Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Perilla citriodora
Species name
Perilla frutescens var. hirtella is a varietas of beefsteak-mint (Perilla frutescens)
Species info
Gene sequence info
Perilla_citriodora.CHS.fa
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>rna-gnl|WGS:QIYW|chr02_63478122_63478598.mrna1
MNIQLDPAVVQFEKTPTEGTIDRHIREAGLIIHLMKDVPVLISKNIEKSFKEAFRPLGISYWNLIFWIAHPEGPAILDQVESKLGFKAEKLRSTWHVFGDYGNMASACMLLVLDEMRKTSVKEGLSSTRKGLDCGVMFGFGPGLTVETMVLHSVPINK
>rna-gnl|WGS:QIYW|chr02_63539845_63541934.mrna1
MVTVEDIHRAQRAEGPATVLAIGTATPANCVEQSTYPNYYFRITNSEHKTDLKEKFKRMCENSMIRKRYIHLTEEFLKENPNVTEYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWRQPKSKITHIIFCTTSGVDMPGADYQLTKLLGLRLSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAATFRGPSETHLDNLVGQALFGDGACAVIIGSDPIIGVEQPLFQIVSAAQTILPNSEGAIDGHVREAGLIIHLMKDIPVLISKNIEKSLKEAFGPLGISDWNSIFWIAHPGGPAILDQVESKLGLKAEKLRSTRHVLGEYGNMASACVLFVLDEMRKTSAEEGLSSTGEGLDWGVLFGFGPGLTVETVVLHSVPINK
>rna-gnl|WGS:QIYW|chr03_10638939_10641262.mrna1
MAEVERAPRAEGPASILAIGRATPTHCFDQSTYPDFYFRITKSEHMKELKEKFTRICERSTIKKRYMHLTEEILQENPNICAYKEPSFDARQEIAVVEIPKLGKSAAEAAIKEWGQPKSSITHLIFCTSGCIDLPGADYQLTKLLGLRPSVNRFMLYQQACFAGAAALRLAKDMAENNAGARVLIVCSEMTVMTFRGPSEAHVDSLVGQALFGDGAAAVIVGSDPVEGVERPLFQIFSAAQTLVPGSDGAVEGHSREVGLTFHLKKEVPRLISMNVGKYLEEAFAPVGISDWNSIFWAPHPGGPQILNQVEAELDLKPEKLRSTRRVLSEYGNISSATLLFILDEIRKVSAEEGRSSTGEGLEWGVLFGFGPGFTVETVVLRSVPI
>rna-gnl|WGS:QIYW|chr03_10618337_10620823.mrna1
MAEVERAPRAEGPASILAIGRATPTHCFDQSTYPDFYFRITKSEHMKELKDKFTRICEKSTIKKRYMHLTEEILQENPNISAHMAPSFDARQQIAVAEIPKLGKSAAEAAIKEWGQPKSSITHLIFCTSGCLDLPGADYQLTKLLGLRPSINRSMIYQQACFAGATALRLAKDMAENNAGARVLIVCSEMTVMTFRGPSEAHVDSLVGQALFGDGAAAVIVGSDPVVGVERPLFQIFSAAQTLVPGSDGAVEGLSREVGLTFHLTKEVPRLISMNVGKCLEEAFAPMGISDWNSIFWAPHPGGPQILNQVEAALDLNTEKFRLTRRVLSEYGNISSATVLFILDEIRKVSAEEGRSSTGEGLEWGVLFGFGPGFTVETVVLRSVPTQY
>rna-gnl|WGS:QIYW|chr03_10699891_10701174.mrna1
