Enzyme
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
ROMT
Enzyme
Trans-resveratrol di-O-methyltransferase
Enzyme name
EC:2.1.1.240
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase
Sysname
2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction) [RN:R09872];(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene [RN:R09870];(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene [RN:R09871]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];pterostilbene [CPD:C10287];3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]
Product
Species information
Momordica charantia
Species name
Bitter melon (Momordica charantia) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Momordica_charantia.ROMT.fa
Download
>rna-XM_022280044.1
MDLEQGEEMAVDEILEAQSHICSHIFSFINPMALKCAVQLGIPDAIHSHGPNPMPLSQLVSALQLSPQKTPHIYRLMRLLVHSGFFVMHKLSSQNGAEQKEEEGYVLTNSSRLFLKDNPLNLAPYLLYMFEPFRVEPWQFLSAWFRSEDRTPFDTAHGMSFWEYMGRKPRDSEVFNAAMASDSRLVMSALMGKYKGVFEGLGSLVDVGGGIGTVAKAIAEAFPSIECSVFDLPQVVADLKGEGNLKYVEGDMFEAIPPADALLLKAILHDWNDEECLKILKKCKEAIMVSGKKGKVIVIDVVVEEEKMEDKFVQTQLFLDMSMMAVVGGKERNEKEWSQLFSKVGFRDYKIFPILGLKSLIELYP
>rna-XM_022280313.1
MDLEQGGETAIDEILEAQSHICSHIFSFINPMALKCAVQLGIPDAIHRHGPNPMPLSQLVSALQLSPQKTPHVYRLMRLLVHLGFFVMQKLSQNGEQEKEEEGYVLTNSSRFLLKDNPLTLTPFVLSMLDPGLVEPWRFLSASFQSSDDHRTAFDMAHGTPFWEFMASRQKDSDVFNAGMASDAKLVIGVLLEKYKGVFEGLGSVVDVGGGTGALAKAIAEAFPQIECTVLDLPQVVADFKGNGKNNLNYVGGDMFEAIPPANALLLKWVLHDWSDEGCIKILKKCKEAITEHGKKGKVMVIEMVVGNKKMDDKVVQTQLFFDILLMTMLVGGRERSEEEWAQIFYASGFSDYKIFPILGLRSLMEIYP
>rna-XM_022279979.1
MNMELGGDIAVPSHELLEAQAHIWNHIFNFINSMALKCAVQLGIPDAIHRHGPNPMPLSQLVSALQLSPQKTQYIYRLMRLLTHSSFFVTHKMMTKNGEEEAYVLTNSSRLLLNDNPSAVTPFLLSMLEPALVEPWQLLAAWLQSEDRTPFHTTHGMPFWEFFSEKPKDGDVFNVAMASDARLVMSILLDKYKGVFEGVGSLVDVGGGTGTVAKAIAKAFPQIECIVFDLHQVVGNLKGEDNLKYVEGNMFEAVPSADALLLKWILHDWNDEECVEILKKCKEAITNNGKKGKMIVIDMVVGNKQGDDSIETQLFFDMLMMNLAGGKERDEKEWAQLIKEAGLSGYKIFPIMGLRSLIEIYP
