Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Melastoma candium
Species name
Species info
Gene sequence info
Melastoma_candium.COMT.fa
Download
>Mecan_G10643.1
MTSSHHVNVPSPPTATPPLAGDDSEDVHLGKLAIRLANGVVVPMVLKSVLELGVVDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVRESVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWLVFQNPVAS
>Mecan_G20795.1
MRMDSIDDEEEAIVRASILTSFFMVPMVLNATIELGVLDIIHRASVDGGISAAGIASSISHRNPGAALVLDRMMRLLASHSILTCSSCTTLDDNRRMTTEKLYRLAPIGKLFTKDAEGGSMAGFLTFSQHQAILDIRHRVCHNWGDDKCSKILQKCHEALPRGGKLIMIESILAETPDPSEESKYVSQFDNLMLSQHEGKERTEGEFASLGKESGFAGFEVVCCACAHWVMEFRKGT
>Mecan_G30276.1
MKSILHVYSGFEGLTSLVDVGGGTGKCFNMVITEYPGIKGINFDLDHVTKSAPSSTFILKVEAIMLKDDESGVKILKNCYEALPVEGKCSRRSRRPQWNKCTRLSGGQERTVNEFRALSEADGFAELKAVCTVSKLWVAIKLHKMRAPEN
>Mecan_G00581.1
MISSPLPSSLNHKMSVQEVQITTPAEDDDFLFAMEIASISALPFVTKTIIELGIIDAVAASPLSPSEVASRISSRNPDAPALLDRMSRLLASYSILSCSLHEEDGTFKTLYGLGPKGKFFLRRDTGSVSPLLLYLQHKRVVDGWSHLKDVILEGGIPFNRANGMTLFESHDKDTKFGEWIVHAEDDANCAKLMKNCWDALPEHGKVLIVDAVVPEQPNSDIVAWNSFLPDMIMLNVAPGKGRDRSMKEFEAIAAQAGFHPPKVVWRAYNSWVIEFEKM
>Mecan_G09115.1
MGYYLKEAVLDGGIPFNKAYGMTAFETEKEFAALAKGAGFPGFRVACSAYGCYIMEFLKKP
>Mecan_G03048.1
PPPAKTRPGPSSSGSGSWVSPDWLTSLTRSISLRGDDDSGIPIASAKLEDVSDLLGGALFLPLFKWMEENGPIYRLAAGPRDFVVVSDPAIAKHVLRNYGKYAKGLVAEVSEFLFGSGFAIAEGPLWTARRRAVVPSLHKKYLSIIVDRVFCRCAERLVEKLQDAASDGTAVNMEAKFCQLTLDVIGLSVFNYNFDSLTADSPVIDAVYTALKEAEARSTDILPYWKASRPCAVSIYLSTGSAWVQFLCKIIPRQIKAEKAVTVIRETVEELITKCKIIVESEGEKIDQEEYVNDTDPSILRFLLASREEVSSVQLRDDLLSMLVAGHETTGSVLTWTLYLLSKDKSSLRKAQEELDEVLQGRRPSFDDIPKLKFLTCCINESLRLYPHPPVLIRRATMPDVLPGNYKVNAGQDIMISVYNIHHSSQVWDRAEEFLPERFDTGGPLPNETNTDFRFIPFSGGPRKCVGDQFAMLEAIVALAICLQRLDFELVPNQTINMTTGATIHTTNSEATGECTGDRMSRLQANQSSEIDRDRSGAEKEEEEEEEEEIHQIPISRTMEEKGDDCSSRLAIMELANMLSVPMCLNAVVRLRVPDAIWQGGSNLPLTPSQILSRLSLPHPADSLNLQRILRMLSSYGVFRETISEDDAARTYSLTDVGKTLVTGDDGLSYGAYVLQHHQEELMRAWPLVHEAVLDPSAEPFVKANGEPAYSYYGKRPEMNGLMQAAMSATSVPFMRAMLEGYDGFSGAERVVDVGGSAGDCLRMILARYPTVREGLNFDLPEVVAKAPAIPGVTHVGGDMFNYVPSGDVIFMKWILTTWTEDECKLILENCYKALPPGGKLIACEPVLPKHTDDSHRTRALLEGDIFVMTIYRAQGRHRTEEEFRMLGAAAGFPKFKPFYVDHFYTVLEFQK
>Mecan_G07711.1
