Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Morus notabilis
Species name
Morus notabilis is a species of eudicot in the family Moraceae (mulberry family).
Species info
Gene sequence info
Morus_notabilis.4CL.fa
Download
>rna-XM_010089179.2
MISVANNSSIETQQQTPAERISPNDNSSTTTASHVFKSKLPDITISNNIPLHAYCFERLSEFADRPCIISGSTGKTYTYAETHLITRKIAAGLVRLGVKKGDVCMILLQNCPEFVFSFMAASMIGAVATTANPFYTAAEICKQFTLANAKLIITQSQYVDKLRDAPAAADDKKLPKMGEDFKVITVDDPPEDCLHFWSLLLKRNKKKTETIQDQSEEEEDDDDQLLDAIKISADDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLHLTTQDVFLCVLPLFHIFSMNSVMLNSLRSGAAVLLMHKFEIGALLELVQKHRVSIAAVVPPLVLALAKNPKVAEYDLSSIRIVLSGAAPLGKELQDALRSRVPRAILGQGYGMTEAGPVISMSLSFAKQPFPPKLGSCGCVVRNAELKVIDPETGSSLGYNQPGEICIRGSQIMKGYLNDDKATAGTIDVEGWLHTGDIGYVDDDQEIFIVDRVKELIKFKGFQVPPAELESLLVSHPSIADAAVVPQKDDAAGEVPVAFVVRSNSGLTEEAVKEFIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDLRARLATASPLS
>rna-XM_024161846.1
METSPLNPSQIIDDEHIFHSRYPPVQVPDDVTLPEFVLGGFELYAEKVAIVDAVTGKELTHGEVAKNTRRFGAALRSLGLRKGHVVIVVLPNVAEYAIVALGIMSAGGVFSGSNPQALAVEIAKQVKDADAKLIVTNALNYEKVKGLGIPVITMDEEPVEGAINWRKLLEAGDRAGTNKAAKEEVLQTDLCALPFSSGTTGVSKGVMLSHKNLVANLCSTLFAVKPEMVGEVTVLGLMPFFHIYGITGICFATLRNKGKVVVMGRYDVRTYIHALISHEVTFAPIVPPIISDMVHNPIVDEFDLSRLKLQAVMSAAAPLAPPLLQAFEAKFPTIHVQEAYGLTEHSCITLTHGDLENYSRAKKNSVGFILPNLEVKFIDPDTGLSLPKNTPGEICVRSQCVMQGYYKNKEETERAIDKENWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVRFAEVEAILLTHPSVEDAAVFPMPDEEAGEIPAACVVLGPDTEETEEEIIKFVASNVANYKKVRAVYFVESIPKSPSGKIMRRLLRDERVKASNLRRL
>rna-XM_010093797.2
MADSADQKDIIFRSKLPDIYIPKHLPLHTYCLSNKSQQRSRPCLINGPTGDVYTYADVDLKARKVAAGLHKLGVRKGDVVMVVLPNSPEFVLTFLGASYRGAMTTAGNPFFTSAEILKQARASDAKLVVTQACYYDKVKDLKLDNEDDNITIVCVDAPVPEGCLHFSELTNSDENALPAVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYYGEDDVVLCVLPLFHIYSLNSVLLCGLRAGATVVIMPKFEIGSLLELIQKYKISVVPIVPPIVLAIAKYPSLDKYDLSSLRVLKSGGAPLGKELEYTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEPMEVKPGACGTVVRNAELKIVDPETGSSLPRNQPGEICIRGDQIMKGYLNNPEATKNTIDKEGWLHTGDIGLVDDDEELFIVDRLKELIKYKGFQVAPAELEALLLTHPHISDAAVVPMKDEAAGEVPVAFVVRANGSQITEDEIKQFVSKQVVFYKRINRVIFIEAIPKSPSGKILRKDLRAKLAAGFPN
