Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Momordica charantia
Species name
Bitter melon (Momordica charantia) is a species of eudicot in the family Cucurbitaceae (cucumber family).
Species info
Gene sequence info
Momordica_charantia.4CL.fa
Download
>rna-XM_022295608.1
MKIVDPETGASLPANSAGEICIRGDQIMKGYLNDPESTKRTIDKEGWLHTGDIGLIDDDDELFIVDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVVGMPDEQAGEVPVAFAVKANGGAVTEEEVKQFIAKQVVFYKRLKRVFFVNAIPKAPSGKILRKELRAKLASGAYN
>rna-XM_022302156.1
MTIASASLNNHLNCDTSENQTAGMQKIPHSEYPDWYSPDSGICRSHYPSIDLPSDPFLDVVSFIFSFQHNGVSALIDSSTGHSISYRELYPLVKSMACGLDKLGISQGDVVLILLPNSILYPIILLGVLYLGAVVTTMFPQSSFSEIKKRSSDCNVRLAFAIPQKVEDFEALGIHAIGVPENVNLNSRSIGFSSFYELISGGFDFNKKPEIKQQDTAAILYSSGTTGVSKGVILTHRNLIATIELFVRFEASQYEYLSTENVYLAVVPMFHIYGLALYVMGLLSLGSSIVVMSKFDIKEAVKAIDKYNVTHFPVVPPILTALTRTAKEICGRRFQSLKQVSCGAASSSKKAIEEFVQALPHVDFIQGYGMTESAAVATRGFNTKKAQNYSSVGLLAPNMEAKVVDCINGSFLPPGRHGQLLLRGPSLMKGYLNNTEATMSTIDHEAWLHTGDVVYFDQDGYLYVIDRLKEIIKYKGFQIPPADLEAVLIAHPEVLEVAVTAEVDEECGEIPVAFIVKRPGSRLSQKDVIDFVAQQVAPYKKIRKVVFTEALPKSAAGKVLRRE
>rna-XM_022279555.1
HIYSLNCIMMCSLRVGAAILIVHKFDINSLVKFVPKYKVTVAPLVPPIVLAIAESPAVESSDMSSIRMVLSGAAPLGKELEDAVKAKLPQAILGQGYGMTEGLVFTMSLAFAKERFEVKSGACGTLMRNSEMKIINPQTGASLPRNQPGEICIRSTQFMKGYLHDEEATKGIIDKNGWLHSGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLISHGHIADAAVVPMKDEVAGEVPAAFIVRSDSSNIAEDEIKQYISKQVVFYKRINRVFFVDSIPKSSSGKILRRQLRALLAASIPN
>rna-XM_022296199.1
MLWFVYKESLQTCHNEWRESTISHQKRPMPISPPITLHISHSQSMKTEPSSMPVANISAMGTLIRDLVEDEEHIFRSQLPEVQVPDDITLPEFVLQNAESYAENVAFVEAVSGKAYTYREVVRDTKRFAKALSSLRLRKGQVVIVVLPNVAEYAIVALGIMAAGGVFSGVNPAAHISEIKKQVEAADAKLVVTNSPNFEKVKELKLPVIVLGEELIEGSMNWHKLLEAADRAGNNHVKEDIKQSDLCALPFSSGTTGVSKGVMLTHRNLVANLCSTLSGVPRETEGKVTTLGLIPFFHIYGITGICCATLRNKGKVVVMGRFDLRTFINALITQEVTFAPIVPPIILALVKNPIVEEFDLSSLKLQAIMTAAAPLAPEIQTAFEKKFPGVDVQEAYGLTEHSCITLNYGSIGKENLTAKKNTVGRILPNLEVKFIDPESGRSLPKNTPGEICVRSQCVMQGYYNNEEETSRTIDNRGWLHTGDIGYIDDNGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVIAPNSKETEEEIIQYVASNVAYYKKVRVVHFVDSIPKSPSGKVMRRLIKEKMIDKIRAKTAS
>rna-XM_022297166.1
