Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Momordica charantia
Species name
Bitter melon (Momordica charantia) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Momordica_charantia.COMT.fa
Download
>rna-XM_022285596.1
MGSTAAQTQTQITPTQVSDEEAHLFAMQLASASVLPMVLKAAIELDVLEIVARAGPGALLSPSQIAAQLPAVTNPHADVALDRILRLLASYSILTCSLRTHPDGTPQRLYGLAPVCKFLTNNQDGVSIAPLCLMNQDKVLMESWYHLKDAVVEGGIPFNRAYGMTAFDYHGTDPRFNKVFNRGMSEHSSITMKKILESYKGFEGVSSVVDVGGGTGAVLNMIVSRYPSIRGINFDLPHVIQDAPPYPGVQHLGGDMFVSVPKGDAIFMKWICHDWSDQHCLKLLKNCHDALPEHGKVIVAECILPVEPDTSLATKGVVHIDVIMLAHNPGGKERTQKEFHELANAAGFQGFNLHCCAFNTYVMEFLKTV
>rna-XM_022287805.1
MALQDSVAVLSSSKKAQASSTGAASSEFCSKILTCRRDGIILAKAGPGAELAAAEIAAKITATNPNAASMVDRILRLLATHSVVVCSTAEDEGGNVKRLYSLTPVSKYFVGNEDGVSLGPAMELIQDKVLLDSWRQLKNAVIEGGVPFNRAHGGAHAFEYPCLDPRFSKVFNTAMINHTTMGINKIVEFYKGFENLKQLVDVGGGLGVTLQVITSKYRSIKGINFDLPRVIRDAPTYPGVEHIGGDMFESVPKGDAIFMKWILHDWSDKHCVKLLKXCHVAIPDEGKVIVVDAVVPMVIETTSTMKFVTQGDVLMMTQSPGGKERTRDEFKALATKARFKHINFECFVYNLWVMEFIK
>rna-XM_022287836.1
MEQKAINSSSADDQEQQHFAYAAHLVTLSVFPFTLQAAFELGVFEILTKAGPGAELSAAEIAAKITATNPNAASMVDRILRLLATHSVVGCSTAEDEGGNVKRLYSLTPVSKYFVRNEDGVSLGPVMELIQDKVFLDSWRELKNAVIEGGVAFNRAHGGVHAFEYPGLDPRFNKVFNTAMINHTTMGIKKIVESYKGFGNLNQLVDVGGGLGVTLQVITSKYPSIKGINFDLPHVIRDAPAYPGVEHIGGDMFESVPKGDAIFMKWILHDWSDEHCVKLLKNCYAAIPNDGKVIAVDAVVPLVIETTITMKSITQGDVLMMTQNPGGKERTRDEFKALATKTGFKRINFECFVYNLWVIEFIK
>rna-XM_022289103.1
MVVGKEKSPMGKETAESESQNRARLAILELANMISVPMSLNAIVRLNIADAIWQEGSNDPLSASEILSRVLPSGGDADNLNRILRMLTSYGVFEEHLSHNSSERRYSLTDVGKTLVTDSDGLSYAPYVLQHHQDALMRAWPRVHEAASDATTEPFVRANGEPAYSYYGKRPEMNELMQRAMSGVSVPFMKAILDGYDGFGGVEKLVDVGGSAGDCLRMILQKHPHIKEGINFDLPEVVARAPSIPGVTHVGGDMFKSIPTGDAIFMKWVLSTWTDEECKIILENCCRSLPAGGKLIACEPTLPEKTDDSHRTRALLANDVFIMTIYRAKSKQRTEEQFRQLGLSAGFSALRPFHIDYFYCLLEFQK
>rna-XM_022298415.1
MEQKAINSSSADDQXQQHFAYAAHLVTLSVFPFTLQAALELGVFKILAKASPGAELSAAEIAAKITATNRNAASMVDRMLRLLATHSVVGCSTVEDEGGNVKRLHSLTPVSKYFVRNEDGVSLGPMISLIQDQVFLDSCPAIPVSRIDNKSWEIIRRAQGRSLKYALWGEALVLNSHLFSSGLSSHDQPDEFKKLPKPRQHSSQKRKAPEEMASKF
>rna-XM_022303638.1
