Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Parasponia andersonii
Species name
Parasponia andersonii is a species of eudicot in the family Cannabaceae (hemp family).
Species info
Gene sequence info
Parasponia_andersonii.COMT.fa
Download
>rna-gnl|WGS:JXTB|PanWU01x14_014230.1
MASSLELENGGSPKVVRDDERKKVEESFSYAAQLVNSAVLSMSLQSTIELGVFDIIGKAGEGGKLSASEIVAQMPSNNPDAPRMLDRILRMLASHSVLTCSVVADDLRVYGLNDVTKLFVTNEDGVSLGPLMSLLQDKVFLDSWSELKGAILEGGIPFNRAYGMHAFQYPGLDSRFNQVFNKAMYNQTTLVIKKILEVYKGFEDLKQLVDVGGGLGVTLSQITSKYPHIKGINFDLPHVIEHAPSYPGVEHVSGDMFESVPSGDAIFLKWILHDWSDEHCLKLLKNCYKAIPENGKIIVMEAFLPTVPETTSGDKAISEMDVLMMTQNPGGKERNEKEFLALANGAGFSGIRFECFVCNFWIMEFYK
>rna-gnl|WGS:JXTB|PanWU01x14_014270.1
MAPSRELDNQHSKLVESKGVEEEEEESFCYAVQLATSSVLPMSLHAAVELGVFEIIAKASNGAKLSADEIAAQMAANNNPDAAVMLDRVLRLLASHSVLACSVINADDHDGRSFRRVYSLAPVSKYFVTNGDGVSLRPFMALIQDKMHVYYYTTQYCCTEYYLNRSQLKDAILEGGLPFNRAHGMHAFKYTELNPKFNQLYNKAMYNVATIVVNKILESYNGFEHLTHLVDVGGNLGITLNLIISKYPRIKAINFDLPQVIEHAPSYPGVEHIGGDMFENVPTGDAILLKSILHDWSDEPCLKILNNCYKAIPENGKVIVVEEILPVKPETKNSVKSTSQTDVLMMTKNPGGKERSQEEYLALATAAGFTGVYFESCGCNFWVMEFFK
>rna-gnl|WGS:JXTB|PanWU01x14_067920.1
MGSTGSETQITPTQVSDEEANLFAMQLASASVLPMVLKTAIELDLLEIIAKAGPGAYLSPSDIASQLPTTNPDAPVMLDRVLRLLASYSILTYSLRELPHGKVERLYGLASVSKYLIKNEDGVSIAPLCLMNQDKVLMESW
>rna-gnl|WGS:JXTB|PanWU01x14_067930.1
MLAIYRYHLKDAILEGGIPFNRAYGMTAFEYHGTDLRFNKIFNRGMSDHSTITMKKILETYKGFEGLNTVVDVGGGTGAVLSMIVAKYPSIKGINFDLPHVIHDAPPYPGVEHVGGDMFESVPKGDAIFMKWICHDWSDEHCSKFLKNCFDALPENGKVILAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTQKEFEALAKGAGFQGFQVQCNAFNTYVIELLKKP
>rna-gnl|WGS:JXTB|PanWU01x14_104460.1
MGSTAMAPTSEEEACLNAMQLSSAWVLPIVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSILTYSLRDLPDGKVEWLYGLSPVSKFFLNNEDDYTFAPHCLLGLDKVVIESWHQLKDTVLEGGIPFKRAYGMSIFEYQATDPRFGKVWDRAMRTHSTITMKKMLETYKGFEGLNSVVDVGGGSGAIISVIVSTYPSIKGINYDLPHIVNAAPRYPGVEHVGGDMFASVPKADAVFMKGILHNWSDERCLILLKNCYAALPETGKVIAADCIVPVSLDSSSITKGVVHTDIIMLAQTPSGKERTEKEFEALAKGAGFRGFQIICRVLNTYIMEFLKN