>rna-XM_024167889.1
MDVPHHHQKDHDHQEEYIFRSKLPDIYIPNHLPLHSYCFENISNYQDKPCLINGSTGETHSYADVELTARKVAAGLDEMGIKQGDVILLLLQNCPEFVFTFLAASYIGAISTTANSFYTPAEIAKQAKASKAKLILTVSTYVDKVKNFADENSVKIVCIDDAPPEGCLHFSELSNADESAIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPPIVLAIAKSPDLHRYDLSSIRMVMSGGAPMGKDLEEAVKDKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIIDPDTGASLPRNQAGEICIRGSQIMKGYVNDPEATKATIDERGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVPMNDEAAGEIPVAYVVRSNGSKITENDIKKYISDQVVFYKRIGKVIFIDKIPKSPSGKILRKDLRARLTAEVLAN
>rna-XM_010103319.2
MARSFNPQTLIYTSPRPPVNFPSDHHHSLTSFLFQSSSSFPHNTALIDDDSGETLTFLELKTLVSNLSHALRNAMGIKKGDVVLIVAANSIRYPICFFAIAALGAITTTCNPAYTFFELSKQVKDCNPKLVITVPELYEKTAKFNLPAIILDSSKSSEIVPNSRVWSFSDLIKTTAFSDRLSNLPASDVTQSDVAALMYSSGTTGTSKGVILTHRNFITTSLMVTADQDWYGEPNNVFLCFVPMFHIFGLSVIAYSQLRRGNTFVSMAKFELEKVLRAVEKYRVTHLYLVPPVVIALAKQIGVVRKYDLSSLKNILSGASPLAKDVMEGCAKNVPNALVMQGYGMTESCGIISTENSWEGTRFSGSTGILAPGIEAQIISVETMKPLPPNQLGEICFRGPNMMQGYYNSPQATKSAIDKQGWVHTGDLGYFDEEGQLFVVDRIKDLIKCYGYQVAPAELEGLLLSHPEILEAVVIPFPDEKAGEVPIAFIVRSPNSSLTEQGVQRFVEKQVAPFKRLRRVTFVSSVPKSASGKTLRRELVQKVRSNI
>rna-XM_010112427.2
MDPAHHDHKEENGHEQFIFRSKLPNIHIPNHLPLHTYCFQNISKFKDRPCLINASTGDAHTYADVDLAARRVAAGLHGLGIRKGDVVMLLLHNCPEFVFAFLGASHLGAVTTAANPLFTPAEVAKQATNSKAKLIITFSAYVGKVEELALEKNHNGLRIACIDAPPEGRVDFSEVMLADEKEKPTVEIEPDDVVALPYSSGTTGLPKGVMVTHKALVTSVAQQVDGENPNLYYRSEDVILCVLPLFHIYALNSILLCGLRVGSAILIMPRFEIGKLLKLVEWYKVTVTPFVPPILLSIAKNPDLDRYDLSSIRMIITGGAPMGKELEEAVKDKLPHAKLGQGYGMTEAGSVSMCLAFAKEPFPIKSGACGTVVRNAKIIDPNTVLSLPRNRAGEICIRGSQIMKGEVPVAFVVKSGASDINEEDIKQYISKQDLAGLQANLYQEMLKIDGLDDDQVHDATNSLATKHDLLRVFYNIPDQLKKGYILKILSRGV
>rna-XM_024175519.1