MEKSGYGRDGIFRSLRPPLVFPKDHNLSMISFLFRNSSSYPNRLAIVDAESSETVSYSQLKASAIRVSNGLLQLGIKKNDVVLIFAPNSIQFSICFIGIIAIGAIATTCNPVFTVSELTKQVNDAKPKLVITVAELWDKAKNLNLPAMLLEQKIPPEISSRSKIYCFDDLINMAGNESGPEFPIVGVNQNDTATLLYSSGTTGASKGVILTHRNFIASSLMITMDQTMRGETNCVFLNFLPMFHVFGLACITYAQLQKGNTIVSMPRFNLEKALWAVEKYKVTDLWVVPPVVLALAKQSVVKKYDLSSVKHVGSGAAPLGRELMEECAKNIPSAVVLQGYGMTETCGVVALENPAVGKRNSGSAGTLAPGVEAQIVSVDTLKPLPPNQYGEIWVRGPNMMLGYFNNPQATKQTIDKYGWVHTGDLGYFDENGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPQILDAVVIPYPDAEAGEVPIAYVVRSTNSSLTEEDILKFVANQVSPYKRLRRVTFISSVPKSVSGKILRRELIEKVRAKI
>rna-XM_022297597.1
MDSQIPTGDDFIFRSKLPDIYIPDHLPLHTYCFDRLSQFQHRPCLINAATGHVHTYAAVHLTARRVAAGLANIGISQGDVIMILLQNSPEFVFAFLGASYGGAISTTANPLYKPAEIAKQARAANAKVIITQSAFVDKIKGFAEERGVKILCTDSPPDGCLSFSELTEADENDIPAVKINSNDVVALPYSSGTTGIPKGVMLTHKSLVTSVAQQVDGENPNLYFKSKDVILCILPLFHIYSLNSVLLCGLRVGAAILIIQKYDMSSLLHLIQAHKATVAPFVPPIVLDLAKNPDIHRYDLSSIRIVMSGAAPLGKDLEDTLKARLPNANLGQGYGMTEAGPVLSMSLTFAKEPMAVKSGACGTVVRNAEMKIIHPQTGASLPRNQPGEICIRGSQIMKGYLNNKEATEETIDKDGWLHTGDLGFIDDDDEIFIVDRLKELIKYKGYQVAPAELEALLTSNPNIAAAAVIPMKDEAAGEIPVAFVVRSGGSKISEDEIKEYVSEQVIFYKKIRKVFLVDSIPIAPSGKILRKVLRDQLQAGAF
>rna-XM_022297701.1
GDNPNLYFRNDDVILCVLPLFHIYSLNSVLLCGLRAGATILILPKFEIASLLQLVQKYRVSIAPVVPPIVLAIAKSPDLDKYDLSSIRVLKSGGAPLGKELEDTVRAKFPKAVLGQGYGMTEAGPVLTMGLAFAKEPFPMKPGACGTVVRNAEMKIVDTENGASLPRNTPGEICIRGDQIMKGYLNNPEATVATIDADGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHTVITDAAVVPMKDEQAGEVPVAFVVKSKSSEVTEDEIKQFISKQVVFYKRINRVFFIDAIPKSPSGKILRKELRAKLADVSPNSK
MKIVDPETGASLPANSAGEICIRGDQIMKGYLNDPESTKRTIDKEGWLHTGDIGLIDDDDELFIVDRLKELIKFKAFQVAPAELEALLITHPKLSDAAVVGMPDEQAGEVPVAFAVKANGGAVTEEEVKQFIAKQVVFYKRLKRVFFVNAIPKAPSGKILRKELRAKLASGAYN
>rna-XM_022302156.1
MTIASASLNNHLNCDTSENQTAGMQKIPHSEYPDWYSPDSGICRSHYPSIDLPSDPFLDVVSFIFSFQHNGVSALIDSSTGHSISYRELYPLVKSMACGLDKLGISQGDVVLILLPNSILYPIILLGVLYLGAVVTTMFPQSSFSEIKKRSSDCNVRLAFAIPQKVEDFEALGIHAIGVPENVNLNSRSIGFSSFYELISGGFDFNKKPEIKQQDTAAILYSSGTTGVSKGVILTHRNLIATIELFVRFEASQYEYLSTENVYLAVVPMFHIYGLALYVMGLLSLGSSIVVMSKFDIKEAVKAIDKYNVTHFPVVPPILTALTRTAKEICGRRFQSLKQVSCGAASSSKKAIEEFVQALPHVDFIQGYGMTESAAVATRGFNTKKAQNYSSVGLLAPNMEAKVVDCINGSFLPPGRHGQLLLRGPSLMKGYLNNTEATMSTIDHEAWLHTGDVVYFDQDGYLYVIDRLKEIIKYKGFQIPPADLEAVLIAHPEVLEVAVTAEVDEECGEIPVAFIVKRPGSRLSQKDVIDFVAQQVAPYKKIRKVVFTEALPKSAAGKVLRRE
>rna-XM_022279555.1
HIYSLNCIMMCSLRVGAAILIVHKFDINSLVKFVPKYKVTVAPLVPPIVLAIAESPAVESSDMSSIRMVLSGAAPLGKELEDAVKAKLPQAILGQGYGMTEGLVFTMSLAFAKERFEVKSGACGTLMRNSEMKIINPQTGASLPRNQPGEICIRSTQFMKGYLHDEEATKGIIDKNGWLHSGDIGFVDDDDEVFIVDRLKELIKYKGFQVAPAELEALLISHGHIADAAVVPMKDEVAGEVPAAFIVRSDSSNIAEDEIKQYISKQVVFYKRINRVFFVDSIPKSSSGKILRRQLRALLAASIPN
