Enzyme
Specific for quercetin. Related enzymes bring about the 3-O-methylation of other flavonols, such as galangin and kaempferol.
COMT
Enzyme
Flavone 3'-O-methyltransferase
Enzyme name
EC:2.1.1.76
Entry
Transferases;Transferring one-carbon groups;Methyltransferases
Class
S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase
Sysname
S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxyflavone [RN:R02157]
Reaction
S-adenosyl-L-homocysteine [CPD:C00021];3-methoxy-5,7,3',4'-tetrahydroxyflavone [CPD:C04443]
Product
Species information
Lonicera japonica
Species name
Japanese honeysuckle (Lonicera japonica) is a species of eudicot in the family Caprifoliaceae (honeysuckle famly).
Species info
Gene sequence info
Lonicera_japonica.COMT.fa
Download
>Lj1C1028G12.1
MKSTSNGGVDKQNISEAAKQTEEEEAACLFAFQLAGASALPMVLKTAVELDLLEIIAKSGPGAFLSPWEIASHLPPHTNPNLHVVLDRILRLLAANSVLKCNLRNLPAADGSGRVIVERLYGLAPVCKFLTKNPDGVSIAPLLLMNHDKVLMDSWYHLKDAVLDGGIPFNKTHGMSAFEYHGTDVRFNKVFNQGMSNSSTIIMKKLLDTYTGFDGLTSVVDVGGGIGASLNMIVSRHPTIKGINFDLPHVIQVAPSYPGVENVGGDMFVSVPKGDAIFLKCGMILKNCHVALRSNGKVIVAECILPEAPDTQVSTRIVINVDAIMLAHNPGGKERTEAEFEALAKGAGFKGYRKACYAFNICVMEFFK
>Lj1A711G15.1
MLMMVSLNGKERNEKEWANLFNAAGFNGGFMITPILGLRSIIETNSEFFSLWILHDWNDEDQCVKIIKLSEEAIPSKEEGGMVIIIEMALNNCNNQKKNDNSVETQLLHVRLVPAAVFFVSLHSQAGNLLGSEHLRFVGGDMFVAIPPANAALLKSILHDWNDEECAKILKQSKEEGGKEIFIDMVVNYSNSQKKDDNSVETQLLIDMLMMVSVNGKERNQKNGQSSSRLLPSMVVLSLFLFLV
>Lj2C151T1.1
MAEQDQDNHLLQYAMELASASALPMVLRSTIELGVLEIVAKAGPTALLSSFQIVSHLPSTNPHAHNMLDRMLSQLASHSILTCSVDTHPDGYWVQRLYGLVPVVKYFIRNEDGAPSAPLLDAIQASL
>Lj2C151T2.1
MNASEYIRQDARYLEIFKASMRDYNSMFMKKMLEIYGGFEGLKALVDVGDGDGTILNLIASNYPTIKATNFDLAQIIEKSPSYPASPLVKRTTWNCTGWFFGSRNLHGFPLEQWMLHSWDNEHCLKLLKNCYEALLGHGKVIAVDLVVLESPETSVAVKSVLQFDLYMMNMNPGGKERTERELESLAKAAGFSRIRVACCAYNFSVVEIYKTM
>Lj3A893G82.1
