Enzyme
Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.
HIDH
Enzyme
2-hydroxyisoflavanone dehydratase
Enzyme name
EC:4.2.1.105
Entry
Lyases;Carbon-oxygen lyases;Hydro-lyases
Class
2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)
Sysname
(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O
Reaction
daidzein [CPD:C10208];H2O [CPD:C00001];genistein [CPD:C06563]
Product
Species information
Malcolmia maritima
Species name
Malcolmia maritima is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Malcolmia_maritima.HIDH.fa
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>Mamar.0005s0233.1.v1.1
MDSEISFDRSPNYRIFKSGRIERLTGETTVPPSLTPQNGVVSKDVIYSPEKNLSLRIYLPEKAFITDEKLPILIYFHGGGFIVETAFSPTYHTFLTSTVAAVNCLAISVDYRCAPEFPIPIPYEDSWDSLKWVFTHISRSGPDHWINKHGDFGKVFIAGDSAGGNITHHLTTRAKREKLYDSLISAIILIHPYFWGKTPIDAFEVRNVIKSQKIEGSWRVASPNSKDGVDDPWLNVVGSDDSDLSGLGCGRVLVMVAGNDQFVRQGWCYAEKLKKSGWEGDEVEVMESKDESHVFHLKDPNSDNARLVVMKLAEFINKNEFVDKRLQ
>Mamar.0011s0011.1.v1.1
MATISLPHSHQSSDNRRGGSHPHRHGPVVEEIEGLIKVFNDGCVERPPIVPTVSPTLHPSAKATAFDIKLSNDTWARVYIPDATAASPSVTLPLLVYFHGGGFCVGSTAWSCYHEFLTNLAVKARCIVVSVNYRLAPEHRLPAAYEDGVNVVSWLVKQQISNGGYSSWVSKCNLSNVFLAGDSAGANIAYQVAVRITGSGKFVNTVNLKGVILIHPFFGGEARTSSEKQQHHSKSSALTLSASDTYWRLALPRGVSRDHPWCNPLVSLAGAKLPTTLVFVAEFDILKDRNLEMCRVMRSHGKRVEGVVHGGVGHAFHILDNSSVSRDRINDMMCRLRNFLHP
>Mamar.0014s0541.1.v1.1
MDSEIAFDYSPRFRLFKNGRIERLATEIFVPPSLNLETGVVSKDAVYSPEENLSLRIYLPEKSGEKKIPLLIYFHGGGFIMETAFSTIYHTFLNSVVSAADCIAVSVDYRRAPEHPIPTAYEDSWDAIKWILTHIDGSGPEDWLNKHADYSNVFLAGDSAGANIAHHMVMKSEKDKIYKISGMVLFHPYFFSKASIEEMGLGGFKYYEGLWQIASPSSENGVEDPWINVEGSDLSGLGCGRVLVMVAENDVLASGGWGYAAKLEKSGWDGKVEVMETKDQGHVFHLRFPLSHNARLLLQTFVQFLKDQTS
>Mamar.0037s0009.1.v1.1
MDDEIAADFSPMLIIYKSGRIERLIGETTVPPSSHPLNGVVSKDVVYSPHNNLSVRMYLPEKAATTGEKTCDEKLPLLVYFHGGGFLIETAFSPTYHTFLTAVVIASDCVAVSVDYRRAPESPIPIPYDDSWTALKWVFSHIAGSGQEDWLNKHADFSKVFLAGDSAGANITHHMVMRAAKEKLRPELGSSGILGIILVHPYFWSKTPVDDKETTDVATRTKIESVWMLASPNSKDGVDDPFINVVQSELVDLSGLDCGRVLVMVAEKDILVRQGFGYWSKLGKSPWNGELDPVMETKGEGHVFHLKDPTSEKAHQLVNKFARFIKGGDN
>Mamar.0047s0008.1.v1.1
