Enzyme
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
CHS
Enzyme
Chalcone synthase
Enzyme name
EC:2.3.1.74
Entry
Transferases;Acyltransferases;Transferring groups other than aminoacyl groups
Class
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Sysname
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2[RN:R01613]
Reaction
CoA [CPD:C00010];naringenin chalcone [CPD:C06561];CO2 [CPD:C00011]
Product
Species information
Malus domestica
Species name
Apple (Malus domestica) is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Malus_domestica.CHS.fa
Download
>rna-XM_017325318.2
MKCEDVPIKEKLELLCKTTTLKTGYTVMSKEILDKYPELATEGTATIKQRLEIANPVVVEMALEASLACIKEWGRPVEDIIHIVYVSSNEIRLPGGDL*LSSKLGLRNDVGRVMLYFLGFYGGVTGLRISKDIAENYPGSCVLLTTSETTILGFWPPNKACPYDLVGAALFGDGAAAVIIGSNPIAGQESPFMELNYAVQQFLAETHNVIDGRLFEEGINFKLGRDLPQKIDQNIEVFCKKLVVAANAELRDFNELFWAVHPGGPAILNKLESTLKRSSDKLESSRRALMDYGNVSSNTIFYVMENMREELELKLKKKVRREEEC*LALAFGPGITFEGILLRSL
>rna-NM_001319257.1
MVTVEEVRKAQRAEGPATVMAIGTATPSNCVDQATYPDYYFRITNSEHKVELKEKFQRMCDKSMIKKRYMYLTEEILKENPSVCEYMAPSIDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVGLTA
>rna-NM_001328985.1
MVTVEEVRKAQRAEGPATVLAIGTATPSNCVDQATYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMYLTEEILKENPTVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPLPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVESKLALKPEKLEATRQVLSNYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVAA
>rna-NM_001319252.1
MVTVEEVRKAQRAEGPATVLAIGTATPPNCVDQATYPDYYFRITNSEHKTELKEKFQRMCDKSMIKTRYMYLTEEILKENPTVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGSDPVPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVESKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVGA
>rna-XM_008374649.2
MGSEHVVQGGFPMKANAGNATILALGKAFPHQLVMQDFLVDGYFKDTNSDDPQLKQKLARLCKTTTVKTRYVVMSEEILEKYPELTTEGTPTIKQRLHICNEAVTKMAIEASQACITKWGRPTSDITHLVYVSSSEARLPGGDLYLAKGLGLSPQTKRVMLYFSGCSGGVAGVRVAKDIAENNPGSRVLLATSETTIIGYKPPSANRPYDLVGVALFGDGAGAMMIGSDPELVSENPLFELHTALQEFLPGTEKTIDGRVTEEGISFKLERELPQIIEDHIEGFCGRLMGVVGYDNKEYNKMFWAVHPGGPAILNRMEKRLDLSPEKLNASRRALADYGNASSNTIVYVLEYIIEESKKMKKEGEGDGGWGMILAFGPGVTFEGILARNLAV
>rna-XM_008377514.3
MSKVERNGTNGSSGQYRSPSRYAPTPGKATVLALGKAFPSQLIPQDCLVEGYIRDTKCEDAAIKEKLERLCKTTTVKTRYTVMSKEILDKYPELATEGTATIKQRLEIANPAVVEMALEASLACIKEWGRPVEDITHIVYVSSSEIRLPGGDLYLSSKLGLRNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIIGSNPIAGQESPFMELNYAVQQFLPGTHNVIDGRLSEEGINFKLGRDLPQKIDENIEEFCKKLTVPAKAELKNFNELFWAVHPGGPAILNKMESTLKLSSDKLECSRRALMDYGNVSSNTIFYVMENMREELKLKKKEGRDEEWGLALAFGPGITFEGILLRSL
>rna-XM_029091251.1