MGSTGETQITPLEAKEEEQALLFAMQLASASVLPMVLKSAIELDLLEIIAKAGPGAHVSPAEVAAQLPTQNPGALVMLDRILRLLASYSVLNCKLRNLPSGGVERLYGLEPVYAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTITMKKILETYSGFDGLGSVVDVGGGTGATLNMIVSKHPSIKGINFDLPHVIEDANSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLKNCYEALPENGKVIVAECLLPEAPDTKMETKNVVHIDVIMLAHNPGGKERTEKEFEALAKGSGFKSFKKACCAFNTWVMEFCK
>Lj4A628T60.1
MSTSHNQDPQNQDQEEEEIGKLAVRLANAVVLPMVLKSALELNLIGIISAAGDGAWLSPSEIAARVPTSNPQAAVLLDRMLRLLASYEVVKCSVRTGADGDVERVYGVGPICKFMRNDGGDEGGSVGPLFLLHHDKIFMESWYHLNEVILEGGIPFNRAYGMTAFEYPRTDQRFNRVFNRAMSNHTTLIIKKILEIYKGFEGLNVLVDVGGGIGVTLSIITSKYPHLKAINFDLPHVLADAPSYSGVEHVGGDMFVSVPKGDAIFMKWILHDWSDEHCLKLLANCNEALPDSGKVIIVESILPDVPESSVSSQIVFEQDLIMLAQNPGGKERTQKDYNALAVKSGFSGCEVICCAYNSWVMEFKK
>Lj4C629G0.1
MSNPQAAVLLDRMLRLLASYEVVKCSVRTGGEGDVGRVYHLNEVILEGGIPFNRAYGMTAFEYPRTDQRFNRVFNRAMPNHTTLIIKKILEILKGFEGLNVLVDVGGGIGVTLSIITSKYPHLKAINFDLPHGLADAPSYSALPDSGKVIIVESILPDVPKSSVSSQIVFEQDLTMLAQNPGGKERTQKDYNALAVKSRFSGCEIICCAYNSWVMEFKNDQTLKFD
>Lj7A332G22.1
MTTNPTFKEEDAFACAMLVTYSYIVPIVVKASIELGLFDIIAKKGQISPSEMASHLLTKNKDAPTILDCMLRLLATHSIITCSLSNLEEGGGAEVERLYGLPPAEELFVQEVGCCSRFLTSFSQFSNTGNGIDFCGIGTTLELITSKYPSIKGINFDFPRVIKNAPLQHGIELVA
>Lj7A334T39.1
MTSIEINPINKEEDEAIACAMQLSSSFVVPMVLNVAIELGLLKIIAKTGQMSPSEMASHLPTKNKDAPAMLDSIMRLLATHSVVTCSLSNPEGGGEVERLYGLTPTGELFAQNRSSFLFPYGRKYIDTWYHLKDAILEGGNPFERAYGMPFYKHIGANSNESNHFHRAISQSDVVMTKILKAYKGFEGIKSLVDVGGAIGTTLHLITSKYPSIKGINFDLPHVIDNAPLQNGIEHVAGDMFVSVPTSEAILLKWVCHNWDDEHCLKLLNNCYKALPTSGKVILVEYIMPLAPNTSIANKYITQLDNIMLSNFGGKERTINEFQAVSKAAGFSKIRLHSYDCIPSVVEIFK
>Lj7C334G12.1
MSFMKTNPTFKEENDAFTCALQVTSSYIVPMVLKAAFELGLLDIIAKKGQISPSEMASHFLAKNKDAPALLGSVLRLIATHSILTCSLSNLEEGGDGEFERLYGLPPAGELLVQEVGCCSSLLTSFFQFSNIRNGIDFWLELVAAILLKWILHNWDDEQCLKILKNCYEAIPTSAKIILVEYVGTRRQHCQQVNFST
>Lj7C331T9.1
