Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Anacardium occidentale
Species name
Cashew (Anacardium occidentale) is a species of eudicot in the family Anacardiaceae (sumac family).
Species info
Gene sequence info
Anacardium_occidentale.DFR.fa
Download
>Anaoc.0001s2387.1.v0.9
MEDVVNVVERRREGAKTYCVTGATGYIGSWLVKSLLEIGCIVHATVRDPDIALFVSLLTSSDRLSLFQADLQVEGSFDDAVKGCDGVFHVAASMEFDVPEKKNIGTVLKKLMFHQILSTLQSEADGEGKWRSVVDESCQTPIDHVWSAKASGWVYVLSKLLTEEAAFKFAEENNINIVSVITTTVAGPFLTLSVPPSIRVLLSPITGDSKFFSILSAVNTRMGSVALVHIEDICNAHIFLMDNARAEGRYICCAKSCLMTELVEYLNRVYPSSYLHKGRITVQYLLDGGFLSPITK
>Anaoc.0006s1737.1.v0.9
MENRNCKVCVTGGAGYVGSWLVNKLLEKGYTVHATLRNLDDGSKVNFLKSFPHADTRLVLFEADLYDPDTFELAIQGCEFVFHVATPFKHKEGSQFKNLTEATIAAAKSIAKLCIRCGTVKRLIYTSSMISGSPLMDDGTSFKDCIDETCWTPLNLSLNYDNHIIMEYRHSKILTEKELLRYGSNAEDGERLEVVTLDIGLVGGETLLSYTPSTVSMYISQLTNSKYLYQALRFAEDLLGKVPMVHIDDVCEAHIFCMEKPSINGRFLCASSYVSSAEIAKYYQQHYPEFEVKQEYLDGPKRDIKWGGTKLTEKGFEYKYDSEMILDDSIKCARRTGGLNR
>Anaoc.0009s0339.1.v0.9
MASESELVCVTGAAGFIGSWLIMRLLEKGYTVRATVRDPNNLNKVKHLVELPNAKTHLTLWKADMTEEGSFDEAIKGCAGVFHVATPMFFDAKDPEAEMIKPTINGMLDIMKACKKANTVRRLVFTSSAATLDVEEHKKAVYDETSWSDMEFVLATKMTGWMYFVSKTLAEQAAWKFAEENNLDFISIIPSLVVGPFLKPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLYEKPEAKGRYICSSDSATILEVSKLLREKYPEYNVPTKFKGVDENFQNYKLSSKKLTDLGFKFKYSLEDMYTGAVETCRAKGLIPLSHENRSNE
>Anaoc.0009s0342.1.v0.9
MGSESELVCVTGAAGFIGSWLIMRLLEKGYTVRATVRDPNNLNKVKHLVELPNAKTHLTLWKADMTEEGSFDEAIKGCAGVFHVATPMFFDAKDPETEMIKPTIHGMLDIMKACKKAKTVRRLVFTSSAGTLDVEEHKKAVYDETSWSDMEFVLATKMTGWMYFVSKTLAEQAAWKFAEENNLDFISIIPSLVVGPFLMPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLYEKPEAKGRYICSSDSATILEVSKLLREKYPEYNVPTKFKGVDENFQNCKFSSKKLTDLGFEFKYSLEDMYTGAVETCRAKGLIPLSHENRSNE
>Anaoc.0012s0923.1.v0.9
MISESQIVCVTGAAGFIGSWLVMRLLEKRYNVRATVRDPNNLSKVKHLLELPNAKTHLTLWKADMNEEGSFDEPIKGCTGVFHVATPMLFESNDPENEMIKPTINGLLGIMKACKKAKTVRRLVFTSSAGTVDVEEQKKSVYDETCWSDMDYVLAKKMTGWMYFASKTLAEQAAWRFAVENDIDFISIIPPLVVGPFLMPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLFENPEAKGRYMCSSDAATILQLSKMLKQKYPEYNIPSKYEGVDENLENIHFSSKKLTDLGFKFKYSLEDMFTGAVDTCRAKGLLPLSSQNPVTE
>Anaoc.0020s0658.1.v0.9
MENVVKMVECMREGDNKTYCVTGATGYIGSWLVKSLLEKGSTVHAAVRDPAKILHFVSLWTGCDRLKLFQADLHVEGSFDDAVKGCDGVFHVAASMEFDILEKQNIETYVQSNIIDPAIRGTLNLLKACLKSESVKRVVLTSSISTITAKDSDGKWRSVVDESCQTPIDHVWFTKASGWVYVLSKLLTEEAAFKFAKENNIDLVSITTTTVAGPFLTSSVPSSIRVLLSPITGNSKFLSILSAVSTRMGSIALVHIEDICDAHIFLMDNARAEGQYICCTTSCLTSELIDHLNRVYPFSNLHKFKGENPSSIPSEISSKKLKDLGFTYKHSIEDVICQTIDCCIDCGFLSAIVK
>Anaoc.0858s0004.1.v0.9
MENRNCKVCVTGGAGYVGSWLVNKLLEKGYTVHATLRNLDDGSKVNFLKSFPHADTRLVLFEADLYDPDTFELAIQGCEFVFHVATPFKHKEGSQFKNLTEATIAAAKSIAKLCIRCGTVKRLIYTSSMISGSPLMDDGTSFKDCIDETCWTPLNLSLNYDNHIIMEYRHSKILTEKELLRYGSNAEDGERLEVVTLDIGLVGGETLLSYTPSTVSMYISQLTNSKYLYQALRFAEDLLGKVPMVHIDDVCEAHIFCMEKPSINGRFLCASSYVSSAEIAKYYQQHYPEFEVKQEYLDGPKRDIKWGGTKLTEKGFEYKYDSEMILDDSIKCARRTGGLNR
