Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Manihot esculenta
Species name
Cassava (Manihot esculenta) is a species of eudicot in the family Euphorbiaceae (spurge family).
Species info
Gene sequence info
Manihot_esculenta.4CL.fa
Download
>rna-XM_021755062.1
MIKSVPQSLTEQIPLVFSSEFSMERSGYGRDGIYRSLRPTLVVPKDPNLSMVSFLFRNSNSYPDKPALIDADLSLTLSFAQLKSIVIKVSNGLRHLGISKNDVVLIFAPNSYQFPICFLAITSIGAIVTTANPLYTATELSKQIKDSKPKLVITVPELWNKAKGSNLPAVFLGSKESSSVEPNSRVKSFHHLVELGASNSEFPVSNVKQTDTAALLYSSGTTGTSKGVILTHGNFIAASLMVTMDQEMAGEMHHVFLCFLPMFHVFGLSIITYSQLQKGNAIVSMGKFDFEMVLKNVEKYRVTHLWVVPPVILALAKQSLVKKYDLSSLQHVGSGAAPLGKELMEECAKSIPHAAVAQGYGMTETTGIVSVENPRIGVRHRGSAGILASGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYLNNPQATKQTIDKKGWVHTGDLGYFNEDGQLYVVDRIKELIKFKGYQVAPAELEGLLVSHHEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVNFINSVPKSVSGKILRRELIEKAKSKI
>rna-XM_021755297.1
METQLINQQGEIIFRSKLPDIYIPKHLTLHSYIFENISSHSSRPCLINGATGDIYTYAEVELTGRRVASGLNKLGVKQGDVIMLLLHNSPQFVLSFLGASFRGAIATAANPFFTPAEIAKQAKASNTKLIITQAAYAEKVKDLARDHGIKVLCIDSAPDGCLHFSELSEADERDMPDVNISSEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFDIGALLQLIQKYKITVAPIVPPIVLSIAKSPDTDKYDLSSIRMLKSGAAPLGKELEDTVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKEPFSIKPGACGTVVRNAEMKIVDPETGESLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLAHLEISDAAVVGMKDENAGEVPVAFVVRSDKSQITEDEIKQYIYKQVVFYKRIGKVFFVESIPKAPSGKILRKILRENLTSDFQK
>rna-XM_021765695.1
MTSIASETSRPEVFPPQNSDTHIFRSKLPDIPISTHLSLYAYCFEKLFSFFDRPCLISGSTGKKYSFAESHRISQKTAAGLSNLGIKKGDVIMILLHNCPEFVFSFLGASMIGAVTTTANPSYTPNEIFKQFTASHAKLIITQSQYVDKLRDSHENHPKLSKDFTVITIDDPPENCLPLTVLTEANESEVPDVTINPDDPVALPFSSGTTGLPKGVILTHKNLITNVAQQVDGENPNLYLKEEDVVLCILPLFHMFALDTVLLCSLRSGAAVLLMQQFEMGALLELIQKHKVSVAALVPPLVVALAKNPMVAAFDLSTIRVVISGAAPLGKEVEDAFRSRVPQATLGQGYGMTEAAAAITLCLGFAKQPFPTKLGSCGTVLRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKAYLDDLETTLNTIDVEGWLHTGDIGYVDDDEEVFIVDRIKEIIKFKGFQVSPTELEALLLNHPSIADAAVVPQKDEVAGEVPVAFVVPSDGSELTEETVKEYIEKQVVFYKKLSKVYFVHAIPKSPSGKILRKDLKARLAAASLLP
>rna-XM_021767492.1
