Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Origanum majorana
Species name
Sweet marjoram (Origanum majorana) is a species of eudicot in the family Lamiaceae (mint family).
Species info
Gene sequence info
Origanum_majorana.COMT.fa
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>120.g708.t1
MNSSSPSSFALQLSTSSALPAALKCAVELDLLELIKKAGRPVSAAELAARIAAPNPQAHIMIDRILHLLAANDILRCTGGGAGRLYSLAPVGEYLTVNDDGVSLAPLFLLNHDSIFMECWDHLKDSVVEGVVPFERAHGMGGFEYAATDPRFNKLLNEAMSGHSTIVMREILKEYKGFEGVKRLVDVGGGTGASLKMVVSEYPSIEAVNFDLPHVIEVAPPHIGVEHVSGDMFVSVPRGDAFLMKTVCHDWGDEECLRLLKNCHESLPSNGKLIIIERIISEITEKDPSASVNLAFDVIMLAYFVSGKERTESEFQALAKASGFKQLKKAGCAMGFWIMELYK
>120.g707.t1
MGKFEYAAEDARVNKIFNRAMPEHSTIVMREILKEYKGFEGVKRLVDVGGGTGALLKMFVSEYPSIEAINFDLAHVIQVAAPHKGLEHVSGDMFASVPRGDDMLALKWICHDLGDEDCLRLLKNCHESLPNNGKLIIIERIISEMTEKDPSASINLAFDVIMLA
>120.g709.t1
MDESEEERAFAFAMDLAAGSVLPMVVKSAIDLDLFELIKSAGQEGASASELAARIPATNPKATAEMIERILQLLAANSVLTCRPETPTAGGVARRRYYLAAVCKFLTRDGDGVSLAPLSLLVQHPVFMEPWYHLKDAILEGGVPFEKAHGANAFEYHAKDPKFNKIFNEAMHNPSIIFMKKILQIYDGFEGLKSLVDVGGGTGASLKMIVSKYPSIKAINFDLPHVIQDASPNPGIEHIGGDMFVNVPKAEAIFLKWICHDWSDEHCLKLLKNCYEAIPVNGKVIIAESMLPEHPNKGSDARHTTRGDVIMLTVNAGGKERTEMEFRALAQQAGFKRLVKVCAAFHTWTMECHK
>120.g710.t1
MEKSKEEADFVVAMKLATGSALPMALRFAVELNLLQLIGDAEAGASASEVAARIPARNPEAAAMIDRVLRLLATHSVLTCTLPHSGTEWRYSVAPVGKHLVGNEDGVSAAPLSLLVQDKVFIDTWYHLKDVVLEGGSPFERAHGMNAFEYPATDPRFNKIFNQAMHEHSTIFMKMILEKYYGFEGVESLVDVGGGRGASLKMIISKHPSIKAINFDLPHVIQDTPFIPGVEHIGGDMFVSVPKADAIFMKWICHDWSDSHVEKLLKNCYEALPENGKVIVAESTLPEDPEQGLGESLAVQSDVLMLAFNPGGKERTEKEFNALAINAGFKQFLKVCCACDTWIMEFHK
>201.g338.t1
MNPQASAIDSDEDESFLFAMQLASASVLPMVLKSAIELDLLELIKKAGAGAFVSPAELAAQIPTSNAEAAVMLDRILRLLATYAVLECRLKALPSGGSERLYGLAPVCKFLTKNEDGVSMAPLALMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNQGMSNHSTITMKKILETYKGFDGLNTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVEHVGGDMFVRVPKGDAIFMKWICHDWSDEHCVKFLKNCYEALPQNGKVILAECVLPEAPDTGLATKNVVHIDVIMLAHNPGGKERTEKEFQALAKAAGFKHFNKACCAYNSWIMELLK
>277.g133.t1