MEDVVNVVERRREGAKTYCVTGATGYIGSWLVKSLLEIGCIVHATVRDPDIALFVSLLTSSDRLSLFQADLQVEGSFDDAVKGCDGVFHVAASMEFDVPEKKNIGTVLKKLMFHQILSTLQSEADGEGKWRSVVDESCQTPIDHVWSAKASGWVYVLSKLLTEEAAFKFAEENNINIVSVITTTVAGPFLTLSVPPSIRVLLSPITGDSKFFSILSAVNTRMGSVALVHIEDICNAHIFLMDNARAEGRYICCAKSCLMTELVEYLNRVYPSSYLHKGRITVQYLLDGGFLSPITK
>Anaoc.0006s1737.1.v0.9
MENRNCKVCVTGGAGYVGSWLVNKLLEKGYTVHATLRNLDDGSKVNFLKSFPHADTRLVLFEADLYDPDTFELAIQGCEFVFHVATPFKHKEGSQFKNLTEATIAAAKSIAKLCIRCGTVKRLIYTSSMISGSPLMDDGTSFKDCIDETCWTPLNLSLNYDNHIIMEYRHSKILTEKELLRYGSNAEDGERLEVVTLDIGLVGGETLLSYTPSTVSMYISQLTNSKYLYQALRFAEDLLGKVPMVHIDDVCEAHIFCMEKPSINGRFLCASSYVSSAEIAKYYQQHYPEFEVKQEYLDGPKRDIKWGGTKLTEKGFEYKYDSEMILDDSIKCARRTGGLNR
>Anaoc.0009s0339.1.v0.9
MASESELVCVTGAAGFIGSWLIMRLLEKGYTVRATVRDPNNLNKVKHLVELPNAKTHLTLWKADMTEEGSFDEAIKGCAGVFHVATPMFFDAKDPEAEMIKPTINGMLDIMKACKKANTVRRLVFTSSAATLDVEEHKKAVYDETSWSDMEFVLATKMTGWMYFVSKTLAEQAAWKFAEENNLDFISIIPSLVVGPFLKPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLYEKPEAKGRYICSSDSATILEVSKLLREKYPEYNVPTKFKGVDENFQNYKLSSKKLTDLGFKFKYSLEDMYTGAVETCRAKGLIPLSHENRSNE
>Anaoc.0009s0342.1.v0.9
MGSESELVCVTGAAGFIGSWLIMRLLEKGYTVRATVRDPNNLNKVKHLVELPNAKTHLTLWKADMTEEGSFDEAIKGCAGVFHVATPMFFDAKDPETEMIKPTIHGMLDIMKACKKAKTVRRLVFTSSAGTLDVEEHKKAVYDETSWSDMEFVLATKMTGWMYFVSKTLAEQAAWKFAEENNLDFISIIPSLVVGPFLMPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLYEKPEAKGRYICSSDSATILEVSKLLREKYPEYNVPTKFKGVDENFQNCKFSSKKLTDLGFEFKYSLEDMYTGAVETCRAKGLIPLSHENRSNE
>Anaoc.0012s0923.1.v0.9
MISESQIVCVTGAAGFIGSWLVMRLLEKRYNVRATVRDPNNLSKVKHLLELPNAKTHLTLWKADMNEEGSFDEPIKGCTGVFHVATPMLFESNDPENEMIKPTINGLLGIMKACKKAKTVRRLVFTSSAGTVDVEEQKKSVYDETCWSDMDYVLAKKMTGWMYFASKTLAEQAAWRFAVENDIDFISIIPPLVVGPFLMPSMPPSLITALSPITGNEDHYSIIKQGQFVHLDDLCNAHIFLFENPEAKGRYMCSSDAATILQLSKMLKQKYPEYNIPSKYEGVDENLENIHFSSKKLTDLGFKFKYSLEDMFTGAVDTCRAKGLLPLSSQNPVTE
>Anaoc.0020s0658.1.v0.9
MENVVKMVECMREGDNKTYCVTGATGYIGSWLVKSLLEKGSTVHAAVRDPAKILHFVSLWTGCDRLKLFQADLHVEGSFDDAVKGCDGVFHVAASMEFDILEKQNIETYVQSNIIDPAIRGTLNLLKACLKSESVKRVVLTSSISTITAKDSDGKWRSVVDESCQTPIDHVWFTKASGWVYVLSKLLTEEAAFKFAKENNIDLVSITTTTVAGPFLTSSVPSSIRVLLSPITGNSKFLSILSAVSTRMGSIALVHIEDICDAHIFLMDNARAEGQYICCTTSCLTSELIDHLNRVYPFSNLHKFKGENPSSIPSEISSKKLKDLGFTYKHSIEDVICQTIDCCIDCGFLSAIVK
>Anaoc.0858s0004.1.v0.9
MENRNCKVCVTGGAGYVGSWLVNKLLEKGYTVHATLRNLDDGSKVNFLKSFPHADTRLVLFEADLYDPDTFELAIQGCEFVFHVATPFKHKEGSQFKNLTEATIAAAKSIAKLCIRCGTVKRLIYTSSMISGSPLMDDGTSFKDCIDETCWTPLNLSLNYDNHIIMEYRHSKILTEKELLRYGSNAEDGERLEVVTLDIGLVGGETLLSYTPSTVSMYISQLTNSKYLYQALRFAEDLLGKVPMVHIDDVCEAHIFCMEKPSINGRFLCASSYVSSAEIAKYYQQHYPEFEVKQEYLDGPKRDIKWGGTKLTEKGFEYKYDSEMILDDSIKCARRTGGLNR
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University