Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Origanum majorana
Species name
Sweet marjoram (Origanum majorana) is a species of eudicot in the family Lamiaceae (mint family).
Species info
Gene sequence info
Origanum_majorana.CHS.fa
Download
>171.g68.t1
MTEAILKQNPNMAVYMAPSLDARQDMVVAAVPKLGKEAAEKAIKEWGQPKSSITHLVFCTNSGVDMPGADFQLINLLGLGPSVKRLMMYQQGCHGGAAALRMAKDLAENTAAARVLLVCSEINSTFGFRGPSMAHTDNLVGQALFGDGAAAVIVGSAPIALGAEPPLFQIVSTAQTILPDSGGTICGHMREAGLIAHFHPDVPALISKNIGKSLKEVFGPLGISDWNSVFWIVHPGGPAILDQVEAELGLRPEKLRSTRHVLSEYGNMSSTTVLFILDEMTKFSAKEGLSSTGEGLDWGVLFGFGPGLTVETVVLRSMPININ
>171.g64.t1
MPSLWGTTPCCENSTIKRRYIHLTEDLLKENPNMTSYSAPSLNARQDMLETAVPMLAKEAAEKAIKEWGQPLSNITHLIFCTTSGIHMPGADFQLAKLLGLRPSVNRLMLYQQGCHGGGTALRMAKDLAENNAGARVLAVCSEITAVTIFRGPNETHPDNLVGQALFGDGAGAVVVGSDPVVGAERPLFQLVSASQAFIPDTEDMIQGLLRESGVMIRLSKDVPETVSGNIEARLKLAFGPLGITDWNSIFWIAHPGGPAILDKIESGLGLRPEKLRMSRHSLSEYGNVWSTSVLLIMDEMRKSSAQEGLSTTGEGLDLGVLFGFGPGLTVETVVLRSMPIN
>171.g58.t1
MVTVEEIRRAQRAEGPATVLAIGTAVPSNCVDQSEYPDYYFRITNSEHKTELKEKFKRMCEKSMIKKRYMHLTEEYLKENPNITAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIVGSDPVVGVERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFAPMGISDWNSVFWIAHPGGPAILDQVELKLGLKPEKLRSTRHVLSEYGNMSSACVLFILDEMRKSSAKEGMSSTGEGLDWGVLFGFGPGLTVETVVLHSVAIN
>171.g63.t1
MAMLQGTHNAQRAEGLATVLAIGTAVPANSVEQSTFPDYYFRNTDSARVAHLKPKFERICEISNCSISSIYK
>213.g7.t1
MNAKRIPISQALACHVTLRPPPHSGKDHQPPHRESLPSPARAHEVGVVDDQAAPCRHIAPGGARDGEGGQCGIPEDVEEIGGGNHLHRLRQRDLPPGCDLATELRLCHDVSRVMLYLPSSYVGITGLRVAKDIAENNRVLLVSSKTTITGFTPPSGGEANLLDEIEESYSRIFQVIDDEGEAEEGELDDAVQFWGVGVVLLGEGGGGAGEGEGAVEKRRGMGGCCDGVGGGVEEWVVVGGGGSGVELVVVDE
>411.g33.t1
MAMIFSGPSGSRPEELMGQSLFDDGASAVIVGSDPAAPAERPIFQIVAAAQSFIPESEEAMSGQLGEAGVVYRLARTVPAFISDNIEGCLEEAFGPLGLAGPDWNSIFWIVHPGRPAILDGVEAKLRLRPDKLRATRHVLSEYGNMMSACVGFVMDEMRKGSAAEGRSSAGEGAEWGVLVGMGWGMTVETLVLRSVN
>411.g32.t1
MATAEEIRRAQRAEGPATILAIGTANPLNCEKSTIKKRHMHLTEEILKQNPSMCEQLAPSLDARQAILVAEVPKLGKIAAEIAIGEWGQPRSRICHLIFCTSNGIDMPGADLRLAKLLGLRPTVRRLLMYQQGCFGGAAALRMAKDLA
>582.g76.t1
MTSLSARRPTPGKATVLAIGKAFPRQLVLQDLLVEGYIRDTNCDDAAIKEKLQRLCKTTTVKTRYTVLSKEILDEYPELATEGSPTIKQRLDIAHPAVLEMAKEASLACLKEWNRPAADITHIVYVSSSEIRLPGGDLYLATELNLRHDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPNKSRPYDLVGAALFGDGAAAVVVGSDPIPGAETPFMELNNAVQQFLPGTSHVIDGRLSEEGIYFKLGRDLPQKIEENIEAFCKKLMAGAGLKEYNEMFWAVHPGGPAILNRLESTLGLKKEKLECSRRALMDYGNVSSNTVLYVMEYMREELRKKREEGEEGEEWGLALAFGPGITFEGILLRSLH
>81103.g2.t1
MVSVEEIHRPQRAEGPATVLAIGTAVPSNCVDQSSFPDYYFRVTNSESSTIKKRYIHLTEELLSEYPSIAACMAPSLDARQAIVAAEVPRLGKEAAEKAIKEWGQPRSSITHLIFCTSTSGVDVPSADFHLTKLLGLRPSVNRLMMCQHGCYGGASALRVAKDLAENNAGARVLVVCCEVTAMFFRGPNEAHLGDLVAQAIFGDAAGAAVVGSDLVPGSERPLFEIVSGAQTIIPDSEGRIEAQVGEAGMIVQLRKDVPELISGNMEECLKSAFSPLGIMDWNSIFWIVHPGGPRILDEVGTGLGLKPDKLRASRHVLSEYSNVSSPIVLLVLDEMRKFSAEEGRSTTGEGLDWGVLFGFGPSLTVETLVLRSMPIDH
