Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Nelumbo nucifera
Species name
Sacred lotus (Nelumbo nucifera) is a species of flowering plant in the family Nelumbonaceae (lotus family).
Species info
Gene sequence info
Nelumbo_nucifera.HIDH.fa
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>rna-XM_010265002.2
MAAISVDPRMSLSIGHDRRQHGIVTDEIEGIITVYKDGHLERPLVVPNVACTVAPQPHVTSRDVIINKVSNVWARFYVPRCQRKLPLLVYFHGGGFCVGSAAWKCYHEFLANLASRAGCLIMSVNYRLAPENRLPAAYEDGCNALLWVKQQASDGSSTDQRWWWSQCNFSKVFLAGDSAGANIAHNVATRLGSFESSESMASKPFCLKGTILIQPFFGGEGRTHSELYTAQPSTSALSLTASDVYWRLALPVGANRDHPWCNPLVNNGSAMLETSRIPPTMVFISEMDILKDRNLEFCSAMIKAGNKRVEQLMCRGVGHAFQILHNSHLSQPRTREMISHISAFINL
>rna-XM_010270798.2
MDSSAAEIAYEFPPFYVLYKDGHVKRLIGTDFVQASLDPQTGVSSKDVIIVPETGVSARLYLPKITDPHQKLPLLIYFHGGGFVIETAFSPTYHYYLNSLVAQANIVAVSVEYRRAPEYPLPIAYDDSWAVLQWVVSHSMDQDGAEPWLRDHVDCKRIFLAGDSAGANIAHDMAMRAGATGLKLRGIALIHPYFWGEKRIGSEAEDPDKAKMADKMWLLACPSSAGADDPRINPVGEGAPSLSRLGCSRLLVCVGEKDILKDRGLIYYETLVKSGWSGEAEIMESQGEDHVFHLFNPTCEKAVTLMKRLVSFVNIDD
>rna-XM_010275879.2
MKNTLHVSHRCTSSNGEIAHDFFPLIREYKDGRVERFKDHDFVPPSLDPCSGVSSKDVVIAPETGISARLYLPSTTYYPHRKIPLLAYLHGGAFCIESAFSSTYHRFVSSLVAEAHVVHPLPTAYDDCFEALKWVASHSKGDGPEAWLNDHVDFDRVFLAGDSAGANLAHYVAMRVGESRVDGLNKNKLIGLVLIHPYFEVKEPLGPEASDEEKKAKVGKLWQYLCPSIIGCNDPKINPAADPKISGLGCRQVGIWVAEKDFLREKGGLLYYEVVKKSGWGGVAEVIEEEGEDHVFHLVKPDSEKAVAMTKRLAAFLNHHYQDKV
>rna-XM_010279482.2
MDSGAQRVSAELPPLLRVYEDGLVERLVGSGFVPATLNDPQTGVSSKDVLISPESAVSARLYLPKLTCNRRKLPILVYFRGGAFCIESAFSFLDHRYLNILVNEANVVAVFVEYRRAPEHLLPVAYDDCWAALEWVSSHSVGRGANYEPWLTDYADFDRIFLGGDSAGGNIVHNVAMRARAQSLPHNVRVRGALPIPVSTNREKGALQERSFGISNTELRFHSG
>rna-XM_019197039.1
MESSNREIAYEFPPRSKHNSFPVFIRVYRDGSVDRFVGTDIVPPSLHPVAGVCSKDIVAIPETGVSARLYLPNINPLRKLPLLVYFHGGGFCIETPFSPIYHSFINSLVAEANIVAISVHYRRVPEYPLPIAYDDSWAVLQWVAAHAESRVDDDASESWLRDYVDFDRVFLGGDSAGGNIAHNLALRSGAEELNNGGIKLLGMALIGSYLWGKERIGSEATDPEKYITEETTWLHACPSAKDNDDPRINPVAPGAPSLEGLGCRRVLVLVAGKDGLRDRGWLYHDSLVKSGWNGVVEIMETEEEGHVFHLFNPNCEKAELRIKRLASFLNQV
>rna-XM_010256086.2
MAIVAEAPGFLQVFSDGSVKRFAPEISAALPELSNGYRSKDVIIDPSRPISARIFLPETKNSNTRLPVLVYFHGGGFCIGSTTWFGYHHFLGDLCFTSQSIVVSVDYRLAPENRLPIAYDDCYFALDWLSTHIYTDPWLEQADLSRVFLSGDSAGGNISHHVALQVMRNRPNYVTVVGLLIIHPYFGSERRTEREMAVEAAGDVEMNDMFWRLSLPEGSSRDHFACNFEMAELSKIGWQQFPAVTVFVAGLDFLKERGVMYAEFLKRKGVREVKLVEAEGESHVYHVFRPESEATRLLQQQMSEFMIDPKRRISSKIGL
