Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Mikania micrantha
Species name
Bittervine (Mikania micrantha) is a species of eudicot in the family Asteraceae (daisy family).
Species info
Gene sequence info
Mikania_micrantha.CHS.fa
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>rna-gnl|WGS:SZYD|E3N88_mrna01078
MVSIQEFRNTQRAEGPAMIMAIGIATPPNCVLQSTYPDNYFGITKGDHMQELKQKFKRICNNSTIKKRYLYLTDDMLKDKPNICDYMAPSLNDRQDITVEEVPKLGEQAATVAMTEWGQPKSKITHLVFGTSCGVDMPAADYQLTKLMGLNPSIKRFVMYQHGCYGGGSILRLAKDLAENNKGARVLIVCSELSSAVCFHGPDETNIDNLVGRALFGDGAAALIVGSDPLVGVEKPLFEIVNVSQTIVPESEGVLVGHTRECGLLFHISEKIPRLVSKNIEGCLEEAFKPFNIKNWNSIFWVVHPGGPAILNEVENKLALEPDKLRASRHVLREYGNMWGATVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGLTIETVVLRAVDLIHLAALNTQIENNLDRVIGYIGRKPLKVLVQVNTSGETCFKPFVEACIDADEKSEVVKYISKLADPREKQSWFTGLRTIFTTYSSSGITTTSHYGVEQVVHDQKDDDQRWRSWGRQGAEPVARVILLVTVSMKAMGSQSGRGKSDALKSDYKNELKRHFDAYGGYDNVENEKNHPPDTQTREAWEKIIDELFINANFMKRSVKNASNRSKQLYATAGGNARYGNFKHAQGLEEDTHEERRWKGE
>rna-gnl|WGS:SZYD|E3N88_mrna01076
MYLTDEILKEKTSICNYMAPSLNDRQDIVVEEVPKLGEQAATQAITEWGQHKSKITHLVFSTSSGINMPTADYRLAKLMGLNPSIKRFVMYQNGCYGGGLVLRLAKDLAENNKGARVLVVCSEISSATCFHGPDETNIDNLIGRALFADGAAALIVGSDPLIGVEKPMFEIVNVTQTIVPDSDADLTGHTRECGLLYHISEKIPSLISKNIEGCLEEAFQPFNIKNWNSIFWVVHPGGPAILNEVEKKLALEPDKLRASRHVLHEYGNMWSGTVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGVTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna02403
MASSIDIAAIREAQRAQGPATILAIGTATPSNCVYQADYPDYYFRITKSEHMVDLKQKFKRMCDKSMIRKRYMHLTEEFLKENPQICEYEAPSLNSRQDVVVVEVPKLGKEAAVKAIKEWGKSKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSDTHLDSMVGQALFGDGAAAVVVGSDPDLTTERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKALAQAFSPLGIADWNSIFWIAHPGGPAILDQVELKLGLKEEKMRATRHVLSEYGNMSSACVLFILDEMRKKSVEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMLVAPQD
>rna-gnl|WGS:SZYD|E3N88_mrna02404
MASSIDIAAIREAQRAQGPATIFAIGTANPSNCVYQADYPDYYFRITKSEHMVDLKQKFKRMCDKSMIRKRYMHLTEEFLKENPQICEYEAPSLNSRQDVVVVEVPKLGKEAAVKAIKEWGKSKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSDTHLDSMVCQALFGDGAAAVIVGSDPDLTTERPLFELVSAAQTILPDSEGAIEGHLREVGLTFHLLKDVPGLISKNIEKALTQAFSPLGIADWNSIFWITHPGGPAILDQVELKLGLNKEKMRATRHVLSEYGNMSSVCVLFILDEMRKKSVEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMLVAPQD
>rna-gnl|WGS:SZYD|E3N88_mrna01162
MVSIQEFRNTQRAEGPAMIMAIGIATPPNCVLQSTYPDNYFGITKGEHMQELKQKFKRICNNSTIKKRYLYLTDDMLKDKPNICDYMAPSLNDRQDITVEEVPKLGEQAATVAMTEWGQPKSKITHLVFGTSCGVDMPAADYQLTKLMGLNPSIKRFVMYQHGCYGGGSILRLAKDLAENNKGARVLIVCSELSSAVCFHGPDETNIDNLVGRALFGDGAAALIVGSDPLVGVEKPLFEIVNVSQTIVPESEGVLVGHTRECGLLFHISEKIPRLVSKNIEGCLEEAFKPFNIKNWNSIFWVVHPGGPAILNEVEKKLALKPDKLRASRHVLREYGNMWGATVLFILNEMRHASVMRGLETTGEGLEWGVLFGIGPGLTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna01161
