Enzyme

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

HIDH

Enzyme

2-hydroxyisoflavanone dehydratase

Enzyme name

EC:4.2.1.105

Entry

Lyases;Carbon-oxygen lyases;Hydro-lyases

Class

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Sysname

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction

daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]

Product

Species information

Nissolia schottii

Species name

Nissolia schottii is a species of eudicot in the family Fabaceae (pea family).

Species info

Gene sequence info

Nissolia_schottii.HIDH.fa

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>Nissc524920S03610
MNNPTNPQISLEVPPYLRVHTDGTVERLAGTQVSPPGLHPQTNVLSKDIVILPQTGVTARLYLPNSASTTATNKNKLPLIIYFHGGAFCISSAADPFYHTSLNNLVSEANAVALSVNYRLAPEHPLPAAYNDSWDAIQWVASHAVDDEEHHETWLKESVDFDRVFLAGDSAGANIAHHVAIQLSVTNWGPTKYVKIPGLVMVNPYFWGKEPIGVEITDLDRKRMVDTWWDFVCPSGKGSDDPLINPFVEEAPGFEGVDCNKVLVTVAEKDILKERGKLYHKKLVNSGWKGRAELHETEGEDHDFHIFNPDCDKAKILIKRIAAFINEQD
>Nissc8054S11251
MGSLAHVVEDCMGFLQLYSDGTVSRSAQIQFPDSPIQDDAVSFKDVLFHKRFNLFLRLYKPHCQNALKLPVLIFLHGGGFCFGSRTWPHVHNCCTRLASALTAVVIAPDYRLAPEHRLPAAVDDAVEAVRWLQRQGLSGAVGGDGWLTGGDVDFDRVLVVGDSSGGNIAHQLAVRFGAGSTEMEPVRLRGYVLLAPFFGGEVRTKSEEGPPEHMLTLDLLDSRFWRLSMPVGESRDHPLANPFGHGSPNLGEMKLDPILVIVGGNELLKDRAQNYAKRLKELGKDIVYVEFEGREHGFFTHDSYSQVAEEVIQILRGFMLQNF
>Nissc27020S07583
MATATAPDKEITHQFRFFRVYKDSAVQLHHDPTTGLRSKDVVISTDPPVSARIFLPRMPDSNKKLPVLLYIHGGGFCMDSASSPVYHNLVAAISAKAKAVAVSVEYGLFPTRPRKRRVAESEDETGRRGYRVPQSVGVCS
>Nissc1614S15598
MDSNKDREVTMYLPTLVRVFIDGSIERLQNSPLVPPSLHQHPIVSSKDASSPTAPPSPPASTSLQQPSPPNPATTKKSQSWSTFTAAASSSSPPSTTATTTTSTPSSPRRTSSSSPLAPEIPLPAAYHDCWDALKWVAANTDTWLSIHGDFNRVFLGGDSAGANIVNYAALRAGAEELPRGDKLLGAFLSQPYFFGSEPIGSEAVEGHEQSVPYLVWGLVYPSAPGGVDNPLINPLARGAPSLAGIGCSKVLVCVAEKDSMRERGVWYYEGVKKSGWEGEVEPYEVEGEVHPFNIHNPRSQNAKRMMKRLADFLQHVERLMSSPTVPPSPEDPETGVSSKDIVISNDPPVSARIFLPKTHHQTQKLPVLVYFHAGAFCVESASSFFSHRYLNLVSSQANVIAVSVDYRLLPHHPLPAAYEDGWNALKFVASHATGDPINPEPWLLSHADLNRVYIGGDANGANIAHNVVMRAGGEALPGNVKIHGAMLCCPYFWGSKAIGSEPVEGHENSLAIKVWSFVYPDAPGGIDNPRVNPCGPGAPSLATLGCSKMLVCVAGKDEFRERDILYHETVKKSGWKGELEELFEAGDEEHCFQIFKPECDNAKNLLKRLASFLL