MSTLNNKTIDYHNKQSYPHWYSPETGIYNSTYPPINLPSDPFLDAVSFLFSRQHEGVTALIDAPSGISIPYSELYPLVKSFASGLHSKGVSKGDVVLVLLPNSVYFPVIIMGVMYLGAIFTPMNPLSSVTEIKKRVTDCKPCLAFTAPEKEEVFQKLGVGAIRVPEGVTYLDKRSPKTGNFSDFSKLISCHDFDNMAPRPLIRQQDTAAIMYSSGTTGVSKGAVISHGNFIAMMELFVRFEVSQYKEFYSPSEIVYLVFLPMFHIYGLCHFAIGMLSLGSTVVVMSKYDVKEVVKAIEKYKITHLPLVPPILAALTKVAKDDIEGNGGKTFQSLKQISWGAAPSSRKMIEDLVQTLPHIDLIQGYGMTESTAIGARGLNTKKLRNYFSVGLLAPNTHAKVVDCSTGSLLPPGKSGELWLKGPGIMKGYLNDPETTMSAIDKDGWLRTGDIVYINQNGYLHIIDRLKEMIKYKGFQIAPADLETVLTSHPEILEVGVTGIPDEECGEIPVAFVVRKQGSKLSHKDVMDYVASQVAPYKKIRKVIFTNSIPKSPAGKILRRELKESLTSKL
>rna-XM_024175676.1
MEKSGYGRDGIFRSLRPPLVLPKDPNLSAVSFLFRNSSSYPNKPALIDADSGEILSFSQLKSTVAKVSHGFLHLGIKKNDVVLIFAPNSIHFPVCFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLIITVPELWEKVKGFNLPTVMLSAEHKSVPKKVLTFNGLVNLSGSASDFPSVNVKRSDTAVLLYSSGTTGTSKGVVLTHGNFIAASLMVAMDQEIAKEMHNVFLCVLPMFHVFGLAVITYSQLQRGNAVVSMAKFDLEKILMTVERYKITHFWVVPPIVLALAKNSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVIQGYGMTETCGIVSVEDTRGGKRNTGSAGTLVSGVEAQIVGVDTLKPLPPNQLGEIWVRGPNMMQGYLNNPQATKSTMDKKGWVHTGDLGYFDEDGHLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVQKFIANQVAPFKRLRKVTFINSVPKSASGKILRRELIEKVRSKI
MISVANNSSIETQQQTPAERISPNDNSSTTTASHVFKSKLPDITISNNIPLHAYCFERLSEFADRPCIISGSTGKTYTYAETHLITRKIAAGLVRLGVKKGDVCMILLQNCPEFVFSFMAASMIGAVATTANPFYTAAEICKQFTLANAKLIITQSQYVDKLRDAPAAADDKKLPKMGEDFKVITVDDPPEDCLHFWSLLLKRNKKKTETIQDQSEEEEDDDDQLLDAIKISADDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLHLTTQDVFLCVLPLFHIFSMNSVMLNSLRSGAAVLLMHKFEIGALLELVQKHRVSIAAVVPPLVLALAKNPKVAEYDLSSIRIVLSGAAPLGKELQDALRSRVPRAILGQGYGMTEAGPVISMSLSFAKQPFPPKLGSCGCVVRNAELKVIDPETGSSLGYNQPGEICIRGSQIMKGYLNDDKATAGTIDVEGWLHTGDIGYVDDDQEIFIVDRVKELIKFKGFQVPPAELESLLVSHPSIADAAVVPQKDDAAGEVPVAFVVRSNSGLTEEAVKEFIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDLRARLATASPLS
>rna-XM_024161846.1
