Enzyme

Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.

COMT

Enzyme

Flavone 3'-O-methyltransferase

Enzyme name

EC:2.1.1.76

Entry

Transferases;Transferring one-carbon groups;Methyltransferases

Class

S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase

Sysname

S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]

Reaction

S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]

Product

Species information

Melaleuca alternifolia

Species name

Tea tree (Melaleuca alternifolia) is a species of eudicot in the family Myrtaceae (myrtle family).

Species info

Gene sequence info

Melaleuca_alternifolia.COMT.fa

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>scf7180000028351_mRNA_210
MGSISSETRVGPTQVPDDDETILVAMQLAGAAELPMVLKTALELDLLEIMAKAGPEARLSPREIASQLPTKNPDAPMMLDRILRLLAANSIVACTVRELPDGQAERLYGIAPVCKFLTKNEDGVSVAPLCLMNHDKVLMESWYYLKDAILEGGVPFHKAYGMTAFEYPRTDPRFNKLFNKAMSDFSTITMNKVLEMYKGFEGLKSVVDVGGGTGAVLNMIVSKYPSIKGINFDLPHVIANAPSYPGIEHVGGDMFVNVPTGDAIFMKWICHDWSDGHCLKFLKNCYDALPEDGKVIVVECILPELLDTSFASKLASHSDLIMMAYNPGGKERTEKEFEALAKAAGFKGFRVACVAFYHIMEFLKY
>scf7180000028351_mRNA_211
MGSISSDTPVTPNQVPNDDEAIVFAMQLAGAVQLHMVLKAALELDLLEIIAKAGPGARLSPREIASQLPTENPDAATVLDRILCLLAANSIVTCTLSELPDGRTERLYGIAPVSKFLIKNEDGVSIGPLCLLSRDKVFIESCYHLKDAVLEGVVPFNKAHGMTAFEYCCADPRFSERFNKAMSDVSTITMKEVLEKYKGFKGLKSVVDVGGGTGAVLNMIISKYPSIKGINFDLPHVIENAPSYPGIEHVGGDMFASVPRGDAIFVKWICHNWGDEHCLKLLKNCYNALPKDGKVIVADIVSPELPDTSLAAKIAFQFDTTMMAYHVGGKERTEKDFRALAKAAGFKGFRIAVASKLYDNVMRIDCPVTGWRGREGVRVSELPEIILCTVQSAVVCRGGASGVSGVGRGGERERGRKVDEAGSKQYWRCPKCSVYVHKMSGRPMVKGKLVLF
>scf7180000028351_mRNA_212
MGSKSSETPVAPNQVPNDDEAILFAMQLAGAVQLPMVLKAALELDLLEIIAKAGPRARLSPREIASQLPTENPDAATMLDRILRLLAANSIVTCTLSELPDGRAERLYGIAPISKFLIKNEDGVSIGPLCLLNHDKVLIESWSAT
>scf7180000028351_mRNA_213
MIVSKYPSIKGINFDLPHVIENAPSYPGVEHVGGDMFVSVPRGDAIFMKWICHDWSNEHCLKLLKNCYNALPEDGKVIVTESVLPEVPDTSLAAKVACQTDMLMMAYYVGGKERTEKDFRALAKAAGFKGFRIACVAFDHIMEFLKN
