Enzyme

Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.

COMT

Enzyme

Flavone 3'-O-methyltransferase

Enzyme name

EC:2.1.1.76

Entry

Transferases;Transferring one-carbon groups;Methyltransferases

Class

S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase

Sysname

S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]

Reaction

S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]

Product

Species information

Mikania micrantha

Species name

Bittervine (Mikania micrantha) is a species of eudicot in the family Asteraceae (daisy family).

Species info

Gene sequence info

Mikania_micrantha.COMT.fa

Download
>rna-gnl|WGS:SZYD|E3N88_mrna00564
MAKPKSGSIVPSKETRLLILELANMLSVPMSLNAVVHLKVADAMWQDGSNTPLTASEIVARLPDAANADAENLQRILRMLTSYGVFNEKINASERRYSLTDVGKTLVTDENGLSYGAYVLQHHQDPLMKAWPIVHEAVLDSSTEPFVIANGMSAYDMYSQNPEMNKLMQQAMSGVSVPFMNAILETYHGFDGAETLVDVGGSSGESLKMIIDKHPEIKTAINFDLPEVLAEAPDIPGITKWPGDFFESVPNGDTLFMKWILTTWTDDEVKQILNNCHKALPDQGDGRIKICSISRHHCLGDTPAKHDMLSQWLMNLVMVDTNSFEAGSIDTTQPNLAVSAYEGDDVVHPSTLRRHPYSCVETDGISPK
>rna-gnl|WGS:SZYD|E3N88_mrna00555
MAKPKSGSIVPSKETRLLILELANMLSVPMSLNAVVHLKVADAMWQDGSNTPLTASEIVARLPDAANADAENLQRILRMLTSYGVFNEKINASERRYSLTDVGKTLVTDENGLSYGAYVLQHHQDPLMKAWPIVHEAVLDSSTEPFVIANGMSAYDMYSQNPEMNKLMQQAMSGVSVPFMNAILETYHGFDGAETLVDVGGSSGESLKMIIDKHPEIKTAINFDLPEVLAEAPDIPGITKWPGDFFESVPNGDTLFMKWILTTWTDDEVKQILNNCHKALPDQGGKLIVCEPVLPPDTDDSNRTRALLEGDIFVMTIYRAKGYHRTEEQYKELGIATGFPNFKSFPYFDDFWTLFEYTK
>rna-gnl|WGS:SZYD|E3N88_mrna00420
MENRNAETRTSGTIVHSNETRLAILELANMISVPMALNAVVNLKVADSMWQNGSNTPLTASEIVSHIHPSGTADAENLQRILRMLTSFGVFNEHINAAERRYSLTDVGKTLVTDENGLSYGAYVLQHHQDPLMKAWPNVHEAVLDSSTEPFVKANGMSAYDMYGENPEMNDLMQKAMSGVSVPFLNAILETYDGFDGLERLVDVGGSSGESLKMIIEKHPKIKEAINFDLPEVVARAPEIDGVTHVGGDMFACVPKGDAIFMKWILTTWTDDEVKQILNNCFKAIPDGGKVIACEPVLPHNTDDTHRTRALLEGDIFVMTIYRAKGYHRTEEEYSKLGKLTGFTSFRAIYIDYFWTILEYKK
>rna-gnl|WGS:SZYD|E3N88_mrna21646
MELANSVSLAMVLVNIVKLKVLETIAEKGPDARLSSHEIASRLSISNQDAPDMLDRMLRLLASHSIVTCSEGVHDSKPVRVYGLTPVAKYFIPNDNGASLGPFLELVQDKVFIQSCSWIDARFNEVFNKAMVNHTTIVMTEILKHYNGFDNLKSLVDVGGGLGIALSMIVSKNPTIKGINFDLPHVIQHSPIYQGIEHVGGDMFIEVPQGDVIFMKWILHDWSDDYCAKLLKNCYKALPENGKVIIVEAILPFLPNTSSSFRVSTYLDVSMMTQNPGGKERTENEFLTLAKCAGFRGIRKERFVCNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna21644
MGSDMDHFTYALELVSSTSLTMVLVNIIKLKVLETMAEVGPNARLSAHDIASRLSIPNQDAADMIDRMLRLLASHSIVTCTEGVHDSKPVRVYGLTPVAKYFIPNEDGASLGPLIQLAQDKVFIKSWFELEDSVLKGGVPFHNLYGRHIFEYSALDPRFNDVLNVAMVNYNTMVFKQILKHYHGFDTLKCVVDVGGGFGVTLNMILSKYPTIKGINFDLAHVIQHAPIYPGIEHVGGDMFKKVPQGDAIFMKWILHDWSDDYCVNLLKNCHKALPEHGKVIVVEAILPFLPDTSCSVKVTTNFDAIMMTQNPGGRERTEVEFLALAKDAGFSGIRKKCFVCNLWVFEIYK
