Enzyme
A cytochrome P-450 (heme-thiolate) protein found in plants. The enzyme is involved in flavonoid biosynthesis.
C4H
Enzyme
Cinnamate 4-hydroxylase
Enzyme name
EC:1.14.14.91
Entry
Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Class
trans-cinnamate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (4-hydroxylating)
Sysname
trans-cinnamate + [reduced NADPH---hemoprotein reductase] + O2 = 4-hydroxycinnamate + [oxidized NADPH---hemoprotein reductase] + H2O[RN:R02253]
Reaction
4-hydroxycinnamate [CPD:C00811];[oxidized NADPH---hemoprotein reductase] [CPD:C03161];H2O [CPD:C00001]
Product
Species information
Lonicera japonica
Species name
Japanese honeysuckle (Lonicera japonica) is a species of eudicot in the family Caprifoliaceae (honeysuckle famly).
Species info
Gene sequence info
Lonicera_japonica.C4H.fa
Download
>Lj1C114T2.1
MKIAIETTLWSVEWGIAELVNHQEIQNKLRHELDTVLGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLNDAKLGSYDIPAESKILVNAWWLANNPAKWKNPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRSF
>Lj1A114T68.1
MDLLLLEKSLLALFFAAVIAITVSKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGDVFMLRMGQRNLVVVSSPDLAKDGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKKMPEAATTGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPMFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKDRRLQLFKDYFVDERKKLGSTKSMDNNTLKCAIDHILEAQEKGEINEDNVLYIVENINVAGTLLLLLLLLLFLTSI
>Lj2C1102T6.1
MDLLLLEKTLLALFAAIIIAITISKLRGKKFKLPPGPLPVPVFGNWLQVGDDLNHRNLTDLAKKFGEIFLLRMGQRNLVVVSSPDLAKDVLHTQGIEFGSRTRNVVFDIFTGEGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRFGWEDEMARVVEDVRKNPESATNGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFDYNYGDFIPVLRPFLRGYLKICREVKQKRLKLFKDYFVDERKKLGSTKSMDNNSLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPEIQEKLRREIDTVLGPGNFELMPPPGQSKIDTSEKGGQFSLHILKHSTIVAKPRSF*FFFFF*KSVFSFVL
>Lj5C765G5.1
MSQTYGPVFLLKLGSKNLVVVSEPELAKQVLHTQGVEFGSRTRNVVFDIFTGNGQSVVFTTYGDHWRKMRRLMTVPFFTNKVVHQYSDMWEEEVDLVVDDLRSSESAKKEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATKFNSERSQLAQSFEYNYGDFIPLLRPFLRGDIMAKNGDKRKISCGIDHIIDAQMNGEITEENVLYIVENINVAAIETTLWSMEWAIADLVNHPAVQCKIREEISTVLKGNPVTESNLYKLPYLQATIKETLALHTVPLLLPHMNLEEATLGGYTIPKESKVVVNAWWLANNPAWWKNPSEFRPERFMEEEGGTEAVTGGKVDFRYLPFGMGRRSCPGFMLALPILGLAIAKLIMNFEIRVPPGIGEIDVSEKGGQFSLHISTHSTVVFNPIVA
