Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Nelumbo nucifera
Species name
Sacred lotus (Nelumbo nucifera) is a species of flowering plant in the family Nelumbonaceae (lotus family).
Species info
Gene sequence info
Nelumbo_nucifera.COMT.fa
Download
>rna-XM_010258115.2
MSSVYDLGRSFSEGKDNNEENCLLALQLASATVFPMVLKAALELDVLEIISRAGPSAYLSTSDIASQLPTQNPDAPAILDRILRLLAVHSVIKSSVVERDDNQVQMVYGLAPVCKFLTGNQDDISLRPYLLLLQDKTFMDSWQCLKDAVLEGGVPFIKAHGMHVFEYTGVDARFNKVVNKAMSNITTMTMVKILETYKGFEGLKVVVDVGGGIGVTINMITAEYPQIKGINFDLPHVIADAPSYPGVEHLGGDMFEYVPNADAIFMKCILHDWNDEDCLKLLKNCWKALPNLGKVIALESILPETLEATDPVSKVVWEQDLLMLSQSPGGKERTYKQFQDLALSSGFTSFQVVCSAYHSCVLEFQK
>rna-XM_010262973.2
MDAEDRASRLSGLRLAGLICVPMALRAAIKLKVFDIMAQAGPDARLSASEMVHRMAATNPNAATALDRILRILAANSILSFSLRPRDDGSEPEKVYGLTSESRWLVPGDDGASVAPEMLLTLDKAVVESFYCLQDAVVEEGCIPFEKAHGTDVFEYGAKEPEFNKAYPDAMNNGSAIALAEVFKVYKGFDGVTEMVDVGGGTGVSIGFIVSRYPNFRGVNFDLPHIISHPPPLQGVEHVGGNMFEEIPNEETIFMKWILHNWDDGRCVTLLKKCWRALPHGGKVIIVEFVIPPVLGTDAVSRYTLSADLFMMACNPGGKERTVTEFYGLAMAAGFAEMKNCPIGHGLHVIEFHK
>rna-XM_010264702.1
MASTHDDAKSINVQDKEEENFAFAMRLARASVLPMVLKAAIELDVLEIISSAGPDAYLSPSEIASQLQTYNPDASTMIDRMLRLLASCSVLNCSLVKRENGQVERCYGLAPVCKFLTRNQDGVSIAPLLLLLQDKVFMDSWYHLRDTVIQGGIPFNKAHGMSAFEYPRIDSRFNKVFNKAMSDATVIVTNKILETYKGFEGLKVVVDVGGGIGVALNLITSKYPQIKGINFDLPHVVAGASSYPGVEHVGGDMFESVPQGDAIFMKLILHDWSDEHCLKLLKNCWKALPKSGKIIIVELILPDPEAPDEIKMFSDTTFTDLIMLAQNPGGKERSYKEFEALAMSSAFSSCEMVCRAYNYRVLEFCK
>rna-XM_010269016.2
MADETTEIRNNARLAILELANMISVPMSLNAIVRLKVPDAIWQSGSNVPLSASEILARALPTGDPENLQRILRMLTTYDVFSEHIADGSSERKYSLTEIGKTLVTDGEGLSYAAYVLQHHQDALMKAWPILHEAVVDPKEEPFVKANGEPAYSYYGDKSEMNELMQKAMSGVSVPFMKAILEGYNGFKGVERLVDVGGSAGDCLRMILHKHPHVREGINFDLPEVVAKAPNIPGVTHVGGDMFESIPAGDAIFMKWVLTTWTDDECKLIMRNCYEALPPGGKMIACEPVLPKESDRSHRTRALLEGDIFVMAIYRAKGKHRTEEEFKQLGLASGFPHFRAFYIDQFYTVLEFQK
>rna-XM_010269377.2
