Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Lunaria annua
Species name
Honesty (Lunaria annua) is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Lunaria_annua.4CL.fa
Download
>Luann.0007s0245.1.v1.1
MVLQQQTLFLTKKTTDQEEEPSHDFIFRSKLPDIFIPNHLPLTDYVFQKFSGDGDGDSTTTCLIDGATGRIFTYADVQINSRRIAAGIHRLGIRHLDVVMVLLPNSPEFALSFLAVAYLGAVSTTANPFYTQQEITKQAKDSAAKMIITKRCYVDKLTTLQNDGVLIVCVNDEDDVVSSKAETDSYVSFTELTQADETEFPKPEISPEDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNLNFTKDDVILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLAFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKNPFKTKSGACGTVIRNAEMKVVDTITGVSLPRNKTGEICVRGHQLMKGYLNNPDATARTIDKDGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPYIEDAAVVAMKDEVADEVPVAFIVRSEGSQLTEEDVKSYVNKQVVHYKRIKKVFFIEAIPKAVSGKILRKELRAKLETEYPK
>Luann.0026s0136.1.v1.1
MVLQQQTLFLTKKTDQEEEEPSHDFIFRSKLPHIFIPNHLPLTDYVFQKFSDDGDGDSTTTCLIDGATGTIFTYADVQINSRRIAAGIHRLGIRHRGVVMLLLPNSPEFAFSFIAVAYLGAVSTTANPFYTQSEIAKQAKASAAKMIITKRCYVEKLTNLQNDGVLIVCIDDADDVVSIADGCVSFTELTQADETEFTRPEISPDDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNLNFTGDDIILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLAFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKKPFKTKSGACGTVIRNAEMKVVDTITGISLPRNKSGEICIRGHQLMKGYLNDPEATARTIDKDGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPYIDDAAVVAMKDEIADEVPVAFVVRSEGSQLTEDEVKSYVNKQVVHYKRIKIVFFIEAIPKAPSGKILRKELRAKLETEYP
>Luann.0034s0125.1.v1.1
MAATHLHISPNTKTPTSHQTTPFWFSPETGIYTSKYPSVHLPVDPNLDVVSALFSHIHDGDDSAAALVDSLTGFSISHIELRTMVQSMAAGIYHDLGVNQGDVVSLVLPNSVYFPLIFLSLISLGAIVTTMNPSSSLGEIKKQVSECNVSLAFTSRENVEKLSSLGIMVIWVPESYDFDSIRIENPKFYAIMKGHFGFVPKPLINQDDVAAIMYSSGTTGASKGVLITHRNLIATMELFVRFEASQYEYPGSSNVYLAALPLCHIYGLSLFVLGLLSLGSTIVVMRRFDASDVINVIERFKITHFPVVPPMLMALTKKAKGVCGKVFKSLKQVSSGAAPLSRKFIEDFLGTLPHVDLIQGYGMTESTAVGTRGFNSQKLRKYSSVGLLAPNMQAKIVDWSSGSFLPPENRGELWIKGPGVMKGYLNNPEATQMTIFEDSWLRTGDIAYFDEDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTSAPNEECGEIPVAFVVRRQETSLSEQDVISYVAAQVAPYRKVRKVVMVNFIPKSPAGKILRKELKRILTSCVSSRL
>Luann.0036s0030.1.v1.1
MITAAQHEPQIHKPADTSPVVVSGDASPPSPRIFRSKLPDIDIPNHLPLHTYCFDKLSSVSDKPCLIVGSTGKSYSYGETHLICRRVAAGLYKIGIRKGDVIMILLQNSAEFVFSFMGASMIGAVSTTANPFYTSQEIYKQLLSSGAKLIITHSQYVEKLRNLELKIGQDLTVITTDDPPPENCLPFSILTDEKNPPEESIDVGGEDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGDNPNLYLNQNDVVLCVLPLFHIYSLNSVLLNSIRSGATVLLMHKFEIGSLLDLIQRHKVTITALVPPLVIALAKNPAVNSYDLSSVRLVLSGAAPLGKDLQNNLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPFPTKSGSCGTVVRNAELKVVHLETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDEEGWLYTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHNSIADAAVVPQNDEVAGEVPVAFVVQSNGNDITEEDIKEYIAKQVVFYKRLHKVFFVPSIPKSPSGKILRKDLKARFC