>Lj5C765T3.1
MSQTYGPVFLLKLGSKNLTVVSEPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTIYGDHWRRCDFKSQDDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRDAQMKGEISEENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQCKIRGRDLDPTVKETRGYTPDTFTSPTYEPRTSYPRRLHHPKRVKGGGQRWWLANNPAWWRNPSEFRPGGSWRRKAAQRLREGTDRDEKIDVSEKGGQFSLHIAKHSTVVFNPIVA
>Lj5C765T5.1
MVFTIDSDHWLKMQRIITLPFFTKKVVHQYSDMREEEMDLVVDDLRSSESVKNEGVVIQKCLQLMLYNIMYRMMFNANFESQDDPLFIEATKFNSERSRLAQSFGYNYGNFIP
>Lj5C749T3.1
MVFTIDSDHWLKMQRIITLPFFTNKVVHQYSDMREEEMDLVVDDLRSSESVKNEGVVIQKCLQLMLYNIMYRMMFNANFESQDDPLFIEATKFNSERSRLAQSFGYNYGNFIP
>Lj5C749T4.1
MLYNIMYRMMFDAKFESQDDPLFIEATKFNSERSQLAQSFEYNYGDFIPLLRPFLRGYLNKCKDLQSRRLAFFDKYYVQKRRDIMAKNGDKRKISCGIDHIIDAQMNGEITEENVLYIVENINVAAIETTLWSMEWAIADLVNHPAVQCKIREEISTVLKGNPVTESNLYKLPYLQATIKETLRLHTPVPLLLPHMNLEEATLGGYTIPKESKVVVNAWWLANNPAWWKNPSEFRPERFMEEEGGTEAVTGGKVDFRYLPFGMGRRSCPGFMLALPILGLAIAKLIMNFEIRVPPGMGEIDVSEKGGQFSLHISTHSTVVFNPIVA
>Lj5C749T5.1
MSQTYGPVFLLKLGSKNLTVVSEPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTIYGDHWRKMRRIMTLPFFTNKVVHQYSDMWEEEMDLVVDDLRSSESVKKEGMVIRKRLQLMLYNIMYRMMFDAKFKSQDDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCKDLQRRRLAFFDKYYVQQRRDIMAKNGEKHKISCAIDHIIDAQMKGEISEENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQCKIRDEISTVLKGNSVTESNLHELPYLQATVKETLRLHTPIPLLVPHMNLEQATLGGYTIPKESKVVVNAWWLANNPAWWRNPSEFRPERFMEEEGSTDAVAGGKVDFRYLPFGVGRRSCPGIILALPILGLVIAKLVMNFEIRAPIGTEKIDVSEKGGQFSLHIAKHSTVVFNPIVA
MKIAIETTLWSVEWGIAELVNHQEIQNKLRHELDTVLGPGVQITEPDTHKLPYLQAVIKETLRLRMAIPLLVPHMNLNDAKLGSYDIPAESKILVNAWWLANNPAKWKNPEEFRPERFLEEEAKVEANGNDFRYLPFGVGRRSCPGIILALPILGITLGRLVQNFELLPPPGQNKIDTTEKGGQFSLHILKHSTIVAKPRSF
>Lj1A114T68.1
MDLLLLEKSLLALFFAAVIAITVSKLRGKRFKLPPGPIPVPVFGNWLQVGDDLNHRNLTDLAKKFGDVFMLRMGQRNLVVVSSPDLAKDGVEFGSRTRNVVFDIFTGKGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRYGWEDEAARVVEDVKKMPEAATTGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPMFVKLKALNGERSRLAQSFEYNYGDFIPILRPFLRGYLKICKEVKDRRLQLFKDYFVDERKKLGSTKSMDNNTLKCAIDHILEAQEKGEINEDNVLYIVENINVAGTLLLLLLLLLFLTSI
>Lj2C1102T6.1
