Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Nelumbo nucifera
Species name
Sacred lotus (Nelumbo nucifera) is a species of flowering plant in the family Nelumbonaceae (lotus family).
Species info
Gene sequence info
Nelumbo_nucifera.4CL.fa
Download
>rna-XM_010261524.2
MGTVQQDFIYRSKLPDIHIHNHLPLLTYCFQNISEFSSLPCLINGTTGEIYSYAEVELISRKVAAGLHRLGIQQGQVIMVLLRNSPEFVFAFLGAVHRGATTTTANPFYTPAEILKQARDSKTRLIITQACYVDKVRTFAPENDIKIMTIDSPHDGCLHFTQLTESDESALPVTEVCPDDVVALLYSSGTTGLPKGVMLTHRSITTCIAQQVDGENPHSYYHRGDDVTLCVLPMFHIFSLVSVLLAGLRVGAAVLIMQKFEVVAFMELVQKYKVSVASLVPPIILQLIKSPDFDNFNLSSIRLVITGGAPMGKELEASLRAKLPNTKFGQGYGMTEAGLLSLSLGFAKEPFNIKSGSCGTVLRNAEIKIIDLESGKSLHRNEAGEICIRGPQIMKGYLNNQEATQRTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAILINHPNISDAAVVPVKDEAAGEVPVAFVVRSNGPQLTEDEIKEYISKQVVFYKRIKRVFFIDAIPKAPSGKVIRKDLAKKLASGVPV
>rna-XM_010261526.2
MAPAAPVETAMKQKEFIYRSKLPDIYIPNHLPLHSYFFENISQFGSRPCLINGATGETYTYTEVELISRKVAAGLDKLGIKQGQVIMLLLPNSPEFVFAFLGASYRGATNTTANPFYTSAEIAKQAKASNARLIITQACHVEKLREFAKENDVKIMTTDAPTDGCVHFSELTQSDESEMPAVKIHPDDVVALPYSSGTTGLPKGVMLTHRSLVTSIAQQVDGDNPNMYLHSEDVLLCVLPLFHIYSLNSVLFCGLRAGAAILIMQKFEVVAMMELIQKYKVTVTPFVPPIVLALVKNPAVDSYDLSSVRTVMSGAAPMGKELEDALRAKLPNATLGQGYGMTEAGPVLSMSLAFAKEPFEVKSGSSGTPVRNAQMKIVDPETGESLPRNKRGEICIRGAQIMKGYLNDPEATKRTIGTDGWLHTGDIGYIDDNGEVFIVDRLKELIKYNGFQVAPAELEALLLTHSNISDAAVVPMKDERNGEIPVAFIVRSNGSQITEDEIKEYISKQVVYYKRIKRVFFTKAIPKAPSGKILRKELKAKLEVGAPN
>rna-XM_010263243.2
MATMVSVASPETQPPQITPSIHPTKDPATETFIFRSKLPDIPISNHLPLHTFCFEKVSEFSDRPCLITGSNGRIYTFAETHLICQKIAVGLSKFGIKKGDVIMVLLQNSPEFVFSFMGASMLGAVTTTANPFYTPAEIYKQFSTSXAKLIITQSQYVDKLKDPSQKFPKIGEGLTVVTVDDPPENCVHFSVISNSDERELPSVSIDPDDPVALPFSSGTTGFPKGVILTHKSLTSSVAQQVDGENPNLHLKTEDVVLCVLPLFHIYSLNSVLLCSLRARAAVLLMQKFEIGALLDLIQRHRVTVAPVVPPLVLALAKNQMVENFDLSSIRIVLSGAAPLGKELEEALHSRVPQAVFGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPATGASLPHNQPGQICIRGPQIMKGYLNDPDATASTIDVDGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQVPPAELEALLVSHPFISDAAIVPQKDAVAGEIPVAFVVRSNGFDLTEEAVKEFIAKQVVFYKKLHKVYFVPAIPKSPSGKILRKDLRAKLAAASQQEIKLL
>rna-XM_010267151.2