>rna-XM_010264815.2
MTSAIDPNYSPYEVEDCRGVLRLYSDGSIVRSDQPSFVVPVPDDGSVFWKDVLFDPTNNLHLQLYKPASPSPTKLPVFYYIHGGGFCIGARTWPHCQSYCLRLASHLQAVVISPDYRLGPEHRLPAAIDDGFTAVMWLQAQAVSENPDPWLTGVADFGRVFISGDSAGGNIAHNLAVRLADGSAQLAPLRIRGFVLLAPFFGGTVRTRSEAEGPTEAFLNLELIDRYWRLSIPVGDNADHPLVNPFGPASPILEPVEFGPVLVVVGSSDLLRDRIEDYARRLKELGKKVEYVEFEGKQHGFFTIEPNSEAANELMRVTKRFIAQNSE
>rna-XM_010266892.2
MATISLDPRLNLSIAKDHRQHGVVTDEIEGIIRVYKDGHVERPPIVPNVVCTVASEPDVASRDVAINKITNVWARFYVPRCQQGKLPFLVYFHGGGFCVGSAAWKCYHEFLAKLAARAGCLIMSVNFRSAPENRLPAAYEDGCNAVLWAKQQALNGSNDQRWWWSQCNFTKVFLAGDSAGANIAHNVAIRLGSLELSEAVPKQFCLKGTILIQPFFGGEARTHSEINTAQSSSSALSLAASDVYWRLSLPVGANRDHPWCNPLSKSSTKLEALKLPPETLVCISEMDILKDRNLEFCTAMARAGHNVEQLICKGVGHAFQILHNSHFSQARTHEMISRISAFINR
>rna-XM_010267378.2
MLTSLASSFLHRHHRLLLVLMDANKTLPLLLLFLLLLPLIDSSSTSQQIDYQLIPFFIKYKDGHVKRLIGNDIIVAGLDPQTGVSTKDVTINTKTEVGARIYLPKTTNQPDQKLPLLVYVHGGAFIVETAFSPTYHFYLNSVVAQANVVAVSVNYRRAPENPLPIAYDDSWEVLKWAVSHSTDHPAGGPEEPWLKDHVDFERVFLAGDSAGANIVHNLAMRAGEEVNELPGGVEILGAALICPYFWGEKRIGNEAQTPENLRMLADKTWQIACPTSKGLDDPRINPEAEGAPSLSKLGCSRVLVEVAGKDVLKDRGVLYYDTLVKSGWKGKAELMESDGENHVFYLMNPTTEHAVALMKRFTSFLNVDTED
>rna-XM_010277299.1
MDMSKAEVDHEFLPFLRVYKDGHVERLLGTDSVPASLDSETGVSSKDVLIVPDSGVSARLYLPKLADANQKLPILVYFHGGGFIIGHPSTPMYHHHLNLLVAEANIVAVSVAYRLAPENPIPAAYDDSWAALQWVASHSKGEGPESWLTEHADFGRVFLAGESSGANIAHHMAMRAGDPNSGGLGMEILGIALVHPHFWGATPIGSEAMAPVKALFDRLWPYVCPSQPDNDDPQINPLAANAPSLLGLGCTRVIVFVAGKDALRDRGWLYYESLARSGWIGVVEFAETEGEEHGFHLYNPNTETARELLKRLAFFLNRERPPLV
>rna-XM_010277302.2
MDSCESEVTFDFFPYFRIYKDGHIERLVGSNMVPPSPDPHTGVLSKDVIVSTETGVSARIFLPNVNTSDQPHRKLPLLVYFHGGAFCIGSAFSSAYHHYVSSLVAEANVIAVSVDYRLAPEHLLPTAHLDCLAALKWVASHSKGEGPEAWLNDHSDFDRVFLAGDSAGANLVHYVAMRVGESEVDGLKNLLGIALIHPYFEGREPVAPGTSDEEKKSKVSKFWAYLCPSTSGCDDPLINPAAGPSMSSLGCTRVAVWVAEKDSVRKEGVFYYEWLKKSGWGGVVEISEEQGEEHVFHLVKPDSEKAMAMMKRLSSFLNQKLEHNNSLL
>rna-XM_010277300.2
MDSSKIEVAHDFFPYIRIYKDGRVEKCVIPDFVPPSLDSHSGVSSKDVVITPKGVSARIFLPNIKITDHPHRKLPVLVYFHAFSTIYHRYVSSLVAEADVVAVSVEYRLAPEHPLPTAYDDCFTAFKWVASHSKGDGPEAWLNDHGDLDRVFLAGDSAGANLAHSVAVRIGGEFGVDGVKKISGLALIHPYFEGKEPLGPEASDEEKMAKVGKLWLYLCPSTIGCNDPRINPAADPRVSSLACNRVGVWVSEKDYLREPGGLFYYETLRKSGWGGVAELIEEEGEDHDFHLFTPDSEKAVAMLKGVASFLNQ
