Enzyme
This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)-dihydromyricetin, although some enzymes may act only on a subset of these compounds. Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+, but more slowly.
DFR
Enzyme
Dihydroflavonol 4-reductase
Enzyme name
EC:1.1.1.219
Entry
Oxidoreductases;Acting on the CH-OH group of donors;With NAD+ or NADP+ as acceptor
Class
(2R,3S,4S)-leucoanthocyanidin:NADP+ 4-oxidoreductase
Sysname
a (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH + H+ [RN:R11500]
Reaction
(2R,3R)-dihydroflavonol [CPD:C21417];NADPH [CPD:C00005];H+ [CPD:C00080]
Product
Species information
Macadamia integrifolia
Species name
Macadamia nut (Macadamia integrifolia) is a species of flowering plant in the family Proteaceae (protea family).
Species info
Gene sequence info
Macadamia_integrifolia.DFR.fa
Download
>rna-XM_042639927.1
MEETGSGHRTVCVTGGAGYLGSSLVKKLLEKGHTVHATLRNLDDQSKVDLLKNFPEANTNLRLFKADIYNPDEFDTAIQGCDFVFHVATPVPNSTQISSQCKNMTEAAVAAVESIVKSCIRSGTVKRLIYTGSVVATSPLKEDRSGFKDSMDESCWTPLNLQINYNDSESLKDYVKSKTLSEKKLLNYECKENKLEFVSLVCGLVGGDTVLPYIPTSFAMLMSQPLNDPISYGTLEFLQELLGKVPIVHIDDVCEAHVFCMDQRSLQGRFLFTSDFLTTKEIADYFCRYHPEISIAEAFLGRHVSGVCWGSKKLNDIGFKPSYDAKFILDDSVQCLRKKGALI
>rna-XM_042638015.1
MEERGSGHRTVCVTGGAGYLGSSLVKKLLEKGHTVHATLRNLDDQSKVGLLKNFPEANTKLRLFKADIYNPDEFNPAIQGCDFVFHVATPYQNNTQSSQYKDTTEAAVAAVDSIVKSCVRSGTVKRLIYTGTVMAASALKEDGSGFKDSMDETCWTPLTLQINYNTSQFVKDYTNSKTISEKKLLNYECKVIKLEVVSLACGLVGGDTVLSYIPQSVACLMPQPLNDPISYQSLEFLQELMGKVPIVHIDDVCEAHIFCMDQRSLQGRFLCASDFLTTKEIADYFCRYHPEISIPEQLIGRHGSAVCWGSTKLNDLGFKHWYDAKLILEDSLQCLRKMGKFK
>rna-XM_042643492.1
MSSMPPSMFTALALILGNEAHHSILKQHQLIHLDDLCNAHFFVLEHPKAEGRYICSSRDITIFELAKMLRERYPEYNIPTTFMGIDESIKPVHFSSKKLTDLGFKFKYTAENIFDGAIRSCREKNLIPLKTLEKPCAAENQKLNGAEEKISAVGEENQQRSNPLRHRSVPFVFLQSILV
>rna-XM_042640397.1
MGSAVEMKGPVAVTGAAGYVGSWLIMRLLQQGYTVRATVRDPTNLKKTKHLLDLPEASERLTLWKADLDDEGSFDEAFHGCTGVFHVATPMDFESTDPENEVIKPAINGVLNVMRSCKKASTVKRVVFTSSAGTVDIQEHQQPQYDETWWSNVEFCRRTKMTAWMYFVSKTLAEQAAWDFAKENNLDFISIIPTLVVGPFIMSSMPPSMLTALALILGNEPHYSILKQHQLIHLDDLCNAHIFLLENPKAEGRYICSSRDTTIFELAKMLKEKYPEYNIPTRFKGIDESIKPVHFSSKKLTDLGFEFKYTMEDMFDGAIRSCRERNLIPLQTIDEKPNGVEDKISSAVGEENQPIKA
