Enzyme
The enzyme catalyses the 4'-methylation of naringenin. In vitro it catalyses the 4'-methylation of apigenin, quercetin, daidzein and genistein.
FOMT4
Enzyme
Flavonoid 4'-O-methyltransferase
Enzyme name
EC:2.1.1.231
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase
Sysname
S-adenosyl-L-methionine + a 4'-hydroxyflavanone = S-adenosyl-L-homocysteine + a 4'-methoxyflavanone [RN:R09792]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];4'-methoxyflavanone [CPD:C19895]
Product
Species information
Medicago truncatula
Species name
Barrel medic (Medicago truncatula) is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Medicago_truncatula.FOMT4.fa
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>rna-XM_013613349.3
MASTNNQLEATELFEGQSLLYMHMFGFLKSMALKWAIQLNIPDIIYNHGKPITLSDLVSTLQVPISKQSLVERLMRFLAHNGIFVIHEKGENDDDDDQAYALTPASKLLSKSCCKDHCLTPMVLMSTDPILMGKFHQLGDWICGEIPTLYEAALGSTVWEFLEGKPEYLSLFNQAMASDSQMVNLALKNCSKVFEGIDSIVDVGGGTGTTARIICEAFPKLKCVVYDLPQVVANLSSACDNLSYVGGDMFKSIPQADAIMLKWILHDWTDEICIKILKTCKESVSSNGKKGKVIIMDIIINEEDDEKDMTETKLCLDLIMMGINGKERTGKEWKHLFVEAGFKDYKIFPLFGFRSLIEAYP
>rna-XM_013613348.3
MVSTNDQLEALELFQGQSLLYTHMYASLKPMSLKCAVQLNIPEIIYNHGKPITLPDLVSTLKVPLAKSSLVKRLMRFLAHIGIFAIHGKGEDDHDQTYALTPASKLLSKSCSKDHCLTPMVLMCTDPIFMSLFHQLGDLIHGEVPNLSEGALGVTLWEFLEEKPAYSSLFNEAMASNSQMVSLALKNCSEVFEGIESIVDVGGGNGTTAKIICEAFPKVKCLVFDVPHVVANSSCESQNVSYVGGDIFKSIPKADAIMLKSILHDWSDENCIKILKTCKDSVSSKGRKGKVIIIDILINEKDDEKDITQQNLIMDISMMAFDGGKERTEKEWKHLFIEAGFKDYKIFPLFSYESLIEVYP
>rna-XM_013601496.3
MASKNDLYKPSELFQAQTHLYKIMYSYLNPMSVKWALDLKIPDIIHNHRQAITLSELISALKVPQSKETCVGRLMRLLAHIDFFAIVKIDETKEGYTLTPTSQLLVSTTDHCLSSMVRLLNIPPIVGSYNHLGKWTCGEDLTIVETALGPESYWDFIHQNSSYLKTFNDAMESDSHVVRLALRDCKSVFQGIGSLVDVGGGTGNTAKIICEAFPELKYIVLDLPQVVSGLTGTNNLSFVGGNMFKSIPQADAVSLKWVLHNWSDDDCIKILKNCKKAISGKEKGGKVIIIDAVINEKQDEHEMTEVKLLLDVVMMTCFNGKERNEKEWKQLFLQAGFKYYKIFLTFGFRSLIELYP
>rna-XM_013601497.3