MAAISVDPRMSLSIGHDRRQHGIVTDEIEGIITVYKDGHLERPLVVPNVACTVAPQPHVTSRDVIINKVSNVWARFYVPRCQRKLPLLVYFHGGGFCVGSAAWKCYHEFLANLASRAGCLIMSVNYRLAPENRLPAAYEDGCNALLWVKQQASDGSSTDQRWWWSQCNFSKVFLAGDSAGANIAHNVATRLGSFESSESMASKPFCLKGTILIQPFFGGEGRTHSELYTAQPSTSALSLTASDVYWRLALPVGANRDHPWCNPLVNNGSAMLETSRIPPTMVFISEMDILKDRNLEFCSAMIKAGNKRVEQLMCRGVGHAFQILHNSHLSQPRTREMISHISAFINL
>rna-XM_010270798.2
MDSSAAEIAYEFPPFYVLYKDGHVKRLIGTDFVQASLDPQTGVSSKDVIIVPETGVSARLYLPKITDPHQKLPLLIYFHGGGFVIETAFSPTYHYYLNSLVAQANIVAVSVEYRRAPEYPLPIAYDDSWAVLQWVVSHSMDQDGAEPWLRDHVDCKRIFLAGDSAGANIAHDMAMRAGATGLKLRGIALIHPYFWGEKRIGSEAEDPDKAKMADKMWLLACPSSAGADDPRINPVGEGAPSLSRLGCSRLLVCVGEKDILKDRGLIYYETLVKSGWSGEAEIMESQGEDHVFHLFNPTCEKAVTLMKRLVSFVNIDD
>rna-XM_010275879.2
MKNTLHVSHRCTSSNGEIAHDFFPLIREYKDGRVERFKDHDFVPPSLDPCSGVSSKDVVIAPETGISARLYLPSTTYYPHRKIPLLAYLHGGAFCIESAFSSTYHRFVSSLVAEAHVVHPLPTAYDDCFEALKWVASHSKGDGPEAWLNDHVDFDRVFLAGDSAGANLAHYVAMRVGESRVDGLNKNKLIGLVLIHPYFEVKEPLGPEASDEEKKAKVGKLWQYLCPSIIGCNDPKINPAADPKISGLGCRQVGIWVAEKDFLREKGGLLYYEVVKKSGWGGVAEVIEEEGEDHVFHLVKPDSEKAVAMTKRLAAFLNHHYQDKV
>rna-XM_010279482.2
MDSGAQRVSAELPPLLRVYEDGLVERLVGSGFVPATLNDPQTGVSSKDVLISPESAVSARLYLPKLTCNRRKLPILVYFRGGAFCIESAFSFLDHRYLNILVNEANVVAVFVEYRRAPEHLLPVAYDDCWAALEWVSSHSVGRGANYEPWLTDYADFDRIFLGGDSAGGNIVHNVAMRARAQSLPHNVRVRGALPIPVSTNREKGALQERSFGISNTELRFHSG
>rna-XM_019197039.1
MESSNREIAYEFPPRSKHNSFPVFIRVYRDGSVDRFVGTDIVPPSLHPVAGVCSKDIVAIPETGVSARLYLPNINPLRKLPLLVYFHGGGFCIETPFSPIYHSFINSLVAEANIVAISVHYRRVPEYPLPIAYDDSWAVLQWVAAHAESRVDDDASESWLRDYVDFDRVFLGGDSAGGNIAHNLALRSGAEELNNGGIKLLGMALIGSYLWGKERIGSEATDPEKYITEETTWLHACPSAKDNDDPRINPVAPGAPSLEGLGCRRVLVLVAGKDGLRDRGWLYHDSLVKSGWNGVVEIMETEEEGHVFHLFNPNCEKAELRIKRLASFLNQV
>rna-XM_010256086.2
MAIVAEAPGFLQVFSDGSVKRFAPEISAALPELSNGYRSKDVIIDPSRPISARIFLPETKNSNTRLPVLVYFHGGGFCIGSTTWFGYHHFLGDLCFTSQSIVVSVDYRLAPENRLPIAYDDCYFALDWLSTHIYTDPWLEQADLSRVFLSGDSAGGNISHHVALQVMRNRPNYVTVVGLLIIHPYFGSERRTEREMAVEAAGDVEMNDMFWRLSLPEGSSRDHFACNFEMAELSKIGWQQFPAVTVFVAGLDFLKERGVMYAEFLKRKGVREVKLVEAEGESHVYHVFRPESEATRLLQQQMSEFMIDPKRRISSKIGL
>rna-XM_010264815.2
