Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Nicotiana attenuata
Species name
Nicotiana attenuata is a species of eudicot in the family Solanaceae (nightshade family).
Species info
Gene sequence info
Nicotiana_attenuata.4CL.fa
Download
>rna-XM_019388938.1
MLSVASVEAQKAELSSSVIPPSNQSSEELHVFRSRLPDIPISNNVPLHVYLFERLSEFQDRTCLISGSSGKSYTFAETHLICQKIAAGLNNIGIKKGDVIMTFLQNCAEFVFTFLSASMIGAVITTANPFYTKAEAFKQLKASNAKLIVTQSQYVDKFRDSGENDPKIGEDFSVITIDDPPENCLHFSVLSEANEEKMPKGIVIQPDDPVALPFSSGTTGLPKGVILTHKSLITGVAQLVDGDNPNLYLKNDDVVLCVLPLFHIFALNSVLLVSLRAGASVLLMQKFEIGALLELIQHHRVSVAAVVPPLVLALAKNPMVDSFDLSSIRLVLSGAAPLGKELEEALHRRVPQAIFGQGYGMTEAGPVVTMCPAFAKQPFSTKSGSCGSVVRNADLKVVDPETGGSLGRNQPGEICIRGSQIMKGYLNDDEATARTIDVDGWLHTGDIGYVDDDDEIYIVDRVKELIKFKGFQVPPAELESLLVSHPDIADAAVVPQKDDAAGEVPVAFVVRSANGFEITEEAIKEFIAKQVIFYKRLHKVYFIHSIPKSPSGKILRKELRAKLAAPPASSTE
>rna-XM_019388371.1
MPMESTNETKQSGDLIFRSKLPDIYIPKHLPLHSYCFENISEFSSRPCLINGANDQIYTYAEVELTCRKVAAGLNKLGIQQKDTIMILLPNSPEFVFAFMGASYLGAISTMANPLFTPAEVVKQAKASSAKIIITQSCFVGKVKDYASENDVKVICIDSAPEGCLHFSELTQSDEHEIPEVKIQSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENANLYMHSEDVLMCVLPLFHIYSLNSILLCGLRVGAAILIMQKFDIAPFLELIQKYKVSIGPFVPPIVLAIAKSPIVDSYDLSSVRTVMSGAAPLGKELEDAVRTKFPKAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPDTGCSLPRNQPGEICIRGDQIMKGYLNDPEATTRTIDKEGWLHTGDIGFIDEDDELFIVDRLKELIKYKGFQVAPAEIEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSAITEDEVKDFVSKQVIFYKRVKRVFFVETVPKSPSGKILRKDLRARLAAGVPN
>rna-XM_019392607.1
MEKDTKHGDIIFRSKLPDIYIPNHLPLHSYCFENISEFSSRPCLINGANKQIYTYADVELNSRKVAAGLHKQGIQQKDTIMILLPNSPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIIVTQACHVNKVKDYAFENDVKIICIDSAPEGCLHFSVLTQADEHDIPEIEIQPDDVVALPYSSGTTGLPKGVMLTHKGLVTSLAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQSYKVTIGPFVPPIVLAIAKSPMVDDYDLSSVRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGNSLPRNQSGEICIRGDQIMKGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNESTITEDEVKDFISKQVIFYKRIKRVFFVDAVPKSPSGKILRKDLRAKLATGLPN
>rna-XM_019401953.1