MASKNDLYKPSELFQAQTHLYKIMYGFLNPMSVKWALDLKIPDIIHNHGHAMTLSELISSLKVPQSKETCVRRLMRLLAHIDFFAIVKIDETKEGYALTPTSQLLVSDTDHCLSSMVRLLNTPTLVDAYNHLGKWTCGEDLTIVETALGPESYWDFIHENSAYLKSFNDAMESDSHVVRLALRDCNSVFEGIGSLVDVGGGTGNTAKIICEAFPELKYTVLDLPQVVSGLTGSINLSFVGGNMFKSIPQADTVLLKWVLHNWGDDDCIKILKNCKKAISGKEKGGKVIIIDVVINEKQDEHEMTEVKLLLDVVMMTSLNGKERNEKEWKQLFLQAGFKYYKIFPTFGFRSLIELYP
>rna-XM_003621436.4
MASSINNRKPSEIFKAQALLYKNMYAFVDSMSLKWSIEMNIPNIIHNHGKPITLSNLVSILQIPSTKVDNVQRLMRYLAHNGFFEIITNQELENEEEAYALTVASELLVKGTELCLAPMVECVLDPTLSTSFHNLKKWVYEEDLTLFAVNLGCDLWEFLNKNPEYNTLYNDALASDSKMINLAMKDCNLVFEGLESIVDVGGGNGTTGKIICETFPKLTCVVFDRPKVVENLCGSNNLTYVGGDMFISVPKADAVLLKAVLHDWTDKDCIKILKKCKEAVTSDGKRGKVIVIDMVINEKKDENQLTQIKLLMNVTISCVNGKERNEEEWKKLFIEAGFQDYKISPFTGLMSLIEIYP
>rna-XM_003621830.4
MDSENEYKASELFVAQAHLYNQIFSFMRPVSIKWAVELGIPDIIQNHGKPITLPELVSALRIPEAKAGCVHSVMRLLAHNKIFAIVKIDDNKEAYALSPTSKLLVKGTDHCLTSMVKMVTNPTGVELYYQLTKWTSKEDLTIFDTTLWDFMQQNSAYAELFNDAMESDSNMMRFAMSDCKSVFEGITSLVDVGGGTGNTVKIISEAFPTLKCIVFDLPNVVEGLTGNNYLSFVGGNMFESIPQADAILLKWVIHNWNDDDCVKILKKCKEAASRQKKGGKVIIIDIVINEKQDEHEITEVKLCFDITMMANHNSRERDEKTWKKIITEAGFMSYKIFPIFGFRSLIELSV
>rna-XM_003621832.4
MGSENEHKASELFEVQAHLYNQLFSFLRPVSIKWAVELGIPDIIQNHGKPITLPELVSALRIPEAKAGCVHSVMRLLAHNKIFAIVKIDDNKEAYALSPTSKLLVKGTDHCLSSMVKLLTNPTRVEKHYQLSTWTSMEDLTIFETPLWDLILQNPTHSKLFNDAMESDSNMVRFAMSDCKSVFEGLTSLVDVGGGTGNTVKIICEAFPTLKCIVFDLPNVVEGLTGNNYLSFVGGNMFESIPQADAILLKWILHNWNDDDCVKILRNCKEAVSRKNKEGKVIIIDIVINEEQDEHEMTELKLFFDISMMANFGSTERDEKAWEKIITEAGFTSYKIFHIFGFKSLIELCV
>rna-XM_024770457.2
MASSINNRKASEIFKAQALLYKNMYAFIDSMSLKWSVEMDIPTIIYNHGKPITLSNLVSILQIPSTKVDNVQRLMRLLAHNGFFEIVTNQELENEEEAYALTVTSELLVKGTELCLAPMVECVLDPKFNVSFHNFKKWIYEEDLTLFATSLGCDLWEFLNKNPEYNRLFNDAMASDSKMINLALKDCNFVFEGLDSIVDVGGGNGTTGKIICETYPKLRCVVFDRPKVVENLCGSNNLTYVGGDMFISVPKADAVLLKWILHDWTDRDCIKILKKCKEAVTTEGKRGKVIVIDMVINEKKEENELTQIKLLMNVTISCLNGKERNEEEWKKLFMEAGFENYKISPCLLLFSDSSSLGFALLG
>rna-XM_003621440.4