MDDEIAADYSPYLIIYKSGRIERLSGETTVPPSFDARNGVVSKDVVYSPDNNLSVRMYLSEKAVATCEKLPLLVYFHGGAFLIETAFSPTYHTFLTAAVSASNCVAVSVDYRRAPESPIPILYDDSWTALKWVFSHIAGSGQEDWLNEYADFSKVFLAGDSAGANITHHMAMRAAEEKLRPELGSSGVSGMILVHPYFWSKTPVDDKETTDVAIRKKIESFWMLASPNSKDGVDDPLFNVVQSELVDLSGLDCGRVLVMVAEKDILVRQGLGYWWKLGKSRWKGEVDVMETMGEHHVFHLKDPTSAKAHQLVKKFAGFIKGDHKKLCGYTE
>Mamar.0047s0009.1.v1.1
MDSEIVADYSPMLKIYKSGRVERLMGETTVPPSSIPQNGVVSKDVVYSPDNNLSVRIYLPEKAAVEEGEKLPLLVYFHGGGFIIETAFSPTYHNFLTAAVSASNCVAVSVDYRRAPEHPIPIPFDDSWTALKWVFSHIAGSGSEDWLNKHADFSRVFLAGDSAGANITHHMAIRAAKEKLSPDLNGSGISGIILVHPYFWSKAPIDDKETKDVMLRTKIESIWAMASPNSKDGSDDPLINVVQSESVDLSVLGCGKVLVLVAEKDALARQGWCYAAKLEKCGWKGEVEVVESEGEDHVFHLMRPTCDKAIEAMHKFSGFLKGDK
>Mamar.0052s1073.1.v1.1
MESVNITTDNHLPSNIRIHKNGCVERLRGNEIIPASLNPQNDVVSKDVVYSPEHNLSVRMFLPNKSTQLAASGNKLPLLIYIHGGAYITESPFSPVYHNYLTEVVKTANCLAVSVQYRLAPEHPIPAAYDDSWSAIQWIFTHNSDDWINNMADFDRVFIAGDSAGANIAHHMGIRAGKEKLKPRIKGIVMVHPGFWGKDPIDEHDVEDEEVRKRIEYIWEKIVSPNSVDGVNDPWFNVVGSGSDISGLGCEKVLVAVAGKDVFWRQGLAYVAKLEKSGWQGEVEVVEEGEEGHCFHLHNPNSQLNASKMMKKFVEFINDDKSLIRVD
>Mamar.0052s1071.1.v1.1
MESEIASEFLPFVRIYKDGRIERLCGTEILPPSLDPTHDVLSKDVVYSPEHNLSVRLFIPQKLAAGEKKLPLLIYIHGGAWIIESPFSPIYHNYLTDVVKSANCLAVSIQYRRAPEDPVPAMYEDVWSAIQWIFSHSDGSGEEDWINKHADFGRVYIGGDSAGGNISHHMAMRAGKEKLKPRIKGIAIVHPAFWGTDPVDEYDVQDRETRIGIAQVWEKIASPNSVNGTDDPLFNVNGSGSDFTGLGCEKVLVAVAGKDVFVRQGLAYAAKVKKSEWDGTVEVVEEEDEDHVFHLQNPNSDKALKFLNKVVGFINS
>Mamar.0052s1072.1.v1.1
MLRRITCSSSLAPPSLFLSFFRHLPRSYTSPTTITIPCRYIRRLTTPTSLRCICSHSSSEILSEHPPFVRIYKDGRIERLSGTETVPASLNPQNAVVSKDVKYSPKHNLSVRLFLPHKIAAGNKLPLLIYFHGGAWIIESPFSPIYHNFLTEVVKSANCLAVSVQYRRAPEDPVPAAYEDAWSAIQWIYSHSDGSGQEDWINKYADFGRVYLAGDSAGGNISHHMAMRAGEEKLEPIIKGTAIIHPAFWGKDPVDEHDVQDRELRRRIAEVWEKIASPNSVDGTDDPWFNVVGSGSDFSGLGCEKVLVAVAGKDVFVRQGLAYVAKLKKSGWKGEVEVVEEEDEDHCFHLLNPSSDNAPKFIKRFVDFITG
>Mamar.0084s0127.1.v1.1
MGATKLNHVTTINPNNTNIHGPVVDEVHGLIKVYKDGHVERSNLLPCVGPSLPVELGVSCSDVNIDKLTNVWARLYVPTMNTTKTSFSKLPLLVYFHGGGFCVGSASWSCYHEFLAKLSARSRCLVMSVSYRLAPENPLPAAYEDGVNAILWLKKAKNDNLWAKLGDFDRIFLAGDSAGGNIANQVAARLAATEDLAVLKPLKIEGMILIQPFYSGEARTESEKRVGNNKSAVLTLAGSDAWWRMALPRGANREHPYCKPVKIKSVMRTLVCVAEMDLLMDQNMEMCDGNEEVIKRVVYKGVGHAFHILGKSQLAHTTTLEMLCHIDAFIHDPLN
>Mamar.0098s0029.1.v1.1
