Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Mimulus guttatus
Species name
Spotted monkey flower (Erythranthe guttata) is a species of eudicot in the family Phrymaceae.
Species info
Gene sequence info
Mimulus_guttatus.C4H.fa
Download
>MgTOL.B0683.1.v5.0
MDFHLLQKVFLSLIAAAVTAVVVSKIRGRRRNMPPGPITLPIFGSWFQVGNNLDHHDFIRYAQKFGHVFLLRMGQRRIAVVSSPELAKEVLLTQGKEFGSRSRNIVFDIFTGKGQDMIFTDYGDHWRKMRRIVTVPFFTNKVVHQYHDDWEAEADAVVEDMRNTPAASTEGVVLRRRIELMVYNIVYKIMFNKKFESEQDPLYVKLKNVNGERSRLGQSLEYNFGDFVPIFRPFLRGYLNKCKEVTRRRLNLYKDSFVQVRKKIASTEATDKNLLKCGIDHFLECQANGEINEDNVLYIVENMNVAAIETIIWTMEWAVAELINNPEIQNKLRAELDAVLGPNKQVTEPDIHKLTYLQAVIKETLRLRMVVPCLVPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKKPEEFRPERFLEEESSVEVNGNDIKYIPFGVGRRSCPGIMMAMPVLGITLGRLVQNFELFPPPGQSKIDTAENNGQFATRMSKHSTIVLKPRNII
>MgTOL.B0680.1.v5.0
MNVAAIETVIWTMEWAIAELINHPETQNKLRAELDTVLGPNKQVTESDSHKLPYLQAVIKETLRLRMVVPCLLPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKRPEEFRPERFLEEESNVEANGNDIKYIPFGAGRRNCPGIIMAMPVLNITLGRLVKNFELFPPPGQLKIDTTQNNGQFASRISKHSTIVLKPRNIV
>MgTOL.B0686.1.v5.0
MDFLLLQKVFLSLIAAAVAAVVVSKIRGRRRNMPSGPITLPIFGSWFQVGNMQLRPPRLHQIRPEIRPCLPPPNGPTPHHRRILAGAGKGGPSLRAGKGVLLTQGKEFGSRSRNIVFDIFTSKGQDMIFTDYGDDWRKMRRIVTVPFFTNKVVHQYHGDWEAETDALVEDMRNTPAASTEGVVLRRRIELLVYNNVYKIMFDKKFESEEDPLYVKLKNVNGERSRLGQSLEYNFGDFVPIFRPFLRGYLNKCKEVTRRRLNLYKDSFVEVSK
>MgTOL.D0817.1.v5.0
MDLLLLEKTLIGLFFAVIIATVVSKLRGRKFKLPPGPIPVPIFGNWLQVGDDLNHRNLTDYAKKLGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRHGWEAEIAAVVDDVRSNPAAATEGIVLRRRLQLMMYNNMYRIMFDRRFEREDDPLFVKLKSLNGERSRLAQSFEYNYGDFIPILRPLLKGYLKICKEVKEKRFQLFKDYFVDERKKLGSTKPVDNDGLKCAIDHILEAQQKGEISEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPQIQKKLRDEIDAVVGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPATWRNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGVTLGRLVQNFEMLPPPGQERIDTSEKGGQFSLHILKHSTIVLKPRSL
>MgTOL.N0711.1.v5.0
MCRKIASTEAFDKNRLKCGIDHFLECQANGEINEDNVLYIVENMNVAAIETVIWTMEWAVAELINNPEIQNKLRAELDTMLGPNKQVTEPDTHKLTYLQAVIKETLRLRMVVPCLVPHMNLHKASLGGYEIPAESRIFVNAWWLANDPAQWKKPEEFRPERFLEEDSNVEVNGNDIKYIPFGVGRRSCPGIMMAMPVLGITLGRLVQNFELFPPPGQSKIDTAENNGQFATQMSKHSTVVLKPRNII
>MgTOL.N0701.1.v5.0