MAPIENQLPKSSSEEEEEYCLFAMQLASASVMPMVLRAAVELDVLDIMSRAAPGAQLSPSEIASHMPTKNPDAPVMLDRMLRLLASYSILTCSVVEQEDGRVQRLYGLAPVCKYFVPNEDGASLASMILLSQDKVFMETWYHLKDAVLEGGIPFNKAYRVRSFEYHGMDPRFNQLFNRAMLDHTRITMKSILQAYKGFEDAKVVVDVGGGLGVTINMITSKYPNIKGINFDLPKVIEDAPSYPGVEHVGGDMFACVPKADLIVMKWILHDWSDDHCLKLLKNCYEALPENGKVVVVEGILPVAAEASLAAQSLYQIDVIMMNQHVGGKERTDKEYEALAKRAGFTGIRLVCCVYSNWVIEFHKGD
>rna-XM_010272940.2
MADEKTETRNNARLAILELANMISVPMSLNAIVCLKVPDAIWQGSSNIPLSASEVLAHVLPTGNSENLRRILRMFTSYDVFSEHIADGFSERKYSLTEIGKILVTDGEGLSYAVYVLQHHQDTLVKAWPLQHEAVVDLKEEPFVKANAYYGDKPEMNELMQKAMSGVSVPFVLFMKAIVERRNVGIIRMNTEQRRKTKKSNLSYIFSKNLPYLSYYIKILFFIDIKGKKLPLFARNPKRNGKIRIRPM
>rna-XM_010242748.2
MGSTKTQIKIADQEEEEACNYAMQLASASVVPMVLKAAIELDVLEIIAEAGAGAHISTSEIASHLPTQNPDAPVMLDRMLRLLASFSILTCSLRTHDDGRVERLYGLAPVCKFLVKNEDGVSMAPLVLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSDHSTITMKKILETYKGFEGLNSVVDVGGGTGATLNMIISKYPSIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDAHCLEFLKNCYQALPENGKIIVVESILPVAPETNLSANGVFQLDNIMLAHNPGGKERAEKDFEALAKGAGFAGVGVMCRAFNSYVMEFYKSA
>rna-XM_010243893.1
MDGGDPSISGSPHEDDMEVGLPSAPRFDIDLEEECQSTELAHLEVVAESNRPVKDKTKGSDGVPEIDMEFESEERAYNFYNKYGGKVGFSIRRSWANKCKDGVVRRRLFCCSRQGHRSHDKRDVKNHRPETRTGCLAHMVIALQPNGRYRVCQFEPNHNHDVGKPSKSRMLRSQKASAAAQAAETDISDSTGWGLGRLICIQMSIRAAIELDVFNIIAEAGPGAQLSSSEMVTKMPTTNPNAATALDRILRMLGANCILSMSMRPCNEGEKKHERVYGLTSKSRSLVTTNGEGASVAPIVLASSEKAVIESLYLLKDAVLEQGCIPFNKAHGLSFLEYAAKEPGMKAVFDQALGTRSAIFFHEVLKVYKGFNDIRELVDVGGGTGSLLGMIVSRFPHIRGINFELPHVIADAPKFPGVEHVAGDMFEQVPIAQAILLKWILHDWDDARCTRLLKNCWEALPNGGKVIVVEFALPPVLGNNVESLNALTPDLFGMVLNPGGKERTIAEYTDLAKAAGFSEIKLCPISQGLLVMELYKKNGGPRPLLPRPTLLIPHFILNGAPTTLQ
>rna-XM_010249379.2
MSSIYNRAKSLVEDDDEEIYAFATELAGASVLPMVLKAAIELELLEIISSAGPGAYLSPWDIASHLQTHNPDAPTMVDRMLRLLASFSVLKCSLIKRENGRVERHYALAPVCKFLTRNKDGVSLASLVLLCEDKVFMDSWYEIRNILLLYFVAHKMKENR
>rna-XM_010249375.2
MASTHNAEPLVQGKEEENYVLAMQLANASVFPMVLRAAVELGVLEIIASAGPDACLSSLDIASNLQTQNLEAPIMLERMLRLLASCSILTCSLIKQDNGEVEKHYGLAPIGKLFTRNQDGASVASLLLLIQDKVFMDSWYHLKDAVLQGGIPFNKAHGMSAFEYPGIDSRFNKVFNKAMSDMTVILMKKVLETYKGFEGLKEVVDVGGGIGVTLNMITSKYPQIKGINFDLPHVIANAPSYPGVEHVGGDMFENVPQGDAIFMKLILHDWSDEHCLKLLKNCWKALPESGKIIIVDLILPEAPGISMFSDAVFLADLVMLAQNPGGKERTFKEFEDLALRSAFSSCKMICRVYNYCVMEFHK