MASSLNGRKPSEIFKAQALLYKHIFAFIDSMSLKWAVEMNIPNIIHNHGKPISLSNLVSILQVPSSKIGNVRRLMRYLAHNGFFEIITKEEESYALTVASELLVRGSDLCLAPMVECVLDPTLSGSYHELKKWIYEEDLTLFGVTLGSGFWDFLDKNPEYNRSFNDAMASDSKLINLALRDCDFVFDGLESIVDVGGGNGTTGKIICETFPKLKCIVFDRPQVVENLSGSNNLTYVGGDMFTSIPNADAVLLKYILHNWTDKDCTRILKKCKEAVTNDGKKGKVIIIDMVINEKKDENQVTQIKLLMDVNMACLNGKERNEEEWKKLFIEAGFQDYKISPLTGFLSLIEIYP
MASTNNQLEATELFEGQSLLYMHMFGFLKSMALKWAIQLNIPDIIYNHGKPITLSDLVSTLQVPISKQSLVERLMRFLAHNGIFVIHEKGENDDDDDQAYALTPASKLLSKSCCKDHCLTPMVLMSTDPILMGKFHQLGDWICGEIPTLYEAALGSTVWEFLEGKPEYLSLFNQAMASDSQMVNLALKNCSKVFEGIDSIVDVGGGTGTTARIICEAFPKLKCVVYDLPQVVANLSSACDNLSYVGGDMFKSIPQADAIMLKWILHDWTDEICIKILKTCKESVSSNGKKGKVIIMDIIINEEDDEKDMTETKLCLDLIMMGINGKERTGKEWKHLFVEAGFKDYKIFPLFGFRSLIEAYP
>rna-XM_013613348.3
MVSTNDQLEALELFQGQSLLYTHMYASLKPMSLKCAVQLNIPEIIYNHGKPITLPDLVSTLKVPLAKSSLVKRLMRFLAHIGIFAIHGKGEDDHDQTYALTPASKLLSKSCSKDHCLTPMVLMCTDPIFMSLFHQLGDLIHGEVPNLSEGALGVTLWEFLEEKPAYSSLFNEAMASNSQMVSLALKNCSEVFEGIESIVDVGGGNGTTAKIICEAFPKVKCLVFDVPHVVANSSCESQNVSYVGGDIFKSIPKADAIMLKSILHDWSDENCIKILKTCKDSVSSKGRKGKVIIIDILINEKDDEKDITQQNLIMDISMMAFDGGKERTEKEWKHLFIEAGFKDYKIFPLFSYESLIEVYP
>rna-XM_013601496.3
MASKNDLYKPSELFQAQTHLYKIMYSYLNPMSVKWALDLKIPDIIHNHRQAITLSELISALKVPQSKETCVGRLMRLLAHIDFFAIVKIDETKEGYTLTPTSQLLVSTTDHCLSSMVRLLNIPPIVGSYNHLGKWTCGEDLTIVETALGPESYWDFIHQNSSYLKTFNDAMESDSHVVRLALRDCKSVFQGIGSLVDVGGGTGNTAKIICEAFPELKYIVLDLPQVVSGLTGTNNLSFVGGNMFKSIPQADAVSLKWVLHNWSDDDCIKILKNCKKAISGKEKGGKVIIIDAVINEKQDEHEMTEVKLLLDVVMMTCFNGKERNEKEWKQLFLQAGFKYYKIFLTFGFRSLIELYP
>rna-XM_013601497.3
MASKNDLYKPSELFQAQTHLYKIMYGFLNPMSVKWALDLKIPDIIHNHGHAMTLSELISSLKVPQSKETCVRRLMRLLAHIDFFAIVKIDETKEGYALTPTSQLLVSDTDHCLSSMVRLLNTPTLVDAYNHLGKWTCGEDLTIVETALGPESYWDFIHENSAYLKSFNDAMESDSHVVRLALRDCNSVFEGIGSLVDVGGGTGNTAKIICEAFPELKYTVLDLPQVVSGLTGSINLSFVGGNMFKSIPQADTVLLKWVLHNWGDDDCIKILKNCKKAISGKEKGGKVIIIDVVINEKQDEHEMTEVKLLLDVVMMTSLNGKERNEKEWKQLFLQAGFKYYKIFPTFGFRSLIELYP
>rna-XM_003621436.4