KATQRKNIHRKSVELYRQFGYRDHDLHPSNGGPPPAATSSSDHYSLGVRSSSSAPHHHHHHLGKPGPGRARRFGRSDRGWRLSVGSVILVLSVGLSITLLAYFVLGRDSNSYQGEQDDLRYDSDFLTNVTRTEGVKVLGFGRGSVTRGRDSRYWDKDDRRRDEDYNEDVMEHVKENSNKSTNWEDLSAGVKTGGDKSYDSGRVMGKRGAGLYNEAGRNELKMYEAEYEAALKNSGQSKDEGDHKSHLSDAEQLGKKKDDADIEYEDLDPLEDMIDEHQEKFREVHDHLALSDSQKKESSGKSKSADESSEIGSEGRNAAEQSEEVPRIFYGEESSESREPGEIKMRSQYISRTDGQMTKKTTKKRPKRYPCEMKLSNATAMLVEPVEGRKFARFYLQYVQEEEKPPDAPDWEPRFAGHQSLLQREESFLARDQTIHCGFIRGSDNSQSTGFDLSEDDASYISRCHVAVTSCIFGNSDRLRIPAKQMISRQSRKNVCFVMFVDEVTLETLISEGSMLDTMGFIGLWKIVVVMNLPFNDMRRVGKIPKFLTHRLFPSARYSIWLDSKLRLQLDPILLLEYFLWRKGYEYAISNHYDRHCVWEEVAQNKKLNKYNHTVIDQQFVFYQSDGLKRFNPLDPAKLLPSNVPEGSFIVRAHTPMSNLFSCLWFNEVDRFTPRDQLSFAYTYHKLRRMNPGKPFYLNMFKDCERRRVAKLFHHRSEEKRNIHQAGAVKNFEVRKRKNIITVEDSKVHLRSITENCYHAMPEEGEVIMLDVVLPDVPETTKISMYVSHLDDSTLKHLRVKPHWTSARERQDDHDGTYAPRVSRDHMLPEFLETTESMYASPVNTAMLMQP
>Mecan_G29728.1
WIVHDWNDVESENLPRNCWEALPENGRCILHDRDVFECKKLLRNHWKALPEDGTVMIVGSMLPEDPKHKYKGKDAVITELNMMVLNLKGKERTRSQFEQLAKVPGLAETILIPISNGLYLIESFKRVKTRMDPLRVPHASSRNLSPFPEKPRKNSSHSSSSPTTLQRESKSSNFLCTPAFLFF
>Mecan_G00473.1
MGPRRRDHALRNAAHQRLYPIDGPYGLGQVAKFLANNEDGVSLAPLCLFNQDKVSLESWLVHISSLIFPRKAWAELGLAGQFIATNFIVRPLILNGGIPFNMAHGMNTFEYPRTKPRFNEVFNRAMSEPFTLVMKKILQLYKGFEGLNTLVDVGGGTGTALERTAEAEGAGFQGFRVVCCMIGIYTM
>Mecan_G07468.1
MGYYLTDAVLNGGIPFNKAYGMTAFEYHGTDPRTEKEFAALAKGSGFPGFRVACCAYGSYIMEFLKKP
>Mecan_G00238.1
MTSSHHVHVPSPPTATPPLAGDDSEDVHVGKLAIRLANGVVVPMVLKSVLELGVIDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVREIVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWFRLNEVVMEGGVPFEREYGMTAFEYPATDQRFNNVFNRAMSSHTTLALKKVLDAYKGFDDLMVLVDVGGGIGVALGIITTAHPHIKGINYDLPHVLANAPSYPGVEHVGGDMFESVPHGDAIFMKGLNILFYLQFFVTMYRPDQCASKSNIAQWILHDWRDENCNKLLKNCYEALPQGGKVIILESILPEAPDSDVDANIVFEQDLFMLAQNPGGKERTLKEYEDLATMAGFSGCQVKCRAYNSYVMEFLKT
>Mecan_G24551.1
MQQWKVGASFQGCSNGRWGLHFKDAAMEGGGQFKKVRGMSIFEYMGVDSVFTDIFNNAMALGSIIMDKLLPIYTGFECLTPLVNVGSSTGK
>Mecan_G24517.1
MIENHTQKGGMNPREVDDDPCLKALLLSAYHVFPAILHAAIHSDLFGIISSQGNGAFLSASEVASLLPSRCDDTVDILDRMMRCLSSHSLLCHKTVELKDGRLERRYGISPAGRYYCRGEDGGSIASLSHFAMHHSTRDVWMRATEAVAGGGNLFQKVHGKSIFQYMKEDPQLNTYFNNAMADHSAIQTRKILEVYDGFEGITTLVDVGGGKGATLHAIISKYPSIKGINFDLPQVIEHAPAYPGGTRDLRQGIEHVGGDMFVTVPKGGDAILIKRTCHNWSDESCIKFLKNCYDSLPPKGKVVIIDFIMPEEPEESNTSKLVTLLDNRMLILLGGKERTEKQFQGLCKGAGFSEFRVAARAISALGAIEFLK