MAPSAPVETATKPQEFIYRSKLPNIYIPNHLPLHTYCFENISKFSSRPCLINGATGEIHTYADVELISRKVASGLNKLGIKQGQVIMLLLPNSPEFVFAFLGASYRGATSTTANPFYTPAEISKQAKASKAKLIITQACYVDKVRDFAMANDVMIMTIDSPHEGCLHFSELTQADESEMPTVKIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYLHCEDVMLCVLPLFHIYSLNSVLLCGLRVGSAILIMQKFEVVAMMELIQKYKVTIGPFVPPIVLALAKCPVVDDYDLSSVRTVMSGAAPMGKDLEDTLRLKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFVIKSGSCGTVVRNAEMKLVEPETGESLPRNQPGEICIRGAQIMKGYLNDAEATERTIDKEGWLHTGDVGYIDDDDELFIVDRLKELIKYNGFQVAPAELEAILITHPDISDVAVVPMKDERAGEIPVAFVVRSNGSQITEDEIKEYVSKQVIYYKRVKRVFFIEAIPKAPSGKILRKDLRAKLAAGVSN
>rna-XM_010268895.2
MEKSGYGRDGVYRSLRPPVVFPKDPNLSMVSFLFRNSSSYSDKLALVDADSGDALNFSQLKSTIAKVAHGLVRLGIKKGDVVLILAPNSVQFPICFLGVVAIGAIATTVNPLYTTAEIAKQVNDSGPKLVITVPPLWDKVKDFGLPAVFLGPPSASSIASRARTTSFFDLVNMAGGSVSDFPVASVKQSDTAALLYSSGTTGTSKGVILTHRNFISAAIMATADQDVDRETHNVFLCFLPLFHIFGLSIITYAQLQRGNMVVTMGKFDIEMVLKSIDKYRVTYLFVVPPVMIALAKQSVVKKYNVSSLRKLGSGAAPLGKEIMEECAKNFPQAVVVQGYGLTETCGIVSLDNPRGGARHTGSTGTLVPGIEAQIVSVDTLKLLPPNQLGEIWVRGPNMMQGYFNNPQATKSTIDKQGWVHTGDLGYFDDEGRLFVVDRIKELIKYKGFQVAPAELEGLLLSHPEILDAVVIPLPDAEAGEVPIAYVVRTPNSSLTEEDVQKFIAKQVAPFKRLRRVTFTNSVPKSASGKILRRELIQKVRSKL
>rna-XM_010278575.2
MISVATPETQPPQITPEAPQVTPEPPQITPQIPPTENPAPETFIFRSKLPDIPISNHLPLHRYCFEKLSEFPDRPCLITGSNGRIYTFAETHLICQKTAVGLSNLGIKKGDVIMVLLQNSPEFVFSFMGASMLGAITTTANPFYTPAEIFKQFSTSGAKLIITQSQYVDKLRDSENFPKIGEGLTVVTVDDPPENCIHFSVLSESDERELPSVSIDPDDPVALPFSSGTTGLPKGVILTHKSLISSVAQQVDGENPNLHLKTEDVFLCVLPLFHIFSLNSVLLCSLRAGTGVLLMQKFEIGALLDLIQRYRVSVAAVVPPLVLALAKNQMVENFDLSSIRIILSGAAPLGKELEEALHSKVPQAVFGQGYGMTEAGPVLSMCPGFAKQPFPTKSGSCGTVVRNAEYKGFQVPPAELEALLVSHPSIADAAVVPQKDAVAGEVPVAFVVRSNGFDLTEESVKEFIAKQVVFYKKLHKVYFVHAVPKSPSGKILRKDLRAKLETNSHTEIKSS
>rna-XM_010280196.1
METHPPQPQGLKQEDEHIFRSRLPAVPVPENMTLPDFVLHEAELYANKVAFVEAVTGKAYTYGQVTRDTRRFAKALKSLGLRKGQVVVVVLPNVAEYAIVALGIMMAGGVFSGANPLAHASEIRKQVEDADAKLLVTSGSTYEKVKSLGLPIIAMGEERIENVICWEDLLEAADRAGSDAADETIKQTDLCALPFSSGTTGTSKGVMLSHRNLVANLCSTLFSVGPEMVGQITTLGLMPFFHIYGITGICCATLRNKGTVVVMGRFDLRTFLNALINHEITFAPIVPPIMLALVKDPVVDEFDLRRLKLRAVMTAAAPLAPELLAAFEHKFPDVQVQEAYGLTEHSCITLTHGDPNKGHSIAKRNSVGFILPNLEMKFIDPNSGLSLPVNIPGEVCVRSQCVMQGYYKREEETERTIDAEGWLHTGDVGYIDEDGDVFIVDRIKELIKYKGFQVPPAELEAILLSHPSVEDAAVFPLPDEDAGEIPAACVVMNPNAKESEEEIMNYVASNVASYKKVRLVHFVDSIPKSPSGKIMRRFLREKMEKKETNSSANAAHSSSHTA
