Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Manihot esculenta
Species name
Cassava (Manihot esculenta) is a species of eudicot in the family Euphorbiaceae (spurge family).
Species info
Gene sequence info
Manihot_esculenta.CHS.fa
Download
>rna-XM_021751348.1
MRDHAILSVDEVIRGVSVAVHDGSPLVVFLNTMWMHRLIMLIVFHFMELFYVTQMDMFLRFIGFHSGYFISFCSRSKGVEVKALRETLVWLVSLSLTQVIVEIDSQLVMKAVLSTVVDYSKANTLIAEFLIYNLLTFDNPTINSSSYQTIF*LQHSKMSKSDNHRRIPTTGKATILAIGKAFPKQLIPQECLVEGYIRDTKCEDVSIKEKLERLCKTTTVKRRYTVMSKEILDKYPELATEGTPTIKQRLEIANPAVVEMAKEASIACIKEWGRPAEDITHIVYVSSSEIRLPGGDLYLASQLGLKSDVSRVMLYFLGCYGGVAGLRVAKDIAENNPGSRVLLTTSETTIIGFRPPNKARPYDLVGAALFGDGAAAVIIGANPIINKESPFMELNCAVQQFLPGTQNVIDGRLTEEGINFKLGRDLPQKIEDNIEEFCKKLMLKAGLTEEFNDLFWAVHPGGPAILNRLETNLKLNSGKLECSRRALMDYGNVSSNTIFYVMEYMREELKREGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_021753028.1
MVTVDEVRKAQRAEGPATVLAIGTATPTNCVDQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMHLTEDILKENPNICAYMAPSLDARQDIVVVEIPKLGKEAAVKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGADPVPQVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFQPLGISDWNSLFWIAHPGGPAILDQVEVKLGLKPEKLRATRHVLADYGNMSSACVLFILDEMRKKSTEDGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVAT
>rna-XM_021755671.1
MGSEETVQSGSSKKANPGKATILALGKAFPHQLVMQEFLVDGYFKNTNCDNPDLKQKLARLCKTTTVKTRYVVMSEEILQKYPELAAEGLPTVKQRLDICNDAVTQMAIEASQICIKNWGRSMSDITHLVYVSSSEARLPGGDLYLARGLGLNPETQRIMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSIDRPYDLVGVALFGDGAGAMIIGTDPVSYSERPLFELHTAIQNFLPETEKIIDGKLTEEGISFKLARELPHIIEDNVEGFCHKLMRNAGVAEKEYNKLFWAVHPGGPAILNRIEKRLDLLPEKLNASRRALMDYGNASSNTIVYVLEYMIEESFKIKEKNENCEWGLILAFGPGITFEGILARNLTV
>rna-XM_021753697.1
MAASVEEIRKAQRAQGPATILAIGTATPSNCVNQADYPDYYFRITNSEHMTELKEKFKRMCDKSMIKKRYMHLDEEILKENPNMCAYWEPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGSDPDTSIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPIGINDWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHVLSEYGNMSSACVLFILDEMRKKSLKEGKPTTGEGLEWGVLFGFGPGLTVETVVLHSVPTETTAY
>rna-XM_021771570.1
