Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Medicago truncatula
Species name
Barrel medic (Medicago truncatula) is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Medicago_truncatula.4CL.fa
Download
>rna-XM_013612691.3
MSKNCFNLKTMTYSSPRQPINLPTDPNLSLTSFLFQSTSSVADTIALADAETGNSLTFRQLKIHVSALSHSLLHLGIRRGDVVLLLAPNSIRFPVCFLAIVAIGAIATTSSPLYTLSELSRQIHDSKPKLVITVSELFKKIEALTLGLPLILLDDPSKKFGARVSSYEDLIRESYNSSDDIPVNRDVSQSDVAAILYSSGTTGRSKGVMLTHQNLIATAVAGAVDQDQNGEGKNVFVCFVPMHHVMGLVGITYTQLRRGNTVVSFGGRFDLEKTFAAVEKFKVTHLYVAPPVMVELIKRREVVIGYELSSLKYLVGGAAPLGKDLMQECTKILPHVHVIQGYGMTEACGLVSIENPKEGSLISVSGSTGTLIPSVESRIINLATLKPLPPNQLGEIWLRGPTIMQGYFNNPEATKLAINDQGWMITGDLGYFDEKGQLFVVDRIKELIKCSGYQVAPAELEDLLVSHPEISDAGVIPSPDAKVGEVPVAFVVRLPNSSITKEDIQKFVAKQVAPYKRLRRVTFLEKIPKLATGKILRKDLGYGMTEACGLISFENPKEGAFLSNSGSTGKLVPSVESQIVSLQTSKSLPPNQLGEIWLRGPVMMQGYFNNPEATKQTINDQGWTLTGDLGYFDEKGQLFVVDRIKELIKCNGYQVAPAELEDLLISHPEISDAGVIPSPDAKAGEVPVAFVVRSLNSLITEEDIKKFVAKEVAPYKRLRRVTFIEKIPKSPTGKILRKDLVILDRQMTSKL
>rna-XM_013609908.3
MQKSGYGSDGIYRSLRPSLILPKNPNLSLVTHLFNKVTSSPNKTALIDADSSQTLTFAQLKSLTIKLAHSLIKIGLTKNDVVLFLAPNSYLYPVFFLAVASIGAVASTVNPQYTTVEVSKQAKDSNPKLIITVAELWEKVNHLNIPAVFLNSSGVATPDTVTSFESFVKLGESATEFPKIDVKQTDTAALLYSSGTTGVSKGVILTHQNFIASAAMISMDDELNGEINDVYLVVLPMFHVFGLAVITYSQLQRGNAIVSLKRFEFEVVLKTIEKFRVTRLWIVPPIVLALAKHGLVDKYDLSSLKYIGSGAAPLGKELMEECAKRFPHATVSQGYGMTETCGIVSVENTRMGIRHTGSAGMLVAGVEAQIVSVDTLKPLPPGQLGEIWVRGPNMMPGYYNNPQASRLTIDKKGWVHTGDLGYFDEDGNLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIQKFIADQVAPFKRLRRVTFINTVPKTASGKILRRELIDKARSKI
>rna-XM_013610186.3
MASSKQETKEIIFKSKLPDIYIPNHLPLHSYCFENLSQFGSRPCLINAPTGKVYTYHDVQLTSRKVASGLHKLGLQQGEVIMILLPNSPEFVFSFLAASYLGAVATAANPFFTASEIGKQAKSSNTKLIITQQCYYDKVKDLLNNNDHKVVLVDSSIDDNNNDHVHFSTLIIQEADENDHLPDAKIQPDDVVALPYSSGTTGLPKVMLTHKGLVSSIAQQVDGENPNLYYRSEDVILCVLPLFHIYSLNSVLLCGLRAKATILLMPKFDINSFLNLVNKHGVTVAPVVPPIVLAIAKSPDLNKYDLSSIRILKSGGAPLGKELEDTVRTKFPNAILGQGYGMTEAGPVLTMSLAFAKEPLNVKAGACGTVVRNAEMKIVDPDTGKSLPRNQSGEICIRGDQIMKGYLNDLEATERTIDKEGWLYTGDIGYIDEDDELFIVDRLKELIKYKGFQVAPAELEALLLSHPKISDAAVVPMKDEAAGEVPVAFVVRSNGYTDLTQDEIKHFISKQVVFYKRINQVFFIDAIPKSPSGKILRKDLRAKLAAGVPH