>rna-gnl|WGS:SZYD|E3N88_mrna21643
MDSNMDHFTHAMELANSTSLTMVLVNIIKLKVLETIAEAGPDAQLSSHDIASRLAIPNQNAPDKLDRMLRLLASHSIVTCNEGVHKSRPVRVYGLTPVAKHFIPNKDGASLGPLMELLQDKVFIDSWFELEDAVFNGGVPFDKVHGSHAFEYPALDARSSSQQRLRQLIITLLWSEKSVCKHVEDTSQALDRQEGVGAALETPGQQVRVASRGQAYRLAWVRVAPSLRAGAPDEAPSSSSARIAWDGGFGSGVLPGPYVRPNMPILLF
>rna-gnl|WGS:SZYD|E3N88_mrna24981
MLQDKVFIESCADWRLPWGLPDWGVDFGLHSSGFGRRWDLKKPSLKEVWHLKRFIGVHAFEYLALDARLNEVFNKAMLDHTSIVMKEVLECYDGFNDVKRVVDVGGGLGITINMIVTKHPNIMGINFDLPHVTKCAPFYQGVEHVGGDMFKEVPQGDAIFMKWILHDWSDDHCVKLLKNCYKALPYNGKVIVVDAILSFVPDTSSSTKINSHMDAIMLANHHGKERTEDEFLALAKSAGFMGLRKICFACNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna06672
MGSTSVSVSAVEANQDESFLFAMQLATASVLPMVLKTAIELDLLETINAKAGPDGSLSSAELVAQLPKVNNPEAPVMIDRICSLLASHSVLTCTLKETDDGCVERFYGLAPVCKFLIKNDGGVSLAPLLLMNQDKVLMESWYYLKDAVLDGGIPFNKAYGMSAFEYHGKDQRFNKVFNSGMFNHSTMTMKKIVDLYDGFSGLKTLVDVGGGIGASLNMITSKHTSLKGINFDLPHVIEDATAYHGIEHVGGDMFESVPKGDAIFMKWILHDWSDAHCLKILKNCYKSLPENGKVIVAECILPEAPDSTKATQNVIHIDVIMLAHNPGGKERTEKEFEALAKGAGFKGFNKAACALNTWVMEFCK
>rna-gnl|WGS:SZYD|E3N88_mrna11275
MGSSQEADYRMSEEEEGLLRMNQIKGGIVLPMVIKTAIELDLFETMAKTPGGRFSCFDLASSLPRQNHQTSALIERILRFLASYSVLTSTMVKDEHGESKMLYGMTPVSNDYVRNQDGTSHASSLLLIYDKVLVDCWYHLKDAVQDGGTPFDKAHGVNAFVYPAIDNRFNEVFNKCMYDNTRIVMKMILEKYKGFEGVKQLIDVGGGLGANLELIVSKYPSIKGINFDLPHVIKDAPPYQGVEHVGGDMFQSVPKGDVIFMKWILHDWGDTYCIKLLKNCWAALPECGKLVVVEAIVSDPENDINCSDEVSKTVVGGDIIMLIANPGGKERTIKEYNLLAKEAGFSSLEIVCRVSTFWVMEFYKNT
>rna-gnl|WGS:SZYD|E3N88_mrna11274
MGSSQGADYRMSEEEEGLLRVNQINGGIVLPMVIKTAIELDLFETMAKTPGGRFSCFDLASSLPRQNHQTSALIERILRFLASYSFLTSTMVKDEHGESKMLYGMTPVSNNYVRNQDGTSHASSLLLIYDKVLVDCWYHLKDAVLDGGTPFDKVHGVNAFEYPAKDNRFNEVFNKCMYDNTRIVMKMILEKYKGFEGVKQLIDVGGGLGANLELIVSKYPSIKGINFDLPHVIKDAPPYQGVEHVGGDMFQSVPEGDVIFMKWILHDWGDTYCIKLLKNCWASLPECGKLVVVEAIITDPENDINCSDEVSKTAVGGDIIMLIANPGGKERTVKEYNVLAKEAGFSSLEIVCRVSTFWVMEFYKNT
>rna-gnl|WGS:SZYD|E3N88_mrna10110
MSHYQYLRVLDTIAESGPNAQLSAHEIATCLSISNLDAPNKLDRMLQLLASYSVVTCTQEMRETKPVKVYGLTPVAKHFIKNEDGVSFCSMMDLHLDEVTIKSWLKLKDSVVEGGAPLNKVTGMEIHEYMASDHRFTGVFNKAMKDTSIILLKEILKDYDGFNNLKTLVDVGGGQGGNLYMIVSKYKNIKGINFDLPTVISRAPQLPGVEHVAGDMFCSVPQGDAIFLKNCYKALPDDGIVIIVEKIVPFLPDTGSLMKADTHIDALMLTLTHGGKERTEEEFLKLAIQSGFSGMRKKCFKCTFWVIEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna10111