MESKKKQVSLELLPWLVVHNDGTIERLAGTEVCPPGLDKETGVFSKDIIIDSRTGLSARIYRPFSIEPGQKLPLVIYFHGGAFLISSASFPCYHISLNKLVNQANVIAVSVNYRLAPEHPLPTAYEDSWTVLETIQTVNEPWINDYADLDRFFLVGDSAGANISHHLACRAKQSDQTLKIKGIGMIHPYFWGTQPIGSESKDEARKQMVDGWWEYVCPSDKRSDDPWINPFADGSPDLEGLGCERVMIFVAEKDILNDRGKMYYERLVKSKWRGKVEIMETKEKDHVFHIFEPNCDEAMEMVRRLALFINQVEA
MDSEISFDRSPNYRIFKSGRIERLTGETTVPPSLTPQNGVVSKDVIYSPEKNLSLRIYLPEKAFITDEKLPILIYFHGGGFIVETAFSPTYHTFLTSTVAAVNCLAISVDYRCAPEFPIPIPYEDSWDSLKWVFTHISRSGPDHWINKHGDFGKVFIAGDSAGGNITHHLTTRAKREKLYDSLISAIILIHPYFWGKTPIDAFEVRNVIKSQKIEGSWRVASPNSKDGVDDPWLNVVGSDDSDLSGLGCGRVLVMVAGNDQFVRQGWCYAEKLKKSGWEGDEVEVMESKDESHVFHLKDPNSDNARLVVMKLAEFINKNEFVDKRLQ
>Mamar.0011s0011.1.v1.1
MATISLPHSHQSSDNRRGGSHPHRHGPVVEEIEGLIKVFNDGCVERPPIVPTVSPTLHPSAKATAFDIKLSNDTWARVYIPDATAASPSVTLPLLVYFHGGGFCVGSTAWSCYHEFLTNLAVKARCIVVSVNYRLAPEHRLPAAYEDGVNVVSWLVKQQISNGGYSSWVSKCNLSNVFLAGDSAGANIAYQVAVRITGSGKFVNTVNLKGVILIHPFFGGEARTSSEKQQHHSKSSALTLSASDTYWRLALPRGVSRDHPWCNPLVSLAGAKLPTTLVFVAEFDILKDRNLEMCRVMRSHGKRVEGVVHGGVGHAFHILDNSSVSRDRINDMMCRLRNFLHP
>Mamar.0014s0541.1.v1.1
MDSEIAFDYSPRFRLFKNGRIERLATEIFVPPSLNLETGVVSKDAVYSPEENLSLRIYLPEKSGEKKIPLLIYFHGGGFIMETAFSTIYHTFLNSVVSAADCIAVSVDYRRAPEHPIPTAYEDSWDAIKWILTHIDGSGPEDWLNKHADYSNVFLAGDSAGANIAHHMVMKSEKDKIYKISGMVLFHPYFFSKASIEEMGLGGFKYYEGLWQIASPSSENGVEDPWINVEGSDLSGLGCGRVLVMVAENDVLASGGWGYAAKLEKSGWDGKVEVMETKDQGHVFHLRFPLSHNARLLLQTFVQFLKDQTS
>Mamar.0037s0009.1.v1.1
MDDEIAADFSPMLIIYKSGRIERLIGETTVPPSSHPLNGVVSKDVVYSPHNNLSVRMYLPEKAATTGEKTCDEKLPLLVYFHGGGFLIETAFSPTYHTFLTAVVIASDCVAVSVDYRRAPESPIPIPYDDSWTALKWVFSHIAGSGQEDWLNKHADFSKVFLAGDSAGANITHHMVMRAAKEKLRPELGSSGILGIILVHPYFWSKTPVDDKETTDVATRTKIESVWMLASPNSKDGVDDPFINVVQSELVDLSGLDCGRVLVMVAEKDILVRQGFGYWSKLGKSPWNGELDPVMETKGEGHVFHLKDPTSEKAHQLVNKFARFIKGGDN
>Mamar.0047s0008.1.v1.1
MDDEIAADYSPYLIIYKSGRIERLSGETTVPPSFDARNGVVSKDVVYSPDNNLSVRMYLSEKAVATCEKLPLLVYFHGGAFLIETAFSPTYHTFLTAAVSASNCVAVSVDYRRAPESPIPILYDDSWTALKWVFSHIAGSGQEDWLNEYADFSKVFLAGDSAGANITHHMAMRAAEEKLRPELGSSGVSGMILVHPYFWSKTPVDDKETTDVAIRKKIESFWMLASPNSKDGVDDPLFNVVQSELVDLSGLDCGRVLVMVAEKDILVRQGLGYWWKLGKSRWKGEVDVMETMGEHHVFHLKDPTSAKAHQLVKKFAGFIKGDHKKLCGYTE
>Mamar.0047s0009.1.v1.1
