Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Perilla citriodora
Species name
Perilla frutescens var. hirtella is a varietas of beefsteak-mint (Perilla frutescens)
Species info
Gene sequence info
Perilla_citriodora.4CL.fa
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>rna-gnl|WGS:QIYW|chr01_33570494_33576608.mrna1
MEIPTKQEEIIFRSKLPDIYIPKHLPLHSYCFENISKFSTRPCLINGTTNQVYTYEDVELTARKVATGLSQLSIQQGETVMLLLPNSPEYVFAFLGASYIGAVSTMANPYFTPAEVIKQAKASNAKLIITQACYVDKVRDYAADAGIKVVCTDAPPAGCLPFSELTSADEREMPAVKIHPNDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELMQRYKVTIGPFVPPIVLAIVKSPLVGKYDISSVRMVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGASLGRNQSGEICIRGDQIMKGYLNDPESTKTTIDNEGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPHISDAAVVSMQDEQAGEVPVAYVVRSNGSTITEDEIKQFVSKQVIFYKRVHRVFFIDAIPKSPSGKILRKDLRARLAAAV
>rna-gnl|WGS:QIYW|chr10_52946541_52949270.mrna1
MGTHGKSLVQEEIIFTSKFPPVQVPDDVSLPEFVLSDVEPYLDKMAVVDSITGKGYTYKEVKRDVYRFSKALRSLGLRKGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPHCHASEIEKQVEAADAKLIVTDGSTYHKVKDLGLPVIIQGEDRIDGTVNCVELMEAADKANTDFIDEKVLQTDLCALPFSSGTTGLSKGVMLTHQNLVANLCSTLFSVGPELVGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLSALITHKVTFAPIVPPIMLGLVKNPVVDEFDLSKLSLRSVMTAAAPLAPEILNEFERKFPGVEVQEAYGMTEHSCITMSHGSVIAKRNSVGFILPNLEVKFVSPETGNSLPKNTPGEICVRSKCYYKNEHETTITIDEDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLSHPSVDDAAVVGLPDEEAGEIPGACVVMKAGAKENEEDIIKYVSSNAATYKRVRVVQFVSSIPKSPSGKIMRRIIRENMVKDLHN
>rna-gnl|WGS:QIYW|chr02_49947024_49951504.mrna1
METATRQDDVIFRSKLPDIYIPKHLPLHAYCFENISGYRNKPCLINGATDDVYTYGEVEALSRKAAAGLSRLGLRHGDTIMILLPNSPEFVFAFLGASYIGAVSTMANPFFTPAEVIKQAKASNAKLIITQACHVGKVRDYSSGNGVRVVCVDSPPPEAAANCLLFSELISAEESELPAVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSDDVIMCVLPFFHIYSLNSILLCGLRGGAAILLMQKFDIVPFLELIQRYRVTIGPFVPPIVLAIVKSPVVDKYDLSSVRTVMSGAAPLGKELEEAVRNKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIIDTETGASLGRNQPGEICIKGDQIMKGYLNDVEATERTIDKQGWLHTGDIGFIDEDDELFIIDRLKEIIKYKGYQVAPAELEALLLTHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSTITEDEIKQFVSKQVIFYKRISKVFFIDAIPKNPSGKILRKDLRAKLVATASTN
>rna-gnl|WGS:QIYW|chr03_36027450_36027710.mrna1
MQRYELRLFLSALITHKVTFAPIVPPIMLGLMKNPVVDEFDLRKLSLRFVMTAAAPLAPEILNEFERKFPGVEVQEVKQRLIDEEI
>rna-gnl|WGS:QIYW|chr05_16123461_16131645.mrna1