>Mecan_G24552.1
MKYTLHNWSDENNIKILKNCYEALPRTTSLKGPPWSQYYASYVNAAKHWAVMELRSIDVSIMFFTGTSKNGIRQQKLCFTLLR
>Mecan_G24519.1
MNPSVSEDEDACLNALLFSSYHVFPAILHAAIHSDLFGIISSRGDGAFLSASEVASLLPSRCDDTVDILDRMMRCLSSHSLLCHKTVELEDGRLERRYGISPAGRYYCRGEDGGSIASLSLFAMHRATMEVWMRVTEAVAGGGNLFQKVHGKSIFQYMKEDPQLNTYFNNAMADLSAIQTRKILEVYDGFEGITTLVDVGGGKGATLHAIISKYPSIKGINFDLPQVIEHAPAYSGGTLDLRQGIEHVGGDMFVTVPKGGDAILIKGTCHNWSDESCIKFLKNCYDSLPPKGKVVIIDFIMPEEPEESNTSKYVALLDNAMLIQPGGKERTEMQFQGLCKGAGFSEFRVAARAIYALGAIEFLK
>Mecan_G24549.1
MLAHEEVTAIPSCSRQVPEDIPVGAWDDQALVDSMIFSISNVFPMVLNTATRLELFDIMAEAEPEAFLSAARSMYMSCERTENEFRALSEATGFANFRVACTASKIWVVMVLQK
>Mecan_G09769.1
MTSSHHVNVPSPPTATPPLAGDDSEDVHLGKLAIRLANGVVVPMVLKSVLELGVVDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVRESVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWFRLNEVVMEGGVPFEREYGMTAFEYPATDQRFNNVFNRAMSSHTTLALKKVLDAYKGFDDLMVLVDVGGGIGVALGIITTAHPHIKGINYDLPHVVANAPSYPGVEHVGGDMFESVPHGDAIFMKWILHDWRDENCNKLLKNCYEALPQGGKVIILESILPETPDSDVDANIVFEQDLLMLAQNPGGKERTLKEYEDLATMAGFSGCQVKCRAYNSYVMEFLKT
MTSSHHVNVPSPPTATPPLAGDDSEDVHLGKLAIRLANGVVVPMVLKSVLELGVVDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVRESVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWLVFQNPVAS
>Mecan_G20795.1
MRMDSIDDEEEAIVRASILTSFFMVPMVLNATIELGVLDIIHRASVDGGISAAGIASSISHRNPGAALVLDRMMRLLASHSILTCSSCTTLDDNRRMTTEKLYRLAPIGKLFTKDAEGGSMAGFLTFSQHQAILDIRHRVCHNWGDDKCSKILQKCHEALPRGGKLIMIESILAETPDPSEESKYVSQFDNLMLSQHEGKERTEGEFASLGKESGFAGFEVVCCACAHWVMEFRKGT
>Mecan_G30276.1
MKSILHVYSGFEGLTSLVDVGGGTGKCFNMVITEYPGIKGINFDLDHVTKSAPSSTFILKVEAIMLKDDESGVKILKNCYEALPVEGKCSRRSRRPQWNKCTRLSGGQERTVNEFRALSEADGFAELKAVCTVSKLWVAIKLHKMRAPEN
>Mecan_G00581.1
MISSPLPSSLNHKMSVQEVQITTPAEDDDFLFAMEIASISALPFVTKTIIELGIIDAVAASPLSPSEVASRISSRNPDAPALLDRMSRLLASYSILSCSLHEEDGTFKTLYGLGPKGKFFLRRDTGSVSPLLLYLQHKRVVDGWSHLKDVILEGGIPFNRANGMTLFESHDKDTKFGEWIVHAEDDANCAKLMKNCWDALPEHGKVLIVDAVVPEQPNSDIVAWNSFLPDMIMLNVAPGKGRDRSMKEFEAIAAQAGFHPPKVVWRAYNSWVIEFEKM
>Mecan_G09115.1
MGYYLKEAVLDGGIPFNKAYGMTAFETEKEFAALAKGAGFPGFRVACSAYGCYIMEFLKKP
>Mecan_G03048.1