MISIASLELEPSKPEVSPPHNSDAHIFRSKLPDIPISNHLSLHAYCFENLLSFADRPCLISGSTGKTYSFAETHLVSQKCAAGLSNLGINKGDVVMILLQNCPEFVFSFMGASMIGAVTTTANPFYTSNEIFKQFTSSRAKLIITQSQYVDKLRDSQENQPKLGQDFNVITIDDPPENCLHFTVLSEAKESEIPDVTIHPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLFMQKFEIGALLELIQKHKVSVAAVVPPLVLALAKNPMVAGFDLSSIRVVLSGAAPLGKELEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKGYLNDLEATANTIDVEGWLHTGDIGYVDDDEEVFIVDRVKEIIKFKGFQVPPAELEALLVNHPSIADAAVVPQKDEVAGEAPVAFVVPSNGFELTEEAVKDYIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDIKAKLASTSSVS
>rna-XM_021767737.1
MAKSYNPQTQTYLSPRPPVHLPTNPDLSLTSFLFHSTLSSSSSTALIDADSGETLTFRQLRIRVSKLAHALLKLNIVKSDVVLILAPNSIHIPICFLAIVSTGAIASTCNPAYTAAEISKQVKDCNPKLIITVPQLLHKVKQFNLPLILLNSTNSDDLASNSKVWNYSDLVQLSGEVSDLPVNDVKQNNVAALFYSSGTTGTSKGVILTHRNFIATSLMVTADQDRYKEPQNVFLCFLPMFHIFGFSVVTYSQLRRGNTVVSMEKFELEKMLRSIEKYRVTHMFVVPPVMIALAKQNAVKQFDLSSLKVIGSGAAPLGKDVMEECAKNLPRVDFIQGYGMTETCGIISVENPKEGTRLSGSTGVLVPGVESQIVSVDTSKPLPPYEIGEICLRGANMMQGYFNNPQATKLTIDGQGWLHTGDLGYFNEGGELFVVDRIKELIKCNGFQVNLILCDGQSVLLLKLDFFLEWVSLFRFPDSKAGEVPIAYVVRAPNSSLTEEDIQKFIADQVAPFKRLRRVTFINSVPKSASGKILRREMIDKVRSKI
>rna-XM_021772370.1
METQVLKQQEELIFRSKLPDIYIPKHLPLHSYIFENISSHSSKPCLINGVTGNVYTYSEVELTARRVASGLNNLGIKQGEVIMLLLHNSPEFVLSFLGASFRGAIATAANPFFTPAEIAKQAKGSNTKLIITQAAYAEKVKDLANDYGIKILCIDSAPDGCLHFSELSEADERDMPDVDISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEIGALLQLIQKYKITVAPIVPPIVLAIAKSPDTEKYDLSSIRMLKSGAAPLGKELEDTVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKEPFNIKPGACGTVVRNAEMKIVDPETGDSLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLAHPEISDAAVVGMKDESAGEVPVAFVVRSGKSEITQDEIKQYISKQVVFYKRIGRVFFMEAIPKAPSGKILRKNLREKLATDFQK
>rna-XM_021775759.1
MATPVPFSEPKEHIFRSRYPAVPVPENVTIPDFVLQDAELYADKVAFVEALTGKAYTYGEVVRETRRFAKALRSIGLKKGQVVIVVLPNVAEYGIVALGIMAAGGVYSGANPAAHESEIKKQVQAANAKLIVTNDLSYGKVSSLELPVILTGETRIGSAMNWHELLDSADRATDKYVCEDVHQSDLCALPFSSGTTGISKGVMLTHRNLVANLCSSLFSVGPEMLGQVTTLGLIPFFHIYGITGICFATLRNKGKVVVMSRFELRTFLNALISQEVTFAPIVPPIILALVKNPIVEEFDLSKLKLRAIMTAAAPLAPELLTAFEKKFPGVQVQEAYGLTEHSCITLTHGDPDKEHGIAKKNSVGFILPNLEVKFIDPETGGSLPKNTPGEICVRSQCVMQGYYDNKEETARAIDQDGWLHTGDSGYIDDDGDIFIVDRIKELIKYKGFQVAPAEIEAILLAHPSVEDAAVVPLPDEEAGEIPAACVVKNKEAKENEEDIIKYVASNVAHYKKVRVVQFVESIPKSPSGKIMRRLIKEKMIEKLQHNPKPLPPNSH
>rna-XM_021777985.1