>rna-gnl|WGS:JXTB|PanWU01x14_166560.1
MDFQETLAQSSLSTKEDEACLNAMNFANSQFLPLVLNAAIKLDLFGIIAKAGPDAQLSTSEIASQLPFTQNSNANPSLLDRMLRHFASHSLLTCSTSASKDGDIQRLYGLTPTSEFFVCNRNPNESSLASLVALHCHVAPLKDNILDGCTNSQFERVHGMPVYKYMDSNPSFSNIFHDAMVNRSTIIMKKVLNVYKGFEGLSSLVDVGGGTGHCLNMIISQYPSILGTNNLDLPHVTENAPSYAGIKHVPGVMFSSIPKADQAIMIKEILHNWSDEHCRKLVKNCYEALPQNGKLIVIEIIMPEKPDSKYGFQVHFGTRQHNVNTTRRKGKNQKRIPSFVL
>rna-gnl|WGS:JXTB|PanWU01x14_183670.1
MGDETSQSRNQARLKILELANMISVPMSLNAVVRLNVPDAIWQHGANSPLSASQILTRVLPSGGGDAENLQRVLRMLTSYGVFEEHLSSGASDERKYSLTDVGKTLVTDPDGLSYAPYVLQHHQDALVSAWPLVHEAVVDPTTEPFAKANGEPAYDYYGKKPEMNGLMQKAMSGVSVPFMRSILEGYDGFEGVKTLVDVGGSAGDCLRMILRKHPNVLRGINFDLPEVVARAPRIPGVTHVGGDMFKSIPEADAIFMKWVLTTWTDDECKTIMENSFKALPEAGKLIACEPVLPNESDDSHRTRALLEGDIFVMTIYRAKGKHRTEEEFRELGLSAGFPHFRAIYIDYFYTVLEFRK
>rna-gnl|WGS:JXTB|PanWU01x14_317890.1
MKRRTTSSMPCNFGSSSVLPMVLKAAVELGLLEIIERAGPGALLTPAQIASELPTQNPDCPLVLDRLLRLLSGFMGLPQLPSTSLGMVMEFQWHLYYFPCRTSLTSLVDVGGGDDTILNMIISKYPSIKGFNFDLATILDKSPHHPGIKHCSGDMFASIPKGDAICMKVSGYYMLGMTNMVILGAPETSLAARSLFQFDLFVMNTNITGKERTAREFEGLAKEAGFSQIYLACSAYNFSVVELCKRA
MASSLELENGGSPKVVRDDERKKVEESFSYAAQLVNSAVLSMSLQSTIELGVFDIIGKAGEGGKLSASEIVAQMPSNNPDAPRMLDRILRMLASHSVLTCSVVADDLRVYGLNDVTKLFVTNEDGVSLGPLMSLLQDKVFLDSWSELKGAILEGGIPFNRAYGMHAFQYPGLDSRFNQVFNKAMYNQTTLVIKKILEVYKGFEDLKQLVDVGGGLGVTLSQITSKYPHIKGINFDLPHVIEHAPSYPGVEHVSGDMFESVPSGDAIFLKWILHDWSDEHCLKLLKNCYKAIPENGKIIVMEAFLPTVPETTSGDKAISEMDVLMMTQNPGGKERNEKEFLALANGAGFSGIRFECFVCNFWIMEFYK
>rna-gnl|WGS:JXTB|PanWU01x14_014270.1
MAPSRELDNQHSKLVESKGVEEEEEESFCYAVQLATSSVLPMSLHAAVELGVFEIIAKASNGAKLSADEIAAQMAANNNPDAAVMLDRVLRLLASHSVLACSVINADDHDGRSFRRVYSLAPVSKYFVTNGDGVSLRPFMALIQDKMHVYYYTTQYCCTEYYLNRSQLKDAILEGGLPFNRAHGMHAFKYTELNPKFNQLYNKAMYNVATIVVNKILESYNGFEHLTHLVDVGGNLGITLNLIISKYPRIKAINFDLPQVIEHAPSYPGVEHIGGDMFENVPTGDAILLKSILHDWSDEPCLKILNNCYKAIPENGKVIVVEEILPVKPETKNSVKSTSQTDVLMMTKNPGGKERSQEEYLALATAAGFTGVYFESCGCNFWVMEFFK
>rna-gnl|WGS:JXTB|PanWU01x14_067920.1