MYLTDEILKEKTSICNYMAPSLNDRQDIVVEEVPKLGEQAATQAITEWGQHKSKITHLVFSTSSGINMPTADYRLAKLMGLNPSIKRFVMYQNGCYGGGLVLRLAKDLAENNKGARVLVVCSEISSATCFHGPDETNIDNLIGRALFADGAAALIVGSDPLIGVEKPMFEIVNVTQTIVPDSDADLTGHTRECGLLYHISEKIPSLISKNIEGCLEEAFQPFNIKNWNSIFWVVHPGGPAILNEVEKKLALEPDKLRASRHVLHEYGNMWSGTVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGVTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna02097
MGVFRLQTLVANAKQLIKLNHKHQKDVPKGHLAVYVGEIQRKRFVVPLSYLDQPLFQDLLRRSEEEFGFNHPMGGLTIPCCEEVFNHLTSQLQNNVGKASILALGKAFPNQLVMQDLLVDGYFKDTNCDDPDLKRKLTRLCKTTTVKTRYVVMSQEILKEYPELALEGLPTVKQRLDICNKAVTQMAIEASESCIKKWGRPVSDITHLVYVSSSEARLPGGDIYLAKGLGLSPDTNRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSVKRPYDLVGVALFGDGAGAMIVGSEPVGPESPLFELHTAIQNFLPDTEKVIDGRLTEEGISFRLDRELPEIIEDNVKGFCDKLLGHFKLENIGYNNLFWAVHPGGPAILSRIEKKFDLWPEKLSASRRALADYGNASSNTIVYVLEYLIEESLKRKNEGKDGGPDLGLILAFGPGVTFEGILTRNLTV
>rna-gnl|WGS:SZYD|E3N88_mrna26701
MSNSNSPRLPTPGKATVLAIGKAFPSQLVPQDCLVEGYFRDTNCVDFAMKQKLERLCKTTTVKTRYTVMSKEILDKYPELATEGSSTISQRLTIANQAVTQMAKEASLACFKQWGRSAEHITHLVYVSSSEIRLPGGDLYLASELGLRNDVNRVMLYFLGCYGGVTGLRIAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAALMEKGEGVLEDFNELFWAVHPGGPAILNRLEARLKLRGDKLECSRRALMDFGNVSSNTIFYVLEYMRDELIMKNKAQEWGLALAFGPGITFEGILLRSLNYN
>rna-gnl|WGS:SZYD|E3N88_mrna30005
MASTMAGIDVEMIRKAQRAQGPAAILAIGTATPSNCIYQADYPDYYFRITKSEHMVHLKEKFQRMSDYQLTKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAVIIGSDPDLSVERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGIISKNIEKALTQAFSPLGINDWNSIFWIAHPGGPAILDQVELKLGLEENKMRATRHVLSEYGNMSSACVLFILDEMRKNSVEEGKTTTGEGLDWGVLFGFGPGLTVETVVLHGLPITMPIAT
>rna-gnl|WGS:SZYD|E3N88_mrna11909
MMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPDETHLDSLVGQALFGDGAAAIIVGSDPLPDIEKPLFEILSAAQTILPDSRGAIDGHLREVGLTFHLLKDVPGLISKHIEKSLEEAFQPLGIDDWNSLFWIAHPGGPAILDQVEEKLALTPDKLRASRHVLSEYGNMSSACVLFILNEMRHSSATDGFNTTGEGLKWGVLFGFGPGLTVETVVLHSVPI
>rna-gnl|WGS:SZYD|E3N88_mrna20492
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGRFLDSKSIGKMMFDEIEVTIRTE
>rna-gnl|WGS:SZYD|E3N88_mrna20490
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGVSQLPFACGCRLKMGNRLSRTEARWCSTEWKLLARMMLHRRMAFPNRMASDWKGTNGCADRRKKLRTNEDLSNGGGSRMTERWWSNGGGVRRTKAPNESWPIERG
>rna-gnl|WGS:SZYD|E3N88_mrna20491
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGRFLDSKSIGKMMFDEIEVTIRTE
