Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Malus domestica
Species name
Apple (Malus domestica) is a species of eudicot in the family Rosaceae (rose family).
Species info
Gene sequence info
Malus_domestica.4CL.fa
Download
>rna-XM_008364603.2
MTIASSSVETQKPADIPTNLMPSEINSTSQQNLTQLQPAACTNNIIDSTTATSTATATTNHVFRSKLPDIPIPNHLPLHTYCFQNLPEFSDRPCLIVGSTGKSYSFSETHLIAQKTGAGLSNLGIQKGEVIMILLQNCAEFVFAFMGASMIGAVTTTANPFYTAAEVFKQVKAANAKLIITQSQYVNKLREHPSSADGTDQNNFPKLGEDFKIVTIDNPPENCLHFSVLSEANEKELPDVVIDAEDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKEDDVVLCVLPLFHIFSLNSVLLCSLRAGAGVLLMHKFEIGTLLELIQRYRVSVAAVVPPLVIALAKNPMVAEFDLSSIRVVLSGAAPLGKELEEALKSRVPEAVLGQGYGMTEAGPVLSMCMAFAKEPMPTKSGSCGTVVRNAELKVLDLETGLSLGYNQSGEICIRGSQIMKGYLNDVAATATTVDTEGWLHTGDVGYVDDDNEIFIVDRAKELIKFKGFQVPPAELESLLISHPSIADAAVVPQKDDAAGEVPVAFVVRSNGLELTEEAVKEFIAKQVVFYKRLHKVHFVHAIPKSPSGKILRKDLRAKLATATPSALAN
>rna-XM_029106270.1
MISIASNSVETQKPADTSTNLMPPLINSTSQQNLTQLQPPACTNNIIDSTTATATINHVFRSKLPDIPIPNHLPLHTYCFQNLPEFSDRPCLIVGSTGKSYSFSETHLISQKTGAGLSNLGIQKGDVIMILLQNCAEFVFAFMGASLIGAVTTTANPFYTSAEIFKQVKAANAKLIITQSQYVDKLREHPSSADGADQNNYPKLGEDFKVVTIDDPPENCLHFSVLSEANENELPDVVIDAEDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKEDDVVLCVLPLFHIFSLNSVLLCSLRAGAGVLLMHKFEIGTLLELIQRYRVSVAAVVPPLVIALAKNPMVAEFDLSSIRVVLSGAAPLGKELEEALKSRVPQALLGQGYGMTEAGPVLSMCMAFAKEPMPSKSGSCGTVVRNAELRVLDPETGLSLGYNQPGEICIRGSQFLPGYLNDAAATATTIDTEGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLISHPSIADAAVVPQKDDAAGEVPVAFVVRSDGLELTEEAVKEFIAKQVVFYKRLHKVHFVHAIPKSASGKILRKDLRAKLATATPPLP
>rna-XM_029088590.1
MEKSGFGRDGIFRSLRPPLVLPRDPNLSMVSFLFRNSSYSHKPALIDGESSETLSFSQFKSKVIQVSHGLINLGIKKNDVVLIFAPNSIQFPICLFGIIASGAIATTSNPLYTVSELSKQVRDSNPKLVITVPELWDKVKGFNLPTVFLGSTGFSGESHVGSASKIRTFHDLIESAGSVSDFPSVNIKQTDTAVLLYSSGTTGVSKGVVLTHRNFIASSLMVTMDQELSGEMHYVFLCVLPMFHVFGLAIITYGQLQKGNAVVSMGRFDLEKVLMAVEKYRVTHLWIVPPIVLALAKNSVVKKFNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVAQGYGMTETCGIVSVENTLAGSRHTGSTGMLVSGVECQIVSVDTLKPQPPKQLGEIWVRGPNMMTGYFNNPQATNETIDKNGWVHTGDLGYIDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPAAYCVRTPNSSLTEEDVKSFIASQVASFKRLRRVSFINSVPKSASGKILRRELIEKVRSKI
>rna-XM_029091143.1
MEHHRKDDEFIFRSKLPDIYIPNHLPLHTYCFENISQFMDRPCLINGNNGDTFTYADVELTSRKVASGLHKIGIHQTDVIMLLLQNCPEFVFAFLGASNIGAVVTTANPFYTPAEMAKQTKASNAKLIITQSAYVDKVKDFALKNDVEIMVVDSAETEEDGNTYRHFSEMTSADENDIPAVKINPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEITKLLELVEKYKVTIAPFVPPIVLSIAKSPDLDRYDLSSIRMVMSGAAPLGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGASLPRNQAGEICIRGSQIMKGYLNDPEATERTVDKQGWLHTGDIGYIDGDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVPMKDEAAGEIPVAFVVRSNSSKISEDDIKQYISKQVVFYKRIGRVFFIDKIPKAPSGKILRKDLRAKLAAGLPN