>rna-XM_022296722.1
MGEISELLEAQVHIWNHAFKYINSMSLKCVVELGIPDILHTHGQPMSLSDLVEALHIQPSKAQCLGRLMRLLVHSGFFARTHSENDEQETKYAVTPSSRLLLRHNDTLETLPFLFLILHHAMMASWETMSCWLCSVDENYSSAFEMANGKSIWNYIAEEPEFGNLFHRTIAYDSQLIGRIVTTECREVFEGLKSIVDVGGGTGIMAKAIVEAFPHITYIVFDLPQVVANHQQTTKNLSFIGGDMFEAKIPPTNAVLLKSVLYNWNDEESIQILKNCKDAILSNAEGGKVIIIEVALEYQVEDKESIETQLCGDVLMMTNFAIRKRNEREWKNLFLAAGFSDYKIIPMLGLRSLIEVYP
>rna-XM_022296684.1
MGDNIELLKAQAHVWNHAYRYMDSMSLKCAVELGIPDIIHSHGEPMSLSNLVGALHIQPFKAHCLGRLMSLLVHSGFFVQTHDENEQEVKYTLTSTSRLLLRHNTPFEHISLLLLIFNKAMMASYETMSSWFRSTDERHSCAFETTNDKSVWDYVAQEPDFSNILNKAMMYDSQLIGRVVTRECRRVFKGLKSLVDVGGNRGFMAKAIAEAFPHITCIVFDLPHVVDNLQQTTENLNFIAGNMFEAKIPPANAVLLKWVLHDWNDEKSIKILKNCKDAIPSRAEGGKVIIIEMVTENQIEDKESIETQLCEDVFTMSVVTGRERNESEWKNLFLAAGFSDYKIISMLGLRSLIEVYP
>rna-XM_022300867.1
MEELAGEEVLEAEARIWNHIFSFINSMALKCVVQLGIPDAIARHDCSPMPLSHLISALQLHPQNSQYIHRLMCILAHSGFFITHKNGSEEEAYSLTNSSRLLLKHNPSSLSPFLLSMLDPLLLQPWQLLSAWFHSLNRTPFEMAHGRQFWEHMGNKQQDGDVFNAAMASDARLVSNILLGQYKNMFDGVKSLVDVGGGTGTMAKAIADAFPQTQCVVLDLFHVVADLEGSHNLTYLPGDMFQSIPPADVLLLKWILHDWSDGECVEILKKCKEAITSNGKTGKVILIDMVLGNKKGDDTFIETQLFWDMLMMANVSGKERDEKEWAQLFDKARFAGYKIFPVLGLRSLIEIYPR
>rna-XM_022300859.1
MGEVAGNEVLEAETHIWNHIFSFINSMALKCAVQLGIPDTIAHHGRGPMSLSHLVSALKLHPENSQYLHRLMRILAHSGFFTAHKNDKEQEEAYSLTSSSRLLLKCNPSSLSPLLLSMLDPFLLQPWQLLSAWFHSHDRTAFKMAHGKQFWEHMASKPRDGDVFNAAMASDARLVTSVLLGQYKNIFDGVKSLVDVGGGTGTVARVIADVFPQIQCVVLDLPHVVADLEGSHNLTYLEGDMFQSIPSADVLLLKWILHDWSDGECAEILKKCKEAITSNGKKGRVILIDMVVGNKKVDGDGDRDGDDMFIETQLFWDMLMMVNVGGKERDEKEWVQLFDKAGFGGYKIFPILGLRSLIEIYP
>rna-XM_022300870.1
MGEVVGEEVLEAETHIWNHIFSFINFMALKCVVELDIPDAIARHGHRPMPFSHHVSALKLHPHNSQYLHRSRRILDHYGFFTKYKNGKEEEAYSLTNSSRLLFNHNHSSLSPLLLSLLDSFLLQPWQLLSAWFYSHDRIPFKMAHGKQFWEHTASKPQDGDTFNAAMANDVRLVTSVLLGQYKNMFVGVKSLVDVGGGIGILARVIAEAFLQTQCVVLDLLHVLTNLEESHNLIYPEGEMFQSIPLPMYFY
>rna-XM_022303042.1
