Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Momordica charantia
Species name
Bitter melon (Momordica charantia) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Momordica_charantia.HIDH.fa
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>rna-XM_022297219.1
MAAEDSDNPELELELLPYLRLYKNGVVERLVGTRVTPPGLDPLTGVDSKDIIIVPETGVSARLYRPTAVDPHRKLPLVXXXXXXXXXXXXXXXXXXXXXXYRLAPEHPLPAAYDDSWAALQWIAAQSQSADGELWLKQLVDFQKVFLVGDSAGANISHHMALRAKNSDDLAGKIKITGIALIHPYFWGAEPIGSEITDGEKKAEVDRWWSFACPSERGNDDPLINPFAEGSPEMEGLAGDRALVIVAEKDILKDRGKLYYEKLAKSEWKGTVEIMETEGEDHAFQLFNSTSENAKTLLRRLAFFTNQD
>rna-XM_022292462.1
MALIGEAPGYLKVYSDGTVRRLIPDVVASMATQSSKNFKFKDVVIDPRKAVTGRLFLPDAAADAAGRLPVVVYFHGGGFCIGSTTWIGYHHFLGDLAAASQSVILSVDYRLAPENRLPAAYEDCYSALEWLGHQASSEPWLQQADLSHVFLSGDSAGGNIVHNVAIKTIKSNISNMTIKGLLLIHPYFGSEERTEKEKAEGAEGHVEMNDMFWRLSIPEGRNRDYFGCNFENAQVTEEEWSQFPGVAVFVAGLDFLKERGVLYAKFLQQMKVKEVKLLEAADESHVFHVFHPESEATRLLQKQMSQFMKSY
>rna-XM_022275575.1
MTQGKKSLIHDVSGWLRVYDDGSVDRTWTGPPEVKFMADSVPPHEEFVDGVATRDVVIDRESGLRVRIYLPEVKIADDKKLPVVVHFHGGGFCISEADWFMYYHTYTNLVRSAEAICVSVYLRRAPEHRLPAAVDDGFSALRWLQSVALGDSHEPWIAERADFDRVFLIGDSSGGNLVHSVAALAGSSDLAPLRLAGGIPIHPGFVRAERSKSEMENPQSPFLTLDMVDKFLSLSLPIGSSKDHPITCPMGAAAPPLESLNLPPFLLCISEKDLIIDTEMEYYEAMKAANKEVEILFSKGMGHSFYLNKIALKSDPETAAESDALFAGISRFIKQH
>rna-XM_022292849.1
MDSDAADEVVFEFQPVFRVFRSGRVERLIPGDRVPPSTDQRTGVQSKDILIDPQTGVSVRIYLPPVPDSTKLPLLIYIHGGAFAIGSADSAIYHRHLISLAAEANAVALSVNYRLAPEHPLPAAYDDAWTSVEWAASHANRDGAEIWLNNHADFDRVFLVGDSAGANISYNLVGRAGNGPAGLNIVGLGLIHPFFMIDKPDKLIEYIFPTSAGLEDPRMNPRANPELRSLRCTQVVILVAENDWLKDRGRGFHAALRESGWKGSVEIVETEGEGHVFHLFNPENEKAATLVKQVASFIQSTSGSTLESETHALKI
>rna-XM_022294843.1
MHTSGHNQLYPLKILRHNFCIYPHLHPHSMRSKRMPTINLDQIQSFEEHDNSLDQHNVLVEEIEGLIRVYGNGYVERPHIVPCVSNALPPELGVTSWDVVVDKLNNIWARFYIPQKCQEKLPLLVYFHGGGFCVGSAAWSCYHEFLARLSVKANCIIMSVNYRLAPENPLPAPFEDGLKTLLWLKQVAVVGAKQNWWSRYCDFTKVYLGGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIKGNILIQPFFGGESRTKSEKFLVQPPRSPLTMAVSDKYWRLALPSGANRDHPWCSPSVKGLFKVEDLRVLPSLICISEMDILKDRNLEFCSALHTVGKLVNYVVYEGVGHAFQILNKSQLSQTRTHEMIDHIKDFISV
>rna-XM_022298148.1
MATSSSSSPPFEVEECRGVLRVYSDGSIVRSSNPSFDVPVLDDGSVLWKDLLFDLINRLHVRLYKPANCSSSTSLLPIFFYIHGGGFCIGSRTWPNCQNYCFRLALHLSALVISPDYRLAPENRLPAAIHDGFAALRWLQAQALSDHPDPWLSHVADFSRIFISGDSAGGNIAHHLAVGLGAGSPELAPLRVRGYVLLGPFFGGTVRTRSEAEGPKEAFLNLDLIDRFWRLSIPPGSTTDHPLVNVLGPWSRDLEAVELDPMLVVVGGGDLLKDRAVEYAEKLKEQGKMIELVEFEGKQHGFFTIHPNSEAANQLMLIVNRFITQNSG
>rna-XM_022299328.1
MKFKRMAAISIDPRLKLQMPKSHLQCASTAEEIEGLIRVYADGHVERPPIIPNVPCSTTASNKGVSAKDVLIDNFTNTWARIYIANSQRKLPLLVYFHGGGFCVGSAAWSCYHEFLLDLASKAKCAILSINYRLSPENRLPAAYEDGFNALMWLKQQAISEPNEHKWWLGNCNPSNLFLAGDSAGANIAYNIATRPGLNEPATLKPLTLKGVILIQPFFGGESRTKSEKLAAQPSTSALTLATADTYWRLSLPPGASRDHPWSNPLVNGGTKLRDTKLPPSMVCISELDILVDRNLEFCAAMAAAGKKVERVIFKGVGHGFQILNKDQISAIRTQEMMVSIQNFIHQVVKIY