>rna-XM_013604602.3
MGAYIENFEENEHIFCSQYSPVPVPENVTLPEFVLQNAELYGDKVAFVDAESGKGVTYNEVVRDIHRFSKALRSLGLRKGNVVIVVLPNIVEYAIIALGIMDSGCVFSGANPASHTSEIKKQVESADAKLIVTNSSSHEKVKSLGLPVIVLGDDNVEDAMNWNKLLEAGDRAGNDLKKEPIHQNDLCAMPFSSGTTGMSKGVMLTHRNLVANLCSTLFGVTPEMIGQVTTLGLIPFFHIYGITGICCATIRNKGKVVVMGKYDLKTFLNALITHEVTFAPIVPPIILGLVKNPIVDQFDLSKLKLQAIMTAAAPLAPELLNSFEHKFPGVIVQEAYGLTEHSCITLTYAQKLSGSTHKNSVGFILPNLEVKFIDPETGRSLPRNTPGELCVRSQCVMQGYYKQVDETAQTIDKNGWLHTGDIGFIDDEENVFIVDRIKELIKYKGFQVAPAELEAILLSHSSVEDAAVVPLPDEEAGEIPAASVVLSKGAKESEEDIMNYVASNAAHYKKVRVVHFVEAIPKSPSGKIMRRLVKEKMVEKIKENNSLTKSNKF
>rna-XM_003604079.4
MTIQTMEQELIFKSKLPDIYIPKHLPLHSYCFENLSKYGSRPCLINAPTAEIYTYYDVQLTAQKVASGLNKLGIQQGDVIMVLLPNCPEFVFAFLGASFRGAIMTAANPFFTSAEIAKQAKASNTKLLVTQACYYDKVKDLENVKLVFVDSSPEEDNHMHFSELIQADQNEMEEVKVNIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGENPNLYYHSEDVILCVLPMFHIYSLNSVLLCGLRAKASILLMPKFDINAFFGLVTKYKVTIAPVVPPIVLAIAKSPELDKYDLSSIRVLKSGGAPLGKELEDTVRAKFPKAKLGQGYGMTEAGPVLTMCLSFAKEPIDVKSGACGTVVRNAEMKIVDPQNDSSLPRNQPGEICIRGDQIMKGYLNNPEATRETIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEAIILSHPQISDVAVVPMLDEAAGEVPVAFVVRSNGSIDTTEDDIKKFVSKQVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_039833405.1
MSPSPSPPQQEQKQEFIFRSKLPDIEIPTHLPLHSYCFQNLSQFNNRPCLINGDTGETLTYSDVHLTVRKIAAGLNTLGIQQGDVIMIVLRNSPQFALTFLGASFRGAVITTANPFYTSSELAKQATATKSKLIITQSVYLNKINDFAKLIDIKIVCIDSSPEEDENVVDFSVLTNADENELPEVKINPNDVVALPFSSGTSGLPKGVMLTHENLVTTISQLVDGENPHQYTNYEDVLLCVLPMFHIYALNSILLCGIRSGAAVLIVEKFEITKVLELIEKYKVTVASFVPPIVLALVKSGESMRYDLSSIRVMITGAAPMGMELEQAVKDRLPRTVLGQGYGMTEAGPLSISLAFAKEPFKTKPGACGTVVRNAEMKIVDTETGASLPRNKAGEICIRGTKVMKGYLNDPEATKRTIDKEGWLHTGDIGLIDDDDELFIVDRLKELIKYKGYQVAPAELEALLIAHPNISDAAVVPLKDEAAGEVPVAFVVRSNGSKISEDEIKQYISQQVLFNLYQISRLIFLLCKGVQSKIIFLLLVYCILYYYFTYVCCKNRKCKRIMN
>rna-XM_013600504.3
MQRSGYGPDGIYRSLRPSLALPNNPNLSLVSFLFTSVSSSPNKTALIDADSSQTLSFSQLKTQVAKLAHSLLNFGINKNDVVLILSPNNIEFPVCFLAAASIGAIVTTANPLYTVAELSKQIKDSNPKLVITVPELWSKVKSFNFNFPAIIINSGNATGSYSNFKSFEALIESAGEVTELPENDVKQTDTAALLYSSGTTGVSKGVILTHKNFIAASLMINMDDDLAGELNNVFICVLPMFHVFGLAVITYAQLRRGSTVVSMGRFELEGFLKVIEKYKVTNLWVVPPMILALAKQSVVGKYDVSSLKSIGSGAAPLGKELMEECARHLPHVAIYQGYGMTETCAVVSIENPRVGIRHSGSAGMLVSGVEAQIVSVDTQKPLPPKQLGELCVRGPNMMEGYYNNREATKQTLDNEGWVHTGDLGYFDEIGRLYVVDRIKELIKYKGYQVAPAELEDLLVSHPEIQDAVVVPFPDDEAGEVPIAYVVRLPNSSLSEEEIKKFIANQVAPFKRLRRVTFINSVPKTASGKILRRELIAKARSNI