MMDPIVMDAFHQAGEWFGDESPSPFFTRNGRSFFEVLAKDERWNKVFNEGTSSDAKFVATILVEKCKHVFEGLESFVDVGGRTSVVAKAVVDAFPGMKCVVLELPHVVKGLQNSENLSFVSGDMFEFIPPADVVFLKWVFHAWSDEECVKILEKCKEAITQSKGKNNGGKVIILEMVVDEETEKE
>277.g136.t1
MRILDHSRIFDKVKISRDKGEDEEEAYSLTRVSRLLLRDEPSSFSPYTLAMLDPNITDPFHNLNEWFQDDCPSPFFTRNGRSLLVKECIQFFEGLESVVDVAGGTGEVAKVVSAAFPDLKCIVLDLPHVVDGLEGSQNLSFVSGDMFEFIPPADAVFLKWILHDWSEEECIMILGKCKEAITQSKRNGGKVIIVDMIVNRHDCE
>493.g10.t1
MGSAAMDMMTEARAEAEAWRYSHGFSEMRVVKLMVQMGVTAAVVGPTTLSELSSAVGCPKPALYRIMRFLSHRDRGFFEQKLNPATSEVSYAPTPISRLLTLDNHGAYMLMQLTFDVKLSVEDLKAGRGSGMDPASTTDKLWDHELRGGVKVAFTQAMDVHSRKLAAALVKNAPATFQGIASLVDVGGRLGTTLGVLVKAFPWLRGTNLDLPGVVNRAPSIDGVVHVGGDMFKSVPKADAVMLTWVLHDWADEACINILKKCREAVPVDTGKVIIVDAVLDEDDEEPRDELSGARLLLDMTIMIGTANGKERTAKEWAKLIEAAGFTRHTINHIKANIESVIEAYP
>91801.g2.t1
MVFNEAMACDAGFVTCILNKEFAQVFEGVESMVDVGGGTGATAKAIAAANPGLKCVVFDLPHVVGGLHGCENLSFVSGDMFECIPQADAIFMKFILHDWDDEECVRILKKCKEALTTPSNKDGGKVIIIEIVMEDENETYEAAETKLFIDMQMLNLVKGKERSEEEWAKLFLTAGFRNYKVARLLGLRSVIEVFP
>95052.g6.t1
MATLMEEEDSAAYVAALKLATGSALPMALRFAVELNLLQLIGNGGSASASDLAARLPASNNPRAAAMIDRILRLLAAHSVLSCTLPDGGGEWRYSLAPVCKHLTGNADGVSVAPFSLLVQDKVFIETWYHLKDAVLEGGREFERAHGMNAFEYPATDPRFNKIFNQAMHEHSTIFMKKILEKYDGFEGVGSLVDVGGGKGASLKMILSKHPSIKAINFDLPHVINEAEAINGVQHIGGDMFVSVPKAEAIFMKWICHDWSDTHVEKLLKNCYEALPNNGKVIVAESTLPEDPKQGLGESLAAHIDVFMMAFNPGGKERTEKEFHTLATKVGFKQLVKVCCACNIWITEFHQ
>95052.g1.t1
MNPSSHSSETDLLAMQLVAASVLPRTLAAAIELDLLELIKKAECKVNAGVDRSYSLATVCELFTKNDAGVSFAPLLLVNEDRVFSEAFYHLKDAVVEGGIPFESAHGVGIFEYPATDPKFNGMFNRAMYEQSTLFMHKILEIYDGFEGVESIVGVGGGVGASLKMILRKYPSIKATNFDLPHVIKRAPPHQGVEHISGDMFVSVPRGDVIFMKWICHDWSDSHCLKLLKNCYVALPHKGKVVIAERILPEVPNKEPLPFSMDLLMLAYDAGKERTESEFRTLAKATGFTRFRRVCCAFTVSFMELYK
>95683.g45.t1
MKWVTASVAPKALKAAIELNLLELMKTVGPVSAAELAVQIRAPNPEAHLVIDRTLCVLAANGIIECDLPHDGGDRLYSLTPTSNMFTKNDEGVSLAPLLFLNQDKVFAEAFYHLKDAVVGGIAFIRAHGMSAFEYPATDPRFNKVFNQAMYEQSTMFMHKILENYDGFEGVESIVDVGGGIGASLKMILSKCPSI
>96045.g1.t1
MATSMEEEDFAAGYMAVVKLVTATAVPVALRFAKELNLFELIGNGGPGASASASELAAQLPATNPQAAAMIDRILRLLTAHSLLTRAMPDGGDEWRYSLAPLCRHLIRNEDGVSMAPFPFLVQDKVFVESWYHLKDAVLEGGSPFERAHGLQAFEYAATDLRFNKIFNQAMHEQSTFFMKKILKIYKGFEGVESLLDVGGGMGASLKMILSKHPSIKAINFDLPHVIKDALPIPGVEHVGGDMFVSIPKADAIFLKWICHDWGDSDVEKLLKNCYEALPENGKVIIAESTLPEDPNQGLGESVAVLIDMYMMAFNPSGKERTEKEFHTLAMKAGFKQLIKVCCVCDIWIMEFHK