>scf7180000028395_mRNA_211
MDKHQTIANKEEDESSSSSIPLYAMQLATSSVLPMVLKATVELGVLEILKREGPDAMLSPSQIACKIPVGNNPDAPDMLDKMLSLLASHSILNVSLGKDRQGDGGCRVYGLAPVAEYFLRNREGGSLSDLMLMVQDRVMIDFWFHLKDAVLEGGVPFERAHGSTAPSYIGKDARFSEIFKNSMKEYNKLFMSKIFDRYRGFEGLGSLVDVGGGDGSILGMIISKYPYIKGINFDLASVIEKSPPYPGIEYVAGDMFVSIPKGDAIFMKWILHMFDDEHCIKILKNCYEALPCNGKVMVVDMVIPEVPEANLAAGSLFQMYLFIWGMNSMGKERTEKEFETLAKEAGFCSVRVAYSAHNFSLVELNKNAKSC
>scf7180000028395_mRNA_212
MDKHKMIAVHKEDESSSSSIPLYAMQLATSSVLPMVLKATVELGLLDILEREGPGAMLSPSQIASKIPVRNNPDAHNMIDKMLSLLASHSIVSVQGDGGGRVYGLAPVAEYFLRNREGGSLSDLMLMVQDRVMIDFWFHLKDAVLEGGVPFERAHGMNTISYLQKDARFSEIFKNAMKEYNKLFMSKIFDTYKGFEGLSSLVDVGGGDGYILSMIISKYPHIKAINFDVASVIEKSPSYSGIEYIAGDMFASIPKGDAIFIKWVLHMFDDEHCIKILKNCYEALPDNGKRTEKEFETLAKEAGFGSIRVAYSAHNLWLIELYKNGKSC
>scf7180000028397_mRNA_362
MSSDETLAVTSAQEDEEFLFAFKQTMISSVPLVLKANIELGILKLLSESSAELSPTQITSRLSIKNPDAAVTIDRILRFLASLSFVSCTLVQDKAGRPQRTYGLGPRAKYFVREEGPTFAPWLLFLFDKVSLSAWFCLKDSVVQGKGDPFKLANGTIIFEYTGTDPKYNDSFNDAMKYASTVYMGKVMDSYRGFEGAKTVVDVGGGVGECSKLILAKHPHLRAINFDLPYVVENGLSYPGLEHVGGSFVNDPIPKGDILVLKVTSD
>scf7180000028397_mRNA_364
MSLEDAQVFTSPHEDEEVMSSFEVPSMVFVPMVMKGVFELGILELLAKSGQLSALDIAARLSIDNPAAPGVIDRMLRLLSSYSILSCTLAEDKRGRPQRLYGLGPRSKYFVDNNGVSAVLPHLLLQDKTVLESWHCLKDAVKEGGVDLFTRAHGMNVFDYMSEARDPRFTDTYNKSMRAVSAIVMPKIAHHYRGFSKSKTVVNVGGGLGETLKIIISKNPHIRAINYDMPHVIAAAPPIPGKIDPNDSKSVEHVGGDMLRAVPKADVHFMKGVLQRGNDEFCVKVLKNCWAALPPMGKVVIVEVVIPEYPGTDELSQSTFFMDMNMLSMTPGGKTRTRREFADLAHASGFHAPKYIMRAYNMWLIELHKKI
>scf7180000028461_mRNA_18
MVHGGPSWELMKGNPEVSDLFCGAMEHDSRLMTKVVLDTCGGVFKGLSSVVDVGGGSGTMGKAIAEAFPHLECTVLDLPHVVDGLVGSERLKFVGGDMFVEIPQADAILFKWILHDWSDEKCIKILKRSKEAVSGAVEVGKVIIIDMVVENRSGDHRSSETQLFFDMAMMVSVNAKERDEKEWKQLFVDAGFSGYKIISRLGLRSLIEVYP
>scf7180000029144_mRNA_106
MAHGVPSWEFARRNPEVNGLFNEAMARDSSLMAKAVVDTCGRVFEGLSSVVDVGGGTGTMGKVITEAFPHLECTVLDQPHVVDGLVGSDKLKFVGGDMFVEIPPADAIILKWILHDWSDEKCIEILKRSKEAVSGQGKARKAIMIDMVVGNQTEDHTSTESQLFFDMLMMVTFNGNERNEKEWEKLFVDVGFSNYKIVSRLGLRSLVEIYPSLCFCLFDLLV
