Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Amphicarpaea edgeworthi
Species name
Chinese hog-peanut (Amphicarpaea edgeworthii) is a species of eudicot in the family Fabaceae (pea family).
Species info
Gene sequence info
Amphicarpaea_edgeworthi.4CL.fa
Download
>Ae.00003709
MQRSGYGSDGIYRSLRPSIVLPKNPNLSLVSHLFNRVAPFPSKPALIDADSSETLSFAELKSLTVKVSHGLLRLGVTKNDVVLFLAPNDIRYLVCFLAVASLGAAVTTVNPGYTAGEVSKQASDSNPKLVVTVPELWDKLEHFKLPAVFLRSSHAPSNATSFDALVKLAGSVNEFPDVTIKQSDTAALLYSSGTTGVSKGVVLTHGNFVAASLMIGLDDDLAGVYHSVFLCVLPMFHVFGLTVISYGQLQRGSAVVSLKKFEFELVLKTIEKFKVTHLWVVPPIILALAKHGLVDKYDLSSLKHIGSGAAPLGKDLMVECAKRFPNATVSQGYGMTETCGIASVENTRMGIRHSGSAGMLVAGVEAQVVSVDTLKPLPPGQLGEIWVRGPNMMQGYHNNPQATILTIDKKGWVHTGDLGYFDEDGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPYPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAHFKRLRRVTFINAVPKTASGKILRRQLIEKVRSKI
>Ae.00002732
MAVESSRELIYRSKLPDIDIPKEVPLHSYCFENLREYGSRPCLINAPTGVVYSYEEVESRARKVGWGLQKLLGVKQGEVIMILLPNCPEFVLSFLGASYRGAMATAANPFFTSAEIAKQAKASNAKVVITQASYYDKVKELVLEQHVKLVFVDSCPISDDLHFHFHFTQLYDMDMDMDMEEKKIMIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGDNPNLYYHYEDIILCVLPLFHIYSLNSVLLCGLRSKATILLMPKFEINALLSLIHKHKVTIAPVVPPIVLAISKSPHLNDYDLSSIRVLKSGGAPLGKELEHTLRAKFPNAKLGQGYGMTEAGPVLTMSLAFAKEPIDVKAGACGTVVRNAEMKIVDPETGYSLPRNKSGEICIRGDQIMKGYLNDQEATERTIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVPMKDQAAGEVPVAFVVVSTDTTQDEIKNFISKQVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAPAPN
>Ae.00001563
MGTYEESFASEEEHVFRSQYSPVPVPDNVTLPEFVLQNAELYADKVAFVDAVTGKGITFSEVVKGVHRFSKALRSLGLRKGHVVIVVLPNVVEYAIVALGIMAAGGVFSGANPASHVSEIKKQAESADAKLIVTNVTNYEKLLEAADRAGDDLKKEAIQQSDLCAMPFSSGTTGMSKGVMLTHRNLVANLCSTLFNVTQEMEGLVTTLGLIPFFHIYGITGICCATLRSKGKVVVMGRFELKTFLNALIKHEVTFAPIVPPIILSLVKNPIVDEFDLSKLKLQAIMTAAAPLAPELLNSFEHKFPGVAVQEAYGLTEHSCITLTYAQKGLGSTRKNSVGFILPNLEVKFVDPDTGRSLPRKTPGELCVRSQCVMQGYYKQEDETAQSIDKNGWLHTGDVGFIDDEENVFIIDRIKELIKLPDEEAGEIPAASVVLSPGAKESEEDIMNYVASNAARYKKVRVVHFVEAIPKSPSGKIMRRLVKEKMVEKIKTTNSLTKSKNI
>Ae.00018486