>rna-XM_039832744.1
MDDDLAGELNNIGGYNIRAAKERKYGGFNGEDIPHDIAAQSMYVNQVQIQRSTLQTHLRHFYEIGGYNIRAAKERKYGGFNGEVRGPNMMQGYYNNLEATKQTLGNEGCVHTGDLGYFDEIGQLYVVDRMKELIKYKGYKVAPAALEDLLVSHPEIQDVVVILTYCYRFPDDEAGEVSIAYVVRSPNSSLSEEEIKKFIANQVKKS
>rna-XM_003610795.4
MLSVAPSVDAKQTTEVSTSVSVPKLEQINNQKQKPCDSFEDDSISISLSNQTTHIFKSKLPDIPISNHLPLHTYCFENLSEFADRPCLIVAATGKTYTYAETYLQCQKIAAGLSKLGIQKGDVIMILLQNSAEFVLSFIAASMIGAVATTANPFYTSAEIFKQIKASETKLIITQAMYVDKLRQKDQVGAEFDFKVITTDEPPLNCLHFSVISESNEEDIPVVEIDPEDAVALPFSSGTTGLPKGVILTHKSLTTSVAQQVDGENPNLHLTTEDVLLCVLPLFHIFSLNSVLLCALRAGSGVLLMHKFEIGTLLGLIQKHKVTVAMVVPPLVLALAKSPSVAEFDLSSIRLVLSGAAPLGKELEETLHNRIPQAVLGQGYGMTEAGPVLSMSLGFAKNPFPTSSGSCGTVVRNAELKVLDPETGRSLGYNQPGEICIRGQQIMKGYLNDENATKTTIDEEGWLHTGDVGYIDDNDEIFIVDRVKELIKFKGFQVPPAELEGLLVSHPSIADAAVVPQKDVAAGEVPVAFVVRSNGNDLTEEIVKEFIAKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLKAKLESST
MSKNCFNLKTMTYSSPRQPINLPTDPNLSLTSFLFQSTSSVADTIALADAETGNSLTFRQLKIHVSALSHSLLHLGIRRGDVVLLLAPNSIRFPVCFLAIVAIGAIATTSSPLYTLSELSRQIHDSKPKLVITVSELFKKIEALTLGLPLILLDDPSKKFGARVSSYEDLIRESYNSSDDIPVNRDVSQSDVAAILYSSGTTGRSKGVMLTHQNLIATAVAGAVDQDQNGEGKNVFVCFVPMHHVMGLVGITYTQLRRGNTVVSFGGRFDLEKTFAAVEKFKVTHLYVAPPVMVELIKRREVVIGYELSSLKYLVGGAAPLGKDLMQECTKILPHVHVIQGYGMTEACGLVSIENPKEGSLISVSGSTGTLIPSVESRIINLATLKPLPPNQLGEIWLRGPTIMQGYFNNPEATKLAINDQGWMITGDLGYFDEKGQLFVVDRIKELIKCSGYQVAPAELEDLLVSHPEISDAGVIPSPDAKVGEVPVAFVVRLPNSSITKEDIQKFVAKQVAPYKRLRRVTFLEKIPKLATGKILRKDLGYGMTEACGLISFENPKEGAFLSNSGSTGKLVPSVESQIVSLQTSKSLPPNQLGEIWLRGPVMMQGYFNNPEATKQTINDQGWTLTGDLGYFDEKGQLFVVDRIKELIKCNGYQVAPAELEDLLISHPEISDAGVIPSPDAKAGEVPVAFVVRSLNSLITEEDIKKFVAKEVAPYKRLRRVTFIEKIPKSPTGKILRKDLVILDRQMTSKL
>rna-XM_013609908.3