MNSSSPSSFALQLSTSSALPAALKCAVELDLLELIKKAGRPVSAAELAARIAAPNPQAHIMIDRILHLLAANDILRCTGGGAGRLYSLAPVGEYLTVNDDGVSLAPLFLLNHDSIFMECWDHLKDSVVEGVVPFERAHGMGGFEYAATDPRFNKLLNEAMSGHSTIVMREILKEYKGFEGVKRLVDVGGGTGASLKMVVSEYPSIEAVNFDLPHVIEVAPPHIGVEHVSGDMFVSVPRGDAFLMKTVCHDWGDEECLRLLKNCHESLPSNGKLIIIERIISEITEKDPSASVNLAFDVIMLAYFVSGKERTESEFQALAKASGFKQLKKAGCAMGFWIMELYK
>120.g707.t1
MGKFEYAAEDARVNKIFNRAMPEHSTIVMREILKEYKGFEGVKRLVDVGGGTGALLKMFVSEYPSIEAINFDLAHVIQVAAPHKGLEHVSGDMFASVPRGDDMLALKWICHDLGDEDCLRLLKNCHESLPNNGKLIIIERIISEMTEKDPSASINLAFDVIMLA
>120.g709.t1
MDESEEERAFAFAMDLAAGSVLPMVVKSAIDLDLFELIKSAGQEGASASELAARIPATNPKATAEMIERILQLLAANSVLTCRPETPTAGGVARRRYYLAAVCKFLTRDGDGVSLAPLSLLVQHPVFMEPWYHLKDAILEGGVPFEKAHGANAFEYHAKDPKFNKIFNEAMHNPSIIFMKKILQIYDGFEGLKSLVDVGGGTGASLKMIVSKYPSIKAINFDLPHVIQDASPNPGIEHIGGDMFVNVPKAEAIFLKWICHDWSDEHCLKLLKNCYEAIPVNGKVIIAESMLPEHPNKGSDARHTTRGDVIMLTVNAGGKERTEMEFRALAQQAGFKRLVKVCAAFHTWTMECHK
>120.g710.t1
MEKSKEEADFVVAMKLATGSALPMALRFAVELNLLQLIGDAEAGASASEVAARIPARNPEAAAMIDRVLRLLATHSVLTCTLPHSGTEWRYSVAPVGKHLVGNEDGVSAAPLSLLVQDKVFIDTWYHLKDVVLEGGSPFERAHGMNAFEYPATDPRFNKIFNQAMHEHSTIFMKMILEKYYGFEGVESLVDVGGGRGASLKMIISKHPSIKAINFDLPHVIQDTPFIPGVEHIGGDMFVSVPKADAIFMKWICHDWSDSHVEKLLKNCYEALPENGKVIVAESTLPEDPEQGLGESLAVQSDVLMLAFNPGGKERTEKEFNALAINAGFKQFLKVCCACDTWIMEFHK
>201.g338.t1
MNPQASAIDSDEDESFLFAMQLASASVLPMVLKSAIELDLLELIKKAGAGAFVSPAELAAQIPTSNAEAAVMLDRILRLLATYAVLECRLKALPSGGSERLYGLAPVCKFLTKNEDGVSMAPLALMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFDYHGTDPRFNKVFNQGMSNHSTITMKKILETYKGFDGLNTVVDVGGGTGATLNMIVSKYPSIKGINFDLPHVIEDAPSYPGVEHVGGDMFVRVPKGDAIFMKWICHDWSDEHCVKFLKNCYEALPQNGKVILAECVLPEAPDTGLATKNVVHIDVIMLAHNPGGKERTEKEFQALAKAAGFKHFNKACCAYNSWIMELLK
>277.g133.t1
MMDPIVMDAFHQAGEWFGDESPSPFFTRNGRSFFEVLAKDERWNKVFNEGTSSDAKFVATILVEKCKHVFEGLESFVDVGGRTSVVAKAVVDAFPGMKCVVLELPHVVKGLQNSENLSFVSGDMFEFIPPADVVFLKWVFHAWSDEECVKILEKCKEAITQSKGKNNGGKVIILEMVVDEETEKE
>277.g136.t1