PPPAKTRPGPSSSGSGSWVSPDWLTSLTRSISLRGDDDSGIPIASAKLEDVSDLLGGALFLPLFKWMEENGPIYRLAAGPRDFVVVSDPAIAKHVLRNYGKYAKGLVAEVSEFLFGSGFAIAEGPLWTARRRAVVPSLHKKYLSIIVDRVFCRCAERLVEKLQDAASDGTAVNMEAKFCQLTLDVIGLSVFNYNFDSLTADSPVIDAVYTALKEAEARSTDILPYWKASRPCAVSIYLSTGSAWVQFLCKIIPRQIKAEKAVTVIRETVEELITKCKIIVESEGEKIDQEEYVNDTDPSILRFLLASREEVSSVQLRDDLLSMLVAGHETTGSVLTWTLYLLSKDKSSLRKAQEELDEVLQGRRPSFDDIPKLKFLTCCINESLRLYPHPPVLIRRATMPDVLPGNYKVNAGQDIMISVYNIHHSSQVWDRAEEFLPERFDTGGPLPNETNTDFRFIPFSGGPRKCVGDQFAMLEAIVALAICLQRLDFELVPNQTINMTTGATIHTTNSEATGECTGDRMSRLQANQSSEIDRDRSGAEKEEEEEEEEEIHQIPISRTMEEKGDDCSSRLAIMELANMLSVPMCLNAVVRLRVPDAIWQGGSNLPLTPSQILSRLSLPHPADSLNLQRILRMLSSYGVFRETISEDDAARTYSLTDVGKTLVTGDDGLSYGAYVLQHHQEELMRAWPLVHEAVLDPSAEPFVKANGEPAYSYYGKRPEMNGLMQAAMSATSVPFMRAMLEGYDGFSGAERVVDVGGSAGDCLRMILARYPTVREGLNFDLPEVVAKAPAIPGVTHVGGDMFNYVPSGDVIFMKWILTTWTEDECKLILENCYKALPPGGKLIACEPVLPKHTDDSHRTRALLEGDIFVMTIYRAQGRHRTEEEFRMLGAAAGFPKFKPFYVDHFYTVLEFQK
>Mecan_G07711.1
KATQRKNIHRKSVELYRQFGYRDHDLHPSNGGPPPAATSSSDHYSLGVRSSSSAPHHHHHHLGKPGPGRARRFGRSDRGWRLSVGSVILVLSVGLSITLLAYFVLGRDSNSYQGEQDDLRYDSDFLTNVTRTEGVKVLGFGRGSVTRGRDSRYWDKDDRRRDEDYNEDVMEHVKENSNKSTNWEDLSAGVKTGGDKSYDSGRVMGKRGAGLYNEAGRNELKMYEAEYEAALKNSGQSKDEGDHKSHLSDAEQLGKKKDDADIEYEDLDPLEDMIDEHQEKFREVHDHLALSDSQKKESSGKSKSADESSEIGSEGRNAAEQSEEVPRIFYGEESSESREPGEIKMRSQYISRTDGQMTKKTTKKRPKRYPCEMKLSNATAMLVEPVEGRKFARFYLQYVQEEEKPPDAPDWEPRFAGHQSLLQREESFLARDQTIHCGFIRGSDNSQSTGFDLSEDDASYISRCHVAVTSCIFGNSDRLRIPAKQMISRQSRKNVCFVMFVDEVTLETLISEGSMLDTMGFIGLWKIVVVMNLPFNDMRRVGKIPKFLTHRLFPSARYSIWLDSKLRLQLDPILLLEYFLWRKGYEYAISNHYDRHCVWEEVAQNKKLNKYNHTVIDQQFVFYQSDGLKRFNPLDPAKLLPSNVPEGSFIVRAHTPMSNLFSCLWFNEVDRFTPRDQLSFAYTYHKLRRMNPGKPFYLNMFKDCERRRVAKLFHHRSEEKRNIHQAGAVKNFEVRKRKNIITVEDSKVHLRSITENCYHAMPEEGEVIMLDVVLPDVPETTKISMYVSHLDDSTLKHLRVKPHWTSARERQDDHDGTYAPRVSRDHMLPEFLETTESMYASPVNTAMLMQP
>Mecan_G29728.1
WIVHDWNDVESENLPRNCWEALPENGRCILHDRDVFECKKLLRNHWKALPEDGTVMIVGSMLPEDPKHKYKGKDAVITELNMMVLNLKGKERTRSQFEQLAKVPGLAETILIPISNGLYLIESFKRVKTRMDPLRVPHASSRNLSPFPEKPRKNSSHSSSSPTTLQRESKSSNFLCTPAFLFF
>Mecan_G00473.1
MGPRRRDHALRNAAHQRLYPIDGPYGLGQVAKFLANNEDGVSLAPLCLFNQDKVSLESWLVHISSLIFPRKAWAELGLAGQFIATNFIVRPLILNGGIPFNMAHGMNTFEYPRTKPRFNEVFNRAMSEPFTLVMKKILQLYKGFEGLNTLVDVGGGTGTALERTAEAEGAGFQGFRVVCCMIGIYTM