>rna-XM_008391910.3
MVNLIPSLVSTSLWLPLAPFHIFIMGTFVQNSAQEDEHIFGSRSPSVRVPDNITLPEFVLQNAELYAGNVAFVEAVTGKKITYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYAIVALGIMAAGGVFSGANPSGHASEIKKQVEVADAKIIVTNGATYEKVKSFGVPVILLGEEVIEGAMNWEHLLEAADRAGNRINEEELKQTDLCALPFSSGTTGLSKGVMLTHRNLVANLSSTLFGVTPEMIGKVTVLGLIPFFHIYGITGICCATLRNKGKVVVMGRYELRTFLNALISHEVTYAPIVPPIILNLVKNPIVDEFDLSKLKLQAIMTAAAPLAPEVLNAFENKFPGVQVQEAYGLTEHSCITLTHAGPGLVAKKNSVGFILPNLLVKFIDPDTGRSLPRNTPGELCVLSQCVMQGYFNNEEETARTIDKDGWLHTGDIGCIDDDDNVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDVAVVPLPDEEAGEIPAASVVIAAGTKESEEEIINYVASNVAQYKKVRVVHFVDTIPKSPSGKIMRRLIKESMMEKIKASKLHCLN
>rna-XM_008365460.3
MAIETIPNDIVYRSKLPDIPIPKHLPLHSYCLHNKNHSSSKPCIIDGATGDIYTFADVELNARRVASGLNKLGIQQGDVIMLLLPNSPAFAFAFLGASFRGAMTTAANPFFTPAEILKQAKASKAKLIITLACYYDKVKDLSSSSDDVHDIKLMCVDSPPDPSCLHFSELLQADEKDMPEVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYYSTDDVILCVLPLFHIYSLNSVLLCGLRAGAAILMMNKFEIVSLLGLIDKYKVSIAPIVPPIVLAIAKFPDLDKYDLSSIRVLKCGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKQPFEVKPGGCGTVVRNAELKIVDPESGASLPRNQPGEICIRGDQIMKGYLNDPESTRTTIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLITHPSVSDAAVVPMKDEAAGEVPVAFVVRSNNSQLTEDEVKQFISKQVVFYKRINRVFFIEAIPKSPSGKILRKDLRAKLAAGFPN
MTIASSSVETQKPADIPTNLMPSEINSTSQQNLTQLQPAACTNNIIDSTTATSTATATTNHVFRSKLPDIPIPNHLPLHTYCFQNLPEFSDRPCLIVGSTGKSYSFSETHLIAQKTGAGLSNLGIQKGEVIMILLQNCAEFVFAFMGASMIGAVTTTANPFYTAAEVFKQVKAANAKLIITQSQYVNKLREHPSSADGTDQNNFPKLGEDFKIVTIDNPPENCLHFSVLSEANEKELPDVVIDAEDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKEDDVVLCVLPLFHIFSLNSVLLCSLRAGAGVLLMHKFEIGTLLELIQRYRVSVAAVVPPLVIALAKNPMVAEFDLSSIRVVLSGAAPLGKELEEALKSRVPEAVLGQGYGMTEAGPVLSMCMAFAKEPMPTKSGSCGTVVRNAELKVLDLETGLSLGYNQSGEICIRGSQIMKGYLNDVAATATTVDTEGWLHTGDVGYVDDDNEIFIVDRAKELIKFKGFQVPPAELESLLISHPSIADAAVVPQKDDAAGEVPVAFVVRSNGLELTEEAVKEFIAKQVVFYKRLHKVHFVHAIPKSPSGKILRKDLRAKLATATPSALAN
>rna-XM_029106270.1
MISIASNSVETQKPADTSTNLMPPLINSTSQQNLTQLQPPACTNNIIDSTTATATINHVFRSKLPDIPIPNHLPLHTYCFQNLPEFSDRPCLIVGSTGKSYSFSETHLISQKTGAGLSNLGIQKGDVIMILLQNCAEFVFAFMGASLIGAVTTTANPFYTSAEIFKQVKAANAKLIITQSQYVDKLREHPSSADGADQNNYPKLGEDFKVVTIDDPPENCLHFSVLSEANENELPDVVIDAEDPVALPFSSGTTGLPKGVILTHKSLVTSVAQQVDGENPNLYLKEDDVVLCVLPLFHIFSLNSVLLCSLRAGAGVLLMHKFEIGTLLELIQRYRVSVAAVVPPLVIALAKNPMVAEFDLSSIRVVLSGAAPLGKELEEALKSRVPQALLGQGYGMTEAGPVLSMCMAFAKEPMPSKSGSCGTVVRNAELRVLDPETGLSLGYNQPGEICIRGSQFLPGYLNDAAATATTIDTEGWLHTGDVGYVDDDDEVFIVDRVKELIKFKGFQVPPAELESLLISHPSIADAAVVPQKDDAAGEVPVAFVVRSDGLELTEEAVKEFIAKQVVFYKRLHKVHFVHAIPKSASGKILRKDLRAKLATATPPLP