METSPLNPSQIIDDEHIFHSRYPPVQVPDDVTLPEFVLGGFELYAEKVAIVDAVTGKELTHGEVAKNTRRFGAALRSLGLRKGHVVIVVLPNVAEYAIVALGIMSAGGVFSGSNPQALAVEIAKQVKDADAKLIVTNALNYEKVKGLGIPVITMDEEPVEGAINWRKLLEAGDRAGTNKAAKEEVLQTDLCALPFSSGTTGVSKGVMLSHKNLVANLCSTLFAVKPEMVGEVTVLGLMPFFHIYGITGICFATLRNKGKVVVMGRYDVRTYIHALISHEVTFAPIVPPIISDMVHNPIVDEFDLSRLKLQAVMSAAAPLAPPLLQAFEAKFPTIHVQEAYGLTEHSCITLTHGDLENYSRAKKNSVGFILPNLEVKFIDPDTGLSLPKNTPGEICVRSQCVMQGYYKNKEETERAIDKENWLHTGDIGYIDDDGDIFIVDRIKEMIKYKGFQVRFAEVEAILLTHPSVEDAAVFPMPDEEAGEIPAACVVLGPDTEETEEEIIKFVASNVANYKKVRAVYFVESIPKSPSGKIMRRLLRDERVKASNLRRL
>rna-XM_010093797.2
MADSADQKDIIFRSKLPDIYIPKHLPLHTYCLSNKSQQRSRPCLINGPTGDVYTYADVDLKARKVAAGLHKLGVRKGDVVMVVLPNSPEFVLTFLGASYRGAMTTAGNPFFTSAEILKQARASDAKLVVTQACYYDKVKDLKLDNEDDNITIVCVDAPVPEGCLHFSELTNSDENALPAVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVSQQVDGENPNLYYGEDDVVLCVLPLFHIYSLNSVLLCGLRAGATVVIMPKFEIGSLLELIQKYKISVVPIVPPIVLAIAKYPSLDKYDLSSLRVLKSGGAPLGKELEYTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKEPMEVKPGACGTVVRNAELKIVDPETGSSLPRNQPGEICIRGDQIMKGYLNNPEATKNTIDKEGWLHTGDIGLVDDDEELFIVDRLKELIKYKGFQVAPAELEALLLTHPHISDAAVVPMKDEAAGEVPVAFVVRANGSQITEDEIKQFVSKQVVFYKRINRVIFIEAIPKSPSGKILRKDLRAKLAAGFPN
>rna-XM_024167889.1
MDVPHHHQKDHDHQEEYIFRSKLPDIYIPNHLPLHSYCFENISNYQDKPCLINGSTGETHSYADVELTARKVAAGLDEMGIKQGDVILLLLQNCPEFVFTFLAASYIGAISTTANSFYTPAEIAKQAKASKAKLILTVSTYVDKVKNFADENSVKIVCIDDAPPEGCLHFSELSNADESAIPAVKINPDDVVALPYSSGTTGLPKGVMLTHRGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSILLCGLRVGAAILIMQKFEINKLLELVEKYKVTIAPFVPPIVLAIAKSPDLHRYDLSSIRMVMSGGAPMGKDLEEAVKDKLPHAKLGQGYGMTEAGPVLSMCLAFAKEPFPIKSGACGTVVRNAEMKIIDPDTGASLPRNQAGEICIRGSQIMKGYVNDPEATKATIDERGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVPMNDEAAGEIPVAYVVRSNGSKITENDIKKYISDQVVFYKRIGKVIFIDKIPKSPSGKILRKDLRARLTAEVLAN
>rna-XM_010103319.2
MARSFNPQTLIYTSPRPPVNFPSDHHHSLTSFLFQSSSSFPHNTALIDDDSGETLTFLELKTLVSNLSHALRNAMGIKKGDVVLIVAANSIRYPICFFAIAALGAITTTCNPAYTFFELSKQVKDCNPKLVITVPELYEKTAKFNLPAIILDSSKSSEIVPNSRVWSFSDLIKTTAFSDRLSNLPASDVTQSDVAALMYSSGTTGTSKGVILTHRNFITTSLMVTADQDWYGEPNNVFLCFVPMFHIFGLSVIAYSQLRRGNTFVSMAKFELEKVLRAVEKYRVTHLYLVPPVVIALAKQIGVVRKYDLSSLKNILSGASPLAKDVMEGCAKNVPNALVMQGYGMTESCGIISTENSWEGTRFSGSTGILAPGIEAQIISVETMKPLPPNQLGEICFRGPNMMQGYYNSPQATKSAIDKQGWVHTGDLGYFDEEGQLFVVDRIKDLIKCYGYQVAPAELEGLLLSHPEILEAVVIPFPDEKAGEVPIAFIVRSPNSSLTEQGVQRFVEKQVAPFKRLRRVTFVSSVPKSASGKTLRRELVQKVRSNI