MTEAILKQNPNMAVYMAPSLDARQDMVVAAVPKLGKEAAEKAIKEWGQPKSSITHLVFCTNSGVDMPGADFQLINLLGLGPSVKRLMMYQQGCHGGAAALRMAKDLAENTAAARVLLVCSEINSTFGFRGPSMAHTDNLVGQALFGDGAAAVIVGSAPIALGAEPPLFQIVSTAQTILPDSGGTICGHMREAGLIAHFHPDVPALISKNIGKSLKEVFGPLGISDWNSVFWIVHPGGPAILDQVEAELGLRPEKLRSTRHVLSEYGNMSSTTVLFILDEMTKFSAKEGLSSTGEGLDWGVLFGFGPGLTVETVVLRSMPININ
>171.g64.t1
MPSLWGTTPCCENSTIKRRYIHLTEDLLKENPNMTSYSAPSLNARQDMLETAVPMLAKEAAEKAIKEWGQPLSNITHLIFCTTSGIHMPGADFQLAKLLGLRPSVNRLMLYQQGCHGGGTALRMAKDLAENNAGARVLAVCSEITAVTIFRGPNETHPDNLVGQALFGDGAGAVVVGSDPVVGAERPLFQLVSASQAFIPDTEDMIQGLLRESGVMIRLSKDVPETVSGNIEARLKLAFGPLGITDWNSIFWIAHPGGPAILDKIESGLGLRPEKLRMSRHSLSEYGNVWSTSVLLIMDEMRKSSAQEGLSTTGEGLDLGVLFGFGPGLTVETVVLRSMPIN
>171.g58.t1
MVTVEEIRRAQRAEGPATVLAIGTAVPSNCVDQSEYPDYYFRITNSEHKTELKEKFKRMCEKSMIKKRYMHLTEEYLKENPNITAYMAPSLDARQDIVVVEVPKLGKEAAQKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNAGARVLVVCSEITAVTFRGPSDSHLDSLVGQALFGDGAAAVIVGSDPVVGVERPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLKEAFAPMGISDWNSVFWIAHPGGPAILDQVELKLGLKPEKLRSTRHVLSEYGNMSSACVLFILDEMRKSSAKEGMSSTGEGLDWGVLFGFGPGLTVETVVLHSVAIN
>171.g63.t1
MAMLQGTHNAQRAEGLATVLAIGTAVPANSVEQSTFPDYYFRNTDSARVAHLKPKFERICEISNCSISSIYK
>213.g7.t1
MNAKRIPISQALACHVTLRPPPHSGKDHQPPHRESLPSPARAHEVGVVDDQAAPCRHIAPGGARDGEGGQCGIPEDVEEIGGGNHLHRLRQRDLPPGCDLATELRLCHDVSRVMLYLPSSYVGITGLRVAKDIAENNRVLLVSSKTTITGFTPPSGGEANLLDEIEESYSRIFQVIDDEGEAEEGELDDAVQFWGVGVVLLGEGGGGAGEGEGAVEKRRGMGGCCDGVGGGVEEWVVVGGGGSGVELVVVDE
>411.g33.t1
MAMIFSGPSGSRPEELMGQSLFDDGASAVIVGSDPAAPAERPIFQIVAAAQSFIPESEEAMSGQLGEAGVVYRLARTVPAFISDNIEGCLEEAFGPLGLAGPDWNSIFWIVHPGRPAILDGVEAKLRLRPDKLRATRHVLSEYGNMMSACVGFVMDEMRKGSAAEGRSSAGEGAEWGVLVGMGWGMTVETLVLRSVN
>411.g32.t1
MATAEEIRRAQRAEGPATILAIGTANPLNCEKSTIKKRHMHLTEEILKQNPSMCEQLAPSLDARQAILVAEVPKLGKIAAEIAIGEWGQPRSRICHLIFCTSNGIDMPGADLRLAKLLGLRPTVRRLLMYQQGCFGGAAALRMAKDLA
>582.g76.t1
MTSLSARRPTPGKATVLAIGKAFPRQLVLQDLLVEGYIRDTNCDDAAIKEKLQRLCKTTTVKTRYTVLSKEILDEYPELATEGSPTIKQRLDIAHPAVLEMAKEASLACLKEWNRPAADITHIVYVSSSEIRLPGGDLYLATELNLRHDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLATSETTILGFRPPNKSRPYDLVGAALFGDGAAAVVVGSDPIPGAETPFMELNNAVQQFLPGTSHVIDGRLSEEGIYFKLGRDLPQKIEENIEAFCKKLMAGAGLKEYNEMFWAVHPGGPAILNRLESTLGLKKEKLECSRRALMDYGNVSSNTVLYVMEYMREELRKKREEGEEGEEWGLALAFGPGITFEGILLRSLH
>81103.g2.t1
MVSVEEIHRPQRAEGPATVLAIGTAVPSNCVDQSSFPDYYFRVTNSESSTIKKRYIHLTEELLSEYPSIAACMAPSLDARQAIVAAEVPRLGKEAAEKAIKEWGQPRSSITHLIFCTSTSGVDVPSADFHLTKLLGLRPSVNRLMMCQHGCYGGASALRVAKDLAENNAGARVLVVCCEVTAMFFRGPNEAHLGDLVAQAIFGDAAGAAVVGSDLVPGSERPLFEIVSGAQTIIPDSEGRIEAQVGEAGMIVQLRKDVPELISGNMEECLKSAFSPLGIMDWNSIFWIVHPGGPRILDEVGTGLGLKPDKLRASRHVLSEYSNVSSPIVLLVLDEMRKFSAEEGRSTTGEGLDWGVLFGFGPSLTVETLVLRSMPIDH
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University