MASSINNRKPSEIFKAQALLYKNMYAFVDSMSLKWSIEMNIPNIIHNHGKPITLSNLVSILQIPSTKVDNVQRLMRYLAHNGFFEIITNQELENEEEAYALTVASELLVKGTELCLAPMVECVLDPTLSTSFHNLKKWVYEEDLTLFAVNLGCDLWEFLNKNPEYNTLYNDALASDSKMINLAMKDCNLVFEGLESIVDVGGGNGTTGKIICETFPKLTCVVFDRPKVVENLCGSNNLTYVGGDMFISVPKADAVLLKAVLHDWTDKDCIKILKKCKEAVTSDGKRGKVIVIDMVINEKKDENQLTQIKLLMNVTISCVNGKERNEEEWKKLFIEAGFQDYKISPFTGLMSLIEIYP
>rna-XM_003621830.4
MDSENEYKASELFVAQAHLYNQIFSFMRPVSIKWAVELGIPDIIQNHGKPITLPELVSALRIPEAKAGCVHSVMRLLAHNKIFAIVKIDDNKEAYALSPTSKLLVKGTDHCLTSMVKMVTNPTGVELYYQLTKWTSKEDLTIFDTTLWDFMQQNSAYAELFNDAMESDSNMMRFAMSDCKSVFEGITSLVDVGGGTGNTVKIISEAFPTLKCIVFDLPNVVEGLTGNNYLSFVGGNMFESIPQADAILLKWVIHNWNDDDCVKILKKCKEAASRQKKGGKVIIIDIVINEKQDEHEITEVKLCFDITMMANHNSRERDEKTWKKIITEAGFMSYKIFPIFGFRSLIELSV
>rna-XM_003621832.4
MGSENEHKASELFEVQAHLYNQLFSFLRPVSIKWAVELGIPDIIQNHGKPITLPELVSALRIPEAKAGCVHSVMRLLAHNKIFAIVKIDDNKEAYALSPTSKLLVKGTDHCLSSMVKLLTNPTRVEKHYQLSTWTSMEDLTIFETPLWDLILQNPTHSKLFNDAMESDSNMVRFAMSDCKSVFEGLTSLVDVGGGTGNTVKIICEAFPTLKCIVFDLPNVVEGLTGNNYLSFVGGNMFESIPQADAILLKWILHNWNDDDCVKILRNCKEAVSRKNKEGKVIIIDIVINEEQDEHEMTELKLFFDISMMANFGSTERDEKAWEKIITEAGFTSYKIFHIFGFKSLIELCV
>rna-XM_024770457.2
MASSINNRKASEIFKAQALLYKNMYAFIDSMSLKWSVEMDIPTIIYNHGKPITLSNLVSILQIPSTKVDNVQRLMRLLAHNGFFEIVTNQELENEEEAYALTVTSELLVKGTELCLAPMVECVLDPKFNVSFHNFKKWIYEEDLTLFATSLGCDLWEFLNKNPEYNRLFNDAMASDSKMINLALKDCNFVFEGLDSIVDVGGGNGTTGKIICETYPKLRCVVFDRPKVVENLCGSNNLTYVGGDMFISVPKADAVLLKWILHDWTDRDCIKILKKCKEAVTTEGKRGKVIVIDMVINEKKEENELTQIKLLMNVTISCLNGKERNEEEWKKLFMEAGFENYKISPCLLLFSDSSSLGFALLG
>rna-XM_003621440.4
MASSLNGRKPSEIFKAQALLYKHIFAFIDSMSLKWAVEMNIPNIIHNHGKPISLSNLVSILQVPSSKIGNVRRLMRYLAHNGFFEIITKEEESYALTVASELLVRGSDLCLAPMVECVLDPTLSGSYHELKKWIYEEDLTLFGVTLGSGFWDFLDKNPEYNRSFNDAMASDSKLINLALRDCDFVFDGLESIVDVGGGNGTTGKIICETFPKLKCIVFDRPQVVENLSGSNNLTYVGGDMFTSIPNADAVLLKYILHNWTDKDCTRILKKCKEAVTNDGKKGKVIIIDMVINEKKDENQVTQIKLLMDVNMACLNGKERNEEEWKKLFIEAGFQDYKISPLTGFLSLIEIYP
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University