MAAEDSDNPELELELLPYLRLYKNGVVERLVGTRVTPPGLDPLTGVDSKDIIIVPETGVSARLYRPTAVDPHRKLPLVXXXXXXXXXXXXXXXXXXXXXXYRLAPEHPLPAAYDDSWAALQWIAAQSQSADGELWLKQLVDFQKVFLVGDSAGANISHHMALRAKNSDDLAGKIKITGIALIHPYFWGAEPIGSEITDGEKKAEVDRWWSFACPSERGNDDPLINPFAEGSPEMEGLAGDRALVIVAEKDILKDRGKLYYEKLAKSEWKGTVEIMETEGEDHAFQLFNSTSENAKTLLRRLAFFTNQD
>rna-XM_022292462.1
MALIGEAPGYLKVYSDGTVRRLIPDVVASMATQSSKNFKFKDVVIDPRKAVTGRLFLPDAAADAAGRLPVVVYFHGGGFCIGSTTWIGYHHFLGDLAAASQSVILSVDYRLAPENRLPAAYEDCYSALEWLGHQASSEPWLQQADLSHVFLSGDSAGGNIVHNVAIKTIKSNISNMTIKGLLLIHPYFGSEERTEKEKAEGAEGHVEMNDMFWRLSIPEGRNRDYFGCNFENAQVTEEEWSQFPGVAVFVAGLDFLKERGVLYAKFLQQMKVKEVKLLEAADESHVFHVFHPESEATRLLQKQMSQFMKSY
>rna-XM_022275575.1
MTQGKKSLIHDVSGWLRVYDDGSVDRTWTGPPEVKFMADSVPPHEEFVDGVATRDVVIDRESGLRVRIYLPEVKIADDKKLPVVVHFHGGGFCISEADWFMYYHTYTNLVRSAEAICVSVYLRRAPEHRLPAAVDDGFSALRWLQSVALGDSHEPWIAERADFDRVFLIGDSSGGNLVHSVAALAGSSDLAPLRLAGGIPIHPGFVRAERSKSEMENPQSPFLTLDMVDKFLSLSLPIGSSKDHPITCPMGAAAPPLESLNLPPFLLCISEKDLIIDTEMEYYEAMKAANKEVEILFSKGMGHSFYLNKIALKSDPETAAESDALFAGISRFIKQH
>rna-XM_022292849.1
MDSDAADEVVFEFQPVFRVFRSGRVERLIPGDRVPPSTDQRTGVQSKDILIDPQTGVSVRIYLPPVPDSTKLPLLIYIHGGAFAIGSADSAIYHRHLISLAAEANAVALSVNYRLAPEHPLPAAYDDAWTSVEWAASHANRDGAEIWLNNHADFDRVFLVGDSAGANISYNLVGRAGNGPAGLNIVGLGLIHPFFMIDKPDKLIEYIFPTSAGLEDPRMNPRANPELRSLRCTQVVILVAENDWLKDRGRGFHAALRESGWKGSVEIVETEGEGHVFHLFNPENEKAATLVKQVASFIQSTSGSTLESETHALKI
>rna-XM_022294843.1
MHTSGHNQLYPLKILRHNFCIYPHLHPHSMRSKRMPTINLDQIQSFEEHDNSLDQHNVLVEEIEGLIRVYGNGYVERPHIVPCVSNALPPELGVTSWDVVVDKLNNIWARFYIPQKCQEKLPLLVYFHGGGFCVGSAAWSCYHEFLARLSVKANCIIMSVNYRLAPENPLPAPFEDGLKTLLWLKQVAVVGAKQNWWSRYCDFTKVYLGGDSAGGNIAFNVAARLGGKTTASGAVVLKPLVIKGNILIQPFFGGESRTKSEKFLVQPPRSPLTMAVSDKYWRLALPSGANRDHPWCSPSVKGLFKVEDLRVLPSLICISEMDILKDRNLEFCSALHTVGKLVNYVVYEGVGHAFQILNKSQLSQTRTHEMIDHIKDFISV
>rna-XM_022298148.1
MATSSSSSPPFEVEECRGVLRVYSDGSIVRSSNPSFDVPVLDDGSVLWKDLLFDLINRLHVRLYKPANCSSSTSLLPIFFYIHGGGFCIGSRTWPNCQNYCFRLALHLSALVISPDYRLAPENRLPAAIHDGFAALRWLQAQALSDHPDPWLSHVADFSRIFISGDSAGGNIAHHLAVGLGAGSPELAPLRVRGYVLLGPFFGGTVRTRSEAEGPKEAFLNLDLIDRFWRLSIPPGSTTDHPLVNVLGPWSRDLEAVELDPMLVVVGGGDLLKDRAVEYAEKLKEQGKMIELVEFEGKQHGFFTIHPNSEAANQLMLIVNRFITQNSG
>rna-XM_022299328.1
MKFKRMAAISIDPRLKLQMPKSHLQCASTAEEIEGLIRVYADGHVERPPIIPNVPCSTTASNKGVSAKDVLIDNFTNTWARIYIANSQRKLPLLVYFHGGGFCVGSAAWSCYHEFLLDLASKAKCAILSINYRLSPENRLPAAYEDGFNALMWLKQQAISEPNEHKWWLGNCNPSNLFLAGDSAGANIAYNIATRPGLNEPATLKPLTLKGVILIQPFFGGESRTKSEKLAAQPSTSALTLATADTYWRLSLPPGASRDHPWSNPLVNGGTKLRDTKLPPSMVCISELDILVDRNLEFCAAMAAAGKKVERVIFKGVGHGFQILNKDQISAIRTQEMMVSIQNFIHQVVKIY
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University