MTSAIDPNYSPYEVEDCRGVLRLYSDGSIVRSDQPSFVVPVPDDGSVFWKDVLFDPTNNLHLQLYKPASPSPTKLPVFYYIHGGGFCIGARTWPHCQSYCLRLASHLQAVVISPDYRLGPEHRLPAAIDDGFTAVMWLQAQAVSENPDPWLTGVADFGRVFISGDSAGGNIAHNLAVRLADGSAQLAPLRIRGFVLLAPFFGGTVRTRSEAEGPTEAFLNLELIDRYWRLSIPVGDNADHPLVNPFGPASPILEPVEFGPVLVVVGSSDLLRDRIEDYARRLKELGKKVEYVEFEGKQHGFFTIEPNSEAANELMRVTKRFIAQNSE
>rna-XM_010266892.2
MATISLDPRLNLSIAKDHRQHGVVTDEIEGIIRVYKDGHVERPPIVPNVVCTVASEPDVASRDVAINKITNVWARFYVPRCQQGKLPFLVYFHGGGFCVGSAAWKCYHEFLAKLAARAGCLIMSVNFRSAPENRLPAAYEDGCNAVLWAKQQALNGSNDQRWWWSQCNFTKVFLAGDSAGANIAHNVAIRLGSLELSEAVPKQFCLKGTILIQPFFGGEARTHSEINTAQSSSSALSLAASDVYWRLSLPVGANRDHPWCNPLSKSSTKLEALKLPPETLVCISEMDILKDRNLEFCTAMARAGHNVEQLICKGVGHAFQILHNSHFSQARTHEMISRISAFINR
>rna-XM_010267378.2
MLTSLASSFLHRHHRLLLVLMDANKTLPLLLLFLLLLPLIDSSSTSQQIDYQLIPFFIKYKDGHVKRLIGNDIIVAGLDPQTGVSTKDVTINTKTEVGARIYLPKTTNQPDQKLPLLVYVHGGAFIVETAFSPTYHFYLNSVVAQANVVAVSVNYRRAPENPLPIAYDDSWEVLKWAVSHSTDHPAGGPEEPWLKDHVDFERVFLAGDSAGANIVHNLAMRAGEEVNELPGGVEILGAALICPYFWGEKRIGNEAQTPENLRMLADKTWQIACPTSKGLDDPRINPEAEGAPSLSKLGCSRVLVEVAGKDVLKDRGVLYYDTLVKSGWKGKAELMESDGENHVFYLMNPTTEHAVALMKRFTSFLNVDTED
>rna-XM_010277299.1
MDMSKAEVDHEFLPFLRVYKDGHVERLLGTDSVPASLDSETGVSSKDVLIVPDSGVSARLYLPKLADANQKLPILVYFHGGGFIIGHPSTPMYHHHLNLLVAEANIVAVSVAYRLAPENPIPAAYDDSWAALQWVASHSKGEGPESWLTEHADFGRVFLAGESSGANIAHHMAMRAGDPNSGGLGMEILGIALVHPHFWGATPIGSEAMAPVKALFDRLWPYVCPSQPDNDDPQINPLAANAPSLLGLGCTRVIVFVAGKDALRDRGWLYYESLARSGWIGVVEFAETEGEEHGFHLYNPNTETARELLKRLAFFLNRERPPLV
>rna-XM_010277302.2
MDSCESEVTFDFFPYFRIYKDGHIERLVGSNMVPPSPDPHTGVLSKDVIVSTETGVSARIFLPNVNTSDQPHRKLPLLVYFHGGAFCIGSAFSSAYHHYVSSLVAEANVIAVSVDYRLAPEHLLPTAHLDCLAALKWVASHSKGEGPEAWLNDHSDFDRVFLAGDSAGANLVHYVAMRVGESEVDGLKNLLGIALIHPYFEGREPVAPGTSDEEKKSKVSKFWAYLCPSTSGCDDPLINPAAGPSMSSLGCTRVAVWVAEKDSVRKEGVFYYEWLKKSGWGGVVEISEEQGEEHVFHLVKPDSEKAMAMMKRLSSFLNQKLEHNNSLL
>rna-XM_010277300.2
MDSSKIEVAHDFFPYIRIYKDGRVEKCVIPDFVPPSLDSHSGVSSKDVVITPKGVSARIFLPNIKITDHPHRKLPVLVYFHAFSTIYHRYVSSLVAEADVVAVSVEYRLAPEHPLPTAYDDCFTAFKWVASHSKGDGPEAWLNDHGDLDRVFLAGDSAGANLAHSVAVRIGGEFGVDGVKKISGLALIHPYFEGKEPLGPEASDEEKMAKVGKLWLYLCPSTIGCNDPRINPAADPRVSSLACNRVGVWVSEKDYLREPGGLFYYETLRKSGWGGVAELIEEEGEDHDFHLFTPDSEKAVAMLKGVASFLNQ
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University