MAASVEEIRMAQRAQGPATILAIGTATPSNYFIQADYPDFYFRVTRSEHMTNLKEKFKRICDKSMIKKRYMHLNEEILKENSNMCAYWEPSLDARQDIAVVEVPKLGKEAAIKAIEEWGQPKSKITHLIFCTTAGVDMPGCDYQLTKLLGLHLSVKRYMLYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITTMIFRGPSDTHLDSLVCQALFGDGAGALIVGSDPDDTIEHPLFQLVSSAQTIIPNSDAALKLHVREVGLTFHLLKEVPELISKNIEKPLAESFNPIGISDWNSIFWIVHPGGAAILDQIEKKLDLKPEKMRASRHVLSEYGNLTSACVLFILDEMRKKSFEEGKVTTGEGVEWGVLFGFGPGLTVETIVLHSVPTGAKK
>rna-XM_021771228.1
MAASVEEIRKAQRAHGPATILAIGTATPSNCVNQADYPDYYFRVTKSEHMTELKEKFKRICDKSMIKKRYMHLTEEILKENPNICTYWEPSLDARQDIMVVEVPKLGNKAATKAIEEWGQPKSKITHLIFCTTSGVDMPGYDYQLIKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITVVTFRGPADTHLDSLVGQALFGDGAAALIVGADPDTSIEHPLFQLVSTAETILPDSDGAIEGHLREVGLSFHLQDRVPSLISKNIEKSLVEVFSPIGINNWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHILSEYGNLSSACVIFILDEMRKKSLEERKVTTGEGLEWGVLFGFGPGLTVETVVLHSVLTETATK
>rna-XM_021771236.1
MVMSAMAGIVEEIREAHRAKGPATILAIGTATPSNSISQDLYPDYYFRITKSDHLTHLKRKFMHLCAKSRIKKRYMHLTEEMLKEHPNLCSYKEPSLSTRKEILKHELPKLGSEAACKAIQEWGQPKSKITHLIFYTTSSIVVMPGCDFYLAKILGLRPCVQRFMMYNLGCFAGGTVLRLAKDLAENNKDARVLVVCSEISVATFRGPSDTHLDSLVGQALFGDGAAALIVGSDIDTSIEHPLFQLVSASQTILPDSDKVIEGNLLEIGLTFHLQKDVPKLISENIEKCLVQAFSPIGISDWNSIFWIAHPGGPAILEQIEMKLNLKQEKLRASWHVLREYGNMSSASVFFIMDEMRNKSVEEGNCSLGEGLEWGVLFGFGPGLTVETVVLPSLQVKASRWEKMIDAFVDDCIARKLFKK
>rna-XM_021771783.1
MAAVSVGEIIKAEKAQGPATILAIGTATPSNCVNQVDYPDYYFRITKSEHMTDLKEKFKRICDKSKVKKRYMHLNEEILKENPNMCAYWEPSLDARQDIAAVEVPKLGKEAAAKAIKEWGQPKSKITHLIFCTTSVIDIPGCDYQLTKLLGLHPAVKRFMIYHQGCYASGMALRVAKDLAENNKGARVLVVCSEIRVATFRGPSETHLDSLVGQAIFSDGAGAIIIGSDPDIPIEYPLFQLISAAQTIIPDSDGAIHGHLREVGLTVHLLKDIPRLISKNIGEILEEAFSPIGISDWNSIFWIAHPGGSAILDQIEVKLSLDPEKLNASKHVLSEYGNMSSASVLFILDEMRKKSLEEGKATTGEGLEWGVLFGFGPGITVETVVLHSVRI
>rna-XM_021771572.1
MAAASVEEIRKAQRAQGPATILAIGTATPSNCVNQADYPDYYFRITKSEHMAELKEKFKRMCDKSMIKKRYMHLDEEILKENPNMCGYWEPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGSDPDTSIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPSLISKNIEKSLVEAFKPIGISDWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHVLSEYGNMSSACVLFILDEMRKKSLEEGKVTTGEGLEWGVLFGFGPGLTVETVVLHSVST
>rna-XM_021772983.1
MHACIYWSVYSSDQINFTVPSMVLTGKTTTVKTRYVVMLDEILKEYPKLAIEGFYYFPTVKQHLDICNNAVTQMAIEASQICINNWGRAMSDITHLVYVSSSEVRLSGGDLYLARALGLNPGTQRVLLYFMGCSGGVAGLHVAKDIAENNLRSRVLLATSKTTIIGFKPLSAERPYDLVGVALFGDGDGTGAGAMIIGTDPVSDIEHPLFELHTAVQSFLPETDKIIDGKLIEEGISFKLSRELPHVIEDNVEDFYRKLMGIAGVTEKEYNELFWAVHPGEPAILNRIEKRLDLVPEKLNASRQALMDYGNASSNTIVFVLEYMIEEESLKMKKNNESCEWGLILAFGPEITLEGILVRNLTV