MSFMTTNPTFKEEDAFACAMLVTYSYIVPIVVKAALELGLFDIMAKKGQISPSEMASHLLTRNKDTPTILDCMLRLLATHSILTCSLSNLEEGGGGEVKILYGLPPDEELFVQEVGCCSHLLTSFFNSRTPEMALTSGTYEGCSS
>Lj7A335T25.1
MTSHILTKNKDAPAMLDSMLRLLATHSILTCSLSNLEVGGGGEVKRLYGLPLQLMKDAVLNGGIPFQRAHGMPFYQYMCVQIPMKASTLIVQ
>Lj7C319T7.1
MSFMTTNPTFKEEDAFACAMLVTYSYIVPIVVKAALELGLFDIMAKKGQISPSEMASHLLTKNKDTPTILDCMLKLLATHSILTCSLSNPEEGGGGEVKILYGLPPAEELFVQEVGCCSHLLTSFFQFSNTGNGIDFWEHMKDAVLDGGIPLQIKSPWDALLPIYVCKSQ
>Lj7A335T26.1
MSLMKSNPTLKDENDAFACALQVTSSYIVPMVLKAALELGLFDIIAKKGQIPPSEMASHLLAKNKDAPAMLDRMLRLLATHSILTCSLSNLEEGGGGEVERLYGLPPAGELFVQEVGCCSRLLTSFFQFSNTANGIDFWQHMKDAILDGGVPFQRARGMPFYQYIRASPDRSKNFDSSMSEQTNAIMTKTLNKYKGFEGINSLVDVGGGIGTALELITSKYPSIKGINFDLPSVIKNAPIQHGIQLVAGDMFVSIPKSEAILLKWILHNWDDEQCLKILKNCYEAIPTSGKVILVEFIVPLVPDTSISSKLISQLDNIMLFLQEGKERTINEFEALSKAAGFSKIQLHSYDYITSVVEIFK
>Lju2200A0T14.1
MSFMKSSPTLKDENDAFACASQVTSSYIVPMVLKAALELGLFDIIAKKGQIPPSEMASHLLAKNKDAPAMLDRMLRLLATHSILTCSLSNLEEGGGGEVERLYGLPPAGELFVQEVGCCSRLLTSFFQFSNTANGIDFWQHLKDAILDGGVPFQRACGMPFYQYIRASPDRSKNFDSSMSEQTNTIMTKTLNTYKGFEGINSLVDVGGGIGTTLKLITSKYPSIKGINFDLPSVIKNAPIQHGIQLVAGDMFVSIPKSEAILLKWILHNWDDEQCLKILKNCYEAIPTSGKVILVEFIVPLVPDTSISSKLISQLDNIMLFLLGGKERTINEFEALSKAAGFSKIQLHSYDYITSVVEIFK
>Lju2200E0T1.1
MTSHILTKNKDAPAMLDSMLRLLATHSILTCFLSNLEEGGGGEVKRLYGLPLAKELFMKEVGCCSRWLTSFFQFSNTGNDIDL
MKSTSNGGVDKQNISEAAKQTEEEEAACLFAFQLAGASALPMVLKTAVELDLLEIIAKSGPGAFLSPWEIASHLPPHTNPNLHVVLDRILRLLAANSVLKCNLRNLPAADGSGRVIVERLYGLAPVCKFLTKNPDGVSIAPLLLMNHDKVLMDSWYHLKDAVLDGGIPFNKTHGMSAFEYHGTDVRFNKVFNQGMSNSSTIIMKKLLDTYTGFDGLTSVVDVGGGIGASLNMIVSRHPTIKGINFDLPHVIQVAPSYPGVENVGGDMFVSVPKGDAIFLKCGMILKNCHVALRSNGKVIVAECILPEAPDTQVSTRIVINVDAIMLAHNPGGKERTEAEFEALAKGAGFKGYRKACYAFNICVMEFFK
>Lj1A711G15.1
MLMMVSLNGKERNEKEWANLFNAAGFNGGFMITPILGLRSIIETNSEFFSLWILHDWNDEDQCVKIIKLSEEAIPSKEEGGMVIIIEMALNNCNNQKKNDNSVETQLLHVRLVPAAVFFVSLHSQAGNLLGSEHLRFVGGDMFVAIPPANAALLKSILHDWNDEECAKILKQSKEEGGKEIFIDMVVNYSNSQKKDDNSVETQLLIDMLMMVSVNGKERNQKNGQSSSRLLPSMVVLSLFLFLV