MDTKQGDIIFKSKLPDIYIPNHLPLHSYCFENISEFSTRPCLINGANDQIYTYADVELISRKVAAGFNKLGIKQKDTIMILLPNSPEFVFTFLGASYLGAISTMANPLFTQVEVVKQAKASNPKLIVTQECNLDKVKSYAFEHDVKVICIDSSSERCLHFSDLILNPGFASSIEHDLSEVEIQPDDILALPFSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPTLYIHSEDVILCVLPLFHIYSLDSVLLCGLRVGAAILIMQKFDIVPFLELIQKYKVTIAPFVPPIVLAIAKSAMVDNYDLSSVRIVMCGAAPLGKDLEDAVRTKFPNAKLGQGYGMTEAGSVLAMCLAFAKEPFEIKSGACGTVIRNAEMKIMDLNTGSSLPRNKSGEICIRGDQIMKGYLNDPEATAQTIDKEGWLHSGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLNLPYISDAAVVPMKDEQAGEVPVAFVVKSSGCTITEDEIKDFISKQVIFYKRIKRVFFVDAVPKSPSGKILRKDLRASLADGLPN
>rna-XM_019409088.1
MEMVKNKENHNDQYIFRSKLPDIYIPNHLPLHTYCFENISQFSSRTCLINSATGATYTYADVELTSKRVAIGLYKLGIQQRDVIMLLLPNSPEFVFAFLGASFRGAISTTANPFYTPSEITKQAKASNVKLIITQSCYVDKVKSFAEENEVKIMCTDNSPPEYGCLSFAELITDQSEEDNHNYDYNTILSDIEIFSDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGENPNLYFNSEDVIMCVLPLFHIYSLNSVLLCGLRVGATILIMQKFEIKGLMELVEKYRVTIAPFVPPIVLAIAKSPLVDKYDLSSIRMIMSGAAPMGKELEDTVRAKLPNAILGQGYGMTEAGPVLSMCLAFAKQQFEVKSGSCGTVVRNAEMKIVDTNTGASLPRNHAGEICIRGDQIMKGYLNNPKATEETIDKEGWLHTGDIGYIDDDDQVFIVDRLKELIKYKGYQVAPAELEALLISNPNITDAAVVPMKDEVAGEVPVAFVVRANGSNISEEEIKKYISEQVIFYKRINRVFFTEAIPKAPSGKILRKDLRAKLATGLAC
>rna-XM_019375887.1
MEKSGYGRDGIYRSLRPPLFLPKNQNLSMVSFLFRNISSFPEKTALFDADSGQTLTFSQFKTIVSKISHGLIHQFGIKKNDVVLIFAPNSIQFPCCFFGVIALGAIATTVNPMYTVSELSKQIKDCKPKLIITVPELLDKISGFNLPILLLGHKKNSNFSGVTFTELVDKAGYVNLDNNGIKQSDTAALLYSSGTTGISKGVVLSHRNFIAASLMVTADQDLKGEMHNVFLCVLPMFHVFGLAVIMYAQLQRGSAIVSMAKFDLEMILKTVDKYRVTHLWIVPPVVLALAKNPVVKKYNLTSLRNIGSGAAPLGKELMEECAKNFPQAVVVQGYGMTETCGIAALESPYVGPRHTGSAGTLVPGVEAQIISVDKLKPLPPGQLGEIWVRGPNMMQGYFNNPQATKLTIDNQGWVHTGDLGYFDEEGMLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRKVTFVNSVPKSASGKILRRELIEKVRSKL
>rna-XM_019383208.1
MGTHAVESSQQQECEHIFRSRYPPVQVPDNVTLPDFVLHNVELYTDKMAFVDATTGKGYTYGEVARDIRRFAKALRSLGLRKGRVVVVVLPNVPEYAIVALGIMAAGGVFSGANPAAHSSEIMKQVESADGKLIVSDLPTYHKVKDCGLPVIILGEEHVEGTIHWDELLEAAERAGSRTDHITNQEDEMVQQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVSPEMIGQVTTLGLIPFFHIYGITGICCATIRNKGKVVVMRRYELRAFLNALIAHEVTFAPIVPPIILALVKNPIVDEFDLNKLKLRSIMTAAAPLAPEILNEFEKKFPDVQVQEAYGMTEHSCITLSHSDQHTAKRNSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVKSQCVMKGYYKNEFETCLTIDKDGWLHTGDIGYIDDDGDIFLVDRIKELIKYKGFQVAPAELEGILLTHPSVEDAAVVGLPDEEAGEIPAAWVVLNSKAKESEEDIINYIASTVAQYKRVRVVQFVDSIPKSPSGKIMRRLIKDKMLERLKNA