>Luann.0073s0065.1.v1.1
MDDQKQVNEYIFRSLYPSVHIPDNLTLPEFVLQGVEEFTEKVAFVEAVTGKAVTYGDVVRDTRRLAKALTSLGLRKGQVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALVSEIKKQVEASGARGIITDANNYEKVKTLGLPVIVLGEENIEGAVKWKDLLEAGDKCGDNNNIFENKEEIILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSSLFSVRSEMIGQIVTLGLIPFFHIYGIVGICFATMKNKGKVVAMNRYDLRIFLNALIAHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMTAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGRSLPKNSSGELCVRSQCVMQGYFKNKEETEKTIDQEGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPVACVVINPKAKEKEEDILNFVAANVAHYKKIRAVHFVDSIPKSLSGKIMRRLLRDKILTINNNK
>Luann.0081s0070.1.v1.1
MEKSGYGRDGIYRSLRPMLVLPKDYNTSLVSFLFRNSSSYPSKPALVDSDSGDSLSFSQLKSAVSRLAQGFLRLGIRQHDVVLIFAPNSYQFPLCFLAVTAIGGVFTTANPLYTVNEVSKQIKDSKPKIIITVQQLFDTVKGFDLPIVLLGSDKSVQIPGSNSKILSFGDVMELSDPVSDLPFVDIKQSDTAALLYSSGTTGTSKGVELTHGNFIAASLMVTMDQDLMGEYHGVFLCFLPMFHVFGLAVITYSQLQRGSCVISMAKFELETVLKSIEKYRVTHLWVVPPVFLALSKDSSVKKYDLSSLKYIGSGAAPLGKDLMEDCGRNIPNVLLMQGYGMTETCGIVSVEDPRLGKRNSGSAGTLSPGIEAQIVSVETGKSQPPNQLGEIWVRGPNMMKGYLNNPQATKETIDKKGWVHTGDLGYFNEDGNLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPLPDEEAGEVPIGFVVRSPNSSLTEEDIQKFIAKQVAPYKRLRRVSFINSVPKSTAGKILRRELVQQVRSKM
>Luann.0103s0038.1.v1.1
MKINSRSAGFHRLGIRHYDVLMLLLLNSPELVLSFLSVADLGLVSTTANPLYTHTIAKFHSNFNDVTIFAIIAVSRLCFESNLLCRKSLTFDCTI
>Luann.0225s0048.1.v1.1
MAPQEATQKQSSNTDVIFRSKLPDIYIPNHLSLHDYIFQNISEFASKPCLINGPTGQVYTYSDVHVTSRRIAASFHKLGVNRNDVVMILLPNCPEFVLSFLAASFRGATATAANPFFTPAEIAKQAKASNSKLIITESRYVDKIKDLQNDGVLIVCTDESAPTPEGCLRFTELTQSDVIDSVEISPDDVVALPYSSGTTGLPKGVMLSHKGLVTSVAQQVDGENPNLYFDRDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSPETEKYDLRTIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPETGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEVAGEVPVAFVVKSKDSNLSEDEVKQFVSKQVVFYKRINKVFFTETIPKAPSGKILRKDLRAKLANGLMN
>Luann.0313s0047.1.v1.1
MASPQEVMQKQSKSDVIFRSKLPDIYIPNHLSLHDYIFQNISEFASTPCLINGPTGHVYTYSDVHLISRQIAAGFHKLGVNQHDVVMILLPNCPEFVLAFLAASFRGAIATAANPFFTPAEIAKQAKASNTKLIITESRYVDKIKDLQKDGVIIVCIDESSPIPEGCLRFTELTQSTESDVINSVEISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFNGDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPIVPPIVLAIAKSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSRNKPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEESAGEVPVAFVVKSKDSELSEDEVKQFVSKQVVFYKRINKVFFVDSIPKAPSGKILRKDLRAKLANGF