MQKSGYGGDGIYRSLRPPLVLPKDPNLSLVAFLFQSVSSFQSKTALVDADSSKTLTFAQLKSQVAKLAHGFIKLGLTKNDVVLLFTPNSIHFPVCFLAVTAIGAVVSTANTVYTIAEVTKQVNDSNPKLVITVPKLWNKLAKNLNLPAVIIGTTSELISFEAPKTMSLDAVMEMAGPVTELPESGVKQGDTAALLYSSGTTGLSKGVVVTHRNFIAASVIMGSGEQSDVYICVLPMFHVFGLMVVTYAPLRRGCAVVVMGRFELEALLKAIEKHRVTKLLLVPSIVLALAKQSVVRNYDLSSLRLIGSGAAPLGKELMEECARRFPHAAICQGYGMTEACGNITLDNQNVGVRRHSGSAGTLCSGFEAQIVSVDTEKPLPPRQLGEIWVRSPSIMQGYHNNPQATRFTIDENGWLHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILEAVVVPYPDDEAGEVPVAYVVRSPNSSLAEEQVKKFIANQVAPFKKLRRITFINSVPKTASGKILRRELTAKAKSKI
>Ae.00019157
MQKSGYGGDGIYRSLRPPLVLPKDPNLSLVSFLFQSVSSFQSKTALVDADSSKTLTFAQLKSQVAKLAHGFLKLGLTKNDVVLLFAPNSIQFPVCFLAATAIGAVVSTANPVYTIAEVAKQAKDSNPKLVITVPELWDKAKNLNLPALIIDSANQLKDLIDRCNGPTNAASRITSLDAVMEMAGPETELPESGVKQGDTAALLYSSGTTGLSKGVVLTHRNFIAAAVMIGMDDDLAGVLDDVYMCVLPMFHVFGLAVVTYAALRRGSAVVVMKRFELEVLLKAIQKHRVTNLWLVPPILLALAKQSVVRNYDLSSLRRIGSGAAPLGKDLMQDCGKRFPHVAICQGYGMTETCGIVSVENPRVGVRHSGSTGMLGSGIEAQIVNVDTHKSLPPRQFGEIWVRGPNMMQGYHNNPQATRLTIDEKGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVVPYPDDEAGEVPIAYVVRSPNSSLNEEEVKKFIANQVAPFKKLRRVTFINSVPKTASGKILRRELTAKARSKI
>Ae.00014291
MEEQQPHHDFIFRSKLPDIYIPTHLPLHTYIFQNLSLFKGRPCLINAATGGTFSYAAVELTARKVAAGLNKLGIEKGDVILLLLQNCTQFVLAFLGASYRGATVTAANPFHTPEEVAKQAAASNSKLIITQASYVDKVKDFATEYDVKVMCIDAAPEGYLHFSELTEADETEIPAVSISPDDVVALPYSSGTTGLPKGVMLTHKGLVTNVAQQVDGENPNLYFRSDDVVLCVLPLFHIYALNSILLCSLRVGAAVLVVPKFEMKTLLELVQKHKASIAPFVPPVVLAIAKRADLNRYDLSSIRVIMCGAAPMGKELEDSVRAKLPNAILGQGYGMTEAGPVLSMSLAFAKEAMEVKSGACGTVVRNAEMKILDPHTGASLLRNQPGYLNDQEATERTIDKEGWLHTGDVGYIDDNNELFIVDRLKDLIKYKGFQVAPAELEAILIAHPAISDAAVVSMKDEVAGEVPIAFVVRSHGSKISQDEIVQYISKQVVFYKRIGMVFFVDSIPKAPSGKILRKNLRARF
>Ae.00013679
MASSPREFIFRSPLPDIPIPTHLPLYSYCFQNLSQFHDRPCLIDGDSGEILTYSDVDLAARRISAGLHKIGIRQGDVVMLVLRNCSQFALAFLGATNLGAVVTTANPFYTPAELAKQATATKTRLVITQSAQVEKIKSFADSSSDVMVMCIDDDYFSSENDGVLRFSTLANADETEAPAVKINPDDLVALPFSSGTSGLPKGVMLSHKNLVTTIAQLVDGENPHQYTHSEDVLLCVLPMFHIYALNSILLCGIRSGAAVLIVQKFEITTLLELIEKYKVTVASFVPPIVLALVKSGETHRYDLSSIRAVVTGAAPLGGELQEAVKSRLPHATFGQGYGMTEAGPLAISMAFAKEPLKIKPGACGTVVRNAEMKIVDTETGDSLPKNKPGEICIRGTKVMKGYLNDPEATERTIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIAHPNISDAAVVGMKDEAAGEIPVAFVVRSNGSEITEDEIKKYISQQVVFYKRIGRVFFTDSIPKAPSGKILRKVLTARLNEGLVVAN