>rna-XM_010112427.2
MDPAHHDHKEENGHEQFIFRSKLPNIHIPNHLPLHTYCFQNISKFKDRPCLINASTGDAHTYADVDLAARRVAAGLHGLGIRKGDVVMLLLHNCPEFVFAFLGASHLGAVTTAANPLFTPAEVAKQATNSKAKLIITFSAYVGKVEELALEKNHNGLRIACIDAPPEGRVDFSEVMLADEKEKPTVEIEPDDVVALPYSSGTTGLPKGVMVTHKALVTSVAQQVDGENPNLYYRSEDVILCVLPLFHIYALNSILLCGLRVGSAILIMPRFEIGKLLKLVEWYKVTVTPFVPPILLSIAKNPDLDRYDLSSIRMIITGGAPMGKELEEAVKDKLPHAKLGQGYGMTEAGSVSMCLAFAKEPFPIKSGACGTVVRNAKIIDPNTVLSLPRNRAGEICIRGSQIMKGEVPVAFVVKSGASDINEEDIKQYISKQDLAGLQANLYQEMLKIDGLDDDQVHDATNSLATKHDLLRVFYNIPDQLKKGYILKILSRGV
>rna-XM_024175519.1
MSTLNNKTIDYHNKQSYPHWYSPETGIYNSTYPPINLPSDPFLDAVSFLFSRQHEGVTALIDAPSGISIPYSELYPLVKSFASGLHSKGVSKGDVVLVLLPNSVYFPVIIMGVMYLGAIFTPMNPLSSVTEIKKRVTDCKPCLAFTAPEKEEVFQKLGVGAIRVPEGVTYLDKRSPKTGNFSDFSKLISCHDFDNMAPRPLIRQQDTAAIMYSSGTTGVSKGAVISHGNFIAMMELFVRFEVSQYKEFYSPSEIVYLVFLPMFHIYGLCHFAIGMLSLGSTVVVMSKYDVKEVVKAIEKYKITHLPLVPPILAALTKVAKDDIEGNGGKTFQSLKQISWGAAPSSRKMIEDLVQTLPHIDLIQGYGMTESTAIGARGLNTKKLRNYFSVGLLAPNTHAKVVDCSTGSLLPPGKSGELWLKGPGIMKGYLNDPETTMSAIDKDGWLRTGDIVYINQNGYLHIIDRLKEMIKYKGFQIAPADLETVLTSHPEILEVGVTGIPDEECGEIPVAFVVRKQGSKLSHKDVMDYVASQVAPYKKIRKVIFTNSIPKSPAGKILRRELKESLTSKL
>rna-XM_024175676.1
MEKSGYGRDGIFRSLRPPLVLPKDPNLSAVSFLFRNSSSYPNKPALIDADSGEILSFSQLKSTVAKVSHGFLHLGIKKNDVVLIFAPNSIHFPVCFLGIIAIGAIATTSNPLYTVSELSKQVKDSNPKLIITVPELWEKVKGFNLPTVMLSAEHKSVPKKVLTFNGLVNLSGSASDFPSVNVKRSDTAVLLYSSGTTGTSKGVVLTHGNFIAASLMVAMDQEIAKEMHNVFLCVLPMFHVFGLAVITYSQLQRGNAVVSMAKFDLEKILMTVERYKITHFWVVPPIVLALAKNSVVKKYNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVIQGYGMTETCGIVSVEDTRGGKRNTGSAGTLVSGVEAQIVGVDTLKPLPPNQLGEIWVRGPNMMQGYLNNPQATKSTMDKKGWVHTGDLGYFDEDGHLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVQKFIANQVAPFKRLRKVTFINSVPKSASGKILRRELIEKVRSKI
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University