MRDHAILSVDEVIRGVSVAVHDGSPLVVFLNTMWMHRLIMLIVFHFMELFYVTQMDMFLRFIGFHSGYFISFCSRSKGVEVKALRETLVWLVSLSLTQVIVEIDSQLVMKAVLSTVVDYSKANTLIAEFLIYNLLTFDNPTINSSSYQTIF*LQHSKMSKSDNHRRIPTTGKATILAIGKAFPKQLIPQECLVEGYIRDTKCEDVSIKEKLERLCKTTTVKRRYTVMSKEILDKYPELATEGTPTIKQRLEIANPAVVEMAKEASIACIKEWGRPAEDITHIVYVSSSEIRLPGGDLYLASQLGLKSDVSRVMLYFLGCYGGVAGLRVAKDIAENNPGSRVLLTTSETTIIGFRPPNKARPYDLVGAALFGDGAAAVIIGANPIINKESPFMELNCAVQQFLPGTQNVIDGRLTEEGINFKLGRDLPQKIEDNIEEFCKKLMLKAGLTEEFNDLFWAVHPGGPAILNRLETNLKLNSGKLECSRRALMDYGNVSSNTIFYVMEYMREELKREGGEEWGLALAFGPGITFEGILLRSL
>rna-XM_021753028.1
MVTVDEVRKAQRAEGPATVLAIGTATPTNCVDQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMHLTEDILKENPNICAYMAPSLDARQDIVVVEIPKLGKEAAVKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAIIVGADPVPQVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFQPLGISDWNSLFWIAHPGGPAILDQVEVKLGLKPEKLRATRHVLADYGNMSSACVLFILDEMRKKSTEDGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVAT
>rna-XM_021755671.1
MGSEETVQSGSSKKANPGKATILALGKAFPHQLVMQEFLVDGYFKNTNCDNPDLKQKLARLCKTTTVKTRYVVMSEEILQKYPELAAEGLPTVKQRLDICNDAVTQMAIEASQICIKNWGRSMSDITHLVYVSSSEARLPGGDLYLARGLGLNPETQRIMLYFMGCSGGVAGLRVAKDIAENNPGSRVLLATSETTIIGFKPPSIDRPYDLVGVALFGDGAGAMIIGTDPVSYSERPLFELHTAIQNFLPETEKIIDGKLTEEGISFKLARELPHIIEDNVEGFCHKLMRNAGVAEKEYNKLFWAVHPGGPAILNRIEKRLDLLPEKLNASRRALMDYGNASSNTIVYVLEYMIEESFKIKEKNENCEWGLILAFGPGITFEGILARNLTV
>rna-XM_021753697.1
MAASVEEIRKAQRAQGPATILAIGTATPSNCVNQADYPDYYFRITNSEHMTELKEKFKRMCDKSMIKKRYMHLDEEILKENPNMCAYWEPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGSDPDTSIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLVEAFTPIGINDWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHVLSEYGNMSSACVLFILDEMRKKSLKEGKPTTGEGLEWGVLFGFGPGLTVETVVLHSVPTETTAY
>rna-XM_021771570.1
MAASVEEIRMAQRAQGPATILAIGTATPSNYFIQADYPDFYFRVTRSEHMTNLKEKFKRICDKSMIKKRYMHLNEEILKENSNMCAYWEPSLDARQDIAVVEVPKLGKEAAIKAIEEWGQPKSKITHLIFCTTAGVDMPGCDYQLTKLLGLHLSVKRYMLYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITTMIFRGPSDTHLDSLVCQALFGDGAGALIVGSDPDDTIEHPLFQLVSSAQTIIPNSDAALKLHVREVGLTFHLLKEVPELISKNIEKPLAESFNPIGISDWNSIFWIVHPGGAAILDQIEKKLDLKPEKMRASRHVLSEYGNLTSACVLFILDEMRKKSFEEGKVTTGEGVEWGVLFGFGPGLTVETIVLHSVPTGAKK