>Ae.00013941
MDEFIFRSKLSDIYIPTHLPLHTYIFQNLSLFKDRPCLINAATGETFSYAAVELTARKVAAGLSKLGIQKGDVILLLLQNCTQFVFTFLGASYLGTTITTANPFYTPAEVAKQAITSNSKLIITQAYYVDKVKDFAREHDVKVMCIDVAPEGYLHFSELTEANEGDIPAVKIYPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFRSDDVVVCVLPLFHIYSLNSVLLCSLRVGAAVLIVPKFEIVTLLELVQKHKVSVAPFVPPIVLAISKSPDLERYDLSSIRIIMSGAASMGKELEDSVRAKLPKATLGQGYGMTEAGPVLSMCLAFAKEPMLVKSGACGTVVRNAEMKIIDPDTATSLHRNQPGEICIRGNQIMKGYLNDQEATERTIDKGGWLHTGDIGYIDDNDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVSMKDEVAGEVPVAFVVRSNGFKISEDEIKQFISKQVVFYKRISRVFFVGSIPKAPSGKILRKDLRARLANDLAILG
>Ae.00023417
MLTVAPSVDAAKEVVVSSPKTDQNHNQTTHVFKSKLPDIPISNHLPLHAYCFEKLSEFAHRPCLIVGPAAKTYTYAETHLISRKIAAGLSNLGICKGDVVMILLQNSAEFVFSFLAASMIGAVATTANPFYTAAEILKQLTVSKAKLIITQAMYVDKLRNHDGANLGEDFKVVTVDDPPENCLHFSVLSEANESEMPEVEIHPENAVAMPFSSGTTGLPKGVVLTHKSLTTSVAQQVDGENPNLYLTTEDVLLCVLPLFHIFSLNSVLLCALRAGSAVLLMQKFEIGTLLELIQRHRVSVAMVVPPLVLALAKNPMVADFDLSSIRLVLSGAAPLGKDLEEALKNRVPQAVLGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVVEPETGRSLGYNQPGEICIRGQQIMKGYLNDENSTALTIDAEGWLHTGDVGYVDDDDEIFIVDRVKELIKYKGFQVPPAELEGLLVSHPSIADAAVVPQKDVAAGEVPVAFVVRSNGFDLTEEAVKEFVAKQVVFYKRLHKVYFIHAIPKSPSGKILRKDLRAKLEG
MQRSGYGSDGIYRSLRPSIVLPKNPNLSLVSHLFNRVAPFPSKPALIDADSSETLSFAELKSLTVKVSHGLLRLGVTKNDVVLFLAPNDIRYLVCFLAVASLGAAVTTVNPGYTAGEVSKQASDSNPKLVVTVPELWDKLEHFKLPAVFLRSSHAPSNATSFDALVKLAGSVNEFPDVTIKQSDTAALLYSSGTTGVSKGVVLTHGNFVAASLMIGLDDDLAGVYHSVFLCVLPMFHVFGLTVISYGQLQRGSAVVSLKKFEFELVLKTIEKFKVTHLWVVPPIILALAKHGLVDKYDLSSLKHIGSGAAPLGKDLMVECAKRFPNATVSQGYGMTETCGIASVENTRMGIRHSGSAGMLVAGVEAQVVSVDTLKPLPPGQLGEIWVRGPNMMQGYHNNPQATILTIDKKGWVHTGDLGYFDEDGQLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPYPDAEAGEVPVAYVVRSPNSSLTEEDVKKFIANQVAHFKRLRRVTFINAVPKTASGKILRRQLIEKVRSKI
>Ae.00002732
MAVESSRELIYRSKLPDIDIPKEVPLHSYCFENLREYGSRPCLINAPTGVVYSYEEVESRARKVGWGLQKLLGVKQGEVIMILLPNCPEFVLSFLGASYRGAMATAANPFFTSAEIAKQAKASNAKVVITQASYYDKVKELVLEQHVKLVFVDSCPISDDLHFHFHFTQLYDMDMDMDMEEKKIMIKPDDVVALPYSSGTTGLPKGVMLTHKGLVTSIAQQVDGDNPNLYYHYEDIILCVLPLFHIYSLNSVLLCGLRSKATILLMPKFEINALLSLIHKHKVTIAPVVPPIVLAISKSPHLNDYDLSSIRVLKSGGAPLGKELEHTLRAKFPNAKLGQGYGMTEAGPVLTMSLAFAKEPIDVKAGACGTVVRNAEMKIVDPETGYSLPRNKSGEICIRGDQIMKGYLNDQEATERTIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLTHPNISDAAVVPMKDQAAGEVPVAFVVVSTDTTQDEIKNFISKQVVFYKRINRVFFIDAIPKSPSGKILRKDLRAKLAAPAPN
