHRIGKEASYPKMVELEEKTWIHAYPNSTGLDDPASNPGLDPNLWRLGCKKVLVYVAENDVLRDRGLYYKKALEKSKWDGIVKAVEVKGVTHVFNLQSPNTTKAKQMLKHVALFLNGRDWRSRDYNLINLQ
>rna-gnl|WGS:QIYW|chr02_38207972_38208973.mrna1
MSQAKKVVDHVAGWLTVFDDGSVDRTWTGPPEVKFVMDAVPPHTHFIDGVAVADTITDDGLKLRIYLPEKQETEPKKLPVLLHFHGGGFCLSDADWFMYYAVYTRLAREARAIVVSPYLRQAPEHRLPAACDDGFAALLWLRSFAQGKSHHEWLDAAADFNRVFLIGDSSGGNIVHQVAARAGEEDLSPLKLVGAIPIHTDFCRTQRSKSEMEKAETPFLTPEMMDKLFSMALPEGATKDHPITCPMGEAAPPLETLKLPPYLYCMADHDLVRDRELEFYEAMKKANKEVELFMSHDVGHSFYLNKIAVDSDAKAAEETRKLFQGIIQFVNNH
>rna-gnl|WGS:QIYW|chr02_34946544_34947482.mrna1
MAANSDELLHDFLPMLRVHKNGRIERLTGTEFVPPSLDPATAVNSKDVEISPEINLSARIYLPGNADRSKKLPLLVYFHGGGFIIESAFSPLYQKHLNHVVAEANVVAVSVNYRLAPEFPLPIAFEDSWRALKWATAGNDEWINEFADRNRLYLGGDSAGGTIAHNIAMRVGSENPVGFNLRGVFLNCPFFWGVDPIGCETEEQFKFWKEFSDRLLPFACPIVSNHDEPWINPGKDLNVSSLGCKKVLIYVGGKDFLKERGWYYKEVLSKSGWNGEVECVEIAGEEHVFSVFFPDGETGMAMIKKVASFINE
>rna-gnl|WGS:QIYW|chr02_34953598_34954533.mrna1
MESDPTQITHDFPPFFRVHTTGHIHRYQQHDFLPPSHDPQTDVVSRDVVLSPENPLSVRIYLPKTTKTDPKLPLIFYTHGGGFSIESAFSSTYHRYINILASRSRSVVVSVEYRLAPEHPIPACYDDSYAALKWVDSHSHPGQGPDPWLNDHADLRRVFLAGDSAGANIAHNTLVRAKKEGGFGIHFSGLILVHPFFGTGKPDRVWDYVCPETSGPDDFRLHPMAHPELLSGLGCARVLVCVAEKDFLKNRGLNYYQSLKKSDWNGVVEIFETAGEPHVFHLFDPTRDNAVSLMTRIVEFVTSGVHVVSHV
>rna-gnl|WGS:QIYW|chr02_34955923_34956834.mrna1
MASPTKEIAVNMSPYFRLFTDGTIERLPPPLKTPPSDDPDLAVRSKDVVIDAETGVSVRIYVPRHRDPPRKFPLVVYIHGGAFCMGSASSPAFHNFITNLVEKGDVVAVSVSYRLAPENPLPIPFDDSWAAFQWIVAHADGRGADPWLNECADFRRVFIGGESAGATIANDVAIRAGVERFLGVDILGVFLVHPFFGSKEEDKLYKLLCPTSSGRDDDPRLNPAVDPRIREMAGRRVVFFVAEKDFLRDRGRAYYEGLKKSEWNGEVEIVESEGEGHCFHLFNPKTEKAAAITDRLVALFNAA
>rna-gnl|WGS:QIYW|chr02_34943386_34944333.mrna1
MAANSDEILHDFTPMLRAYKNGRIERLAGQDFVPPSLDPATAVNSKDVQIAPEINLSARLYLPGNADRRKKLPLLVYFHGGGFVIESAFSPQYQKHLNRLVAEANVVAVSVNYRLAPEFPLPIAFDDSWVALKWAAAEGSDEWITEFADLNRLYLGGDSAGANIAHNITMRVGSDYPERFNLRGIFMNCPFFGGVDPVGSESVEQFKPWKEFADKLWQFVCPTASDCDEPWINPGKDPNISRLVCKKVLIYVAEKDLLKERGWYYKEVLSKSGWNGKVECVEIAGEEHVFSVFFPDGENGMAMFKKLASFINDNE