MVLQQQTLFLTKKTTDQEEEPSHDFIFRSKLPDIFIPNHLPLTDYVFQKFSGDGDGDSTTTCLIDGATGRIFTYADVQINSRRIAAGIHRLGIRHLDVVMVLLPNSPEFALSFLAVAYLGAVSTTANPFYTQQEITKQAKDSAAKMIITKRCYVDKLTTLQNDGVLIVCVNDEDDVVSSKAETDSYVSFTELTQADETEFPKPEISPEDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNLNFTKDDVILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLAFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKNPFKTKSGACGTVIRNAEMKVVDTITGVSLPRNKTGEICVRGHQLMKGYLNNPDATARTIDKDGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPYIEDAAVVAMKDEVADEVPVAFIVRSEGSQLTEEDVKSYVNKQVVHYKRIKKVFFIEAIPKAVSGKILRKELRAKLETEYPK
>Luann.0026s0136.1.v1.1
MVLQQQTLFLTKKTDQEEEEPSHDFIFRSKLPHIFIPNHLPLTDYVFQKFSDDGDGDSTTTCLIDGATGTIFTYADVQINSRRIAAGIHRLGIRHRGVVMLLLPNSPEFAFSFIAVAYLGAVSTTANPFYTQSEIAKQAKASAAKMIITKRCYVEKLTNLQNDGVLIVCIDDADDVVSIADGCVSFTELTQADETEFTRPEISPDDTVAMPYSSGTTGLPKGVMITHKGLVTSIAQKVDGENPNLNFTGDDIILCFLPMFHIYALDALMLSAMRTGAALLIVPRFELNLVMELIQRYKVTVVPVAPPVVLAFVKSPETERYDLSSVRMMLSGAATLKKELEDAVRLKFPNAIFGQGYGMTESGTVAKSLAFAKKPFKTKSGACGTVIRNAEMKVVDTITGISLPRNKSGEICIRGHQLMKGYLNDPEATARTIDKDGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPYIDDAAVVAMKDEIADEVPVAFVVRSEGSQLTEDEVKSYVNKQVVHYKRIKIVFFIEAIPKAPSGKILRKELRAKLETEYP
>Luann.0034s0125.1.v1.1
MAATHLHISPNTKTPTSHQTTPFWFSPETGIYTSKYPSVHLPVDPNLDVVSALFSHIHDGDDSAAALVDSLTGFSISHIELRTMVQSMAAGIYHDLGVNQGDVVSLVLPNSVYFPLIFLSLISLGAIVTTMNPSSSLGEIKKQVSECNVSLAFTSRENVEKLSSLGIMVIWVPESYDFDSIRIENPKFYAIMKGHFGFVPKPLINQDDVAAIMYSSGTTGASKGVLITHRNLIATMELFVRFEASQYEYPGSSNVYLAALPLCHIYGLSLFVLGLLSLGSTIVVMRRFDASDVINVIERFKITHFPVVPPMLMALTKKAKGVCGKVFKSLKQVSSGAAPLSRKFIEDFLGTLPHVDLIQGYGMTESTAVGTRGFNSQKLRKYSSVGLLAPNMQAKIVDWSSGSFLPPENRGELWIKGPGVMKGYLNNPEATQMTIFEDSWLRTGDIAYFDEDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTSAPNEECGEIPVAFVVRRQETSLSEQDVISYVAAQVAPYRKVRKVVMVNFIPKSPAGKILRKELKRILTSCVSSRL
>Luann.0036s0030.1.v1.1
MITAAQHEPQIHKPADTSPVVVSGDASPPSPRIFRSKLPDIDIPNHLPLHTYCFDKLSSVSDKPCLIVGSTGKSYSYGETHLICRRVAAGLYKIGIRKGDVIMILLQNSAEFVFSFMGASMIGAVSTTANPFYTSQEIYKQLLSSGAKLIITHSQYVEKLRNLELKIGQDLTVITTDDPPPENCLPFSILTDEKNPPEESIDVGGEDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGDNPNLYLNQNDVVLCVLPLFHIYSLNSVLLNSIRSGATVLLMHKFEIGSLLDLIQRHKVTITALVPPLVIALAKNPAVNSYDLSSVRLVLSGAAPLGKDLQNNLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPFPTKSGSCGTVVRNAELKVVHLETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDEEGWLYTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHNSIADAAVVPQNDEVAGEVPVAFVVQSNGNDITEEDIKEYIAKQVVFYKRLHKVFFVPSIPKSPSGKILRKDLKARFC