MQKSGYGSDGIYRSLRPSLILPKNPNLSLVTHLFNKVTSSPNKTALIDADSSQTLTFAQLKSLTIKLAHSLIKIGLTKNDVVLFLAPNSYLYPVFFLAVASIGAVASTVNPQYTTVEVSKQAKDSNPKLIITVAELWEKVNHLNIPAVFLNSSGVATPDTVTSFESFVKLGESATEFPKIDVKQTDTAALLYSSGTTGVSKGVILTHQNFIASAAMISMDDELNGEINDVYLVVLPMFHVFGLAVITYSQLQRGNAIVSLKRFEFEVVLKTIEKFRVTRLWIVPPIVLALAKHGLVDKYDLSSLKYIGSGAAPLGKELMEECAKRFPHATVSQGYGMTETCGIVSVENTRMGIRHTGSAGMLVAGVEAQIVSVDTLKPLPPGQLGEIWVRGPNMMPGYYNNPQASRLTIDKKGWVHTGDLGYFDEDGNLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDIQKFIADQVAPFKRLRRVTFINTVPKTASGKILRRELIDKARSKI
>rna-XM_013610186.3
MASSKQETKEIIFKSKLPDIYIPNHLPLHSYCFENLSQFGSRPCLINAPTGKVYTYHDVQLTSRKVASGLHKLGLQQGEVIMILLPNSPEFVFSFLAASYLGAVATAANPFFTASEIGKQAKSSNTKLIITQQCYYDKVKDLLNNNDHKVVLVDSSIDDNNNDHVHFSTLIIQEADENDHLPDAKIQPDDVVALPYSSGTTGLPKVMLTHKGLVSSIAQQVDGENPNLYYRSEDVILCVLPLFHIYSLNSVLLCGLRAKATILLMPKFDINSFLNLVNKHGVTVAPVVPPIVLAIAKSPDLNKYDLSSIRILKSGGAPLGKELEDTVRTKFPNAILGQGYGMTEAGPVLTMSLAFAKEPLNVKAGACGTVVRNAEMKIVDPDTGKSLPRNQSGEICIRGDQIMKGYLNDLEATERTIDKEGWLYTGDIGYIDEDDELFIVDRLKELIKYKGFQVAPAELEALLLSHPKISDAAVVPMKDEAAGEVPVAFVVRSNGYTDLTQDEIKHFISKQVVFYKRINQVFFIDAIPKSPSGKILRKDLRAKLAAGVPH
>rna-XM_013604602.3
MGAYIENFEENEHIFCSQYSPVPVPENVTLPEFVLQNAELYGDKVAFVDAESGKGVTYNEVVRDIHRFSKALRSLGLRKGNVVIVVLPNIVEYAIIALGIMDSGCVFSGANPASHTSEIKKQVESADAKLIVTNSSSHEKVKSLGLPVIVLGDDNVEDAMNWNKLLEAGDRAGNDLKKEPIHQNDLCAMPFSSGTTGMSKGVMLTHRNLVANLCSTLFGVTPEMIGQVTTLGLIPFFHIYGITGICCATIRNKGKVVVMGKYDLKTFLNALITHEVTFAPIVPPIILGLVKNPIVDQFDLSKLKLQAIMTAAAPLAPELLNSFEHKFPGVIVQEAYGLTEHSCITLTYAQKLSGSTHKNSVGFILPNLEVKFIDPETGRSLPRNTPGELCVRSQCVMQGYYKQVDETAQTIDKNGWLHTGDIGFIDDEENVFIVDRIKELIKYKGFQVAPAELEAILLSHSSVEDAAVVPLPDEEAGEIPAASVVLSKGAKESEEDIMNYVASNAAHYKKVRVVHFVEAIPKSPSGKIMRRLVKEKMVEKIKENNSLTKSNKF
>rna-XM_003604079.4
MTIQTMEQELIFKSKLPDIYIPKHLPLHSYCFENLSKYGSRPCLINAPTAEIYTYYDVQLTAQKVASGLNKLGIQQGDVIMVLLPNCPEFVFAFLGASFRGAIMTAANPFFTSAEIAKQAKASNTKLLVTQACYYDKVKDLENVKLVFVDSSPEEDNHMHFSELIQADQNEMEEVKVNIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGENPNLYYHSEDVILCVLPMFHIYSLNSVLLCGLRAKASILLMPKFDINAFFGLVTKYKVTIAPVVPPIVLAIAKSPELDKYDLSSIRVLKSGGAPLGKELEDTVRAKFPKAKLGQGYGMTEAGPVLTMCLSFAKEPIDVKSGACGTVVRNAEMKIVDPQNDSSLPRNQPGEICIRGDQIMKGYLNNPEATRETIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEAIILSHPQISDVAVVPMLDEAAGEVPVAFVVRSNGSIDTTEDDIKKFVSKQVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAGVPN
>rna-XM_039833405.1
MSPSPSPPQQEQKQEFIFRSKLPDIEIPTHLPLHSYCFQNLSQFNNRPCLINGDTGETLTYSDVHLTVRKIAAGLNTLGIQQGDVIMIVLRNSPQFALTFLGASFRGAVITTANPFYTSSELAKQATATKSKLIITQSVYLNKINDFAKLIDIKIVCIDSSPEEDENVVDFSVLTNADENELPEVKINPNDVVALPFSSGTSGLPKGVMLTHENLVTTISQLVDGENPHQYTNYEDVLLCVLPMFHIYALNSILLCGIRSGAAVLIVEKFEITKVLELIEKYKVTVASFVPPIVLALVKSGESMRYDLSSIRVMITGAAPMGMELEQAVKDRLPRTVLGQGYGMTEAGPLSISLAFAKEPFKTKPGACGTVVRNAEMKIVDTETGASLPRNKAGEICIRGTKVMKGYLNDPEATKRTIDKEGWLHTGDIGLIDDDDELFIVDRLKELIKYKGYQVAPAELEALLIAHPNISDAAVVPLKDEAAGEVPVAFVVRSNGSKISEDEIKQYISQQVLFNLYQISRLIFLLCKGVQSKIIFLLLVYCILYYYFTYVCCKNRKCKRIMN
>rna-XM_013600504.3
MQRSGYGPDGIYRSLRPSLALPNNPNLSLVSFLFTSVSSSPNKTALIDADSSQTLSFSQLKTQVAKLAHSLLNFGINKNDVVLILSPNNIEFPVCFLAAASIGAIVTTANPLYTVAELSKQIKDSNPKLVITVPELWSKVKSFNFNFPAIIINSGNATGSYSNFKSFEALIESAGEVTELPENDVKQTDTAALLYSSGTTGVSKGVILTHKNFIAASLMINMDDDLAGELNNVFICVLPMFHVFGLAVITYAQLRRGSTVVSMGRFELEGFLKVIEKYKVTNLWVVPPMILALAKQSVVGKYDVSSLKSIGSGAAPLGKELMEECARHLPHVAIYQGYGMTETCAVVSIENPRVGIRHSGSAGMLVSGVEAQIVSVDTQKPLPPKQLGELCVRGPNMMEGYYNNREATKQTLDNEGWVHTGDLGYFDEIGRLYVVDRIKELIKYKGYQVAPAELEDLLVSHPEIQDAVVVPFPDDEAGEVPIAYVVRLPNSSLSEEEIKKFIANQVAPFKRLRRVTFINSVPKTASGKILRRELIAKARSNI
>rna-XM_039832744.1
MDDDLAGELNNIGGYNIRAAKERKYGGFNGEDIPHDIAAQSMYVNQVQIQRSTLQTHLRHFYEIGGYNIRAAKERKYGGFNGEVRGPNMMQGYYNNLEATKQTLGNEGCVHTGDLGYFDEIGQLYVVDRMKELIKYKGYKVAPAALEDLLVSHPEIQDVVVILTYCYRFPDDEAGEVSIAYVVRSPNSSLSEEEIKKFIANQVKKS
>rna-XM_003610795.4
MLSVAPSVDAKQTTEVSTSVSVPKLEQINNQKQKPCDSFEDDSISISLSNQTTHIFKSKLPDIPISNHLPLHTYCFENLSEFADRPCLIVAATGKTYTYAETYLQCQKIAAGLSKLGIQKGDVIMILLQNSAEFVLSFIAASMIGAVATTANPFYTSAEIFKQIKASETKLIITQAMYVDKLRQKDQVGAEFDFKVITTDEPPLNCLHFSVISESNEEDIPVVEIDPEDAVALPFSSGTTGLPKGVILTHKSLTTSVAQQVDGENPNLHLTTEDVLLCVLPLFHIFSLNSVLLCALRAGSGVLLMHKFEIGTLLGLIQKHKVTVAMVVPPLVLALAKSPSVAEFDLSSIRLVLSGAAPLGKELEETLHNRIPQAVLGQGYGMTEAGPVLSMSLGFAKNPFPTSSGSCGTVVRNAELKVLDPETGRSLGYNQPGEICIRGQQIMKGYLNDENATKTTIDEEGWLHTGDVGYIDDNDEIFIVDRVKELIKFKGFQVPPAELEGLLVSHPSIADAAVVPQKDVAAGEVPVAFVVRSNGNDLTEEIVKEFIAKQVVFYKRLHKVYFVHAIPKSPAGKILRKDLKAKLESST
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University