>rna-XM_021771228.1
MAASVEEIRKAQRAHGPATILAIGTATPSNCVNQADYPDYYFRVTKSEHMTELKEKFKRICDKSMIKKRYMHLTEEILKENPNICTYWEPSLDARQDIMVVEVPKLGNKAATKAIEEWGQPKSKITHLIFCTTSGVDMPGYDYQLIKLLGLRPSVKRFMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITVVTFRGPADTHLDSLVGQALFGDGAAALIVGADPDTSIEHPLFQLVSTAETILPDSDGAIEGHLREVGLSFHLQDRVPSLISKNIEKSLVEVFSPIGINNWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHILSEYGNLSSACVIFILDEMRKKSLEERKVTTGEGLEWGVLFGFGPGLTVETVVLHSVLTETATK
>rna-XM_021771236.1
MVMSAMAGIVEEIREAHRAKGPATILAIGTATPSNSISQDLYPDYYFRITKSDHLTHLKRKFMHLCAKSRIKKRYMHLTEEMLKEHPNLCSYKEPSLSTRKEILKHELPKLGSEAACKAIQEWGQPKSKITHLIFYTTSSIVVMPGCDFYLAKILGLRPCVQRFMMYNLGCFAGGTVLRLAKDLAENNKDARVLVVCSEISVATFRGPSDTHLDSLVGQALFGDGAAALIVGSDIDTSIEHPLFQLVSASQTILPDSDKVIEGNLLEIGLTFHLQKDVPKLISENIEKCLVQAFSPIGISDWNSIFWIAHPGGPAILEQIEMKLNLKQEKLRASWHVLREYGNMSSASVFFIMDEMRNKSVEEGNCSLGEGLEWGVLFGFGPGLTVETVVLPSLQVKASRWEKMIDAFVDDCIARKLFKK
>rna-XM_021771783.1
MAAVSVGEIIKAEKAQGPATILAIGTATPSNCVNQVDYPDYYFRITKSEHMTDLKEKFKRICDKSKVKKRYMHLNEEILKENPNMCAYWEPSLDARQDIAAVEVPKLGKEAAAKAIKEWGQPKSKITHLIFCTTSVIDIPGCDYQLTKLLGLHPAVKRFMIYHQGCYASGMALRVAKDLAENNKGARVLVVCSEIRVATFRGPSETHLDSLVGQAIFSDGAGAIIIGSDPDIPIEYPLFQLISAAQTIIPDSDGAIHGHLREVGLTVHLLKDIPRLISKNIGEILEEAFSPIGISDWNSIFWIAHPGGSAILDQIEVKLSLDPEKLNASKHVLSEYGNMSSASVLFILDEMRKKSLEEGKATTGEGLEWGVLFGFGPGITVETVVLHSVRI
>rna-XM_021771572.1
MAAASVEEIRKAQRAQGPATILAIGTATPSNCVNQADYPDYYFRITKSEHMAELKEKFKRMCDKSMIKKRYMHLDEEILKENPNMCGYWEPSLDARQDIVVVEVPKLGKEAATKAIKEWGQPKSKITHLIFCTTSGVDMPGCDYQLTKLLGLRPSVKRFMMYQQGCFAGGTVLRMAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAGALIVGSDPDTSIERPLFQLVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPSLISKNIEKSLVEAFKPIGISDWNSIFWIAHPGGPAILDQVEAKLSLKPEKMRATRHVLSEYGNMSSACVLFILDEMRKKSLEEGKVTTGEGLEWGVLFGFGPGLTVETVVLHSVST
>rna-XM_021772983.1
MHACIYWSVYSSDQINFTVPSMVLTGKTTTVKTRYVVMLDEILKEYPKLAIEGFYYFPTVKQHLDICNNAVTQMAIEASQICINNWGRAMSDITHLVYVSSSEVRLSGGDLYLARALGLNPGTQRVLLYFMGCSGGVAGLHVAKDIAENNLRSRVLLATSKTTIIGFKPLSAERPYDLVGVALFGDGDGTGAGAMIIGTDPVSDIEHPLFELHTAVQSFLPETDKIIDGKLIEEGISFKLSRELPHVIEDNVEDFYRKLMGIAGVTEKEYNELFWAVHPGEPAILNRIEKRLDLVPEKLNASRQALMDYGNASSNTIVFVLEYMIEEESLKMKKNNESCEWGLILAFGPEITLEGILVRNLTV
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University