MGTVEEIRRAQRAEGPPTILAIGTANPLNCVHQTTYPDYYFRITNSEHMIQLKQKFKRICEKSMINKRYMHLTEDLLKQNPNMCAHAAPTLDARQEIVGAEVPKLGKSAVEKAIEEWGQPRAKITHLIFCTNNGTDMPGANFHLPNLLGLRSTVNRYMMYQQGCYGGAGALRLAKDLAENNSGARVLVVCSEIMAMTFPGPSEAHLDHLMGQPLVGDGAVAVIVGSDPVAGVERPLFKLIVAAQSFLLGSEDAINGQLREVGVIYDIKKTVPGFISENIEKCLERVFTPLGISDWNLNKVYIQQLWIHKYLTTTA
>rna-gnl|WGS:QIYW|chr05_22018532_22019326.mrna1
MSKEILEQYPELATEGSPTIKQRLEVAHPAVLEMAKEASIACLTEWKRPPQDITHIVYISSSEIRLPGGDLYLATELALKNDVARVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPNKSRPYDLVGAALFGDGAAAVVIGADPIEGVECPFMELNSAVQQFLPGTSDVIDGRISEEGINFKLGRDLPEKIEENIEEFCKKLMGKAGLQDYNELFWAVHPGGPAILNRLESRLGLDSGKLECSRRALMDYGN
>rna-gnl|WGS:QIYW|chr07_12976610_12978234.mrna1
MVTIEDIHRAQRAQGPATVLAIGTAAPANCVDQSTYPDYYFRITNSEHKTDLKEKFKRICNNSMIKKRYMHLTEEFLKENPNLASYTTPSLNLRQDILVAEVPKLGKEAAQNAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLSPSVKRCMMYQQGCFAGGTVLRMAKDFAENNAGARVLIVCSELTIVTFRGPSESHLSTLVGQALFGDGAAAVIVGSDPMVGVERPLFQLLSSMQTILPDSEGAICGHLREVGLTFHLLREVPVIISKNIETCLKEAFGPLGISDWNSIFWIAHPGGPEILDQVESKLGLKPKKLRATRHVLGEYGNMWSACVLFILDEMRKTSAKEGLSSTGEGCEWGVLFGFGPGLTVETVVLHSVPINNSE
>rna-gnl|WGS:QIYW|chr07_13173903_13175552.mrna1
MVTVEDIRRAQRAEGPATVMAIGTATPENCVDQSTYPDYYFRITNSEHRTDLKEKFKRMCEKSMIRKRYMHLTEEFLKENPNMTAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAVIVGSDPVVGVERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFGPLGISDWNSVFWIAHPGGPAILDQVEAKLGLKPEKLRSTRHVLGEYGNMSSACVLFILDEMRKSSAKEGMSSTGEGLDWGVLFGFGPGLTVETVVLHSVPINN
>rna-gnl|WGS:QIYW|chr07_13234253_13235796.mrna1
MATVEEIRRAQRAEGPATVLAIGTAMPSNCVHQSTFPDYYFRITNSEHMTEELKQKMKRICEKSTIKKRYIHLTEEIVKENPNIAAYKAPSLDARQDIVVVEVPKLGKEAAEKAIKEWGQPKSKITHLIFCTSSGVDMPGADYQLTKLLGLPPSVKRFMMYHQGCYGGATALRMAKDLAENNNGARVLVVCSEITAISFRGPTETETHFDNLIGHALFGDGAAAAIIGSEPVVGVELPLFQIVSAAQTIVPDSEGRISGHVREAGLIINLLRDIPDLISNNIEKSLKEAFGPLGISDWNSIFWIAHPGGPAILDKFESKLGLKPDKLRVSRRVLSEYGNVWSTSVMLVMDEMRKSSAAKGLTSTGEGLDWGVLLGFGAGLTVETLVLHSMPIN
>rna-gnl|WGS:QIYW|chr08_55093724_55096635.mrna1
MATVEVIRQAQRAEGPATILAIGTANPLNCVDQSTFPDYYFRITNSEHMIQLKQKLKRICEKSMINKRYMHLTEDLLKQNPNLCAHATPSLDARQKILVAEVPKLGYSAAEKAIEEWGQPRTKITHLIFCTNNGIDMPGADFRLANLLSLRPTVNRYMMYQQGCYGGAGTLRLAKDLAENNSGARVLIVCSEIMAMTFHGPSDAHSGNLLAQALLGDGAAAVIVGSDPVAGVEWPIFQLISAAQSFLPGSEDAIYGQLREVGLIYEIMKTVPGFISDNIEKCLEGVFGPLGISDWNSIFWIVHPGGPAILDGIEAKLELKPEKLQATRRVLSEYGNMMSACVLFVMDEMRKAEGEGMKWGVLLGFGWGLTVETLVLRSLLTN