MDLLLLEKTLLALFAAIIIAITISKLRGKKFKLPPGPLPVPVFGNWLQVGDDLNHRNLTDLAKKFGEIFLLRMGQRNLVVVSSPDLAKDVLHTQGIEFGSRTRNVVFDIFTGEGQDMVFTVYGEHWRKMRRIMTVPFFTNKVVQQYRFGWEDEMARVVEDVRKNPESATNGIVLRRRLQLMMYNNMYRIMFDRRFESEEDPLFVKLKALNGERSRLAQSFDYNYGDFIPVLRPFLRGYLKICREVKQKRLKLFKDYFVDERKKLGSTKSMDNNSLKCAIDHILEAQQKGEINEDNVLYIVENINVAAIETTLWSVEWGIAELVNHPEIQEKLRREIDTVLGPGNFELMPPPGQSKIDTSEKGGQFSLHILKHSTIVAKPRSF*FFFFF*KSVFSFVL
>Lj5C765G5.1
MSQTYGPVFLLKLGSKNLVVVSEPELAKQVLHTQGVEFGSRTRNVVFDIFTGNGQSVVFTTYGDHWRKMRRLMTVPFFTNKVVHQYSDMWEEEVDLVVDDLRSSESAKKEGIVIRKRLQLMLYNIMYRMMFDAKFESQDDPLFIEATKFNSERSQLAQSFEYNYGDFIPLLRPFLRGDIMAKNGDKRKISCGIDHIIDAQMNGEITEENVLYIVENINVAAIETTLWSMEWAIADLVNHPAVQCKIREEISTVLKGNPVTESNLYKLPYLQATIKETLALHTVPLLLPHMNLEEATLGGYTIPKESKVVVNAWWLANNPAWWKNPSEFRPERFMEEEGGTEAVTGGKVDFRYLPFGMGRRSCPGFMLALPILGLAIAKLIMNFEIRVPPGIGEIDVSEKGGQFSLHISTHSTVVFNPIVA
>Lj5C765T3.1
MSQTYGPVFLLKLGSKNLTVVSEPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTIYGDHWRRCDFKSQDDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRDAQMKGEISEENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQCKIRGRDLDPTVKETRGYTPDTFTSPTYEPRTSYPRRLHHPKRVKGGGQRWWLANNPAWWRNPSEFRPGGSWRRKAAQRLREGTDRDEKIDVSEKGGQFSLHIAKHSTVVFNPIVA
>Lj5C765T5.1
MVFTIDSDHWLKMQRIITLPFFTKKVVHQYSDMREEEMDLVVDDLRSSESVKNEGVVIQKCLQLMLYNIMYRMMFNANFESQDDPLFIEATKFNSERSRLAQSFGYNYGNFIP
>Lj5C749T3.1
MVFTIDSDHWLKMQRIITLPFFTNKVVHQYSDMREEEMDLVVDDLRSSESVKNEGVVIQKCLQLMLYNIMYRMMFNANFESQDDPLFIEATKFNSERSRLAQSFGYNYGNFIP
>Lj5C749T4.1
MLYNIMYRMMFDAKFESQDDPLFIEATKFNSERSQLAQSFEYNYGDFIPLLRPFLRGYLNKCKDLQSRRLAFFDKYYVQKRRDIMAKNGDKRKISCGIDHIIDAQMNGEITEENVLYIVENINVAAIETTLWSMEWAIADLVNHPAVQCKIREEISTVLKGNPVTESNLYKLPYLQATIKETLRLHTPVPLLLPHMNLEEATLGGYTIPKESKVVVNAWWLANNPAWWKNPSEFRPERFMEEEGGTEAVTGGKVDFRYLPFGMGRRSCPGFMLALPILGLAIAKLIMNFEIRVPPGMGEIDVSEKGGQFSLHISTHSTVVFNPIVA
>Lj5C749T5.1
MSQTYGPVFLLKLGSKNLTVVSEPELANQVLHAQGVEFGSRPRNVVFDIFTGNGQDMVFTIYGDHWRKMRRIMTLPFFTNKVVHQYSDMWEEEMDLVVDDLRSSESVKKEGMVIRKRLQLMLYNIMYRMMFDAKFKSQDDPLFIEATKFNSERSRLAQSFEYNYGDFIPLLRPFLRGYLNKCKDLQRRRLAFFDKYYVQQRRDIMAKNGEKHKISCAIDHIIDAQMKGEISEENVLYIVENINVAAIETTLWSMEWAIAELVNHPTVQCKIRDEISTVLKGNSVTESNLHELPYLQATVKETLRLHTPIPLLVPHMNLEQATLGGYTIPKESKVVVNAWWLANNPAWWRNPSEFRPERFMEEEGSTDAVAGGKVDFRYLPFGVGRRSCPGIILALPILGLVIAKLVMNFEIRAPIGTEKIDVSEKGGQFSLHIAKHSTVVFNPIVA
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University