>Mecan_G07468.1
MGYYLTDAVLNGGIPFNKAYGMTAFEYHGTDPRTEKEFAALAKGSGFPGFRVACCAYGSYIMEFLKKP
>Mecan_G00238.1
MTSSHHVHVPSPPTATPPLAGDDSEDVHVGKLAIRLANGVVVPMVLKSVLELGVIDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVREIVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWFRLNEVVMEGGVPFEREYGMTAFEYPATDQRFNNVFNRAMSSHTTLALKKVLDAYKGFDDLMVLVDVGGGIGVALGIITTAHPHIKGINYDLPHVLANAPSYPGVEHVGGDMFESVPHGDAIFMKGLNILFYLQFFVTMYRPDQCASKSNIAQWILHDWRDENCNKLLKNCYEALPQGGKVIILESILPEAPDSDVDANIVFEQDLFMLAQNPGGKERTLKEYEDLATMAGFSGCQVKCRAYNSYVMEFLKT
>Mecan_G24551.1
MQQWKVGASFQGCSNGRWGLHFKDAAMEGGGQFKKVRGMSIFEYMGVDSVFTDIFNNAMALGSIIMDKLLPIYTGFECLTPLVNVGSSTGK
>Mecan_G24517.1
MIENHTQKGGMNPREVDDDPCLKALLLSAYHVFPAILHAAIHSDLFGIISSQGNGAFLSASEVASLLPSRCDDTVDILDRMMRCLSSHSLLCHKTVELKDGRLERRYGISPAGRYYCRGEDGGSIASLSHFAMHHSTRDVWMRATEAVAGGGNLFQKVHGKSIFQYMKEDPQLNTYFNNAMADHSAIQTRKILEVYDGFEGITTLVDVGGGKGATLHAIISKYPSIKGINFDLPQVIEHAPAYPGGTRDLRQGIEHVGGDMFVTVPKGGDAILIKRTCHNWSDESCIKFLKNCYDSLPPKGKVVIIDFIMPEEPEESNTSKLVTLLDNRMLILLGGKERTEKQFQGLCKGAGFSEFRVAARAISALGAIEFLK
>Mecan_G24552.1
MKYTLHNWSDENNIKILKNCYEALPRTTSLKGPPWSQYYASYVNAAKHWAVMELRSIDVSIMFFTGTSKNGIRQQKLCFTLLR
>Mecan_G24519.1
MNPSVSEDEDACLNALLFSSYHVFPAILHAAIHSDLFGIISSRGDGAFLSASEVASLLPSRCDDTVDILDRMMRCLSSHSLLCHKTVELEDGRLERRYGISPAGRYYCRGEDGGSIASLSLFAMHRATMEVWMRVTEAVAGGGNLFQKVHGKSIFQYMKEDPQLNTYFNNAMADLSAIQTRKILEVYDGFEGITTLVDVGGGKGATLHAIISKYPSIKGINFDLPQVIEHAPAYSGGTLDLRQGIEHVGGDMFVTVPKGGDAILIKGTCHNWSDESCIKFLKNCYDSLPPKGKVVIIDFIMPEEPEESNTSKYVALLDNAMLIQPGGKERTEMQFQGLCKGAGFSEFRVAARAIYALGAIEFLK
>Mecan_G24549.1
MLAHEEVTAIPSCSRQVPEDIPVGAWDDQALVDSMIFSISNVFPMVLNTATRLELFDIMAEAEPEAFLSAARSMYMSCERTENEFRALSEATGFANFRVACTASKIWVVMVLQK
>Mecan_G09769.1
MTSSHHVNVPSPPTATPPLAGDDSEDVHLGKLAIRLANGVVVPMVLKSVLELGVVDLLRDAGEGVMLSCSEIAERISSRNPDAPGLLDRMLRLLASYGVVKGAVRESVVGVPERVYGAGTICRFLGLKEEDGGEGSVAPLFLIHHDKVFMQSWFRLNEVVMEGGVPFEREYGMTAFEYPATDQRFNNVFNRAMSSHTTLALKKVLDAYKGFDDLMVLVDVGGGIGVALGIITTAHPHIKGINYDLPHVVANAPSYPGVEHVGGDMFESVPHGDAIFMKWILHDWRDENCNKLLKNCYEALPQGGKVIILESILPETPDSDVDANIVFEQDLLMLAQNPGGKERTLKEYEDLATMAGFSGCQVKCRAYNSYVMEFLKT
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University