MVSIQEFRNTQRAEGPAMIMAIGIATPPNCVLQSTYPDNYFGITKGDHMQELKQKFKRICNNSTIKKRYLYLTDDMLKDKPNICDYMAPSLNDRQDITVEEVPKLGEQAATVAMTEWGQPKSKITHLVFGTSCGVDMPAADYQLTKLMGLNPSIKRFVMYQHGCYGGGSILRLAKDLAENNKGARVLIVCSELSSAVCFHGPDETNIDNLVGRALFGDGAAALIVGSDPLVGVEKPLFEIVNVSQTIVPESEGVLVGHTRECGLLFHISEKIPRLVSKNIEGCLEEAFKPFNIKNWNSIFWVVHPGGPAILNEVENKLALEPDKLRASRHVLREYGNMWGATVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGLTIETVVLRAVDLIHLAALNTQIENNLDRVIGYIGRKPLKVLVQVNTSGETCFKPFVEACIDADEKSEVVKYISKLADPREKQSWFTGLRTIFTTYSSSGITTTSHYGVEQVVHDQKDDDQRWRSWGRQGAEPVARVILLVTVSMKAMGSQSGRGKSDALKSDYKNELKRHFDAYGGYDNVENEKNHPPDTQTREAWEKIIDELFINANFMKRSVKNASNRSKQLYATAGGNARYGNFKHAQGLEEDTHEERRWKGE
>rna-gnl|WGS:SZYD|E3N88_mrna01076
MYLTDEILKEKTSICNYMAPSLNDRQDIVVEEVPKLGEQAATQAITEWGQHKSKITHLVFSTSSGINMPTADYRLAKLMGLNPSIKRFVMYQNGCYGGGLVLRLAKDLAENNKGARVLVVCSEISSATCFHGPDETNIDNLIGRALFADGAAALIVGSDPLIGVEKPMFEIVNVTQTIVPDSDADLTGHTRECGLLYHISEKIPSLISKNIEGCLEEAFQPFNIKNWNSIFWVVHPGGPAILNEVEKKLALEPDKLRASRHVLHEYGNMWSGTVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGVTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna02403
MASSIDIAAIREAQRAQGPATILAIGTATPSNCVYQADYPDYYFRITKSEHMVDLKQKFKRMCDKSMIRKRYMHLTEEFLKENPQICEYEAPSLNSRQDVVVVEVPKLGKEAAVKAIKEWGKSKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSDTHLDSMVGQALFGDGAAAVVVGSDPDLTTERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGLISKNIEKALAQAFSPLGIADWNSIFWIAHPGGPAILDQVELKLGLKEEKMRATRHVLSEYGNMSSACVLFILDEMRKKSVEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMLVAPQD
>rna-gnl|WGS:SZYD|E3N88_mrna02404
MASSIDIAAIREAQRAQGPATIFAIGTANPSNCVYQADYPDYYFRITKSEHMVDLKQKFKRMCDKSMIRKRYMHLTEEFLKENPQICEYEAPSLNSRQDVVVVEVPKLGKEAAVKAIKEWGKSKSKITHLIFCTTSGVDMPGADYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSDTHLDSMVCQALFGDGAAAVIVGSDPDLTTERPLFELVSAAQTILPDSEGAIEGHLREVGLTFHLLKDVPGLISKNIEKALTQAFSPLGIADWNSIFWITHPGGPAILDQVELKLGLNKEKMRATRHVLSEYGNMSSVCVLFILDEMRKKSVEDGAATTGEGLDWGVLFGFGPGLTVETVVLHSLPTTMLVAPQD
>rna-gnl|WGS:SZYD|E3N88_mrna01162
MVSIQEFRNTQRAEGPAMIMAIGIATPPNCVLQSTYPDNYFGITKGEHMQELKQKFKRICNNSTIKKRYLYLTDDMLKDKPNICDYMAPSLNDRQDITVEEVPKLGEQAATVAMTEWGQPKSKITHLVFGTSCGVDMPAADYQLTKLMGLNPSIKRFVMYQHGCYGGGSILRLAKDLAENNKGARVLIVCSELSSAVCFHGPDETNIDNLVGRALFGDGAAALIVGSDPLVGVEKPLFEIVNVSQTIVPESEGVLVGHTRECGLLFHISEKIPRLVSKNIEGCLEEAFKPFNIKNWNSIFWVVHPGGPAILNEVEKKLALKPDKLRASRHVLREYGNMWGATVLFILNEMRHASVMRGLETTGEGLEWGVLFGIGPGLTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna01161