MNIQLDPAVVQFEKTPTEGTIDRHIREAGLIIHLMKDVPVLISKNIEKSFKEAFRPLGISYWNLIFWIAHPEGPAILDQVESKLGFKAEKLRSTWHVFGDYGNMASACMLLVLDEMRKTSVKEGLSSTRKGLDCGVMFGFGPGLTVETMVLHSVPINK
>rna-gnl|WGS:QIYW|chr02_63539845_63541934.mrna1
MVTVEDIHRAQRAEGPATVLAIGTATPANCVEQSTYPNYYFRITNSEHKTDLKEKFKRMCENSMIRKRYIHLTEEFLKENPNVTEYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWRQPKSKITHIIFCTTSGVDMPGADYQLTKLLGLRLSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAATFRGPSETHLDNLVGQALFGDGACAVIIGSDPIIGVEQPLFQIVSAAQTILPNSEGAIDGHVREAGLIIHLMKDIPVLISKNIEKSLKEAFGPLGISDWNSIFWIAHPGGPAILDQVESKLGLKAEKLRSTRHVLGEYGNMASACVLFVLDEMRKTSAEEGLSSTGEGLDWGVLFGFGPGLTVETVVLHSVPINK
>rna-gnl|WGS:QIYW|chr03_10638939_10641262.mrna1
MAEVERAPRAEGPASILAIGRATPTHCFDQSTYPDFYFRITKSEHMKELKEKFTRICERSTIKKRYMHLTEEILQENPNICAYKEPSFDARQEIAVVEIPKLGKSAAEAAIKEWGQPKSSITHLIFCTSGCIDLPGADYQLTKLLGLRPSVNRFMLYQQACFAGAAALRLAKDMAENNAGARVLIVCSEMTVMTFRGPSEAHVDSLVGQALFGDGAAAVIVGSDPVEGVERPLFQIFSAAQTLVPGSDGAVEGHSREVGLTFHLKKEVPRLISMNVGKYLEEAFAPVGISDWNSIFWAPHPGGPQILNQVEAELDLKPEKLRSTRRVLSEYGNISSATLLFILDEIRKVSAEEGRSSTGEGLEWGVLFGFGPGFTVETVVLRSVPI
>rna-gnl|WGS:QIYW|chr03_10618337_10620823.mrna1
MAEVERAPRAEGPASILAIGRATPTHCFDQSTYPDFYFRITKSEHMKELKDKFTRICEKSTIKKRYMHLTEEILQENPNISAHMAPSFDARQQIAVAEIPKLGKSAAEAAIKEWGQPKSSITHLIFCTSGCLDLPGADYQLTKLLGLRPSINRSMIYQQACFAGATALRLAKDMAENNAGARVLIVCSEMTVMTFRGPSEAHVDSLVGQALFGDGAAAVIVGSDPVVGVERPLFQIFSAAQTLVPGSDGAVEGLSREVGLTFHLTKEVPRLISMNVGKCLEEAFAPMGISDWNSIFWAPHPGGPQILNQVEAALDLNTEKFRLTRRVLSEYGNISSATVLFILDEIRKVSAEEGRSSTGEGLEWGVLFGFGPGFTVETVVLRSVPTQY
>rna-gnl|WGS:QIYW|chr03_10699891_10701174.mrna1
MGTVEEIRRAQRAEGPPTILAIGTANPLNCVHQTTYPDYYFRITNSEHMIQLKQKFKRICEKSMINKRYMHLTEDLLKQNPNMCAHAAPTLDARQEIVGAEVPKLGKSAVEKAIEEWGQPRAKITHLIFCTNNGTDMPGANFHLPNLLGLRSTVNRYMMYQQGCYGGAGALRLAKDLAENNSGARVLVVCSEIMAMTFPGPSEAHLDHLMGQPLVGDGAVAVIVGSDPVAGVERPLFKLIVAAQSFLLGSEDAINGQLREVGVIYDIKKTVPGFISENIEKCLERVFTPLGISDWNLNKVYIQQLWIHKYLTTTA