MSSVYDLGRSFSEGKDNNEENCLLALQLASATVFPMVLKAALELDVLEIISRAGPSAYLSTSDIASQLPTQNPDAPAILDRILRLLAVHSVIKSSVVERDDNQVQMVYGLAPVCKFLTGNQDDISLRPYLLLLQDKTFMDSWQCLKDAVLEGGVPFIKAHGMHVFEYTGVDARFNKVVNKAMSNITTMTMVKILETYKGFEGLKVVVDVGGGIGVTINMITAEYPQIKGINFDLPHVIADAPSYPGVEHLGGDMFEYVPNADAIFMKCILHDWNDEDCLKLLKNCWKALPNLGKVIALESILPETLEATDPVSKVVWEQDLLMLSQSPGGKERTYKQFQDLALSSGFTSFQVVCSAYHSCVLEFQK
>rna-XM_010262973.2
MDAEDRASRLSGLRLAGLICVPMALRAAIKLKVFDIMAQAGPDARLSASEMVHRMAATNPNAATALDRILRILAANSILSFSLRPRDDGSEPEKVYGLTSESRWLVPGDDGASVAPEMLLTLDKAVVESFYCLQDAVVEEGCIPFEKAHGTDVFEYGAKEPEFNKAYPDAMNNGSAIALAEVFKVYKGFDGVTEMVDVGGGTGVSIGFIVSRYPNFRGVNFDLPHIISHPPPLQGVEHVGGNMFEEIPNEETIFMKWILHNWDDGRCVTLLKKCWRALPHGGKVIIVEFVIPPVLGTDAVSRYTLSADLFMMACNPGGKERTVTEFYGLAMAAGFAEMKNCPIGHGLHVIEFHK
>rna-XM_010264702.1
MASTHDDAKSINVQDKEEENFAFAMRLARASVLPMVLKAAIELDVLEIISSAGPDAYLSPSEIASQLQTYNPDASTMIDRMLRLLASCSVLNCSLVKRENGQVERCYGLAPVCKFLTRNQDGVSIAPLLLLLQDKVFMDSWYHLRDTVIQGGIPFNKAHGMSAFEYPRIDSRFNKVFNKAMSDATVIVTNKILETYKGFEGLKVVVDVGGGIGVALNLITSKYPQIKGINFDLPHVVAGASSYPGVEHVGGDMFESVPQGDAIFMKLILHDWSDEHCLKLLKNCWKALPKSGKIIIVELILPDPEAPDEIKMFSDTTFTDLIMLAQNPGGKERSYKEFEALAMSSAFSSCEMVCRAYNYRVLEFCK
>rna-XM_010269016.2
MADETTEIRNNARLAILELANMISVPMSLNAIVRLKVPDAIWQSGSNVPLSASEILARALPTGDPENLQRILRMLTTYDVFSEHIADGSSERKYSLTEIGKTLVTDGEGLSYAAYVLQHHQDALMKAWPILHEAVVDPKEEPFVKANGEPAYSYYGDKSEMNELMQKAMSGVSVPFMKAILEGYNGFKGVERLVDVGGSAGDCLRMILHKHPHVREGINFDLPEVVAKAPNIPGVTHVGGDMFESIPAGDAIFMKWVLTTWTDDECKLIMRNCYEALPPGGKMIACEPVLPKESDRSHRTRALLEGDIFVMAIYRAKGKHRTEEEFKQLGLASGFPHFRAFYIDQFYTVLEFQK
>rna-XM_010269377.2
MAPIENQLPKSSSEEEEEYCLFAMQLASASVMPMVLRAAVELDVLDIMSRAAPGAQLSPSEIASHMPTKNPDAPVMLDRMLRLLASYSILTCSVVEQEDGRVQRLYGLAPVCKYFVPNEDGASLASMILLSQDKVFMETWYHLKDAVLEGGIPFNKAYRVRSFEYHGMDPRFNQLFNRAMLDHTRITMKSILQAYKGFEDAKVVVDVGGGLGVTINMITSKYPNIKGINFDLPKVIEDAPSYPGVEHVGGDMFACVPKADLIVMKWILHDWSDDHCLKLLKNCYEALPENGKVVVVEGILPVAAEASLAAQSLYQIDVIMMNQHVGGKERTDKEYEALAKRAGFTGIRLVCCVYSNWVIEFHKGD