WILHDWSDEHCVKXLKNCYAAIPNDGKVIAVDAVVPLVIETTITMKSITQGDVLMMTQNPGXKERTRDEFKALATKTGSELKNAVIEGGVAFNRAHGGVHAFEYPGLDTRFNKVFNTXMLNETTMGIKKIVESYKDFANLN
MGSTAAQTQTQITPTQVSDEEAHLFAMQLASASVLPMVLKAAIELDVLEIVARAGPGALLSPSQIAAQLPAVTNPHADVALDRILRLLASYSILTCSLRTHPDGTPQRLYGLAPVCKFLTNNQDGVSIAPLCLMNQDKVLMESWYHLKDAVVEGGIPFNRAYGMTAFDYHGTDPRFNKVFNRGMSEHSSITMKKILESYKGFEGVSSVVDVGGGTGAVLNMIVSRYPSIRGINFDLPHVIQDAPPYPGVQHLGGDMFVSVPKGDAIFMKWICHDWSDQHCLKLLKNCHDALPEHGKVIVAECILPVEPDTSLATKGVVHIDVIMLAHNPGGKERTQKEFHELANAAGFQGFNLHCCAFNTYVMEFLKTV
>rna-XM_022287805.1
MALQDSVAVLSSSKKAQASSTGAASSEFCSKILTCRRDGIILAKAGPGAELAAAEIAAKITATNPNAASMVDRILRLLATHSVVVCSTAEDEGGNVKRLYSLTPVSKYFVGNEDGVSLGPAMELIQDKVLLDSWRQLKNAVIEGGVPFNRAHGGAHAFEYPCLDPRFSKVFNTAMINHTTMGINKIVEFYKGFENLKQLVDVGGGLGVTLQVITSKYRSIKGINFDLPRVIRDAPTYPGVEHIGGDMFESVPKGDAIFMKWILHDWSDKHCVKLLKXCHVAIPDEGKVIVVDAVVPMVIETTSTMKFVTQGDVLMMTQSPGGKERTRDEFKALATKARFKHINFECFVYNLWVMEFIK
>rna-XM_022287836.1
MEQKAINSSSADDQEQQHFAYAAHLVTLSVFPFTLQAAFELGVFEILTKAGPGAELSAAEIAAKITATNPNAASMVDRILRLLATHSVVGCSTAEDEGGNVKRLYSLTPVSKYFVRNEDGVSLGPVMELIQDKVFLDSWRELKNAVIEGGVAFNRAHGGVHAFEYPGLDPRFNKVFNTAMINHTTMGIKKIVESYKGFGNLNQLVDVGGGLGVTLQVITSKYPSIKGINFDLPHVIRDAPAYPGVEHIGGDMFESVPKGDAIFMKWILHDWSDEHCVKLLKNCYAAIPNDGKVIAVDAVVPLVIETTITMKSITQGDVLMMTQNPGGKERTRDEFKALATKTGFKRINFECFVYNLWVIEFIK
>rna-XM_022289103.1
MVVGKEKSPMGKETAESESQNRARLAILELANMISVPMSLNAIVRLNIADAIWQEGSNDPLSASEILSRVLPSGGDADNLNRILRMLTSYGVFEEHLSHNSSERRYSLTDVGKTLVTDSDGLSYAPYVLQHHQDALMRAWPRVHEAASDATTEPFVRANGEPAYSYYGKRPEMNELMQRAMSGVSVPFMKAILDGYDGFGGVEKLVDVGGSAGDCLRMILQKHPHIKEGINFDLPEVVARAPSIPGVTHVGGDMFKSIPTGDAIFMKWVLSTWTDEECKIILENCCRSLPAGGKLIACEPTLPEKTDDSHRTRALLANDVFIMTIYRAKSKQRTEEQFRQLGLSAGFSALRPFHIDYFYCLLEFQK
>rna-XM_022298415.1
MEQKAINSSSADDQXQQHFAYAAHLVTLSVFPFTLQAALELGVFKILAKASPGAELSAAEIAAKITATNRNAASMVDRMLRLLATHSVVGCSTVEDEGGNVKRLHSLTPVSKYFVRNEDGVSLGPMISLIQDQVFLDSCPAIPVSRIDNKSWEIIRRAQGRSLKYALWGEALVLNSHLFSSGLSSHDQPDEFKKLPKPRQHSSQKRKAPEEMASKF
>rna-XM_022303638.1
WILHDWSDEHCVKXLKNCYAAIPNDGKVIAVDAVVPLVIETTITMKSITQGDVLMMTQNPGXKERTRDEFKALATKTGSELKNAVIEGGVAFNRAHGGVHAFEYPGLDTRFNKVFNTXMLNETTMGIKKIVESYKDFANLN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University