MGTVQQDFIYRSKLPDIHIHNHLPLLTYCFQNISEFSSLPCLINGTTGEIYSYAEVELISRKVAAGLHRLGIQQGQVIMVLLRNSPEFVFAFLGAVHRGATTTTANPFYTPAEILKQARDSKTRLIITQACYVDKVRTFAPENDIKIMTIDSPHDGCLHFTQLTESDESALPVTEVCPDDVVALLYSSGTTGLPKGVMLTHRSITTCIAQQVDGENPHSYYHRGDDVTLCVLPMFHIFSLVSVLLAGLRVGAAVLIMQKFEVVAFMELVQKYKVSVASLVPPIILQLIKSPDFDNFNLSSIRLVITGGAPMGKELEASLRAKLPNTKFGQGYGMTEAGLLSLSLGFAKEPFNIKSGSCGTVLRNAEIKIIDLESGKSLHRNEAGEICIRGPQIMKGYLNNQEATQRTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAILINHPNISDAAVVPVKDEAAGEVPVAFVVRSNGPQLTEDEIKEYISKQVVFYKRIKRVFFIDAIPKAPSGKVIRKDLAKKLASGVPV
>rna-XM_010261526.2
MAPAAPVETAMKQKEFIYRSKLPDIYIPNHLPLHSYFFENISQFGSRPCLINGATGETYTYTEVELISRKVAAGLDKLGIKQGQVIMLLLPNSPEFVFAFLGASYRGATNTTANPFYTSAEIAKQAKASNARLIITQACHVEKLREFAKENDVKIMTTDAPTDGCVHFSELTQSDESEMPAVKIHPDDVVALPYSSGTTGLPKGVMLTHRSLVTSIAQQVDGDNPNMYLHSEDVLLCVLPLFHIYSLNSVLFCGLRAGAAILIMQKFEVVAMMELIQKYKVTVTPFVPPIVLALVKNPAVDSYDLSSVRTVMSGAAPMGKELEDALRAKLPNATLGQGYGMTEAGPVLSMSLAFAKEPFEVKSGSSGTPVRNAQMKIVDPETGESLPRNKRGEICIRGAQIMKGYLNDPEATKRTIGTDGWLHTGDIGYIDDNGEVFIVDRLKELIKYNGFQVAPAELEALLLTHSNISDAAVVPMKDERNGEIPVAFIVRSNGSQITEDEIKEYISKQVVYYKRIKRVFFTKAIPKAPSGKILRKELKAKLEVGAPN
>rna-XM_010263243.2
MATMVSVASPETQPPQITPSIHPTKDPATETFIFRSKLPDIPISNHLPLHTFCFEKVSEFSDRPCLITGSNGRIYTFAETHLICQKIAVGLSKFGIKKGDVIMVLLQNSPEFVFSFMGASMLGAVTTTANPFYTPAEIYKQFSTSXAKLIITQSQYVDKLKDPSQKFPKIGEGLTVVTVDDPPENCVHFSVISNSDERELPSVSIDPDDPVALPFSSGTTGFPKGVILTHKSLTSSVAQQVDGENPNLHLKTEDVVLCVLPLFHIYSLNSVLLCSLRARAAVLLMQKFEIGALLDLIQRHRVTVAPVVPPLVLALAKNQMVENFDLSSIRIVLSGAAPLGKELEEALHSRVPQAVFGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPATGASLPHNQPGQICIRGPQIMKGYLNDPDATASTIDVDGWLHTGDIGYVDDDEEVFIVDRVKELIKFKGFQVPPAELEALLVSHPFISDAAIVPQKDAVAGEIPVAFVVRSNGFDLTEEAVKEFIAKQVVFYKKLHKVYFVPAIPKSPSGKILRKDLRAKLAAASQQEIKLL
>rna-XM_010267151.2