MYLTDEILKEKTSICNYMAPSLNDRQDIVVEEVPKLGEQAATQAITEWGQHKSKITHLVFSTSSGINMPTADYRLAKLMGLNPSIKRFVMYQNGCYGGGLVLRLAKDLAENNKGARVLVVCSEISSATCFHGPDETNIDNLIGRALFADGAAALIVGSDPLIGVEKPMFEIVNVTQTIVPDSDADLTGHTRECGLLYHISEKIPSLISKNIEGCLEEAFQPFNIKNWNSIFWVVHPGGPAILNEVEKKLALEPDKLRASRHVLHEYGNMWSGTVLFILNEMRHASVTRGLETTGEGLEWGVLFGIGPGVTIETVVLRGVSI
>rna-gnl|WGS:SZYD|E3N88_mrna02097
MGVFRLQTLVANAKQLIKLNHKHQKDVPKGHLAVYVGEIQRKRFVVPLSYLDQPLFQDLLRRSEEEFGFNHPMGGLTIPCCEEVFNHLTSQLQNNVGKASILALGKAFPNQLVMQDLLVDGYFKDTNCDDPDLKRKLTRLCKTTTVKTRYVVMSQEILKEYPELALEGLPTVKQRLDICNKAVTQMAIEASESCIKKWGRPVSDITHLVYVSSSEARLPGGDIYLAKGLGLSPDTNRVMLYFSGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGYKPPSVKRPYDLVGVALFGDGAGAMIVGSEPVGPESPLFELHTAIQNFLPDTEKVIDGRLTEEGISFRLDRELPEIIEDNVKGFCDKLLGHFKLENIGYNNLFWAVHPGGPAILSRIEKKFDLWPEKLSASRRALADYGNASSNTIVYVLEYLIEESLKRKNEGKDGGPDLGLILAFGPGVTFEGILTRNLTV
>rna-gnl|WGS:SZYD|E3N88_mrna26701
MSNSNSPRLPTPGKATVLAIGKAFPSQLVPQDCLVEGYFRDTNCVDFAMKQKLERLCKTTTVKTRYTVMSKEILDKYPELATEGSSTISQRLTIANQAVTQMAKEASLACFKQWGRSAEHITHLVYVSSSEIRLPGGDLYLASELGLRNDVNRVMLYFLGCYGGVTGLRIAKDIAENNPGSRVLLTTSETTILGFRPPNKSRPYDLVGAALFGDGAAAALMEKGEGVLEDFNELFWAVHPGGPAILNRLEARLKLRGDKLECSRRALMDFGNVSSNTIFYVLEYMRDELIMKNKAQEWGLALAFGPGITFEGILLRSLNYN
>rna-gnl|WGS:SZYD|E3N88_mrna30005
MASTMAGIDVEMIRKAQRAQGPAAILAIGTATPSNCIYQADYPDYYFRITKSEHMVHLKEKFQRMSDYQLTKLLGLRPSVKRYMMYQQGCFAGGTVLRLAKDLAENNKDARVLVVCSEITAVTFRGPSESHLDSLVGQALFGDGAAAVIIGSDPDLSVERPLFELVSAAQTILPDSEGAIDGHLREVGLTFHLLKDVPGIISKNIEKALTQAFSPLGINDWNSIFWIAHPGGPAILDQVELKLGLEENKMRATRHVLSEYGNMSSACVLFILDEMRKNSVEEGKTTTGEGLDWGVLFGFGPGLTVETVVLHGLPITMPIAT
>rna-gnl|WGS:SZYD|E3N88_mrna11909
MMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPDETHLDSLVGQALFGDGAAAIIVGSDPLPDIEKPLFEILSAAQTILPDSRGAIDGHLREVGLTFHLLKDVPGLISKHIEKSLEEAFQPLGIDDWNSLFWIAHPGGPAILDQVEEKLALTPDKLRASRHVLSEYGNMSSACVLFILNEMRHSSATDGFNTTGEGLKWGVLFGFGPGLTVETVVLHSVPI
>rna-gnl|WGS:SZYD|E3N88_mrna20492
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGRFLDSKSIGKMMFDEIEVTIRTE
>rna-gnl|WGS:SZYD|E3N88_mrna20490
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGVSQLPFACGCRLKMGNRLSRTEARWCSTEWKLLARMMLHRRMAFPNRMASDWKGTNGCADRRKKLRTNEDLSNGGGSRMTERWWSNGGGVRRTKAPNESWPIERG
>rna-gnl|WGS:SZYD|E3N88_mrna20491
MIKKRFMVLTEEFLKNSPNMCEYMTPSLNTRQDLMITEIPMLGKEAATKAIDEWGLPRSKITHLIFCTTSGIDMPSADIRLIKLLGLSPSVNRLMMYQQGCSGGGMVLRLAKDIAENNKGSRVLVVCSETMASIFCGPSENHVDLLVGQALFGDGAAAIIVGSDPDSETERPLFEIVSANQTFIPNTEMAIRLQMREEGLILHLDKETPDIISENIQNVLTKAVSPHGLSDWNSLFWVVHPGGRRILDNLELKLNLNKHKLRASRHVLSEYGNMTSACALFVIDEMRRKSLEDGKSTTGEGLDWGVLIGRFLDSKSIGKMMFDEIEVTIRTE
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University