>Lj2C151T1.1
MAEQDQDNHLLQYAMELASASALPMVLRSTIELGVLEIVAKAGPTALLSSFQIVSHLPSTNPHAHNMLDRMLSQLASHSILTCSVDTHPDGYWVQRLYGLVPVVKYFIRNEDGAPSAPLLDAIQASL
>Lj2C151T2.1
MNASEYIRQDARYLEIFKASMRDYNSMFMKKMLEIYGGFEGLKALVDVGDGDGTILNLIASNYPTIKATNFDLAQIIEKSPSYPASPLVKRTTWNCTGWFFGSRNLHGFPLEQWMLHSWDNEHCLKLLKNCYEALLGHGKVIAVDLVVLESPETSVAVKSVLQFDLYMMNMNPGGKERTERELESLAKAAGFSRIRVACCAYNFSVVEIYKTM
>Lj3A893G82.1
MGSTGETQITPLEAKEEEQALLFAMQLASASVLPMVLKSAIELDLLEIIAKAGPGAHVSPAEVAAQLPTQNPGALVMLDRILRLLASYSVLNCKLRNLPSGGVERLYGLEPVYAVLDGGIPFNKAYGMTAFEYHGTDPRFNKVFNQGMSNHSTITMKKILETYSGFDGLGSVVDVGGGTGATLNMIVSKHPSIKGINFDLPHVIEDANSYPGVEHVGGDMFVSVPKGDAIFMKWICHDWSDEHCLKFLKNCYEALPENGKVIVAECLLPEAPDTKMETKNVVHIDVIMLAHNPGGKERTEKEFEALAKGSGFKSFKKACCAFNTWVMEFCK
>Lj4A628T60.1
MSTSHNQDPQNQDQEEEEIGKLAVRLANAVVLPMVLKSALELNLIGIISAAGDGAWLSPSEIAARVPTSNPQAAVLLDRMLRLLASYEVVKCSVRTGADGDVERVYGVGPICKFMRNDGGDEGGSVGPLFLLHHDKIFMESWYHLNEVILEGGIPFNRAYGMTAFEYPRTDQRFNRVFNRAMSNHTTLIIKKILEIYKGFEGLNVLVDVGGGIGVTLSIITSKYPHLKAINFDLPHVLADAPSYSGVEHVGGDMFVSVPKGDAIFMKWILHDWSDEHCLKLLANCNEALPDSGKVIIVESILPDVPESSVSSQIVFEQDLIMLAQNPGGKERTQKDYNALAVKSGFSGCEVICCAYNSWVMEFKK
>Lj4C629G0.1
MSNPQAAVLLDRMLRLLASYEVVKCSVRTGGEGDVGRVYHLNEVILEGGIPFNRAYGMTAFEYPRTDQRFNRVFNRAMPNHTTLIIKKILEILKGFEGLNVLVDVGGGIGVTLSIITSKYPHLKAINFDLPHGLADAPSYSALPDSGKVIIVESILPDVPKSSVSSQIVFEQDLTMLAQNPGGKERTQKDYNALAVKSRFSGCEIICCAYNSWVMEFKNDQTLKFD
>Lj7A332G22.1
MTTNPTFKEEDAFACAMLVTYSYIVPIVVKASIELGLFDIIAKKGQISPSEMASHLLTKNKDAPTILDCMLRLLATHSIITCSLSNLEEGGGAEVERLYGLPPAEELFVQEVGCCSRFLTSFSQFSNTGNGIDFCGIGTTLELITSKYPSIKGINFDFPRVIKNAPLQHGIELVA
>Lj7A334T39.1