MELKQESEHIFRSKLPDIYIPTHLPLHTYCFQNLSTHRARPYLLNAATGDTFTHAEFELTARRVAVGLHTLGIHKSDVIMLLLHNSSEFALAFLGASFIGAVSTTANPLYTASEIALQAEISRPKLIITHACHVEKVKHLASAAGAKVVTIDPPPSPEIIHFSELTRSDEKMLPPVEIHPDDTAALPFSSGTTGLPKGVMLSHKNLVTCVSQQVDGENPAVHIDREDRMLCVLPLFHVYSMISVMLCSLRVGASMLIMPKFEIHELMELIQRYRVTIAPFVPPILLGIAKNAAAEFDLSSVRRVTCGAAPMDRKLELALKAKLPNAIIGQGYGMTEAGVLSMSLGFAKSPFKFKAGSCGTVIRNARMKIVNPATGASLPRNQTGEICIKGNAVMKGYYNDPEATKRTIDEEGWLHTGDIGYVDDDDEVFIVDRLKELIKYKGFHVAPAELEALLIAHPSISDAAVVPMADEAAGEVPIAFVVRANGANISELEIKKYIAQQVVSYKRIKRVFFTDKIPKGPSGKTLRKNLRPRI
>rna-gnl|WGS:QIYW|chr06_27877679_27878150.mrna1
MQRYELRLFLSALITHKVTFAPIVPPIMLNLVKNPVVDEFDLGKLSLRSVMTAAAPLAPEILNKFERKFPRVEVQEAYGMTEHSCITLSHGSVIAKRNSVGFILPNLEVKFVSPETGNSLPKKTLWERRNFNF
>rna-gnl|WGS:QIYW|chr08_13718956_13722463.mrna1
MEKSGYGRDGVFRSLRPPLFFPRDPNLSMIPFLFRNASSFADKPALIDAHTGKTLTFSQFKSMVAKFSHALLHLGINKNDVVLIFAPNSIQFPVAFFGIIAIGAVATTVNPTYTVSELSKQLKDSTAKIIVTVEDLLPKVKDFNLPVILLGDGENEKPILPIGKIPSIVPFSEFVNNEGSVDLDGNSFGIKQDDTAVLLYSSGTTGASKGVVLSHRNFIAASLMVTADQEMAGEINNVFLLVLPMFHVFGLAVIMFSQLQRGSAIVSMSKFELGMILRTVEKHGVTHLWVVPPIILALAKNSIVKNYNLSSLKQVGSGAAPLGKELMQECAKNIPLAVVMQGYGMTETCGIVCVESPYSGPRHSGSAGMLVPGVECQIVSVDKLKPLPPTQLGEIWVRGPNMMQGYFRNPQATKLTIDRQGWVHTGDLGYFDEEGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIADQVAPFKRLRRVTFIKSVPKSASGKILRRELIAEVKSKL
MEIPTKQEEIIFRSKLPDIYIPKHLPLHSYCFENISKFSTRPCLINGTTNQVYTYEDVELTARKVATGLSQLSIQQGETVMLLLPNSPEYVFAFLGASYIGAVSTMANPYFTPAEVIKQAKASNAKLIITQACYVDKVRDYAADAGIKVVCTDAPPAGCLPFSELTSADEREMPAVKIHPNDAVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELMQRYKVTIGPFVPPIVLAIVKSPLVGKYDISSVRMVMSGAAPLGKELEDAVRAKFPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGASLGRNQSGEICIRGDQIMKGYLNDPESTKTTIDNEGWLHTGDIGFIDADDELFIVDRLKEIIKYKGFQVAPAEIEALLLNHPHISDAAVVSMQDEQAGEVPVAYVVRSNGSTITEDEIKQFVSKQVIFYKRVHRVFFIDAIPKSPSGKILRKDLRARLAAAV
>rna-gnl|WGS:QIYW|chr10_52946541_52949270.mrna1
MGTHGKSLVQEEIIFTSKFPPVQVPDDVSLPEFVLSDVEPYLDKMAVVDSITGKGYTYKEVKRDVYRFSKALRSLGLRKGRVVVVLLPNVAEYATIALGIMAAGGVFSGANPHCHASEIEKQVEAADAKLIVTDGSTYHKVKDLGLPVIIQGEDRIDGTVNCVELMEAADKANTDFIDEKVLQTDLCALPFSSGTTGLSKGVMLTHQNLVANLCSTLFSVGPELVGQVATLGLIPFFHIYGLTGICCATIKNKGKVVVMQRYELRLFLSALITHKVTFAPIVPPIMLGLVKNPVVDEFDLSKLSLRSVMTAAAPLAPEILNEFERKFPGVEVQEAYGMTEHSCITMSHGSVIAKRNSVGFILPNLEVKFVSPETGNSLPKNTPGEICVRSKCYYKNEHETTITIDEDGWLHTGDIGYIDDDGDVFLVDRIKELIKYKGFQVAPAELEAILLSHPSVDDAAVVGLPDEEAGEIPGACVVMKAGAKENEEDIIKYVSSNAATYKRVRVVQFVSSIPKSPSGKIMRRIIRENMVKDLHN