>Luann.0073s0065.1.v1.1
MDDQKQVNEYIFRSLYPSVHIPDNLTLPEFVLQGVEEFTEKVAFVEAVTGKAVTYGDVVRDTRRLAKALTSLGLRKGQVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALVSEIKKQVEASGARGIITDANNYEKVKTLGLPVIVLGEENIEGAVKWKDLLEAGDKCGDNNNIFENKEEIILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSSLFSVRSEMIGQIVTLGLIPFFHIYGIVGICFATMKNKGKVVAMNRYDLRIFLNALIAHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMTAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGRSLPKNSSGELCVRSQCVMQGYFKNKEETEKTIDQEGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVPLPDEEAGEIPVACVVINPKAKEKEEDILNFVAANVAHYKKIRAVHFVDSIPKSLSGKIMRRLLRDKILTINNNK
>Luann.0081s0070.1.v1.1
MEKSGYGRDGIYRSLRPMLVLPKDYNTSLVSFLFRNSSSYPSKPALVDSDSGDSLSFSQLKSAVSRLAQGFLRLGIRQHDVVLIFAPNSYQFPLCFLAVTAIGGVFTTANPLYTVNEVSKQIKDSKPKIIITVQQLFDTVKGFDLPIVLLGSDKSVQIPGSNSKILSFGDVMELSDPVSDLPFVDIKQSDTAALLYSSGTTGTSKGVELTHGNFIAASLMVTMDQDLMGEYHGVFLCFLPMFHVFGLAVITYSQLQRGSCVISMAKFELETVLKSIEKYRVTHLWVVPPVFLALSKDSSVKKYDLSSLKYIGSGAAPLGKDLMEDCGRNIPNVLLMQGYGMTETCGIVSVEDPRLGKRNSGSAGTLSPGIEAQIVSVETGKSQPPNQLGEIWVRGPNMMKGYLNNPQATKETIDKKGWVHTGDLGYFNEDGNLFVVDRIKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPLPDEEAGEVPIGFVVRSPNSSLTEEDIQKFIAKQVAPYKRLRRVSFINSVPKSTAGKILRRELVQQVRSKM
>Luann.0103s0038.1.v1.1
MKINSRSAGFHRLGIRHYDVLMLLLLNSPELVLSFLSVADLGLVSTTANPLYTHTIAKFHSNFNDVTIFAIIAVSRLCFESNLLCRKSLTFDCTI
>Luann.0225s0048.1.v1.1
MAPQEATQKQSSNTDVIFRSKLPDIYIPNHLSLHDYIFQNISEFASKPCLINGPTGQVYTYSDVHVTSRRIAASFHKLGVNRNDVVMILLPNCPEFVLSFLAASFRGATATAANPFFTPAEIAKQAKASNSKLIITESRYVDKIKDLQNDGVLIVCTDESAPTPEGCLRFTELTQSDVIDSVEISPDDVVALPYSSGTTGLPKGVMLSHKGLVTSVAQQVDGENPNLYFDRDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSPETEKYDLRTIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPETGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEVAGEVPVAFVVKSKDSNLSEDEVKQFVSKQVVFYKRINKVFFTETIPKAPSGKILRKDLRAKLANGLMN
>Luann.0313s0047.1.v1.1
MASPQEVMQKQSKSDVIFRSKLPDIYIPNHLSLHDYIFQNISEFASTPCLINGPTGHVYTYSDVHLISRQIAAGFHKLGVNQHDVVMILLPNCPEFVLAFLAASFRGAIATAANPFFTPAEIAKQAKASNTKLIITESRYVDKIKDLQKDGVIIVCIDESSPIPEGCLRFTELTQSTESDVINSVEISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFNGDDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPIVPPIVLAIAKSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSRNKPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEESAGEVPVAFVVKSKDSELSEDEVKQFVSKQVVFYKRINKVFFVDSIPKAPSGKILRKDLRAKLANGF
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University