MVTVQEVRKAQRAEGPATVFAIGTATPPNCVDQATYPDYYFRITNSEHKAELKEKFQRMCDKSMIKKRYMYLTEEILKENPSVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEVEKPLFELVSAAQTILADSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLETTGEGLEWGVLFGFGPGLTVETVVLHSVAA
MKCEDVPIKEKLELLCKTTTLKTGYTVMSKEILDKYPELATEGTATIKQRLEIANPVVVEMALEASLACIKEWGRPVEDIIHIVYVSSNEIRLPGGDL*LSSKLGLRNDVGRVMLYFLGFYGGVTGLRISKDIAENYPGSCVLLTTSETTILGFWPPNKACPYDLVGAALFGDGAAAVIIGSNPIAGQESPFMELNYAVQQFLAETHNVIDGRLFEEGINFKLGRDLPQKIDQNIEVFCKKLVVAANAELRDFNELFWAVHPGGPAILNKLESTLKRSSDKLESSRRALMDYGNVSSNTIFYVMENMREELELKLKKKVRREEEC*LALAFGPGITFEGILLRSL
>rna-NM_001319257.1
MVTVEEVRKAQRAEGPATVMAIGTATPSNCVDQATYPDYYFRITNSEHKVELKEKFQRMCDKSMIKKRYMYLTEEILKENPSVCEYMAPSIDARQDMVVVEVPKLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVGLTA
>rna-NM_001328985.1
MVTVEEVRKAQRAEGPATVLAIGTATPSNCVDQATYPDYYFRITNSEHKTELKEKFQRMCDKSMIKKRYMYLTEEILKENPTVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPLPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVESKLALKPEKLEATRQVLSNYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVAA
>rna-NM_001319252.1
MVTVEEVRKAQRAEGPATVLAIGTATPPNCVDQATYPDYYFRITNSEHKTELKEKFQRMCDKSMIKTRYMYLTEEILKENPTVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGSDPVPEVEKPLFELVSAAQTILPDSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVESKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLKTTGEGLEWGVLFGFGPGLTVETVVLHSVGA
>rna-XM_008374649.2
MGSEHVVQGGFPMKANAGNATILALGKAFPHQLVMQDFLVDGYFKDTNSDDPQLKQKLARLCKTTTVKTRYVVMSEEILEKYPELTTEGTPTIKQRLHICNEAVTKMAIEASQACITKWGRPTSDITHLVYVSSSEARLPGGDLYLAKGLGLSPQTKRVMLYFSGCSGGVAGVRVAKDIAENNPGSRVLLATSETTIIGYKPPSANRPYDLVGVALFGDGAGAMMIGSDPELVSENPLFELHTALQEFLPGTEKTIDGRVTEEGISFKLERELPQIIEDHIEGFCGRLMGVVGYDNKEYNKMFWAVHPGGPAILNRMEKRLDLSPEKLNASRRALADYGNASSNTIVYVLEYIIEESKKMKKEGEGDGGWGMILAFGPGVTFEGILARNLAV
>rna-XM_008377514.3
MSKVERNGTNGSSGQYRSPSRYAPTPGKATVLALGKAFPSQLIPQDCLVEGYIRDTKCEDAAIKEKLERLCKTTTVKTRYTVMSKEILDKYPELATEGTATIKQRLEIANPAVVEMALEASLACIKEWGRPVEDITHIVYVSSSEIRLPGGDLYLSSKLGLRNDVGRVMLYFLGCYGGVTGLRVAKDIAENNPGSRVLLTTSETTILGFRPPNKARPYDLVGAALFGDGAAAVIIGSNPIAGQESPFMELNYAVQQFLPGTHNVIDGRLSEEGINFKLGRDLPQKIDENIEEFCKKLTVPAKAELKNFNELFWAVHPGGPAILNKMESTLKLSSDKLECSRRALMDYGNVSSNTIFYVMENMREELKLKKKEGRDEEWGLALAFGPGITFEGILLRSL
>rna-XM_029091251.1
MVTVQEVRKAQRAEGPATVFAIGTATPPNCVDQATYPDYYFRITNSEHKAELKEKFQRMCDKSMIKKRYMYLTEEILKENPSVCEYMAPSLDARQDMVVVEVPRLGKEAATKAIKEWGQPKSKITHLVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLVVCSEITAVTFRGPSDTHLDSLVGQALFGDGAAAVIIGADPVPEVEKPLFELVSAAQTILADSDGAIDGHLREVGLTFHLLKDVPGLISKNIEKSLNEAFKPIGISDWNSLFWIAHPGGPAILDQVEAKLALKPEKLEATRQVLSDYGNMSSACVLFILDEVRRKSAEKGLETTGEGLEWGVLFGFGPGLTVETVVLHSVAA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University