>rna-XM_042642129.1
MKGPVAVTGAAGYVGSWLVMRLLQEGYTVRATVRDPTDLRKTKPLLDFPEASEQLTLWKADLDDEGSFDEAFKGCTGVFHVATPMDFESTDPENEVIKPTINGVLNVMRSCKKAQTVKRVIFTSSAGTVAVQEQQQPQYDETWWSNVEFCRRTKTTGWMYFVSKTLAEKAAWDFAKENCLDFITIIPSLVVGPFIMSSMPPSMITAMALILGNEAHYSILKQHNLVHLDDLCNAHIFLLEYPKAEGRYICSSRDMTIFELAKMMKERYPEYNIPTSFKGIDESIKPLHFSSKKLTDLGFKFKYTTEDMFDGAIRSCREKNLIPLKTVDKPFTVIKE
>rna-XM_042654828.1
MKRRQKACPLHHTASHWPLLWQVDRGFSCPFPLYLLIQNKMITDCPSCVCGLVFFYKNEVIKPAVNGILNVLRSCLKAKTIRRVVFTSSAGAVARQEKQLPVYDESSWSDLEFIKKKKMTGWMYFMSKTLSEKIALEFAEENSLDLITIIPTLVVGQFLTPWMPPSMITAFALITGYARNEAHYSILKQVKFVHLDDLCNAHIFLLEHPEAKGRYICSSHNTNIIELAKMLRKRFPEYHIPTEFNFEGESLEVVAFSSRKLTELGFEFKYSLEDMYVGATESAREKGLLPNQTQLNDKNLKSEEAEKTH
>rna-XM_042655267.1
MASDDHERGTVCVTGAAGFVGSWLVRNLLHRGYSVNATARDPGNINKVKHLLDLPHADTRLKLWKADLVDEGSFDGAIQGCIGVFHVATPTAFESKDTEDKVIKQAENGILNILRSCLKAKTVRRVVYTSSIAAVCAVRQERQPPVYDESSWSDLEFIRQEKMIPWKYFMSKTLSEKGALEFAEQNSIDLVTIIPSLVVGKFLTPWMPPSMITALALITGYEAHYPLMMQVRLVHLDDLCNAHIYLFEHTKAKGRYICSSYHTNIIELAKWLRERFLEYHVPTEFNYEEESLKVVPFSSRKLTELGFEFKYSLEDMYLGAIESAREKGLIPLSNPTPLIDKSSKSEEAEKNQ
>rna-XM_042664812.1
MALERSTVCMTGAAGFVGSWLVMKLLQKGYLVNATVRDPGNVNKVKHLLDLPHAETRLKLWKADLVDEGSFDGAIQGCTGVFHVATPMDFESKDPENEVIKPAVNGMLNIMRSCLKAKTVRGIVFTSSAGTVMGQERPLPKYDESSWSDLEFITTKKMTGWMYFVSKTLSEKAAWDFAEHNNMALIAIIPTLVVGPFIMPSMPPSLITAFALITENEAHYSILKQVQFVHLDDLCNAHIFLFENPDAKGRYICSSHNATIIDLPKTLRERFPEYNVPTEFNYEGESLEVVAFSSRKLTELGFEFKYSLKDM
>rna-XM_042631179.1
MEEEEGGGPMTFCVTGATGYIGSWLVRSLLHRGYFVHATARDPEKVSPLLSSWNGGKRLKVFRADFQEEGSFDEAVQGCHGVYHVAAPMEFGVPANEDIESYVETKLLKPAIKGTLNLLQACSRAKSVKRVIFTSSISTITAKDDAGRWKSTVDESCQSSIDHVWNMKASGWVYVLSKLQSEEAALKFANENGIDLVSILPPTVAGPFFTSTVPVSVQVLLSPITGDPVLYPILSAVHSRLGSISVVHIEDICNAHIFLMEQPAAKGRYICSAHSCVMSKLVDHLALECPWLNITRSCEVDNGLIPSEISSKKLTSLGFEFKHNLEEIIQHSVSSCVEYGFISQPGYNDGCP
>rna-XM_042634969.1
MEFDDHERGPVCVTGAAGFVGSWLVMKLLQLGYVVNATVRDPDNLKKVKHLLDLPHAETRLKLWKADLVDEGSFDGPIQGCTGVFHVATPMDFESKDPENEVIKPAVDGMLNIMRSCLKAKTVRRVVFTSSAGTVNVQERQMPKYDENSWSDLEFVRAKKMTGWMYFVSKTLSEKAAWEFAEKNNMDLITIIPTLVVGPFIMPSMPPSLITALAPITGNEVHYSILKQIQFVHLDDLCNAHIFLFENLEAKGRYICSSHNATIISLAKMLREKFPEYNVPTEFKFEGESLAVVAFSSKKLTELGFEFKYNLEDMYVGAIESAKEKGLLPLSIPTQLNGKSCKAKSKSEETVKNTNGIKEELKGGGAQIGN