>Ae.00001563
MGTYEESFASEEEHVFRSQYSPVPVPDNVTLPEFVLQNAELYADKVAFVDAVTGKGITFSEVVKGVHRFSKALRSLGLRKGHVVIVVLPNVVEYAIVALGIMAAGGVFSGANPASHVSEIKKQAESADAKLIVTNVTNYEKLLEAADRAGDDLKKEAIQQSDLCAMPFSSGTTGMSKGVMLTHRNLVANLCSTLFNVTQEMEGLVTTLGLIPFFHIYGITGICCATLRSKGKVVVMGRFELKTFLNALIKHEVTFAPIVPPIILSLVKNPIVDEFDLSKLKLQAIMTAAAPLAPELLNSFEHKFPGVAVQEAYGLTEHSCITLTYAQKGLGSTRKNSVGFILPNLEVKFVDPDTGRSLPRKTPGELCVRSQCVMQGYYKQEDETAQSIDKNGWLHTGDVGFIDDEENVFIIDRIKELIKLPDEEAGEIPAASVVLSPGAKESEEDIMNYVASNAARYKKVRVVHFVEAIPKSPSGKIMRRLVKEKMVEKIKTTNSLTKSKNI
>Ae.00018486
MQKSGYGGDGIYRSLRPPLVLPKDPNLSLVAFLFQSVSSFQSKTALVDADSSKTLTFAQLKSQVAKLAHGFIKLGLTKNDVVLLFTPNSIHFPVCFLAVTAIGAVVSTANTVYTIAEVTKQVNDSNPKLVITVPKLWNKLAKNLNLPAVIIGTTSELISFEAPKTMSLDAVMEMAGPVTELPESGVKQGDTAALLYSSGTTGLSKGVVVTHRNFIAASVIMGSGEQSDVYICVLPMFHVFGLMVVTYAPLRRGCAVVVMGRFELEALLKAIEKHRVTKLLLVPSIVLALAKQSVVRNYDLSSLRLIGSGAAPLGKELMEECARRFPHAAICQGYGMTEACGNITLDNQNVGVRRHSGSAGTLCSGFEAQIVSVDTEKPLPPRQLGEIWVRSPSIMQGYHNNPQATRFTIDENGWLHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLVSHPEILEAVVVPYPDDEAGEVPVAYVVRSPNSSLAEEQVKKFIANQVAPFKKLRRITFINSVPKTASGKILRRELTAKAKSKI
>Ae.00019157
MQKSGYGGDGIYRSLRPPLVLPKDPNLSLVSFLFQSVSSFQSKTALVDADSSKTLTFAQLKSQVAKLAHGFLKLGLTKNDVVLLFAPNSIQFPVCFLAATAIGAVVSTANPVYTIAEVAKQAKDSNPKLVITVPELWDKAKNLNLPALIIDSANQLKDLIDRCNGPTNAASRITSLDAVMEMAGPETELPESGVKQGDTAALLYSSGTTGLSKGVVLTHRNFIAAAVMIGMDDDLAGVLDDVYMCVLPMFHVFGLAVVTYAALRRGSAVVVMKRFELEVLLKAIQKHRVTNLWLVPPILLALAKQSVVRNYDLSSLRRIGSGAAPLGKDLMQDCGKRFPHVAICQGYGMTETCGIVSVENPRVGVRHSGSTGMLGSGIEAQIVNVDTHKSLPPRQFGEIWVRGPNMMQGYHNNPQATRLTIDEKGWVHTGDLGYFDEDGQLYVVDRIKELIKYKGFQVAPAELEGLLISHPEILDAVVVPYPDDEAGEVPIAYVVRSPNSSLNEEEVKKFIANQVAPFKKLRRVTFINSVPKTASGKILRRELTAKARSKI
>Ae.00014291