MMDLLLLEKTLLGLFAAIVIAAVVSKLRGKKFKLPPGPIPVPIFGNWLQVGDDLNHRNLTEYAKKFGDILMLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRHGWEAEAAAVVDDVRNNPAAATEGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFLKLKALNGERSRLAQSFEYNYGDFIPVLRPFLRGYLKICKEVKEKRIKLFKDYFVDERKKLTSTKGADNEGLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELINHPEIQKKLRDEIDTLVGPGVQITEPDTYKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLAGYDIPAESKILVNAWFLANDEAHWKKPEEFRPERFLEEESNVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFEMLPPPGESKIDTTGKAGQFSLQILKHSTIVLKPRSF
>MgTOL.N0700.1.v5.0
MDFLLLLQKSLVALFAAVAAAIVVSKLRGRRLNLPPGPFKFPIFGSWLQVGNSLDHHDFIKYAKKFGHLFLLKMGQRHIAVISSPELAKEVLLTQGKAFGSRSRNIVFDIFTGKGQDMIFTDYGDHWRKMRRIVTVPFFTNKVVHQYHGDWEAEAAEVVEHVRSNIAAAAAEGVVLRRRLELMIYNNVYKIMFDKKFESEEDPLYVKLKSVNGERSRLGQSLEYNFGDFVPILRPFLKGYLEKCKEVTRRRLNLYKDSFVEERRKIALVEEEKDRNRVKCGIDHFLVSQQNGEINEDNVLYIVENMNVAAIETTVWALEWAIAELINNPETQKKLRAELDAVLGPNKQVTEPDTHKLPYLQAVIKETLRLRMVVPCLVPHMNLDKANLGGYEIPAESRIFVNAWWLANDPARWKNPEEFRPERFLEEESNVEANGNDIKYIPFGVGRRSCPGIIMAIPIMGITLGRLVQNFELFPPPGQSRIDTAENNGQFATRMSKQSIIVLKPRDIA
>MgTOL.O0867.1.v5.0
MVVPCLLPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKRPEEFRPERFLEEESNVEANGNDIKYIPFGAGRRNCPGIIMAMPVLNITLGRLVKNFELFPPPGQLKIDTTQNNGQFASRISKHSTIVLKPRNIV
MDFHLLQKVFLSLIAAAVTAVVVSKIRGRRRNMPPGPITLPIFGSWFQVGNNLDHHDFIRYAQKFGHVFLLRMGQRRIAVVSSPELAKEVLLTQGKEFGSRSRNIVFDIFTGKGQDMIFTDYGDHWRKMRRIVTVPFFTNKVVHQYHDDWEAEADAVVEDMRNTPAASTEGVVLRRRIELMVYNIVYKIMFNKKFESEQDPLYVKLKNVNGERSRLGQSLEYNFGDFVPIFRPFLRGYLNKCKEVTRRRLNLYKDSFVQVRKKIASTEATDKNLLKCGIDHFLECQANGEINEDNVLYIVENMNVAAIETIIWTMEWAVAELINNPEIQNKLRAELDAVLGPNKQVTEPDIHKLTYLQAVIKETLRLRMVVPCLVPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKKPEEFRPERFLEEESSVEVNGNDIKYIPFGVGRRSCPGIMMAMPVLGITLGRLVQNFELFPPPGQSKIDTAENNGQFATRMSKHSTIVLKPRNII
>MgTOL.B0680.1.v5.0
MNVAAIETVIWTMEWAIAELINHPETQNKLRAELDTVLGPNKQVTESDSHKLPYLQAVIKETLRLRMVVPCLLPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKRPEEFRPERFLEEESNVEANGNDIKYIPFGAGRRNCPGIIMAMPVLNITLGRLVKNFELFPPPGQLKIDTTQNNGQFASRISKHSTIVLKPRNIV
>MgTOL.B0686.1.v5.0
MDFLLLQKVFLSLIAAAVAAVVVSKIRGRRRNMPSGPITLPIFGSWFQVGNMQLRPPRLHQIRPEIRPCLPPPNGPTPHHRRILAGAGKGGPSLRAGKGVLLTQGKEFGSRSRNIVFDIFTSKGQDMIFTDYGDDWRKMRRIVTVPFFTNKVVHQYHGDWEAETDALVEDMRNTPAASTEGVVLRRRIELLVYNNVYKIMFDKKFESEEDPLYVKLKNVNGERSRLGQSLEYNFGDFVPIFRPFLRGYLNKCKEVTRRRLNLYKDSFVEVSK