>rna-XM_042634971.1
MILSVALCVTGAAGFVGSWLVKNLLHRGYVVNATVRDPGNVKKVKHLLDLPHADTRLKLWKADLVAEGSFDGAIQGCTGIFHVATPTDFESKDPENEVIKPAVNGILNVLRSCLKAKTIRRVVFTSSAGAVARQERQLPVYDESSWSDLEFIKKKKMTGWMYFMSKTLSEKIALEFAEENSLDLITIIPTLVVGQFLTPWMPPSMITAFALITGNEAHYSILKQVKFVHLDDLCNAHIFLLEHPEAKGRYICSSHNTNIIELAKMLRKRFPEYHIPTD
MEETGSGHRTVCVTGGAGYLGSSLVKKLLEKGHTVHATLRNLDDQSKVDLLKNFPEANTNLRLFKADIYNPDEFDTAIQGCDFVFHVATPVPNSTQISSQCKNMTEAAVAAVESIVKSCIRSGTVKRLIYTGSVVATSPLKEDRSGFKDSMDESCWTPLNLQINYNDSESLKDYVKSKTLSEKKLLNYECKENKLEFVSLVCGLVGGDTVLPYIPTSFAMLMSQPLNDPISYGTLEFLQELLGKVPIVHIDDVCEAHVFCMDQRSLQGRFLFTSDFLTTKEIADYFCRYHPEISIAEAFLGRHVSGVCWGSKKLNDIGFKPSYDAKFILDDSVQCLRKKGALI
>rna-XM_042638015.1
MEERGSGHRTVCVTGGAGYLGSSLVKKLLEKGHTVHATLRNLDDQSKVGLLKNFPEANTKLRLFKADIYNPDEFNPAIQGCDFVFHVATPYQNNTQSSQYKDTTEAAVAAVDSIVKSCVRSGTVKRLIYTGTVMAASALKEDGSGFKDSMDETCWTPLTLQINYNTSQFVKDYTNSKTISEKKLLNYECKVIKLEVVSLACGLVGGDTVLSYIPQSVACLMPQPLNDPISYQSLEFLQELMGKVPIVHIDDVCEAHIFCMDQRSLQGRFLCASDFLTTKEIADYFCRYHPEISIPEQLIGRHGSAVCWGSTKLNDLGFKHWYDAKLILEDSLQCLRKMGKFK
>rna-XM_042643492.1
MSSMPPSMFTALALILGNEAHHSILKQHQLIHLDDLCNAHFFVLEHPKAEGRYICSSRDITIFELAKMLRERYPEYNIPTTFMGIDESIKPVHFSSKKLTDLGFKFKYTAENIFDGAIRSCREKNLIPLKTLEKPCAAENQKLNGAEEKISAVGEENQQRSNPLRHRSVPFVFLQSILV
>rna-XM_042640397.1
MGSAVEMKGPVAVTGAAGYVGSWLIMRLLQQGYTVRATVRDPTNLKKTKHLLDLPEASERLTLWKADLDDEGSFDEAFHGCTGVFHVATPMDFESTDPENEVIKPAINGVLNVMRSCKKASTVKRVVFTSSAGTVDIQEHQQPQYDETWWSNVEFCRRTKMTAWMYFVSKTLAEQAAWDFAKENNLDFISIIPTLVVGPFIMSSMPPSMLTALALILGNEPHYSILKQHQLIHLDDLCNAHIFLLENPKAEGRYICSSRDTTIFELAKMLKEKYPEYNIPTRFKGIDESIKPVHFSSKKLTDLGFEFKYTMEDMFDGAIRSCRERNLIPLQTIDEKPNGVEDKISSAVGEENQPIKA
>rna-XM_042642129.1
MKGPVAVTGAAGYVGSWLVMRLLQEGYTVRATVRDPTDLRKTKPLLDFPEASEQLTLWKADLDDEGSFDEAFKGCTGVFHVATPMDFESTDPENEVIKPTINGVLNVMRSCKKAQTVKRVIFTSSAGTVAVQEQQQPQYDETWWSNVEFCRRTKTTGWMYFVSKTLAEKAAWDFAKENCLDFITIIPSLVVGPFIMSSMPPSMITAMALILGNEAHYSILKQHNLVHLDDLCNAHIFLLEYPKAEGRYICSSRDMTIFELAKMMKERYPEYNIPTSFKGIDESIKPLHFSSKKLTDLGFKFKYTTEDMFDGAIRSCREKNLIPLKTVDKPFTVIKE
>rna-XM_042654828.1