MEEQQPHHDFIFRSKLPDIYIPTHLPLHTYIFQNLSLFKGRPCLINAATGGTFSYAAVELTARKVAAGLNKLGIEKGDVILLLLQNCTQFVLAFLGASYRGATVTAANPFHTPEEVAKQAAASNSKLIITQASYVDKVKDFATEYDVKVMCIDAAPEGYLHFSELTEADETEIPAVSISPDDVVALPYSSGTTGLPKGVMLTHKGLVTNVAQQVDGENPNLYFRSDDVVLCVLPLFHIYALNSILLCSLRVGAAVLVVPKFEMKTLLELVQKHKASIAPFVPPVVLAIAKRADLNRYDLSSIRVIMCGAAPMGKELEDSVRAKLPNAILGQGYGMTEAGPVLSMSLAFAKEAMEVKSGACGTVVRNAEMKILDPHTGASLLRNQPGYLNDQEATERTIDKEGWLHTGDVGYIDDNNELFIVDRLKDLIKYKGFQVAPAELEAILIAHPAISDAAVVSMKDEVAGEVPIAFVVRSHGSKISQDEIVQYISKQVVFYKRIGMVFFVDSIPKAPSGKILRKNLRARF
>Ae.00013679
MASSPREFIFRSPLPDIPIPTHLPLYSYCFQNLSQFHDRPCLIDGDSGEILTYSDVDLAARRISAGLHKIGIRQGDVVMLVLRNCSQFALAFLGATNLGAVVTTANPFYTPAELAKQATATKTRLVITQSAQVEKIKSFADSSSDVMVMCIDDDYFSSENDGVLRFSTLANADETEAPAVKINPDDLVALPFSSGTSGLPKGVMLSHKNLVTTIAQLVDGENPHQYTHSEDVLLCVLPMFHIYALNSILLCGIRSGAAVLIVQKFEITTLLELIEKYKVTVASFVPPIVLALVKSGETHRYDLSSIRAVVTGAAPLGGELQEAVKSRLPHATFGQGYGMTEAGPLAISMAFAKEPLKIKPGACGTVVRNAEMKIVDTETGDSLPKNKPGEICIRGTKVMKGYLNDPEATERTIDKEGWLHTGDIGFIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIAHPNISDAAVVGMKDEAAGEIPVAFVVRSNGSEITEDEIKKYISQQVVFYKRIGRVFFTDSIPKAPSGKILRKVLTARLNEGLVVAN
>Ae.00013941
MDEFIFRSKLSDIYIPTHLPLHTYIFQNLSLFKDRPCLINAATGETFSYAAVELTARKVAAGLSKLGIQKGDVILLLLQNCTQFVFTFLGASYLGTTITTANPFYTPAEVAKQAITSNSKLIITQAYYVDKVKDFAREHDVKVMCIDVAPEGYLHFSELTEANEGDIPAVKIYPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFRSDDVVVCVLPLFHIYSLNSVLLCSLRVGAAVLIVPKFEIVTLLELVQKHKVSVAPFVPPIVLAISKSPDLERYDLSSIRIIMSGAASMGKELEDSVRAKLPKATLGQGYGMTEAGPVLSMCLAFAKEPMLVKSGACGTVVRNAEMKIIDPDTATSLHRNQPGEICIRGNQIMKGYLNDQEATERTIDKGGWLHTGDIGYIDDNDELFIVDRLKELIKYKGFQVAPAELEAMLIAHPNISDAAVVSMKDEVAGEVPVAFVVRSNGFKISEDEIKQFISKQVVFYKRISRVFFVGSIPKAPSGKILRKDLRARLANDLAILG
>Ae.00023417
MLTVAPSVDAAKEVVVSSPKTDQNHNQTTHVFKSKLPDIPISNHLPLHAYCFEKLSEFAHRPCLIVGPAAKTYTYAETHLISRKIAAGLSNLGICKGDVVMILLQNSAEFVFSFLAASMIGAVATTANPFYTAAEILKQLTVSKAKLIITQAMYVDKLRNHDGANLGEDFKVVTVDDPPENCLHFSVLSEANESEMPEVEIHPENAVAMPFSSGTTGLPKGVVLTHKSLTTSVAQQVDGENPNLYLTTEDVLLCVLPLFHIFSLNSVLLCALRAGSAVLLMQKFEIGTLLELIQRHRVSVAMVVPPLVLALAKNPMVADFDLSSIRLVLSGAAPLGKDLEEALKNRVPQAVLGQGYGMTEAGPVLSMCLGFAKQPFPTKSGSCGTVVRNAELKVVEPETGRSLGYNQPGEICIRGQQIMKGYLNDENSTALTIDAEGWLHTGDVGYVDDDDEIFIVDRVKELIKYKGFQVPPAELEGLLVSHPSIADAAVVPQKDVAAGEVPVAFVVRSNGFDLTEEAVKEFVAKQVVFYKRLHKVYFIHAIPKSPSGKILRKDLRAKLEG
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University