MTSIEINPINKEEDEAIACAMQLSSSFVVPMVLNVAIELGLLKIIAKTGQMSPSEMASHLPTKNKDAPAMLDSIMRLLATHSVVTCSLSNPEGGGEVERLYGLTPTGELFAQNRSSFLFPYGRKYIDTWYHLKDAILEGGNPFERAYGMPFYKHIGANSNESNHFHRAISQSDVVMTKILKAYKGFEGIKSLVDVGGAIGTTLHLITSKYPSIKGINFDLPHVIDNAPLQNGIEHVAGDMFVSVPTSEAILLKWVCHNWDDEHCLKLLNNCYKALPTSGKVILVEYIMPLAPNTSIANKYITQLDNIMLSNFGGKERTINEFQAVSKAAGFSKIRLHSYDCIPSVVEIFK
>Lj7C334G12.1
MSFMKTNPTFKEENDAFTCALQVTSSYIVPMVLKAAFELGLLDIIAKKGQISPSEMASHFLAKNKDAPALLGSVLRLIATHSILTCSLSNLEEGGDGEFERLYGLPPAGELLVQEVGCCSSLLTSFFQFSNIRNGIDFWLELVAAILLKWILHNWDDEQCLKILKNCYEAIPTSAKIILVEYVGTRRQHCQQVNFST
>Lj7C331T9.1
MSFMTTNPTFKEEDAFACAMLVTYSYIVPIVVKAALELGLFDIMAKKGQISPSEMASHLLTRNKDTPTILDCMLRLLATHSILTCSLSNLEEGGGGEVKILYGLPPDEELFVQEVGCCSHLLTSFFNSRTPEMALTSGTYEGCSS
>Lj7A335T25.1
MTSHILTKNKDAPAMLDSMLRLLATHSILTCSLSNLEVGGGGEVKRLYGLPLQLMKDAVLNGGIPFQRAHGMPFYQYMCVQIPMKASTLIVQ
>Lj7C319T7.1
MSFMTTNPTFKEEDAFACAMLVTYSYIVPIVVKAALELGLFDIMAKKGQISPSEMASHLLTKNKDTPTILDCMLKLLATHSILTCSLSNPEEGGGGEVKILYGLPPAEELFVQEVGCCSHLLTSFFQFSNTGNGIDFWEHMKDAVLDGGIPLQIKSPWDALLPIYVCKSQ
>Lj7A335T26.1
MSLMKSNPTLKDENDAFACALQVTSSYIVPMVLKAALELGLFDIIAKKGQIPPSEMASHLLAKNKDAPAMLDRMLRLLATHSILTCSLSNLEEGGGGEVERLYGLPPAGELFVQEVGCCSRLLTSFFQFSNTANGIDFWQHMKDAILDGGVPFQRARGMPFYQYIRASPDRSKNFDSSMSEQTNAIMTKTLNKYKGFEGINSLVDVGGGIGTALELITSKYPSIKGINFDLPSVIKNAPIQHGIQLVAGDMFVSIPKSEAILLKWILHNWDDEQCLKILKNCYEAIPTSGKVILVEFIVPLVPDTSISSKLISQLDNIMLFLQEGKERTINEFEALSKAAGFSKIQLHSYDYITSVVEIFK
>Lju2200A0T14.1
MSFMKSSPTLKDENDAFACASQVTSSYIVPMVLKAALELGLFDIIAKKGQIPPSEMASHLLAKNKDAPAMLDRMLRLLATHSILTCSLSNLEEGGGGEVERLYGLPPAGELFVQEVGCCSRLLTSFFQFSNTANGIDFWQHLKDAILDGGVPFQRACGMPFYQYIRASPDRSKNFDSSMSEQTNTIMTKTLNTYKGFEGINSLVDVGGGIGTTLKLITSKYPSIKGINFDLPSVIKNAPIQHGIQLVAGDMFVSIPKSEAILLKWILHNWDDEQCLKILKNCYEAIPTSGKVILVEFIVPLVPDTSISSKLISQLDNIMLFLLGGKERTINEFEALSKAAGFSKIQLHSYDYITSVVEIFK
>Lju2200E0T1.1
MTSHILTKNKDAPAMLDSMLRLLATHSILTCFLSNLEEGGGGEVKRLYGLPLAKELFMKEVGCCSRWLTSFFQFSNTGNDIDL
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University