MATPLVTFSAQEENIFRSRYPAVPVPENVTLPDFVLQDYELYSDRVAFVEAVTGKAYTYGELVRETRRFTKALRSIGIRKGHVVIVVLPNVAEYGIVALGIMATGGVYSGVNPAAHESEIKKQVLAANAKLIVTNDLSYEKVRSLELPVITLGETRIGSAMNWYELLDAADRATDRYVYEDVDQNDLCALPFSSGTTGMSKGVMLTHRNLVANLCSTLFSVAPQMVGQVTTLGLIPFFHIYGILGICFSTLRNKGKVVVMNRFELRTFLNALMTQEVTYAPIVPPIILALVKNPIVDEFDLSELKLRAIMTAAAPLAPELLRAFENKFPGVQVHEAYGLTEHSCITLTHGDPNLGHGISKKNSVGFILPNLEVKFIDPESGRSLPKNTPGEICVRSQCVMQGYYNNKEETARTIDGDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAEIEALLLTHPSVEDVAVVSLPDEEAGEIPAACVVIKQEARQSEEDIINYVSSNVAHYKKVRKVQFVETIPKSPSGKIMRRLLKEKMIEKMQANGQTTVSQLTPTPTNFD
>rna-XM_021779016.1
MEAKNDQREFIFRSKLPDIYIPNHLPLHTYCFENITQFKDNPCLINGPTGDIYTYADVELKSRKVAAGLHKLGIQQGYVIMLLLQNSPEFVFVFLGASYRGAISTTANPFYTPTEIAKQATASKAKLIVTQAVYAEKVKQFAKENDIKIITIDSPPDGCLHFSELTEADENDIPGVKINPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHKKDVILCVLPLFHIYSLNSVLLCGLRVGSAILIMQKFEIISLMELVQKYKVSIAPFVPPIVLAIAKSPVVDQYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKDPFEIKSGACGTVVRNAEMKIVDPETGNSLPRNQAGEICIRGSQIMKGYLNDPEATISTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVIFYKRINRVFFIEAIPKAPSGKILRKDLRVRLIAGVPN
MIKSVPQSLTEQIPLVFSSEFSMERSGYGRDGIYRSLRPTLVVPKDPNLSMVSFLFRNSNSYPDKPALIDADLSLTLSFAQLKSIVIKVSNGLRHLGISKNDVVLIFAPNSYQFPICFLAITSIGAIVTTANPLYTATELSKQIKDSKPKLVITVPELWNKAKGSNLPAVFLGSKESSSVEPNSRVKSFHHLVELGASNSEFPVSNVKQTDTAALLYSSGTTGTSKGVILTHGNFIAASLMVTMDQEMAGEMHHVFLCFLPMFHVFGLSIITYSQLQKGNAIVSMGKFDFEMVLKNVEKYRVTHLWVVPPVILALAKQSLVKKYDLSSLQHVGSGAAPLGKELMEECAKSIPHAAVAQGYGMTETTGIVSVENPRIGVRHRGSAGILASGVEAQIVSVDTLKPLPPNQLGEIWVRGPNMMQGYLNNPQATKQTIDKKGWVHTGDLGYFNEDGQLYVVDRIKELIKFKGYQVAPAELEGLLVSHHEILDAVVIPFPDAEAGEVPVAYVVRSPNSSLTEEDVQKFIADQVAPFKRLRRVNFINSVPKSVSGKILRRELIEKAKSKI
>rna-XM_021755297.1
METQLINQQGEIIFRSKLPDIYIPKHLTLHSYIFENISSHSSRPCLINGATGDIYTYAEVELTGRRVASGLNKLGVKQGDVIMLLLHNSPQFVLSFLGASFRGAIATAANPFFTPAEIAKQAKASNTKLIITQAAYAEKVKDLARDHGIKVLCIDSAPDGCLHFSELSEADERDMPDVNISSEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFDIGALLQLIQKYKITVAPIVPPIVLSIAKSPDTDKYDLSSIRMLKSGAAPLGKELEDTVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKEPFSIKPGACGTVVRNAEMKIVDPETGESLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLAHLEISDAAVVGMKDENAGEVPVAFVVRSDKSQITEDEIKQYIYKQVVFYKRIGKVFFVESIPKAPSGKILRKILRENLTSDFQK