MDSEIVADYSPMLKIYKSGRVERLMGETTVPPSSIPQNGVVSKDVVYSPDNNLSVRIYLPEKAAVEEGEKLPLLVYFHGGGFIIETAFSPTYHNFLTAAVSASNCVAVSVDYRRAPEHPIPIPFDDSWTALKWVFSHIAGSGSEDWLNKHADFSRVFLAGDSAGANITHHMAIRAAKEKLSPDLNGSGISGIILVHPYFWSKAPIDDKETKDVMLRTKIESIWAMASPNSKDGSDDPLINVVQSESVDLSVLGCGKVLVLVAEKDALARQGWCYAAKLEKCGWKGEVEVVESEGEDHVFHLMRPTCDKAIEAMHKFSGFLKGDK
>Mamar.0052s1073.1.v1.1
MESVNITTDNHLPSNIRIHKNGCVERLRGNEIIPASLNPQNDVVSKDVVYSPEHNLSVRMFLPNKSTQLAASGNKLPLLIYIHGGAYITESPFSPVYHNYLTEVVKTANCLAVSVQYRLAPEHPIPAAYDDSWSAIQWIFTHNSDDWINNMADFDRVFIAGDSAGANIAHHMGIRAGKEKLKPRIKGIVMVHPGFWGKDPIDEHDVEDEEVRKRIEYIWEKIVSPNSVDGVNDPWFNVVGSGSDISGLGCEKVLVAVAGKDVFWRQGLAYVAKLEKSGWQGEVEVVEEGEEGHCFHLHNPNSQLNASKMMKKFVEFINDDKSLIRVD
>Mamar.0052s1071.1.v1.1
MESEIASEFLPFVRIYKDGRIERLCGTEILPPSLDPTHDVLSKDVVYSPEHNLSVRLFIPQKLAAGEKKLPLLIYIHGGAWIIESPFSPIYHNYLTDVVKSANCLAVSIQYRRAPEDPVPAMYEDVWSAIQWIFSHSDGSGEEDWINKHADFGRVYIGGDSAGGNISHHMAMRAGKEKLKPRIKGIAIVHPAFWGTDPVDEYDVQDRETRIGIAQVWEKIASPNSVNGTDDPLFNVNGSGSDFTGLGCEKVLVAVAGKDVFVRQGLAYAAKVKKSEWDGTVEVVEEEDEDHVFHLQNPNSDKALKFLNKVVGFINS
>Mamar.0052s1072.1.v1.1
MLRRITCSSSLAPPSLFLSFFRHLPRSYTSPTTITIPCRYIRRLTTPTSLRCICSHSSSEILSEHPPFVRIYKDGRIERLSGTETVPASLNPQNAVVSKDVKYSPKHNLSVRLFLPHKIAAGNKLPLLIYFHGGAWIIESPFSPIYHNFLTEVVKSANCLAVSVQYRRAPEDPVPAAYEDAWSAIQWIYSHSDGSGQEDWINKYADFGRVYLAGDSAGGNISHHMAMRAGEEKLEPIIKGTAIIHPAFWGKDPVDEHDVQDRELRRRIAEVWEKIASPNSVDGTDDPWFNVVGSGSDFSGLGCEKVLVAVAGKDVFVRQGLAYVAKLKKSGWKGEVEVVEEEDEDHCFHLLNPSSDNAPKFIKRFVDFITG
>Mamar.0084s0127.1.v1.1
MGATKLNHVTTINPNNTNIHGPVVDEVHGLIKVYKDGHVERSNLLPCVGPSLPVELGVSCSDVNIDKLTNVWARLYVPTMNTTKTSFSKLPLLVYFHGGGFCVGSASWSCYHEFLAKLSARSRCLVMSVSYRLAPENPLPAAYEDGVNAILWLKKAKNDNLWAKLGDFDRIFLAGDSAGGNIANQVAARLAATEDLAVLKPLKIEGMILIQPFYSGEARTESEKRVGNNKSAVLTLAGSDAWWRMALPRGANREHPYCKPVKIKSVMRTLVCVAEMDLLMDQNMEMCDGNEEVIKRVVYKGVGHAFHILGKSQLAHTTTLEMLCHIDAFIHDPLN
>Mamar.0098s0029.1.v1.1
MESKKKQVSLELLPWLVVHNDGTIERLAGTEVCPPGLDKETGVFSKDIIIDSRTGLSARIYRPFSIEPGQKLPLVIYFHGGAFLISSASFPCYHISLNKLVNQANVIAVSVNYRLAPEHPLPTAYEDSWTVLETIQTVNEPWINDYADLDRFFLVGDSAGANISHHLACRAKQSDQTLKIKGIGMIHPYFWGTQPIGSESKDEARKQMVDGWWEYVCPSDKRSDDPWINPFADGSPDLEGLGCERVMIFVAEKDILNDRGKMYYERLVKSKWRGKVEIMETKEKDHVFHIFEPNCDEAMEMVRRLALFINQVEA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University