>rna-gnl|WGS:QIYW|chr02_49947024_49951504.mrna1
METATRQDDVIFRSKLPDIYIPKHLPLHAYCFENISGYRNKPCLINGATDDVYTYGEVEALSRKAAAGLSRLGLRHGDTIMILLPNSPEFVFAFLGASYIGAVSTMANPFFTPAEVIKQAKASNAKLIITQACHVGKVRDYSSGNGVRVVCVDSPPPEAAANCLLFSELISAEESELPAVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSDDVIMCVLPFFHIYSLNSILLCGLRGGAAILLMQKFDIVPFLELIQRYRVTIGPFVPPIVLAIVKSPVVDKYDLSSVRTVMSGAAPLGKELEEAVRNKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIIDTETGASLGRNQPGEICIKGDQIMKGYLNDVEATERTIDKQGWLHTGDIGFIDEDDELFIIDRLKEIIKYKGYQVAPAELEALLLTHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSTITEDEIKQFVSKQVIFYKRISKVFFIDAIPKNPSGKILRKDLRAKLVATASTN
>rna-gnl|WGS:QIYW|chr03_36027450_36027710.mrna1
MQRYELRLFLSALITHKVTFAPIVPPIMLGLMKNPVVDEFDLRKLSLRFVMTAAAPLAPEILNEFERKFPGVEVQEVKQRLIDEEI
>rna-gnl|WGS:QIYW|chr05_16123461_16131645.mrna1
MELKQESEHIFRSKLPDIYIPTHLPLHTYCFQNLSTHRARPYLLNAATGDTFTHAEFELTARRVAVGLHTLGIHKSDVIMLLLHNSSEFALAFLGASFIGAVSTTANPLYTASEIALQAEISRPKLIITHACHVEKVKHLASAAGAKVVTIDPPPSPEIIHFSELTRSDEKMLPPVEIHPDDTAALPFSSGTTGLPKGVMLSHKNLVTCVSQQVDGENPAVHIDREDRMLCVLPLFHVYSMISVMLCSLRVGASMLIMPKFEIHELMELIQRYRVTIAPFVPPILLGIAKNAAAEFDLSSVRRVTCGAAPMDRKLELALKAKLPNAIIGQGYGMTEAGVLSMSLGFAKSPFKFKAGSCGTVIRNARMKIVNPATGASLPRNQTGEICIKGNAVMKGYYNDPEATKRTIDEEGWLHTGDIGYVDDDDEVFIVDRLKELIKYKGFHVAPAELEALLIAHPSISDAAVVPMADEAAGEVPIAFVVRANGANISELEIKKYIAQQVVSYKRIKRVFFTDKIPKGPSGKTLRKNLRPRI
>rna-gnl|WGS:QIYW|chr06_27877679_27878150.mrna1
MQRYELRLFLSALITHKVTFAPIVPPIMLNLVKNPVVDEFDLGKLSLRSVMTAAAPLAPEILNKFERKFPRVEVQEAYGMTEHSCITLSHGSVIAKRNSVGFILPNLEVKFVSPETGNSLPKKTLWERRNFNF
>rna-gnl|WGS:QIYW|chr08_13718956_13722463.mrna1
MEKSGYGRDGVFRSLRPPLFFPRDPNLSMIPFLFRNASSFADKPALIDAHTGKTLTFSQFKSMVAKFSHALLHLGINKNDVVLIFAPNSIQFPVAFFGIIAIGAVATTVNPTYTVSELSKQLKDSTAKIIVTVEDLLPKVKDFNLPVILLGDGENEKPILPIGKIPSIVPFSEFVNNEGSVDLDGNSFGIKQDDTAVLLYSSGTTGASKGVVLSHRNFIAASLMVTADQEMAGEINNVFLLVLPMFHVFGLAVIMFSQLQRGSAIVSMSKFELGMILRTVEKHGVTHLWVVPPIILALAKNSIVKNYNLSSLKQVGSGAAPLGKELMQECAKNIPLAVVMQGYGMTETCGIVCVESPYSGPRHSGSAGMLVPGVECQIVSVDKLKPLPPTQLGEIWVRGPNMMQGYFRNPQATKLTIDRQGWVHTGDLGYFDEEGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEISDAVVIPFPDAEAGEVPAAYVVRAPNSSLSEEDIKKFIADQVAPFKRLRRVTFIKSVPKSASGKILRRELIAEVKSKL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University