>scf7180000029166_mRNA_27
MAHGVPSWEFARRNPEVNGLFNEAMARDSSLMAKAVVDTCGRVFEGLSSVVDVGGGTGTMGKVITEAFPHLECTVLDQPHVVDGLVGSDKLKFVGGDMFVEIPPADAIILKWILHDWSDEKCIEILKRSKEAVSGQGKARKAIMIDMVVGNQTEDHTSTESQLFFDMLMMVTFNGNERNEKEWEKLFVDVGFSNYKIVSRLGLRSLVEIYPSLCFCLFDLLV
>scf7180000029594_mRNA_140
MANNQEREVRDQEEEVGKLAIRLAAEVVFPMVLRSALELNIIDALVSAGGFLSPAEIASRVGAKNPGAPVMVERMMRLLASRGVIEWRARRSDGDGDGDGAGREYGAGPMCRFLAKDEEGGSVGPLFLLHHDRVFMESWNHLGDVIKEGGVPFERAYGMSAFEYPATDERFNRVFNRAMSGHTTLIMRKVLDVYGGFAGVKVLVDVGGGVGVTLKMITSKHPHIKGINFDLPHVLVDAPPHPGVEHVGGDMFVSVPRGDAIFMKWILHDWSDEHCSKLLKNCCEALPVNGKVIIVESILPMVPEGDVSSNIVFDQDLFMLAQNPGGKERTQKEYEALAVQAGFAGCEVKCSAYNSWVMEFPKTVGH
>scf7180000030315_mRNA_8
MDKHQTIANKEEDESSSSSIPLYAMQLATSSVLPMVLKATVELGVLEILKREGPDAMLSPSQIACKIPVGNNPDAPDMLDKMLSLLASHSILNVSLGNDRQGDGGCRVYGLAPVAEYFLRNREGGSLSDLMLMVQDRVMIDFWFHLKDAVLEGGVPFERAHGSTAPSYIGKDARFSEIFKNSMKEYNKLFMSKIFDRYRGFEGLGSLVDVGGGDGSILGMIISKYPYIKGINFDLASVIEKSPPYPGIEYVAGDMFVSIPKGDAIFMKWILHMFDDEHCIKILKNCYEALPCNGKVMVVDMVIPEVPEANLAAGSLFQMYLFIWGMNSMGKERTEKEFEALAKEAGFCSVRVAYSAHNFSLVELNKNAKSC
>scf7180000030315_mRNA_9
MQLATSSVLPMVLKATVELGLLDILEREGPGAMLSPSQIASKIPVRNNPDAHNMIDKMLSLLASHSIVSVQGDGGGRVYGLAPVAEYFLRNREGGSLSDLMLMVQDRVMIDFWFHLQDAVLEGGVPFERAHGMNTISYLQKDARFSEIFKNAMKEYNKLFMSKIFDTYKGFEGLSSLVDVGGGDGYILSMIISKYPHIKAINFDVASVIEKSPSYSGIEYIAGDMFASIPKGDAIFIKWVLHMFDDEHCIKILKNCYEALPDNGKVITVNLMIPEAPEANLPARSLFQLYVFMHNMNPMGKQRTEKEFETLAKEAGFGSIRVAYSAHNLWLIELYKNGKSC
>scf7180000030524_mRNA_91
MGSTGSETQMTPTHVSDEEANLFAMQLTSASVLPMVLKAAIELDLLEIMAKAGPGAYLSTVEVASQLPTRNPDAPVMLDRIFRLLASYSVLTCTLRDLPDGKVERLYGLAPVCKYLVKNADGVSIAALSLMNQDKVLMESWYYLKDAVLEGGIPFNKAYGMTAFEYHGTDPRFNKIFNQGMSNHSTITMKKILEMYKGFEGLKTVVDVGGGTGAVLSMIVAKYPSIKGINFDLPHVIEDAPSFPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCAKFLKNCYDALPENGKVIVAECILPVYPDPSLATKTTIHIDCIMLAHNPGGKERTEKEFEALAKGAGFKGFRVMCCAFNSHVMEFLKTA
>scf7180000036261_mRNA_68