MLSVASVEAQKAELSSSVIPPSNQSSEELHVFRSRLPDIPISNNVPLHVYLFERLSEFQDRTCLISGSSGKSYTFAETHLICQKIAAGLNNIGIKKGDVIMTFLQNCAEFVFTFLSASMIGAVITTANPFYTKAEAFKQLKASNAKLIVTQSQYVDKFRDSGENDPKIGEDFSVITIDDPPENCLHFSVLSEANEEKMPKGIVIQPDDPVALPFSSGTTGLPKGVILTHKSLITGVAQLVDGDNPNLYLKNDDVVLCVLPLFHIFALNSVLLVSLRAGASVLLMQKFEIGALLELIQHHRVSVAAVVPPLVLALAKNPMVDSFDLSSIRLVLSGAAPLGKELEEALHRRVPQAIFGQGYGMTEAGPVVTMCPAFAKQPFSTKSGSCGSVVRNADLKVVDPETGGSLGRNQPGEICIRGSQIMKGYLNDDEATARTIDVDGWLHTGDIGYVDDDDEIYIVDRVKELIKFKGFQVPPAELESLLVSHPDIADAAVVPQKDDAAGEVPVAFVVRSANGFEITEEAIKEFIAKQVIFYKRLHKVYFIHSIPKSPSGKILRKELRAKLAAPPASSTE
>rna-XM_019388371.1
MPMESTNETKQSGDLIFRSKLPDIYIPKHLPLHSYCFENISEFSSRPCLINGANDQIYTYAEVELTCRKVAAGLNKLGIQQKDTIMILLPNSPEFVFAFMGASYLGAISTMANPLFTPAEVVKQAKASSAKIIITQSCFVGKVKDYASENDVKVICIDSAPEGCLHFSELTQSDEHEIPEVKIQSDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENANLYMHSEDVLMCVLPLFHIYSLNSILLCGLRVGAAILIMQKFDIAPFLELIQKYKVSIGPFVPPIVLAIAKSPIVDSYDLSSVRTVMSGAAPLGKELEDAVRTKFPKAKLGQGYGMTEAGPVLAMCLAFAKEPFDIKSGACGTVVRNAEMKIVDPDTGCSLPRNQPGEICIRGDQIMKGYLNDPEATTRTIDKEGWLHTGDIGFIDEDDELFIVDRLKELIKYKGFQVAPAEIEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSAITEDEVKDFVSKQVIFYKRVKRVFFVETVPKSPSGKILRKDLRARLAAGVPN
>rna-XM_019392607.1
MEKDTKHGDIIFRSKLPDIYIPNHLPLHSYCFENISEFSSRPCLINGANKQIYTYADVELNSRKVAAGLHKQGIQQKDTIMILLPNSPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKIIVTQACHVNKVKDYAFENDVKIICIDSAPEGCLHFSVLTQADEHDIPEIEIQPDDVVALPYSSGTTGLPKGVMLTHKGLVTSLAQQVDGENPNLYIHSEDVMLCVLPLFHIYSLNSVLLCGLRVGAAILIMQKFDIVPFLELIQSYKVTIGPFVPPIVLAIAKSPMVDDYDLSSVRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGMTEAGPVLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPETGNSLPRNQSGEICIRGDQIMKGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLNHPNISDAAVVPMKDEQAGEVPVAFVVRSNESTITEDEVKDFISKQVIFYKRIKRVFFVDAVPKSPSGKILRKDLRAKLATGLPN
>rna-XM_019401953.1