>rna-XM_029088590.1
MEKSGFGRDGIFRSLRPPLVLPRDPNLSMVSFLFRNSSYSHKPALIDGESSETLSFSQFKSKVIQVSHGLINLGIKKNDVVLIFAPNSIQFPICLFGIIASGAIATTSNPLYTVSELSKQVRDSNPKLVITVPELWDKVKGFNLPTVFLGSTGFSGESHVGSASKIRTFHDLIESAGSVSDFPSVNIKQTDTAVLLYSSGTTGVSKGVVLTHRNFIASSLMVTMDQELSGEMHYVFLCVLPMFHVFGLAIITYGQLQKGNAVVSMGRFDLEKVLMAVEKYRVTHLWIVPPIVLALAKNSVVKKFNLSSLKHIGSGAAPLGKELMEECAKIIPQGVVAQGYGMTETCGIVSVENTLAGSRHTGSTGMLVSGVECQIVSVDTLKPQPPKQLGEIWVRGPNMMTGYFNNPQATNETIDKNGWVHTGDLGYIDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDAEAGEVPAAYCVRTPNSSLTEEDVKSFIASQVASFKRLRRVSFINSVPKSASGKILRRELIEKVRSKI
>rna-XM_029091143.1
MEHHRKDDEFIFRSKLPDIYIPNHLPLHTYCFENISQFMDRPCLINGNNGDTFTYADVELTSRKVASGLHKIGIHQTDVIMLLLQNCPEFVFAFLGASNIGAVVTTANPFYTPAEMAKQTKASNAKLIITQSAYVDKVKDFALKNDVEIMVVDSAETEEDGNTYRHFSEMTSADENDIPAVKINPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSEDVILCVLPLFHIYSLNSVFLCGLRVGAAILIMQKFEITKLLELVEKYKVTIAPFVPPIVLSIAKSPDLDRYDLSSIRMVMSGAAPLGKELEDTVRAKLPNAKLGQGYGMTEAGPVLSMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPDTGASLPRNQAGEICIRGSQIMKGYLNDPEATERTVDKQGWLHTGDIGYIDGDDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVPMKDEAAGEIPVAFVVRSNSSKISEDDIKQYISKQVVFYKRIGRVFFIDKIPKAPSGKILRKDLRAKLAAGLPN
>rna-XM_008391910.3
MVNLIPSLVSTSLWLPLAPFHIFIMGTFVQNSAQEDEHIFGSRSPSVRVPDNITLPEFVLQNAELYAGNVAFVEAVTGKKITYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYAIVALGIMAAGGVFSGANPSGHASEIKKQVEVADAKIIVTNGATYEKVKSFGVPVILLGEEVIEGAMNWEHLLEAADRAGNRINEEELKQTDLCALPFSSGTTGLSKGVMLTHRNLVANLSSTLFGVTPEMIGKVTVLGLIPFFHIYGITGICCATLRNKGKVVVMGRYELRTFLNALISHEVTYAPIVPPIILNLVKNPIVDEFDLSKLKLQAIMTAAAPLAPEVLNAFENKFPGVQVQEAYGLTEHSCITLTHAGPGLVAKKNSVGFILPNLLVKFIDPDTGRSLPRNTPGELCVLSQCVMQGYFNNEEETARTIDKDGWLHTGDIGCIDDDDNVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDVAVVPLPDEEAGEIPAASVVIAAGTKESEEEIINYVASNVAQYKKVRVVHFVDTIPKSPSGKIMRRLIKESMMEKIKASKLHCLN
>rna-XM_008365460.3
MAIETIPNDIVYRSKLPDIPIPKHLPLHSYCLHNKNHSSSKPCIIDGATGDIYTFADVELNARRVASGLNKLGIQQGDVIMLLLPNSPAFAFAFLGASFRGAMTTAANPFFTPAEILKQAKASKAKLIITLACYYDKVKDLSSSSDDVHDIKLMCVDSPPDPSCLHFSELLQADEKDMPEVDISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYYSTDDVILCVLPLFHIYSLNSVLLCGLRAGAAILMMNKFEIVSLLGLIDKYKVSIAPIVPPIVLAIAKFPDLDKYDLSSIRVLKCGGAPLGKELEDTVRAKFPNVTLGQGYGMTEAGPVLTMSLAFAKQPFEVKPGGCGTVVRNAELKIVDPESGASLPRNQPGEICIRGDQIMKGYLNDPESTRTTIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLITHPSVSDAAVVPMKDEAAGEVPVAFVVRSNNSQLTEDEVKQFISKQVVFYKRINRVFFIEAIPKSPSGKILRKDLRAKLAAGFPN
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University