>rna-XM_022296199.1
MLWFVYKESLQTCHNEWRESTISHQKRPMPISPPITLHISHSQSMKTEPSSMPVANISAMGTLIRDLVEDEEHIFRSQLPEVQVPDDITLPEFVLQNAESYAENVAFVEAVSGKAYTYREVVRDTKRFAKALSSLRLRKGQVVIVVLPNVAEYAIVALGIMAAGGVFSGVNPAAHISEIKKQVEAADAKLVVTNSPNFEKVKELKLPVIVLGEELIEGSMNWHKLLEAADRAGNNHVKEDIKQSDLCALPFSSGTTGVSKGVMLTHRNLVANLCSTLSGVPRETEGKVTTLGLIPFFHIYGITGICCATLRNKGKVVVMGRFDLRTFINALITQEVTFAPIVPPIILALVKNPIVEEFDLSSLKLQAIMTAAAPLAPEIQTAFEKKFPGVDVQEAYGLTEHSCITLNYGSIGKENLTAKKNTVGRILPNLEVKFIDPESGRSLPKNTPGEICVRSQCVMQGYYNNEEETSRTIDNRGWLHTGDIGYIDDNGDVFIVDRIKELIKYKGFQVAPAELEAILLTHPSIEDAAVVPLPDEEAGEIPAASVVIAPNSKETEEEIIQYVASNVAYYKKVRVVHFVDSIPKSPSGKVMRRLIKEKMIDKIRAKTAS
>rna-XM_022297166.1
MEKSGYGRDGIFRSLRPPLVFPKDHNLSMISFLFRNSSSYPNRLAIVDAESSETVSYSQLKASAIRVSNGLLQLGIKKNDVVLIFAPNSIQFSICFIGIIAIGAIATTCNPVFTVSELTKQVNDAKPKLVITVAELWDKAKNLNLPAMLLEQKIPPEISSRSKIYCFDDLINMAGNESGPEFPIVGVNQNDTATLLYSSGTTGASKGVILTHRNFIASSLMITMDQTMRGETNCVFLNFLPMFHVFGLACITYAQLQKGNTIVSMPRFNLEKALWAVEKYKVTDLWVVPPVVLALAKQSVVKKYDLSSVKHVGSGAAPLGRELMEECAKNIPSAVVLQGYGMTETCGVVALENPAVGKRNSGSAGTLAPGVEAQIVSVDTLKPLPPNQYGEIWVRGPNMMLGYFNNPQATKQTIDKYGWVHTGDLGYFDENGQLYVVDRIKELIKYKGFQVAPAELEALLVSHPQILDAVVIPYPDAEAGEVPIAYVVRSTNSSLTEEDILKFVANQVSPYKRLRRVTFISSVPKSVSGKILRRELIEKVRAKI
>rna-XM_022297597.1
MDSQIPTGDDFIFRSKLPDIYIPDHLPLHTYCFDRLSQFQHRPCLINAATGHVHTYAAVHLTARRVAAGLANIGISQGDVIMILLQNSPEFVFAFLGASYGGAISTTANPLYKPAEIAKQARAANAKVIITQSAFVDKIKGFAEERGVKILCTDSPPDGCLSFSELTEADENDIPAVKINSNDVVALPYSSGTTGIPKGVMLTHKSLVTSVAQQVDGENPNLYFKSKDVILCILPLFHIYSLNSVLLCGLRVGAAILIIQKYDMSSLLHLIQAHKATVAPFVPPIVLDLAKNPDIHRYDLSSIRIVMSGAAPLGKDLEDTLKARLPNANLGQGYGMTEAGPVLSMSLTFAKEPMAVKSGACGTVVRNAEMKIIHPQTGASLPRNQPGEICIRGSQIMKGYLNNKEATEETIDKDGWLHTGDLGFIDDDDEIFIVDRLKELIKYKGYQVAPAELEALLTSNPNIAAAAVIPMKDEAAGEIPVAFVVRSGGSKISEDEIKEYVSEQVIFYKKIRKVFLVDSIPIAPSGKILRKVLRDQLQAGAF
>rna-XM_022297701.1
GDNPNLYFRNDDVILCVLPLFHIYSLNSVLLCGLRAGATILILPKFEIASLLQLVQKYRVSIAPVVPPIVLAIAKSPDLDKYDLSSIRVLKSGGAPLGKELEDTVRAKFPKAVLGQGYGMTEAGPVLTMGLAFAKEPFPMKPGACGTVVRNAEMKIVDTENGASLPRNTPGEICIRGDQIMKGYLNNPEATVATIDADGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHTVITDAAVVPMKDEQAGEVPVAFVVKSKSSEVTEDEIKQFISKQVVFYKRINRVFFIDAIPKSPSGKILRKELRAKLADVSPNSK
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University