>rna-gnl|WGS:QIYW|chr02_01874449_01876897.mrna1
MSCTNEGNTAASVATATPPPPHEVEECRGVLRVYSDGSIWRSSEPSFSVPVEDDGSVLWKDVVFDHTHNLQLRLYKPAKPSSSKLPVFYYIHGGGFCIGSRAWPNCQNYCFKLASQLQAVIVAPDYRLAPENRLPAAVEDGYASVKWLQAQATAEEPDAWLADVADFGRVFISGDSAGGNMAHHLAVWLGSGSAGLAPVRVRGYVYLAPFFGGTVRTEFEAHGPKEAFLNIDLIDRFWRLSIPLGETTDHPIVNPFGPKSPNLENMDLGPILVIVGGCDLLRDRALDYANKLKKWGKKIEYVEFDGQQHGFFTIDPNSHPSQQLMLLINKFIAENSL
>rna-gnl|WGS:QIYW|chr03_65844510_65845475.mrna1
MAAVATATDLSPLIKVYTDGTVQRLIGSSYVPPSPEDPTTAVASKDITISPSISARLYLPKLASAATPQKLPILVYFHGGGFCLESAFSLLHHRYTNLLSAASNALIISVEYRLAPEHPLPAAYDDSDAALKWVCSHALDQTGFDKESWIANHGNFGRVFIGGDASGANIAHNMAMRAGSDPLPGNVKIEGVILAHPFFGGSNPVGNQSKEDLERSFVYRVWSFVYPNAGGGIDNPMINPLAGGAPSLSELGCSKMIVFLAEKDPMAARGRLYTEMVRRSGWGGEMEVVEFEGENHCFQILDTRTQNAKNLINRFVVFISG
>rna-gnl|WGS:QIYW|chr04_03068804_03069184.mrna1
MTWRFESEWTDSSAWRFWGVFLVHHFFGSKEEDKLYKLLCPRIRGRDDLSRLNPAVDPRIREIAGRGVVFFVAEKDFLRDRGRAYYEGLKKSEWNGEVEILEIEGEGHCFHLFNPKTEKAIVAITD
>rna-gnl|WGS:QIYW|chr05_05297069_05298046.mrna1
MEAKDSKIVIHDVPPYIRVYEDGTIERLVGVEFTPAALDDPETGVSSKDVVFQPETGVSARLYRPKRAAAHPNKLPLVVYFHGGAFCISSTGDPKYHAMLNILVNEAQIILVSIDYRRAPEHPLPAAYEDSWAALRWVADHASGGATATEVWLRDHVDFDKVFLAGDSAGANISHHLSIRAGSPDHGLGEMKIRGILMIQPYFWGEEPMGVEAENPVFKAVVDKWWRFVCPSEGGCDDPLINPFVSGAPSLDRIACGRVLVCVAGNDILRERGRFYYSVLRKSKWPGKAEFFETEGEDHVFHVMDPTSENSKILINRCAEFINRE
>rna-gnl|WGS:QIYW|chr06_44778127_44778546.mrna1
MSQEKKVINCVVGWLTVFDNGSVDWTWTGPPEVKFVMDVVPRHTHFIDGVAVTDTTIDDGLKLRIYLPQKQETDPEKLPVLLHFHGGSFCLSDADWFMYYAVYTCLAREARAIMVSPYLRQAPEHRLPAACNDGFAALL
>rna-gnl|WGS:QIYW|chr08_29271110_29272129.mrna1
MLPCKGLSLIFLPLIFTLHSIPTISTDPILYDIYPFIRVYKNGTIQRFIGQDFAPPSTDPSTAVRSKDVKFSPQLNLTARLYLPTNSAAGRKLPLLIYFHGGGFFTESAFSPTYHHHLTSLVARAQIVAVSVNYRLAPEHLLPTAYQDSWVALKWAFSHYGGKGSEPWLNSYANFEYLYLGGDSAGGNIAHRMAIRVGLEKPGGGIKLKGMFLNCPYFLGKKAIGNESANANVYAETQMQKLWEHAYPKSAGLDDPMVNPGMDPGLKMVGCKRVLVYVAGNDVLKWRGEYYAAALGRSGWKGEVKVVEVEGENHVFNLINPNSSKAIAMLRVLASFLNH
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University