MRILDHSRIFDKVKISRDKGEDEEEAYSLTRVSRLLLRDEPSSFSPYTLAMLDPNITDPFHNLNEWFQDDCPSPFFTRNGRSLLVKECIQFFEGLESVVDVAGGTGEVAKVVSAAFPDLKCIVLDLPHVVDGLEGSQNLSFVSGDMFEFIPPADAVFLKWILHDWSEEECIMILGKCKEAITQSKRNGGKVIIVDMIVNRHDCE
>493.g10.t1
MGSAAMDMMTEARAEAEAWRYSHGFSEMRVVKLMVQMGVTAAVVGPTTLSELSSAVGCPKPALYRIMRFLSHRDRGFFEQKLNPATSEVSYAPTPISRLLTLDNHGAYMLMQLTFDVKLSVEDLKAGRGSGMDPASTTDKLWDHELRGGVKVAFTQAMDVHSRKLAAALVKNAPATFQGIASLVDVGGRLGTTLGVLVKAFPWLRGTNLDLPGVVNRAPSIDGVVHVGGDMFKSVPKADAVMLTWVLHDWADEACINILKKCREAVPVDTGKVIIVDAVLDEDDEEPRDELSGARLLLDMTIMIGTANGKERTAKEWAKLIEAAGFTRHTINHIKANIESVIEAYP
>91801.g2.t1
MVFNEAMACDAGFVTCILNKEFAQVFEGVESMVDVGGGTGATAKAIAAANPGLKCVVFDLPHVVGGLHGCENLSFVSGDMFECIPQADAIFMKFILHDWDDEECVRILKKCKEALTTPSNKDGGKVIIIEIVMEDENETYEAAETKLFIDMQMLNLVKGKERSEEEWAKLFLTAGFRNYKVARLLGLRSVIEVFP
>95052.g6.t1
MATLMEEEDSAAYVAALKLATGSALPMALRFAVELNLLQLIGNGGSASASDLAARLPASNNPRAAAMIDRILRLLAAHSVLSCTLPDGGGEWRYSLAPVCKHLTGNADGVSVAPFSLLVQDKVFIETWYHLKDAVLEGGREFERAHGMNAFEYPATDPRFNKIFNQAMHEHSTIFMKKILEKYDGFEGVGSLVDVGGGKGASLKMILSKHPSIKAINFDLPHVINEAEAINGVQHIGGDMFVSVPKAEAIFMKWICHDWSDTHVEKLLKNCYEALPNNGKVIVAESTLPEDPKQGLGESLAAHIDVFMMAFNPGGKERTEKEFHTLATKVGFKQLVKVCCACNIWITEFHQ
>95052.g1.t1
MNPSSHSSETDLLAMQLVAASVLPRTLAAAIELDLLELIKKAECKVNAGVDRSYSLATVCELFTKNDAGVSFAPLLLVNEDRVFSEAFYHLKDAVVEGGIPFESAHGVGIFEYPATDPKFNGMFNRAMYEQSTLFMHKILEIYDGFEGVESIVGVGGGVGASLKMILRKYPSIKATNFDLPHVIKRAPPHQGVEHISGDMFVSVPRGDVIFMKWICHDWSDSHCLKLLKNCYVALPHKGKVVIAERILPEVPNKEPLPFSMDLLMLAYDAGKERTESEFRTLAKATGFTRFRRVCCAFTVSFMELYK
>95683.g45.t1
MKWVTASVAPKALKAAIELNLLELMKTVGPVSAAELAVQIRAPNPEAHLVIDRTLCVLAANGIIECDLPHDGGDRLYSLTPTSNMFTKNDEGVSLAPLLFLNQDKVFAEAFYHLKDAVVGGIAFIRAHGMSAFEYPATDPRFNKVFNQAMYEQSTMFMHKILENYDGFEGVESIVDVGGGIGASLKMILSKCPSI
>96045.g1.t1
MATSMEEEDFAAGYMAVVKLVTATAVPVALRFAKELNLFELIGNGGPGASASASELAAQLPATNPQAAAMIDRILRLLTAHSLLTRAMPDGGDEWRYSLAPLCRHLIRNEDGVSMAPFPFLVQDKVFVESWYHLKDAVLEGGSPFERAHGLQAFEYAATDLRFNKIFNQAMHEQSTFFMKKILKIYKGFEGVESLLDVGGGMGASLKMILSKHPSIKAINFDLPHVIKDALPIPGVEHVGGDMFVSIPKADAIFLKWICHDWGDSDVEKLLKNCYEALPENGKVIIAESTLPEDPNQGLGESVAVLIDMYMMAFNPSGKERTEKEFHTLAMKAGFKQLIKVCCVCDIWIMEFHK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University