>Nissc1614S15529
MELQGRSDQCLPERKGQKRKLDDEFQDDRQISAPPIGDDRDALLSDVKDQVTILTNTFSWKESDRAAAKRATHALADLAKNEEVVNVIVEGGAIPALVQHLQAPPVVEEDLVQRPLPFEHDVEKGSAFALGLLAVKPEHQQLIVDNGALKHLVDLLKRHKNGLTSRAINSLIRRAADAITNLAHENSSIKTRVRMEGGIPPLVHLLEFADTKVQRAAAGALRTLAFKNDENKNQIVECNALPTLILMLRSEDAAIHYEAVGVIGNLVHSSPNIKKEVLLAGALQPVIGLLSSCCSESQREAALLLGQFAATDSDCKVHIVQRGAVRPLIEMLQSPDVQLREMSAFALGRLAQDTHNQAGIAHNGGLIPLLKLLDSKNGSLQHNAAFALYGLADNEDNVSDFIRVGGIQRLLDGEFIVQATKDCVAKTLKRLEEKIHGRVLNHLLYLMRVSEKAFQRRVALALAHLCSADDQRKIFIDHHGMDFLIGLLGSSSPKQQLDGAVALFKVANKAMTLSPVDAPPPSPTPQVYLGEQYVNNCTLSDVTFLVEGKLFYAHRICLLASSDAFRAMFDGGYREKDARDIEIPNIRWEVFELMMRFIYTGSVDVTLDIAQDLLRAADQYLLDGLKRLCEYTIAQDISLDNVSSMYELSEAFNAISLRHTCILFILEQFDKLSARPGLGGIGCSKPQVCIAGKDKIRDIGVWYYEAVKNSEWKGALELFEETEEGHVYPESENAKKLIKRLASFLLEWSNIKECVVIPVKCHCSVEFALAIEMASTETTTMSKEIVSQIPTFIYVYNDGTIERPRNEPRVPPSPKDPATSVSSKDIIFSLNPLLPARLFLPKLTQPNNQKLPILVYFHGGALCGESAFARHHHAYCNRVASQANVIIVSVEHRKAPEHYLPAAYEDCWDGLKWVASHAAHLNGRGDTWLVSHGDFERIFIGGDSSGANIVHNVAMRAGVEELPCGVKLYGAYLNQPFFCGSQPVGSEPVEGHEQSLGYLIWNFVYPDAPGGIDNPMINPFAPGAPSLAALGCTKMFVSVGGRDQLLRDRGVLYYEQVKESGWKGEVQFFEEREEGHAYYMFDLESESSKRLIKLVADFLRQ
>Nissc524528S26883
MSIIEEAPDFLQVYSDGTVKRFAPETAPPSSEPSSNGFRSKDVVIDPSKPITGRFFVPTFDPPSSEKLPVLVYFHGGGFCIGSATWLGYHTFLGDFSAMSRSIVLAVDYRLAPEHRLPTAYEDCYTSLEWLSDQSTRIYRATQASAKTEPWLQLADLSRVFLSGDSAGGNIAHHVAVKAIQNNGYPMKIKGLLPIHPYFGSEKRTDKEMDDEGAGDVKSNDMFWRLSIPKGLNRDYFGCNFEKGELPASVWSKFPAIEVYVAGLDFLKERGVMYAEFVKNKGVKEVKLVEAKGERHVFHVFEPESDATRLLQSQMSQFIKRH
>Nissc13162S14008