>rna-XM_021765695.1
MTSIASETSRPEVFPPQNSDTHIFRSKLPDIPISTHLSLYAYCFEKLFSFFDRPCLISGSTGKKYSFAESHRISQKTAAGLSNLGIKKGDVIMILLHNCPEFVFSFLGASMIGAVTTTANPSYTPNEIFKQFTASHAKLIITQSQYVDKLRDSHENHPKLSKDFTVITIDDPPENCLPLTVLTEANESEVPDVTINPDDPVALPFSSGTTGLPKGVILTHKNLITNVAQQVDGENPNLYLKEEDVVLCILPLFHMFALDTVLLCSLRSGAAVLLMQQFEMGALLELIQKHKVSVAALVPPLVVALAKNPMVAAFDLSTIRVVISGAAPLGKEVEDAFRSRVPQATLGQGYGMTEAAAAITLCLGFAKQPFPTKLGSCGTVLRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKAYLDDLETTLNTIDVEGWLHTGDIGYVDDDEEVFIVDRIKEIIKFKGFQVSPTELEALLLNHPSIADAAVVPQKDEVAGEVPVAFVVPSDGSELTEETVKEYIEKQVVFYKKLSKVYFVHAIPKSPSGKILRKDLKARLAAASLLP
>rna-XM_021767492.1
MISIASLELEPSKPEVSPPHNSDAHIFRSKLPDIPISNHLSLHAYCFENLLSFADRPCLISGSTGKTYSFAETHLVSQKCAAGLSNLGINKGDVVMILLQNCPEFVFSFMGASMIGAVTTTANPFYTSNEIFKQFTSSRAKLIITQSQYVDKLRDSQENQPKLGQDFNVITIDDPPENCLHFTVLSEAKESEIPDVTIHPDDPVALPFSSGTTGLPKGVILTHKSLITSVAQQVDGENPNLYLKQEDVVLCVLPLFHIYSLNSVLLCSLRAGAAVLFMQKFEIGALLELIQKHKVSVAAVVPPLVLALAKNPMVAGFDLSSIRVVLSGAAPLGKELEDALRSRVPQAILGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVIDPETGCSLGYNQPGEICIRGQQIMKGYLNDLEATANTIDVEGWLHTGDIGYVDDDEEVFIVDRVKEIIKFKGFQVPPAELEALLVNHPSIADAAVVPQKDEVAGEAPVAFVVPSNGFELTEEAVKDYIAKQVVFYKKLHKVYFVHAIPKSPSGKILRKDIKAKLASTSSVS
>rna-XM_021767737.1
MAKSYNPQTQTYLSPRPPVHLPTNPDLSLTSFLFHSTLSSSSSTALIDADSGETLTFRQLRIRVSKLAHALLKLNIVKSDVVLILAPNSIHIPICFLAIVSTGAIASTCNPAYTAAEISKQVKDCNPKLIITVPQLLHKVKQFNLPLILLNSTNSDDLASNSKVWNYSDLVQLSGEVSDLPVNDVKQNNVAALFYSSGTTGTSKGVILTHRNFIATSLMVTADQDRYKEPQNVFLCFLPMFHIFGFSVVTYSQLRRGNTVVSMEKFELEKMLRSIEKYRVTHMFVVPPVMIALAKQNAVKQFDLSSLKVIGSGAAPLGKDVMEECAKNLPRVDFIQGYGMTETCGIISVENPKEGTRLSGSTGVLVPGVESQIVSVDTSKPLPPYEIGEICLRGANMMQGYFNNPQATKLTIDGQGWLHTGDLGYFNEGGELFVVDRIKELIKCNGFQVNLILCDGQSVLLLKLDFFLEWVSLFRFPDSKAGEVPIAYVVRAPNSSLTEEDIQKFIADQVAPFKRLRRVTFINSVPKSASGKILRREMIDKVRSKI
>rna-XM_021772370.1