MDIIDDQEDDYTYALQLATSIALPMVLLNVIKLKVLDTIAGSGPDARLSAHEIATRLSISNNDAPDKLDRMLQLLASHSVVTCTQEDHESKPIRVYGLAPVAKHFIQNDDGVSFGPMMDLQQDEVTVKSWLKLRDSVVGGGTPLDKVTGMKGYEYMAFDQRFTGVFNKAMKDTSTILMKEILIHYDGFNNLKTLVDVGGGLGGNLYMIVSKHKNIKGINFDLPTMINRAPQFPGIEHVAGDMFDSVPQGDAIFLKWIVHGWGDDDCIKFLKNCYKALPDDGKVIIVEKIVPFLPNTSSSTKADTHLDAFMLTLTHGGKERTEEEFLMLALESGFSGMRKKCFKCTFWVIEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna18216
MGSNEHFNYAMELVTITALPMVLMTIVKLKILETIAEAGSDAQLTAKEIASRLSITNEDAPDMVDRMLRLLTSYSVVTCSKAIHESIPVRVYGLTPVGKYFTPNEDGASLGDMMLFAQDKVYIESWFGLKDSVFEGGVAFNKIHKMHPFEYPAFDTRYNEVFNKAMKNHTIILMKEILEHYHGFNNLKSVIDVGGGLGININMIVTKYPSITGINFDLPHVTDHAPFYEGIKHVGGDMFKEIPQGDAIFMKWILHDWNDEHCVKLLKNCYKALPQDGKVIVVELILPFVPDTSSTTKYTTLLDAVMLAESPKGKERTEDEYLALAKSAGFTGLKKICYVCNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna18886
MSSNDHFIYAMELATSMSLSMVLVTVIKLKVLEAIAEAGQDAPLTAKEIVSRLLITNQEAPDMVDRMLRLLASYSIVTCTEAIHESKPVRVYGLTPVAKYFIPNEDGASLGATMQLAQDKVFIESWLGLKDSVIEGGVAFDKVHGVHAFEYPSLNARFNEVFNKAMLDHTTIVMKEVLECYDGFKNLKRVVDVGGGLGITINMIVTKYPKITGINFDLPHVTQCAPLYQGIQHVGGDMFKEVPQADAVFMKWILHDWSDDHCVKLLKNCYKALPDDGKVIVVEVILPFVPDTSSSTKLNTLVDAVMLANYHGGKERTEDEFLALAKSAGFMGIRKICFACNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna18817
MKTYPLKRLTGLSKLFNDGMACDARAAVTAVIEGCPEVFEGLKTLVDVGGGDGTALPMIVEACPWIKGFNFDLPHVVSVAPPCVGVEHVGGSMFDHVPKADAVYLMKVLHDWADDDCIAILKNCRDSIPKDTGKVIVVDAIVGREPPKNGPMCFKKLDSLVI
>rna-gnl|WGS:SZYD|E3N88_mrna18891
MSSNEHFNYAMQLVTSTSLTMVLTTIIKLRVLDTIAKAGSDAQLTAKEIVSRLLIPNQEAPDMVDRMLRLLASYSIVTCTEVVHESKPVRAYGLTPIANYFIPNEDGASLCALLQLNQDKASNESWLGLKDSVIEGGVAFNKVHGMHAFEYQALDARSNELFNKAMLDHTTIVMKEVLECYDGFKNLKCVVDVGGGLGITINMIVAKHPNIMGINFDLPHVIQHAPLYQGIEHVGGDMFEDVPQADAILMKSILHDWSDDHCVKLLKNCYKALPNNGKVIVVEMILPFVPDTSSSTKLNTQLDAIMLAIYGRGKERTEDELLALAKSAEFKGLKKICFACNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna18895
MGLNEHFIYAMELVTSTSLIMVLANVIKLKILETIAEAGPDARLTAKEIVSRLLIPNQDAPDMVDRMLCLLASYSVVTCTEAVHESKPVRVYGLTPVAKYFIPNEDGASLGAMFQLSQEKAYFESGLALKDAVIEGGFAFHKVHGMHSFEYQSLDERLNEVFNKAMKEHTTIVMKELLNCYNGFNNLKRVVDVGGGLGITINMIVTKHPNIMGINFDLPHVTRHAPSYQGVEHVGGDMFKEVPQGDAIFMKWILHDWSDDHCVKLLKNCYKALPDDGKVIVVDVILPFVPDTSSFTKLNINMDAQMLAHYHGGKERTEDEFLALAKQAGFIGLKKICTVCNFWVMEFYK
>rna-gnl|WGS:SZYD|E3N88_mrna18893
MSLESIAEAGSDAQLTAKEIVSRLLIPNQEAPDMIDRMLRLLASYSIVTCTKVVRESKPVRVYGLTPIANYFIPNEDGASLGALLQLNQDRVFIESWFGLKDSVIEGGVAFKKVHGVHAFEYQALDASFNEAFNKAMLDHTTIVMKEVLECYDGFKNLKCVVDVGGGLGITINMIVAKHPNIMGINFDLPHVTQHAPLYQGIKHVGGDMFEDVPQADAIFMKWILHDWSDDHCVKLLKNCYKALPNDGKVIVVEMLLPFVSDTSSSTKLIAHLDAIMLANYHGGKERTEDEFLALAKSAQFKGLKKICFVCNFWVMEFYK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University