MDPRQTQPISTPAEDEELVAAFETCILTSVPMVLTSAVELGIIDLLAQEGGASARLSPSQIVAHLGIANPEAPRTIDRMLRLLASFSYVSCTLEGDQKLYGIGPKSKYFVSSEAGSFAPLLRFLQHKTVINGWYGLQEAVKNGGSPFENAIGMTIFECAMKDPAFSALLNNGMKAPTPLYMNKILDSYRGFEGAKTVVDVGGGVGESLKLILDKFPNLRGINYDLPHVVKDATNHPRMEHVGGDLSKSIPKADIIVMKVDFGFFPPLKFDPILA
>scf7180000036742_mRNA_86
MTPAQNTTTPSIAVDPEAADDTWVHALLFASSHVFPMVLNAATRLGVFDIVARAGPGARVSASEVASQLATQSSEAAPKLDRMLRLLASRSLLSCEVCERDDGRVERLYGLTQAARFFVKEGEEGSLASLLELSFHPAAQQVWLQLDDHILEGGNQFKKVHGISIFEFMDIDPAFNNTFNKAMASLTTIVMRKILEVYQGFKDLTTLVDVAGGTGKCLNMIISKYPSIKGINFDLPHVIESAPSYAGIQHVGGSMFSTIPKADAIMIKVNVEYRRFTDFETYSEL
>scf7180000036742_mRNA_88
MFVSVPEGDTIMIKGTCHNWSDESCIKFLKNCYKALPPNGKVIVMDFIMPDEPEETMASKYVSMLDNAMLIQPGGKERTEKQFEYLCKGAGFTGFKVAARAVSALGVIEFTK
>scf7180000036742_mRNA_87
MSSTQNQGSPCHEEEDPCLKALLFSSYHVFPVILHAAVELDLFGIIARAGPGAYVSPAEVVAHLPAQTPDSPEIVDRVLRCLASHSLLKYKSETFDDGRTVERRYAISPVGKYYVKDEDGGSIGSLSLFAFHRATLDVWLQVKEAIVGGGGNLFQKVHGKTIFQYMKEDSALNKYFNDAMADLSATQTRKILEVYHGFDGIATLVDVGGGKGATLNMIVSKYPSIKGINFDLPQVIEHAPSYPGVEHVGGDMFVNVPAGDAIMIKGTCHNWSDESCIKFLKNCYKALPAKGKVIVMDFIMPDEPEETMASKYVSMLDNAMLIQPGGKERTEKQFEYLCKGAGFTGFEVAARAVSALGVIEFTK
>scf7180000037303_mRNA_967
MDNETSDARNTARLRILELTNMISVPMSLNAVVRLGVPDALWQGGSNAPLSASEILARSFPGGGGDAENLQRLLRLLASHGVFEEHVASAAASGCSSPERKYSLTEVGKTLVTDAEGLSYAAYVLQHHQDALLRAWPLVHEAVVDPATEPFVRANGDTAYGHYGKNPEMNELMQRAMSGVSVPFMKAILEGYEGFAGVGRLVDVGGSAGDCLRMIMRKHPHVREGINFDLPEVVAKAPPIPGVTHVGGDMFKSVPTSDAIFMRWILTTWTDNECKQILENCFKALPVGGKLIACEPVLPKHSDDSHRTRALLEGDIFVMTIYRAKGKHRTEQEFQQLGLSAGFPHFQALYIDFFYAMLEFKK
>scf7180000037303_mRNA_971
MDNETSDARNMGGINAPLSASEILALSLPAGGGDAENLQRLLRLLASHGVFEEDVASVATSGCTSPERRYSLTEVGKTLVTDAEGLSCAAYLLQHHQDALMRAWPLVHEAVVDPGTEPFVKVNGDTAYAHYGKNPEMNELMQRAMSGLVDVGGSAGDCLGMIMRKHSHVREGINFDLPEVVAKAPPIPGVTHVGGDMFKSIPTGDAIFLRWVLTTWTDNECKQILENCFKALPLGGKLIACEPVLPKHSDDSHRTRALLGGDIFVMTMYRAKGKHKTEQEFQQLGLSAGFPHFRALYIDYYHAILEFKK

Gene tree

Gene tree

Sheng jun & Dong yang Teams, Yunnan agriculture University