MGSTGSETQITPTQVSDEEANLFAMQLASASVLPMVLKTAIELDLLEIIAKAGPGAYLSPSDIASQLPTTNPDAPVMLDRVLRLLASYSILTYSLRELPHGKVERLYGLASVSKYLIKNEDGVSIAPLCLMNQDKVLMESW
>rna-gnl|WGS:JXTB|PanWU01x14_067930.1
MLAIYRYHLKDAILEGGIPFNRAYGMTAFEYHGTDLRFNKIFNRGMSDHSTITMKKILETYKGFEGLNTVVDVGGGTGAVLSMIVAKYPSIKGINFDLPHVIHDAPPYPGVEHVGGDMFESVPKGDAIFMKWICHDWSDEHCSKFLKNCFDALPENGKVILAECILPVAPDSSLATKGVVHIDVIMLAHNPGGKERTQKEFEALAKGAGFQGFQVQCNAFNTYVIELLKKP
>rna-gnl|WGS:JXTB|PanWU01x14_104460.1
MGSTAMAPTSEEEACLNAMQLSSAWVLPIVLKTAIELDVLEIIAKAGPGALLSPADIASQLPITNNPDAPVMLDRLLRLLATYSILTYSLRDLPDGKVEWLYGLSPVSKFFLNNEDDYTFAPHCLLGLDKVVIESWHQLKDTVLEGGIPFKRAYGMSIFEYQATDPRFGKVWDRAMRTHSTITMKKMLETYKGFEGLNSVVDVGGGSGAIISVIVSTYPSIKGINYDLPHIVNAAPRYPGVEHVGGDMFASVPKADAVFMKGILHNWSDERCLILLKNCYAALPETGKVIAADCIVPVSLDSSSITKGVVHTDIIMLAQTPSGKERTEKEFEALAKGAGFRGFQIICRVLNTYIMEFLKN
>rna-gnl|WGS:JXTB|PanWU01x14_166560.1
MDFQETLAQSSLSTKEDEACLNAMNFANSQFLPLVLNAAIKLDLFGIIAKAGPDAQLSTSEIASQLPFTQNSNANPSLLDRMLRHFASHSLLTCSTSASKDGDIQRLYGLTPTSEFFVCNRNPNESSLASLVALHCHVAPLKDNILDGCTNSQFERVHGMPVYKYMDSNPSFSNIFHDAMVNRSTIIMKKVLNVYKGFEGLSSLVDVGGGTGHCLNMIISQYPSILGTNNLDLPHVTENAPSYAGIKHVPGVMFSSIPKADQAIMIKEILHNWSDEHCRKLVKNCYEALPQNGKLIVIEIIMPEKPDSKYGFQVHFGTRQHNVNTTRRKGKNQKRIPSFVL
>rna-gnl|WGS:JXTB|PanWU01x14_183670.1
MGDETSQSRNQARLKILELANMISVPMSLNAVVRLNVPDAIWQHGANSPLSASQILTRVLPSGGGDAENLQRVLRMLTSYGVFEEHLSSGASDERKYSLTDVGKTLVTDPDGLSYAPYVLQHHQDALVSAWPLVHEAVVDPTTEPFAKANGEPAYDYYGKKPEMNGLMQKAMSGVSVPFMRSILEGYDGFEGVKTLVDVGGSAGDCLRMILRKHPNVLRGINFDLPEVVARAPRIPGVTHVGGDMFKSIPEADAIFMKWVLTTWTDDECKTIMENSFKALPEAGKLIACEPVLPNESDDSHRTRALLEGDIFVMTIYRAKGKHRTEEEFRELGLSAGFPHFRAIYIDYFYTVLEFRK
>rna-gnl|WGS:JXTB|PanWU01x14_317890.1
MKRRTTSSMPCNFGSSSVLPMVLKAAVELGLLEIIERAGPGALLTPAQIASELPTQNPDCPLVLDRLLRLLSGFMGLPQLPSTSLGMVMEFQWHLYYFPCRTSLTSLVDVGGGDDTILNMIISKYPSIKGFNFDLATILDKSPHHPGIKHCSGDMFASIPKGDAICMKVSGYYMLGMTNMVILGAPETSLAARSLFQFDLFVMNTNITGKERTAREFEGLAKEAGFSQIYLACSAYNFSVVELCKRA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University