MSASQSQSPAMDPSSGEEIAHDFSPFLKIHRNGRIQRLIGCDVVPPSLDPTTNVESKDVDISKDQDISARIFMPKPNPSSDDEKLPVLIYFHGGGFCIETPFSPPYHNFLNAVASEARVIGVSVDYRRAPEHPLPAAYEDSWAAIKWAAAHVDGKGPEDWLNRYADFGKVFFAGDSAGANIAHHMGIRVGSEGPLPGVNLVGMALVHTYFWGVDRVGLEATRSEHSGFAESLWRFACPTTSGLDDPMINPAKDPNLGKMGCGKMIVFIAEKDLLKDRGWYYKELLEKSGWQGVVEVMEAKGEDHVFHLFNPKSENALSLLNRMMIRSGRSFSGHRPHNKYHNLPTKPNYHHSIVNLATHSHSFPPSLRPLPSLKMAATPPPSHPPPSTTDPDTEVLHDIPPIMKVYKSGRIERLAGEEVAPPSLDPTTNVESKDVVISEEEGISARLFLPKTGYPHTHKLPLLVYIHGGAFCIETPFSPNYTNFLNNVTSKANAVGVSVHYRRAPEHPVPTGHQDSWAVLKWIASHVGGNGPDEWLNRYADFEKVFFAGDSAGANIASYLGIRVGKEGLPGMRVEGIALVHPYFWGAERIGSESNQAEMGARIDQLWRFSCPATSGSDDPFINPEKDPDLGKLACGRVIVFVAEQDLLRDRGWYYKELLEKSGWRGSVEVVETKDENHVFHMFKPTCENAIVLLNQVVSFIKQD
>Nissc593S10674
MATATAPDKEITHQFRFFRVYKDGTVQLHRPHIETIPPSDDPATGLRSKDAVISTDPPVSARIFLPPMPDPNKKLPVLLYIHGGGFCMDSAFSSVYHNLVAAIAAKANAVAVSVEYGLFPTRPIPACYEDSWAALQWIALHAGGNGPEPWLTDHADLQKIFVGGDSAGGNITHTVVSRVGKMGLPGAKVVGAILVHPYFTGTEDDHMWMYMCPENEGLQDRRMRPAAEDLGNLGCERVLVFAAEKDHLFDAGRNYVDALKNGAWGGSAELVVNWGLDHCFHLFKPEGEKAVELLHKFVSFIKQN
>Nissc593S10672
MDPIPNKEVAREFPHLFRLYKDGTVQRFTGTDTAPPGTNPLTNVLSKDLTINPLTGVAARLYLPPHASGKLPLLIYIHGGAFCICTPFNPAYHRHMNAVSAAATALVVSVHYRLAPEHPLPAAYDDTWEAIQWAASHAAAPGPDPWLNDHADFTRVFFAGDSAGGNLAHNMAMRASSEPLPQLSLEGVVLIHPYFGNEKKDELIEFLYPTYGGPDDPKIHVAKDPKLSGMGCRRVLVLIAEKDFLRERGRSYYHTLKGSGWKGTVDMVETEGEGHVFHLFDPTKEKSVELVNHFVSFITQT
>Nissc593S35672
MNNNKKRAPEHPLPAAYEDGWEALKWIASHSFSPPNNIPWLIDRGNFSRFFTGGDTAGATIAHSTAFHVGGGKSLPGVVKIVGLMLVFPLFWGLKPVLNESVERHDKSSVMQVVNFAYPEAPGRINNLLINPVGPRAPPLVEVGCSKVAVFVAEKNELRDRGV
>Nissc337207S02155
MNEMASSSKTKEIVKELLPFICIYKDGSIERPRERPMVPPSPRDPATSVSSKDILFSLNPLLSARLFLPRLTQPNAQKLPILVYFHGGALCFGSAFADHHHTYCNLIASKANVIIVSVEHRKAPEHYLPAAYNDCWEGLTWVASHADTTTRNPFNMDTWLTNHGDFERVFIGGDSSGANIVHNVAMRAGVEALPNGVRLYGAYLNHPYFCGSKPVGSEPVEGFEQSSPYVMWDFVYPDAPGGIDNPMVNPFAPGAPSLATLGCRKMFVSVAGRDSLYMNERGVLYYEAVKGSGWKGEVEFFEEKDEDHVYHMQNIDSEQAKRLIKLLVDFLRA
>Nissc3271S02080
MAALASSLSLSPQYEYTSDKDYQHHGCVVEEIEGLIRVHKDGYVERPEVVPCVTPSLGPELNVASRDMVIDNSTNTWARFYVPTSSNLQRKKLPLLVYFHGGGFCVGSAAWSCYHDFLAKLSAKTGCLIMSVNYRLAPENPLPAPYDDGFKSLIWVKQQIMYKYESSQWWTQRCNFSSVFLGGDSAGANIAYNVAVRVSSSSSSLRPLSLKGTVLIQPFFGGESRTVSEKCMAKSPGSALNLAASDAYWRLALPRGADRDHPWCNPLAAERAVMLLPPALVCVSETDILKDRNVEFCEAMGRAGKRVECGVYRGVGHAFQILSKSQVSKRRTHEMMGRVKSFIMALS