MAPSAPVETATKPQEFIYRSKLPNIYIPNHLPLHTYCFENISKFSSRPCLINGATGEIHTYADVELISRKVASGLNKLGIKQGQVIMLLLPNSPEFVFAFLGASYRGATSTTANPFYTPAEISKQAKASKAKLIITQACYVDKVRDFAMANDVMIMTIDSPHEGCLHFSELTQADESEMPTVKIHPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYLHCEDVMLCVLPLFHIYSLNSVLLCGLRVGSAILIMQKFEVVAMMELIQKYKVTIGPFVPPIVLALAKCPVVDDYDLSSVRTVMSGAAPMGKDLEDTLRLKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFVIKSGSCGTVVRNAEMKLVEPETGESLPRNQPGEICIRGAQIMKGYLNDAEATERTIDKEGWLHTGDVGYIDDDDELFIVDRLKELIKYNGFQVAPAELEAILITHPDISDVAVVPMKDERAGEIPVAFVVRSNGSQITEDEIKEYVSKQVIYYKRVKRVFFIEAIPKAPSGKILRKDLRAKLAAGVSN
>rna-XM_010268895.2
MEKSGYGRDGVYRSLRPPVVFPKDPNLSMVSFLFRNSSSYSDKLALVDADSGDALNFSQLKSTIAKVAHGLVRLGIKKGDVVLILAPNSVQFPICFLGVVAIGAIATTVNPLYTTAEIAKQVNDSGPKLVITVPPLWDKVKDFGLPAVFLGPPSASSIASRARTTSFFDLVNMAGGSVSDFPVASVKQSDTAALLYSSGTTGTSKGVILTHRNFISAAIMATADQDVDRETHNVFLCFLPLFHIFGLSIITYAQLQRGNMVVTMGKFDIEMVLKSIDKYRVTYLFVVPPVMIALAKQSVVKKYNVSSLRKLGSGAAPLGKEIMEECAKNFPQAVVVQGYGLTETCGIVSLDNPRGGARHTGSTGTLVPGIEAQIVSVDTLKLLPPNQLGEIWVRGPNMMQGYFNNPQATKSTIDKQGWVHTGDLGYFDDEGRLFVVDRIKELIKYKGFQVAPAELEGLLLSHPEILDAVVIPLPDAEAGEVPIAYVVRTPNSSLTEEDVQKFIAKQVAPFKRLRRVTFTNSVPKSASGKILRRELIQKVRSKL
>rna-XM_010278575.2
MISVATPETQPPQITPEAPQVTPEPPQITPQIPPTENPAPETFIFRSKLPDIPISNHLPLHRYCFEKLSEFPDRPCLITGSNGRIYTFAETHLICQKTAVGLSNLGIKKGDVIMVLLQNSPEFVFSFMGASMLGAITTTANPFYTPAEIFKQFSTSGAKLIITQSQYVDKLRDSENFPKIGEGLTVVTVDDPPENCIHFSVLSESDERELPSVSIDPDDPVALPFSSGTTGLPKGVILTHKSLISSVAQQVDGENPNLHLKTEDVFLCVLPLFHIFSLNSVLLCSLRAGTGVLLMQKFEIGALLDLIQRYRVSVAAVVPPLVLALAKNQMVENFDLSSIRIILSGAAPLGKELEEALHSKVPQAVFGQGYGMTEAGPVLSMCPGFAKQPFPTKSGSCGTVVRNAEYKGFQVPPAELEALLVSHPSIADAAVVPQKDAVAGEVPVAFVVRSNGFDLTEESVKEFIAKQVVFYKKLHKVYFVHAVPKSPSGKILRKDLRAKLETNSHTEIKSS
>rna-XM_010280196.1
METHPPQPQGLKQEDEHIFRSRLPAVPVPENMTLPDFVLHEAELYANKVAFVEAVTGKAYTYGQVTRDTRRFAKALKSLGLRKGQVVVVVLPNVAEYAIVALGIMMAGGVFSGANPLAHASEIRKQVEDADAKLLVTSGSTYEKVKSLGLPIIAMGEERIENVICWEDLLEAADRAGSDAADETIKQTDLCALPFSSGTTGTSKGVMLSHRNLVANLCSTLFSVGPEMVGQITTLGLMPFFHIYGITGICCATLRNKGTVVVMGRFDLRTFLNALINHEITFAPIVPPIMLALVKDPVVDEFDLRRLKLRAVMTAAAPLAPELLAAFEHKFPDVQVQEAYGLTEHSCITLTHGDPNKGHSIAKRNSVGFILPNLEMKFIDPNSGLSLPVNIPGEVCVRSQCVMQGYYKREEETERTIDAEGWLHTGDVGYIDEDGDVFIVDRIKELIKYKGFQVPPAELEAILLSHPSVEDAAVFPLPDEDAGEIPAACVVMNPNAKESEEEIMNYVASNVASYKKVRLVHFVDSIPKSPSGKIMRRFLREKMEKKETNSSANAAHSSSHTA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University