>rna-XM_010272940.2
MADEKTETRNNARLAILELANMISVPMSLNAIVCLKVPDAIWQGSSNIPLSASEVLAHVLPTGNSENLRRILRMFTSYDVFSEHIADGFSERKYSLTEIGKILVTDGEGLSYAVYVLQHHQDTLVKAWPLQHEAVVDLKEEPFVKANAYYGDKPEMNELMQKAMSGVSVPFVLFMKAIVERRNVGIIRMNTEQRRKTKKSNLSYIFSKNLPYLSYYIKILFFIDIKGKKLPLFARNPKRNGKIRIRPM
>rna-XM_010242748.2
MGSTKTQIKIADQEEEEACNYAMQLASASVVPMVLKAAIELDVLEIIAEAGAGAHISTSEIASHLPTQNPDAPVMLDRMLRLLASFSILTCSLRTHDDGRVERLYGLAPVCKFLVKNEDGVSMAPLVLMNQDKVLMESWYHLKDAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNRGMSDHSTITMKKILETYKGFEGLNSVVDVGGGTGATLNMIISKYPSIKGINFDLPHVIEDAPSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDAHCLEFLKNCYQALPENGKIIVVESILPVAPETNLSANGVFQLDNIMLAHNPGGKERAEKDFEALAKGAGFAGVGVMCRAFNSYVMEFYKSA
>rna-XM_010243893.1
MDGGDPSISGSPHEDDMEVGLPSAPRFDIDLEEECQSTELAHLEVVAESNRPVKDKTKGSDGVPEIDMEFESEERAYNFYNKYGGKVGFSIRRSWANKCKDGVVRRRLFCCSRQGHRSHDKRDVKNHRPETRTGCLAHMVIALQPNGRYRVCQFEPNHNHDVGKPSKSRMLRSQKASAAAQAAETDISDSTGWGLGRLICIQMSIRAAIELDVFNIIAEAGPGAQLSSSEMVTKMPTTNPNAATALDRILRMLGANCILSMSMRPCNEGEKKHERVYGLTSKSRSLVTTNGEGASVAPIVLASSEKAVIESLYLLKDAVLEQGCIPFNKAHGLSFLEYAAKEPGMKAVFDQALGTRSAIFFHEVLKVYKGFNDIRELVDVGGGTGSLLGMIVSRFPHIRGINFELPHVIADAPKFPGVEHVAGDMFEQVPIAQAILLKWILHDWDDARCTRLLKNCWEALPNGGKVIVVEFALPPVLGNNVESLNALTPDLFGMVLNPGGKERTIAEYTDLAKAAGFSEIKLCPISQGLLVMELYKKNGGPRPLLPRPTLLIPHFILNGAPTTLQ
>rna-XM_010249379.2
MSSIYNRAKSLVEDDDEEIYAFATELAGASVLPMVLKAAIELELLEIISSAGPGAYLSPWDIASHLQTHNPDAPTMVDRMLRLLASFSVLKCSLIKRENGRVERHYALAPVCKFLTRNKDGVSLASLVLLCEDKVFMDSWYEIRNILLLYFVAHKMKENR
>rna-XM_010249375.2
MASTHNAEPLVQGKEEENYVLAMQLANASVFPMVLRAAVELGVLEIIASAGPDACLSSLDIASNLQTQNLEAPIMLERMLRLLASCSILTCSLIKQDNGEVEKHYGLAPIGKLFTRNQDGASVASLLLLIQDKVFMDSWYHLKDAVLQGGIPFNKAHGMSAFEYPGIDSRFNKVFNKAMSDMTVILMKKVLETYKGFEGLKEVVDVGGGIGVTLNMITSKYPQIKGINFDLPHVIANAPSYPGVEHVGGDMFENVPQGDAIFMKLILHDWSDEHCLKLLKNCWKALPESGKIIIVDLILPEAPGISMFSDAVFLADLVMLAQNPGGKERTFKEFEDLALRSAFSSCKMICRVYNYCVMEFHK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University