>Nissc525432S10299
MHISGTKNSFKCFQHILERWSHEYCVTSGYNFTITPKCKCKYLLILSHTRRELPILVYYHCGAFCLESAFSFLHQRYLNIVASQSNVLVVSVDYRRAPEHPLPAAYEDGWEALKWIASHSFSPPNNIPWLIDRGNFSRFFTGGDTAGATIAHSTAFHVGGGKSLPGVVKIVGLMLVFPLFWGLKPVLNESVERHDKSSVMQVVNFAYPEAPGRINNLLINPVGPRAPPLVEVGCSKVAVFVAEKNELRDRGSGWKGGVELFEYEGEEHCFQIYHPETDNSKNMITRIASFLA
>Nissc528543S10432
MGYSCNPSASAMSSYAARYLNIVASQSNVLVVSVEYRRAPENPLPAAYEGGWEALKWIASHSSSPPNSDSWLIDHSDFSKFFIGGDTAGATIAHSAAFRVGGGYVEGHDKSSVMQVWNFVYPEVPGRIVNPLINPVGPGAPPLVEVGCPKMVVFVVEKGELKDRGVWHYGLLRESGWKGEVELFEYEGEKHCFQIYHPETDNSKNMITRIASFLA
>Nissc2464S07256
MEVNNSKSTASTNADQQLVYEFPNLIRVFADGRVERLKGTDFVPPSLHPYPQVDVSSKDITLDSQNDVSVRLFLPPQQHSSSGNNHKLPLLVYFHGGAFCTSSPFNAAYHNHLIALVSEANVVAVSVNYRLAPEHPIPAAYQDSWVALQWVASHRNGYGPEPWLNECADFQRVFLAGNSAGGNIVHNLVMMVGDPDLGLGMDVLGACLVQPFFWGSTPIGSEELNPNKKALVDGLWPFLSPSMPDNDDPRINPVAKGAPSLAWLGCRRVLVCVAEKDVLRDREWLYYDSLSRGGWIGVAEIEETKGEGHGFHLNDPECNKAKDLIKCMAEFFQRDMPPLI
>Nissc373159S08404
MASSADPTANKEIDRELPPLLRVYKDGSVERFLGSSTVPPIPQDPETGVSSKDIVISHNPLVSARLHLPKSENPNDKLPILVYYHGGAFCLESAFSFLHQRYLNIVASQSNVLVVSVEYRRAPEHPLPAAYEDGWEALKWIASHSSSPPNSDPWLIDRGDFSRFFIGGDTAGATIAHSAALRVGSGDSLPGGVKIAGLMLAFPLFWGSKPVLNESVEGHDKSSVMQVWNFVYPEAPGGIDNPLINPVGPGAPPLVEVGCPKVVVFVAEKDELRDRGVWYYGLLRESGWKGEVELFEYEGEEHCFQIYHPETDNSKNMITRIASFLA
>Nissc373159S22437
MDSETPTSPAIVNEVTTGQGTFVRVYSDGTITRPLQSLLVPPTLHDPQTGLCSKDIIISDNPLILARIYLPKLAAGEKVPILVYFHGGGFIIESAFSTLYDGHFKTFAPKANGIVVSVEYRLAPEDPLPACYHDSWSALKWVCSHNHISTEKQSSKTEPWLISHGDFKRVFIGGDSSGGNIAHNVAMRAGKEDLPGGVRILGAFLTQPLFFSSYPVGSEPVTERKQSPSYRVWNMVYPSAASGIDNPVINPVGPRAPSLAQLGCCRMIVCVAGQDRLRDRGVWYYECVKQSGWQGNLELFEEEDENHVYHLFKPESEAADKLMKRLASFLHHSQFVMGSATPTTKEIVVDLPNYIRVFADGTVERTRHSPFVPPSLHDPITVPILVYFHGGGFFFESAFSQLFHTHFTHFVPQANVVLVSVEYRLAPENPLPAGYHDCWNALQWVCSHNNNSNENQSSNREPWLIDHGDFGKVFIGGDSAGGNIVHNIALRAGAEALPNDVKILGAIYSHPYFYGSEPIGTEPVTGLEQNFYYLVWNLVYPNAPGGIENPMINPLGPGAPSLAGLGCEKIIVCVAGKDGLRDRGVWYCESVKQSGWQGKLELFEEEDEVHDYHVFKPESENGNKLIKKLASFLRE