MDTKQGDIIFKSKLPDIYIPNHLPLHSYCFENISEFSTRPCLINGANDQIYTYADVELISRKVAAGFNKLGIKQKDTIMILLPNSPEFVFTFLGASYLGAISTMANPLFTQVEVVKQAKASNPKLIVTQECNLDKVKSYAFEHDVKVICIDSSSERCLHFSDLILNPGFASSIEHDLSEVEIQPDDILALPFSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPTLYIHSEDVILCVLPLFHIYSLDSVLLCGLRVGAAILIMQKFDIVPFLELIQKYKVTIAPFVPPIVLAIAKSAMVDNYDLSSVRIVMCGAAPLGKDLEDAVRTKFPNAKLGQGYGMTEAGSVLAMCLAFAKEPFEIKSGACGTVIRNAEMKIMDLNTGSSLPRNKSGEICIRGDQIMKGYLNDPEATAQTIDKEGWLHSGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLNLPYISDAAVVPMKDEQAGEVPVAFVVKSSGCTITEDEIKDFISKQVIFYKRIKRVFFVDAVPKSPSGKILRKDLRASLADGLPN
>rna-XM_019409088.1
MEMVKNKENHNDQYIFRSKLPDIYIPNHLPLHTYCFENISQFSSRTCLINSATGATYTYADVELTSKRVAIGLYKLGIQQRDVIMLLLPNSPEFVFAFLGASFRGAISTTANPFYTPSEITKQAKASNVKLIITQSCYVDKVKSFAEENEVKIMCTDNSPPEYGCLSFAELITDQSEEDNHNYDYNTILSDIEIFSDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGENPNLYFNSEDVIMCVLPLFHIYSLNSVLLCGLRVGATILIMQKFEIKGLMELVEKYRVTIAPFVPPIVLAIAKSPLVDKYDLSSIRMIMSGAAPMGKELEDTVRAKLPNAILGQGYGMTEAGPVLSMCLAFAKQQFEVKSGSCGTVVRNAEMKIVDTNTGASLPRNHAGEICIRGDQIMKGYLNNPKATEETIDKEGWLHTGDIGYIDDDDQVFIVDRLKELIKYKGYQVAPAELEALLISNPNITDAAVVPMKDEVAGEVPVAFVVRANGSNISEEEIKKYISEQVIFYKRINRVFFTEAIPKAPSGKILRKDLRAKLATGLAC
>rna-XM_019375887.1
MEKSGYGRDGIYRSLRPPLFLPKNQNLSMVSFLFRNISSFPEKTALFDADSGQTLTFSQFKTIVSKISHGLIHQFGIKKNDVVLIFAPNSIQFPCCFFGVIALGAIATTVNPMYTVSELSKQIKDCKPKLIITVPELLDKISGFNLPILLLGHKKNSNFSGVTFTELVDKAGYVNLDNNGIKQSDTAALLYSSGTTGISKGVVLSHRNFIAASLMVTADQDLKGEMHNVFLCVLPMFHVFGLAVIMYAQLQRGSAIVSMAKFDLEMILKTVDKYRVTHLWIVPPVVLALAKNPVVKKYNLTSLRNIGSGAAPLGKELMEECAKNFPQAVVVQGYGMTETCGIAALESPYVGPRHTGSAGTLVPGVEAQIISVDKLKPLPPGQLGEIWVRGPNMMQGYFNNPQATKLTIDNQGWVHTGDLGYFDEEGMLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPIAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRKVTFVNSVPKSASGKILRRELIEKVRSKL
>rna-XM_019383208.1
MGTHAVESSQQQECEHIFRSRYPPVQVPDNVTLPDFVLHNVELYTDKMAFVDATTGKGYTYGEVARDIRRFAKALRSLGLRKGRVVVVVLPNVPEYAIVALGIMAAGGVFSGANPAAHSSEIMKQVESADGKLIVSDLPTYHKVKDCGLPVIILGEEHVEGTIHWDELLEAAERAGSRTDHITNQEDEMVQQNDLCALPFSSGTTGLSKGVMLTHRNLVANLCSTLFSVSPEMIGQVTTLGLIPFFHIYGITGICCATIRNKGKVVVMRRYELRAFLNALIAHEVTFAPIVPPIILALVKNPIVDEFDLNKLKLRSIMTAAAPLAPEILNEFEKKFPDVQVQEAYGMTEHSCITLSHSDQHTAKRNSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVKSQCVMKGYYKNEFETCLTIDKDGWLHTGDIGYIDDDGDIFLVDRIKELIKYKGFQVAPAELEGILLTHPSVEDAAVVGLPDEEAGEIPAAWVVLNSKAKESEEDIINYIASTVAQYKRVRVVQFVDSIPKSPSGKIMRRLIKDKMLERLKNA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University