>rna-gnl|WGS:QIYW|chr05_22018532_22019326.mrna1
MSKEILEQYPELATEGSPTIKQRLEVAHPAVLEMAKEASIACLTEWKRPPQDITHIVYISSSEIRLPGGDLYLATELALKNDVARVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPNKSRPYDLVGAALFGDGAAAVVIGADPIEGVECPFMELNSAVQQFLPGTSDVIDGRISEEGINFKLGRDLPEKIEENIEEFCKKLMGKAGLQDYNELFWAVHPGGPAILNRLESRLGLDSGKLECSRRALMDYGN
>rna-gnl|WGS:QIYW|chr07_12976610_12978234.mrna1
MVTIEDIHRAQRAQGPATVLAIGTAAPANCVDQSTYPDYYFRITNSEHKTDLKEKFKRICNNSMIKKRYMHLTEEFLKENPNLASYTTPSLNLRQDILVAEVPKLGKEAAQNAIKEWGQPKSKITHLIFCTTSGVDMPGADYQLTKLLGLSPSVKRCMMYQQGCFAGGTVLRMAKDFAENNAGARVLIVCSELTIVTFRGPSESHLSTLVGQALFGDGAAAVIVGSDPMVGVERPLFQLLSSMQTILPDSEGAICGHLREVGLTFHLLREVPVIISKNIETCLKEAFGPLGISDWNSIFWIAHPGGPEILDQVESKLGLKPKKLRATRHVLGEYGNMWSACVLFILDEMRKTSAKEGLSSTGEGCEWGVLFGFGPGLTVETVVLHSVPINNSE
>rna-gnl|WGS:QIYW|chr07_13173903_13175552.mrna1
MVTVEDIRRAQRAEGPATVMAIGTATPENCVDQSTYPDYYFRITNSEHRTDLKEKFKRMCEKSMIRKRYMHLTEEFLKENPNMTAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAVIVGSDPVVGVERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFGPLGISDWNSVFWIAHPGGPAILDQVEAKLGLKPEKLRSTRHVLGEYGNMSSACVLFILDEMRKSSAKEGMSSTGEGLDWGVLFGFGPGLTVETVVLHSVPINN
>rna-gnl|WGS:QIYW|chr07_13234253_13235796.mrna1
MATVEEIRRAQRAEGPATVLAIGTAMPSNCVHQSTFPDYYFRITNSEHMTEELKQKMKRICEKSTIKKRYIHLTEEIVKENPNIAAYKAPSLDARQDIVVVEVPKLGKEAAEKAIKEWGQPKSKITHLIFCTSSGVDMPGADYQLTKLLGLPPSVKRFMMYHQGCYGGATALRMAKDLAENNNGARVLVVCSEITAISFRGPTETETHFDNLIGHALFGDGAAAAIIGSEPVVGVELPLFQIVSAAQTIVPDSEGRISGHVREAGLIINLLRDIPDLISNNIEKSLKEAFGPLGISDWNSIFWIAHPGGPAILDKFESKLGLKPDKLRVSRRVLSEYGNVWSTSVMLVMDEMRKSSAAKGLTSTGEGLDWGVLLGFGAGLTVETLVLHSMPIN
>rna-gnl|WGS:QIYW|chr08_55093724_55096635.mrna1
MATVEVIRQAQRAEGPATILAIGTANPLNCVDQSTFPDYYFRITNSEHMIQLKQKLKRICEKSMINKRYMHLTEDLLKQNPNLCAHATPSLDARQKILVAEVPKLGYSAAEKAIEEWGQPRTKITHLIFCTNNGIDMPGADFRLANLLSLRPTVNRYMMYQQGCYGGAGTLRLAKDLAENNSGARVLIVCSEIMAMTFHGPSDAHSGNLLAQALLGDGAAAVIVGSDPVAGVEWPIFQLISAAQSFLPGSEDAIYGQLREVGLIYEIMKTVPGFISDNIEKCLEGVFGPLGISDWNSIFWIVHPGGPAILDGIEAKLELKPEKLQATRRVLSEYGNMMSACVLFVMDEMRKAEGEGMKWGVLLGFGWGLTVETLVLRSLLTN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University