MGESTELLRAQAHVWNHTFKYINSMSLKCVVELGIPDIIHSHGQPMSLSNLVDALHIQPSKAQCLNRLMRLLVHAGFFIQTHGDNEQEEYALTPSSRLLLCRNTAFENIPFVFLILNRAMMAPLETMSSWLCSVDEHSNSAFEMANGKSIWDYVSQEHDFGKLFHQTMVHDSQLIGKVVTRECREVFEGLKSLVDVGGSTGFMAKAIAEAFPHITCTVFDLPQVAANSQQTTKNLSFIGGDMFEAKIPPANAVLLKWILHDWNDEESIRILKNCKDAIPSRAEXGKVIVIDMVVENQIEDKESVEAQLCCDLLVMTSYNGRERNEREWKNLFLTAGFSDYKIISMLGLRSLIEVYP
MDLEQGEEMAVDEILEAQSHICSHIFSFINPMALKCAVQLGIPDAIHSHGPNPMPLSQLVSALQLSPQKTPHIYRLMRLLVHSGFFVMHKLSSQNGAEQKEEEGYVLTNSSRLFLKDNPLNLAPYLLYMFEPFRVEPWQFLSAWFRSEDRTPFDTAHGMSFWEYMGRKPRDSEVFNAAMASDSRLVMSALMGKYKGVFEGLGSLVDVGGGIGTVAKAIAEAFPSIECSVFDLPQVVADLKGEGNLKYVEGDMFEAIPPADALLLKAILHDWNDEECLKILKKCKEAIMVSGKKGKVIVIDVVVEEEKMEDKFVQTQLFLDMSMMAVVGGKERNEKEWSQLFSKVGFRDYKIFPILGLKSLIELYP
>rna-XM_022280313.1
MDLEQGGETAIDEILEAQSHICSHIFSFINPMALKCAVQLGIPDAIHRHGPNPMPLSQLVSALQLSPQKTPHVYRLMRLLVHLGFFVMQKLSQNGEQEKEEEGYVLTNSSRFLLKDNPLTLTPFVLSMLDPGLVEPWRFLSASFQSSDDHRTAFDMAHGTPFWEFMASRQKDSDVFNAGMASDAKLVIGVLLEKYKGVFEGLGSVVDVGGGTGALAKAIAEAFPQIECTVLDLPQVVADFKGNGKNNLNYVGGDMFEAIPPANALLLKWVLHDWSDEGCIKILKKCKEAITEHGKKGKVMVIEMVVGNKKMDDKVVQTQLFFDILLMTMLVGGRERSEEEWAQIFYASGFSDYKIFPILGLRSLMEIYP
>rna-XM_022279979.1
MNMELGGDIAVPSHELLEAQAHIWNHIFNFINSMALKCAVQLGIPDAIHRHGPNPMPLSQLVSALQLSPQKTQYIYRLMRLLTHSSFFVTHKMMTKNGEEEAYVLTNSSRLLLNDNPSAVTPFLLSMLEPALVEPWQLLAAWLQSEDRTPFHTTHGMPFWEFFSEKPKDGDVFNVAMASDARLVMSILLDKYKGVFEGVGSLVDVGGGTGTVAKAIAKAFPQIECIVFDLHQVVGNLKGEDNLKYVEGNMFEAVPSADALLLKWILHDWNDEECVEILKKCKEAITNNGKKGKMIVIDMVVGNKQGDDSIETQLFFDMLMMNLAGGKERDEKEWAQLIKEAGLSGYKIFPIMGLRSLIEIYP
>rna-XM_022296722.1
MGEISELLEAQVHIWNHAFKYINSMSLKCVVELGIPDILHTHGQPMSLSDLVEALHIQPSKAQCLGRLMRLLVHSGFFARTHSENDEQETKYAVTPSSRLLLRHNDTLETLPFLFLILHHAMMASWETMSCWLCSVDENYSSAFEMANGKSIWNYIAEEPEFGNLFHRTIAYDSQLIGRIVTTECREVFEGLKSIVDVGGGTGIMAKAIVEAFPHITYIVFDLPQVVANHQQTTKNLSFIGGDMFEAKIPPTNAVLLKSVLYNWNDEESIQILKNCKDAILSNAEGGKVIIIEVALEYQVEDKESIETQLCGDVLMMTNFAIRKRNEREWKNLFLAAGFSDYKIIPMLGLRSLIEVYP