>Nissc373159S08405
MASTTSTNSNKDIVAEIPGYIQIFNDDSVERSLQSPFAPPMLDDPLTGISSKDVVISHNPTISARIYLPKLSNEKVPILVYFHGGRFFLGSSFSRLFHHYFNNFVPQADAIVVSVEYRLAPENPLPACYHDCWAALQWVCSHDSIENRISNTEPWLIQHGDFDRVFIGGDSAGGNIAHNIAMRVGKEALPGDVKVLGAILCHPFFYSSYPIGSKKSVDVVPKEQNHHRLVWKLVYPSAPGGIDNPMVNPVGPGAPGLDQLGCSRMIVCVAGSKDELRDRGFWYCECVKQSGWQGKLELFEEEEEGHVYHVFHPESDNAHKLFKRLASFLHQ
>Nissc12880S05445
MAAISLKHNPQVNNTSHNQREFVTEEIEGLIRVLRDGRVERPPVVPNVPCAVTLPEHRGVTARDVMINKETNLWARIYVPPLLTASQCNVDNNKLPLLVYFHGGGFCVGSAAWSCYHEFLTQLAFRAGCVVVSLDYRLAPENRLPAAYDDGVTALTWVKREALNASSVQKWWLSHCDLSSMFLAGDSAGANIAYNVATRIGSCTLINPLSLKGVILIQPFFGGEERTISEKHSNQAPNSALTLPVSDTYWRLALPIGSTRDHLYCNPLAHGGAKLRDLKVPSVMVGVSELDILRDRNLEFSNALARAGKRVETFVYKGVGHAFQVLHNCQLSHSRAQQMISHIRAFVNH
>Nissc10616S12628
MSNTLDSNPTLVDECRGVLHVYSDGSIVRSSRPSFNVPVQDDGVVLWKDVVFDTAHDLQLRLYKPADSSGSNLPIFYYIHGGGFCIGSRAWPNCQNYCFRLASELRAVVVAPDYRLAPENRLPAAIEDGFTAVKWLQAQAMSDEPDPWLSEVADFSRVFISGDSAGGNMAHHLAVRLGSGSSEFAPIQVRGYVLLAPFFGGTIRTKSEAEGPKDAFLNLELIDRFWRLSVPAGDTTDHPLVNPFGPVSKSLEEVDLDPILVVVGESDLLKDRAEDYAVRLKNWGKNIEYEEFEGQQHGFFTIDPNSEPAKELMLVIKQFINKHSG
>Nissc1528S00696
MVLEKELVDEVSGWLRIYDDGSVDRTWTGPPEVKFMAEPVPPHEEFIDGVAIRDVISGNHRVRVYLPETAPGDKEKLPILLHFHGGGFCISEPDWYMYYHMYTRFSRSARVICVSPFLRRAPENRLPAAIEDGFSTLVWLQSLARGDATESWLQTHADFKRVFLIGDSSGGNIVHEVAALAGEVRLDPLQLVGGIPIHPGFVRSRRSRSEVEKPESPFLTLDMLDKFLSLALPEGSNKDHPITCPMGEAAPPLSKLKLPPILLCLAEMDLVWDTEMEYYEAMIKANHDVQLYVSKGMTHSFYLNKIAVDMDPNTAAQTDALIARVKEFIEQHQT
>Nissc1394S14528
MNFVSAAAAALVVSVHYRLAPEHPLLAAYDDMWEAIQWAASHAAAPNPEPWLNDHVDFTHVFFAGDSVSTNLAHNMAMRASTEPLLQLTLDGVVLINPYFRNEKKDELIEFLYPTYGGLYDPKIHLAKDPKLSGMNCRRVLVLIAEKDFLRKRAELLPWWCKTSELHWMGGHPLLAAYDDMWEAIQWAASHAAAPNPEPWLNDHVDFTHVFFAGDSVSTNLAHNMAMRASTEPLLQLTLDGVVLINPYFRNEKKDELIEFLYPTYGGLYDPKIHLAKDPKLSGMNCRRVLVLIAEKDFLRKRAELLPWWCKTSELHWMGGVRGGGQNRK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University