MKRRQKACPLHHTASHWPLLWQVDRGFSCPFPLYLLIQNKMITDCPSCVCGLVFFYKNEVIKPAVNGILNVLRSCLKAKTIRRVVFTSSAGAVARQEKQLPVYDESSWSDLEFIKKKKMTGWMYFMSKTLSEKIALEFAEENSLDLITIIPTLVVGQFLTPWMPPSMITAFALITGYARNEAHYSILKQVKFVHLDDLCNAHIFLLEHPEAKGRYICSSHNTNIIELAKMLRKRFPEYHIPTEFNFEGESLEVVAFSSRKLTELGFEFKYSLEDMYVGATESAREKGLLPNQTQLNDKNLKSEEAEKTH
>rna-XM_042655267.1
MASDDHERGTVCVTGAAGFVGSWLVRNLLHRGYSVNATARDPGNINKVKHLLDLPHADTRLKLWKADLVDEGSFDGAIQGCIGVFHVATPTAFESKDTEDKVIKQAENGILNILRSCLKAKTVRRVVYTSSIAAVCAVRQERQPPVYDESSWSDLEFIRQEKMIPWKYFMSKTLSEKGALEFAEQNSIDLVTIIPSLVVGKFLTPWMPPSMITALALITGYEAHYPLMMQVRLVHLDDLCNAHIYLFEHTKAKGRYICSSYHTNIIELAKWLRERFLEYHVPTEFNYEEESLKVVPFSSRKLTELGFEFKYSLEDMYLGAIESAREKGLIPLSNPTPLIDKSSKSEEAEKNQ
>rna-XM_042664812.1
MALERSTVCMTGAAGFVGSWLVMKLLQKGYLVNATVRDPGNVNKVKHLLDLPHAETRLKLWKADLVDEGSFDGAIQGCTGVFHVATPMDFESKDPENEVIKPAVNGMLNIMRSCLKAKTVRGIVFTSSAGTVMGQERPLPKYDESSWSDLEFITTKKMTGWMYFVSKTLSEKAAWDFAEHNNMALIAIIPTLVVGPFIMPSMPPSLITAFALITENEAHYSILKQVQFVHLDDLCNAHIFLFENPDAKGRYICSSHNATIIDLPKTLRERFPEYNVPTEFNYEGESLEVVAFSSRKLTELGFEFKYSLKDM
>rna-XM_042631179.1
MEEEEGGGPMTFCVTGATGYIGSWLVRSLLHRGYFVHATARDPEKVSPLLSSWNGGKRLKVFRADFQEEGSFDEAVQGCHGVYHVAAPMEFGVPANEDIESYVETKLLKPAIKGTLNLLQACSRAKSVKRVIFTSSISTITAKDDAGRWKSTVDESCQSSIDHVWNMKASGWVYVLSKLQSEEAALKFANENGIDLVSILPPTVAGPFFTSTVPVSVQVLLSPITGDPVLYPILSAVHSRLGSISVVHIEDICNAHIFLMEQPAAKGRYICSAHSCVMSKLVDHLALECPWLNITRSCEVDNGLIPSEISSKKLTSLGFEFKHNLEEIIQHSVSSCVEYGFISQPGYNDGCP
>rna-XM_042634969.1
MEFDDHERGPVCVTGAAGFVGSWLVMKLLQLGYVVNATVRDPDNLKKVKHLLDLPHAETRLKLWKADLVDEGSFDGPIQGCTGVFHVATPMDFESKDPENEVIKPAVDGMLNIMRSCLKAKTVRRVVFTSSAGTVNVQERQMPKYDENSWSDLEFVRAKKMTGWMYFVSKTLSEKAAWEFAEKNNMDLITIIPTLVVGPFIMPSMPPSLITALAPITGNEVHYSILKQIQFVHLDDLCNAHIFLFENLEAKGRYICSSHNATIISLAKMLREKFPEYNVPTEFKFEGESLAVVAFSSKKLTELGFEFKYNLEDMYVGAIESAKEKGLLPLSIPTQLNGKSCKAKSKSEETVKNTNGIKEELKGGGAQIGN
>rna-XM_042634971.1
MILSVALCVTGAAGFVGSWLVKNLLHRGYVVNATVRDPGNVKKVKHLLDLPHADTRLKLWKADLVAEGSFDGAIQGCTGIFHVATPTDFESKDPENEVIKPAVNGILNVLRSCLKAKTIRRVVFTSSAGAVARQERQLPVYDESSWSDLEFIKKKKMTGWMYFMSKTLSEKIALEFAEENSLDLITIIPTLVVGQFLTPWMPPSMITAFALITGNEAHYSILKQVKFVHLDDLCNAHIFLLEHPEAKGRYICSSHNTNIIELAKMLRKRFPEYHIPTD
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University