>MgTOL.D0817.1.v5.0
MDLLLLEKTLIGLFFAVIIATVVSKLRGRKFKLPPGPIPVPIFGNWLQVGDDLNHRNLTDYAKKLGDIFLLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRHGWEAEIAAVVDDVRSNPAAATEGIVLRRRLQLMMYNNMYRIMFDRRFEREDDPLFVKLKSLNGERSRLAQSFEYNYGDFIPILRPLLKGYLKICKEVKEKRFQLFKDYFVDERKKLGSTKPVDNDGLKCAIDHILEAQQKGEISEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPQIQKKLRDEIDAVVGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLHEAKLGGYDIPAESKILVNAWWLANNPATWRNPEEFRPERFLEEESKVEANGNDFRYLPFGVGRRSCPGIILALPILGVTLGRLVQNFEMLPPPGQERIDTSEKGGQFSLHILKHSTIVLKPRSL
>MgTOL.N0711.1.v5.0
MCRKIASTEAFDKNRLKCGIDHFLECQANGEINEDNVLYIVENMNVAAIETVIWTMEWAVAELINNPEIQNKLRAELDTMLGPNKQVTEPDTHKLTYLQAVIKETLRLRMVVPCLVPHMNLHKASLGGYEIPAESRIFVNAWWLANDPAQWKKPEEFRPERFLEEDSNVEVNGNDIKYIPFGVGRRSCPGIMMAMPVLGITLGRLVQNFELFPPPGQSKIDTAENNGQFATQMSKHSTVVLKPRNII
>MgTOL.N0701.1.v5.0
MMDLLLLEKTLLGLFAAIVIAAVVSKLRGKKFKLPPGPIPVPIFGNWLQVGDDLNHRNLTEYAKKFGDILMLRMGQRNLVVVSSPELAKEVLHTQGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQNRHGWEAEAAAVVDDVRNNPAAATEGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFLKLKALNGERSRLAQSFEYNYGDFIPVLRPFLRGYLKICKEVKEKRIKLFKDYFVDERKKLTSTKGADNEGLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSIEWGIAELINHPEIQKKLRDEIDTLVGPGVQITEPDTYKLPYLQAVIKETLRLRMAIPLLVPHMNLHDAKLAGYDIPAESKILVNAWFLANDEAHWKKPEEFRPERFLEEESNVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFEMLPPPGESKIDTTGKAGQFSLQILKHSTIVLKPRSF
>MgTOL.N0700.1.v5.0
MDFLLLLQKSLVALFAAVAAAIVVSKLRGRRLNLPPGPFKFPIFGSWLQVGNSLDHHDFIKYAKKFGHLFLLKMGQRHIAVISSPELAKEVLLTQGKAFGSRSRNIVFDIFTGKGQDMIFTDYGDHWRKMRRIVTVPFFTNKVVHQYHGDWEAEAAEVVEHVRSNIAAAAAEGVVLRRRLELMIYNNVYKIMFDKKFESEEDPLYVKLKSVNGERSRLGQSLEYNFGDFVPILRPFLKGYLEKCKEVTRRRLNLYKDSFVEERRKIALVEEEKDRNRVKCGIDHFLVSQQNGEINEDNVLYIVENMNVAAIETTVWALEWAIAELINNPETQKKLRAELDAVLGPNKQVTEPDTHKLPYLQAVIKETLRLRMVVPCLVPHMNLDKANLGGYEIPAESRIFVNAWWLANDPARWKNPEEFRPERFLEEESNVEANGNDIKYIPFGVGRRSCPGIIMAIPIMGITLGRLVQNFELFPPPGQSRIDTAENNGQFATRMSKQSIIVLKPRDIA
>MgTOL.O0867.1.v5.0
MVVPCLLPHMNLHKANLGGYEIPAESRIFVNAWWLANDPAQWKRPEEFRPERFLEEESNVEANGNDIKYIPFGAGRRNCPGIIMAMPVLNITLGRLVKNFELFPPPGQLKIDTTQNNGQFASRISKHSTIVLKPRNIV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University