METQVLKQQEELIFRSKLPDIYIPKHLPLHSYIFENISSHSSKPCLINGVTGNVYTYSEVELTARRVASGLNNLGIKQGEVIMLLLHNSPEFVLSFLGASFRGAIATAANPFFTPAEIAKQAKGSNTKLIITQAAYAEKVKDLANDYGIKILCIDSAPDGCLHFSELSEADERDMPDVDISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEIGALLQLIQKYKITVAPIVPPIVLAIAKSPDTEKYDLSSIRMLKSGAAPLGKELEDTVRAKFPQATLGQGYGMTEAGPVLAMCLAFAKEPFNIKPGACGTVVRNAEMKIVDPETGDSLPRNQPGEICIRGDQIMKGYLNDPEATARTIDKQGWLHTGDIGYIDDDDELFIVDRLKEIIKYKGFQVAPAEIEALLLAHPEISDAAVVGMKDESAGEVPVAFVVRSGKSEITQDEIKQYISKQVVFYKRIGRVFFMEAIPKAPSGKILRKNLREKLATDFQK
>rna-XM_021775759.1
MATPVPFSEPKEHIFRSRYPAVPVPENVTIPDFVLQDAELYADKVAFVEALTGKAYTYGEVVRETRRFAKALRSIGLKKGQVVIVVLPNVAEYGIVALGIMAAGGVYSGANPAAHESEIKKQVQAANAKLIVTNDLSYGKVSSLELPVILTGETRIGSAMNWHELLDSADRATDKYVCEDVHQSDLCALPFSSGTTGISKGVMLTHRNLVANLCSSLFSVGPEMLGQVTTLGLIPFFHIYGITGICFATLRNKGKVVVMSRFELRTFLNALISQEVTFAPIVPPIILALVKNPIVEEFDLSKLKLRAIMTAAAPLAPELLTAFEKKFPGVQVQEAYGLTEHSCITLTHGDPDKEHGIAKKNSVGFILPNLEVKFIDPETGGSLPKNTPGEICVRSQCVMQGYYDNKEETARAIDQDGWLHTGDSGYIDDDGDIFIVDRIKELIKYKGFQVAPAEIEAILLAHPSVEDAAVVPLPDEEAGEIPAACVVKNKEAKENEEDIIKYVASNVAHYKKVRVVQFVESIPKSPSGKIMRRLIKEKMIEKLQHNPKPLPPNSH
>rna-XM_021777985.1
MATPLVTFSAQEENIFRSRYPAVPVPENVTLPDFVLQDYELYSDRVAFVEAVTGKAYTYGELVRETRRFTKALRSIGIRKGHVVIVVLPNVAEYGIVALGIMATGGVYSGVNPAAHESEIKKQVLAANAKLIVTNDLSYEKVRSLELPVITLGETRIGSAMNWYELLDAADRATDRYVYEDVDQNDLCALPFSSGTTGMSKGVMLTHRNLVANLCSTLFSVAPQMVGQVTTLGLIPFFHIYGILGICFSTLRNKGKVVVMNRFELRTFLNALMTQEVTYAPIVPPIILALVKNPIVDEFDLSELKLRAIMTAAAPLAPELLRAFENKFPGVQVHEAYGLTEHSCITLTHGDPNLGHGISKKNSVGFILPNLEVKFIDPESGRSLPKNTPGEICVRSQCVMQGYYNNKEETARTIDGDGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAEIEALLLTHPSVEDVAVVSLPDEEAGEIPAACVVIKQEARQSEEDIINYVSSNVAHYKKVRKVQFVETIPKSPSGKIMRRLLKEKMIEKMQANGQTTVSQLTPTPTNFD
>rna-XM_021779016.1
MEAKNDQREFIFRSKLPDIYIPNHLPLHTYCFENITQFKDNPCLINGPTGDIYTYADVELKSRKVAAGLHKLGIQQGYVIMLLLQNSPEFVFVFLGASYRGAISTTANPFYTPTEIAKQATASKAKLIVTQAVYAEKVKQFAKENDIKIITIDSPPDGCLHFSELTEADENDIPGVKINPDDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHKKDVILCVLPLFHIYSLNSVLLCGLRVGSAILIMQKFEIISLMELVQKYKVSIAPFVPPIVLAIAKSPVVDQYDLSSIRTVMSGAAPMGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKDPFEIKSGACGTVVRNAEMKIVDPETGNSLPRNQAGEICIRGSQIMKGYLNDPEATISTIDKEGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHPSISDAAVVPMKDEAAGEVPVAFVVRSNGSKITEDEIKQYISKQVIFYKRINRVFFIEAIPKAPSGKILRKDLRVRLIAGVPN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University