>rna-XM_022296684.1
MGDNIELLKAQAHVWNHAYRYMDSMSLKCAVELGIPDIIHSHGEPMSLSNLVGALHIQPFKAHCLGRLMSLLVHSGFFVQTHDENEQEVKYTLTSTSRLLLRHNTPFEHISLLLLIFNKAMMASYETMSSWFRSTDERHSCAFETTNDKSVWDYVAQEPDFSNILNKAMMYDSQLIGRVVTRECRRVFKGLKSLVDVGGNRGFMAKAIAEAFPHITCIVFDLPHVVDNLQQTTENLNFIAGNMFEAKIPPANAVLLKWVLHDWNDEKSIKILKNCKDAIPSRAEGGKVIIIEMVTENQIEDKESIETQLCEDVFTMSVVTGRERNESEWKNLFLAAGFSDYKIISMLGLRSLIEVYP
>rna-XM_022300867.1
MEELAGEEVLEAEARIWNHIFSFINSMALKCVVQLGIPDAIARHDCSPMPLSHLISALQLHPQNSQYIHRLMCILAHSGFFITHKNGSEEEAYSLTNSSRLLLKHNPSSLSPFLLSMLDPLLLQPWQLLSAWFHSLNRTPFEMAHGRQFWEHMGNKQQDGDVFNAAMASDARLVSNILLGQYKNMFDGVKSLVDVGGGTGTMAKAIADAFPQTQCVVLDLFHVVADLEGSHNLTYLPGDMFQSIPPADVLLLKWILHDWSDGECVEILKKCKEAITSNGKTGKVILIDMVLGNKKGDDTFIETQLFWDMLMMANVSGKERDEKEWAQLFDKARFAGYKIFPVLGLRSLIEIYPR
>rna-XM_022300859.1
MGEVAGNEVLEAETHIWNHIFSFINSMALKCAVQLGIPDTIAHHGRGPMSLSHLVSALKLHPENSQYLHRLMRILAHSGFFTAHKNDKEQEEAYSLTSSSRLLLKCNPSSLSPLLLSMLDPFLLQPWQLLSAWFHSHDRTAFKMAHGKQFWEHMASKPRDGDVFNAAMASDARLVTSVLLGQYKNIFDGVKSLVDVGGGTGTVARVIADVFPQIQCVVLDLPHVVADLEGSHNLTYLEGDMFQSIPSADVLLLKWILHDWSDGECAEILKKCKEAITSNGKKGRVILIDMVVGNKKVDGDGDRDGDDMFIETQLFWDMLMMVNVGGKERDEKEWVQLFDKAGFGGYKIFPILGLRSLIEIYP
>rna-XM_022300870.1
MGEVVGEEVLEAETHIWNHIFSFINFMALKCVVELDIPDAIARHGHRPMPFSHHVSALKLHPHNSQYLHRSRRILDHYGFFTKYKNGKEEEAYSLTNSSRLLFNHNHSSLSPLLLSLLDSFLLQPWQLLSAWFYSHDRIPFKMAHGKQFWEHTASKPQDGDTFNAAMANDVRLVTSVLLGQYKNMFVGVKSLVDVGGGIGILARVIAEAFLQTQCVVLDLLHVLTNLEESHNLIYPEGEMFQSIPLPMYFY
>rna-XM_022303042.1
MGESTELLRAQAHVWNHTFKYINSMSLKCVVELGIPDIIHSHGQPMSLSNLVDALHIQPSKAQCLNRLMRLLVHAGFFIQTHGDNEQEEYALTPSSRLLLCRNTAFENIPFVFLILNRAMMAPLETMSSWLCSVDEHSNSAFEMANGKSIWDYVSQEHDFGKLFHQTMVHDSQLIGKVVTRECREVFEGLKSLVDVGGSTGFMAKAIAEAFPHITCTVFDLPQVAANSQQTTKNLSFIGGDMFEAKIPPANAVLLKWILHDWNDEESIRILKNCKDAIPSRAEXGKVIVIDMVVENQIEDKESVEAQLCCDLLVMTSYNGRERNEREWKNLFLTAGFSDYKIISMLGLRSLIEVYP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University