Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Lobularia maritima
Species name
Sweet alyssum (Lobularia maritima) is a species of eudicot in the family Brassicaceae (mustard family).
Species info
Gene sequence info
Lobularia_maritima.4CL.fa
Download
>Spe01268.t2
MASMVDPRSGFCNLNSTFYSTRTPIPLPPNPSLDVTTFISSQAHRGRIAFIDASTGQNLTFQQLWRAVESVGDCLYDMGIRKGHVVLLLSPNSILFPVVCLSVMSLGAIITTTNPLNTSGEISKQIKDSNPILAFTTSQLLPKIAAAASGSIPIVLMDEDRVDSVSQVRRLSEMMKREPSRTRVMERVDQDDTATLLYSSGTTGMSKGVISSHRNLIAMVQTIVNRFGTDDGSQGEQRFICTVPMFHIYGLAAFATGLLAYGSTIIVLSKFEMGEMMSAIGKYKATFLPLVPPILVAMINGADQIKAKYDLSSLHTVLCGGAPLSKEVTEGFAEKYPTVKILQGYGLTESTGIGASTDTVEEGRKYGTAGKISASMEGRIVDPVTGRVLGPNQTGELWLKGPSIMKGNVIDAQESSLLLSILSSFGCCCLLFLAGYFSNEEATSSTLDSEGWLRTGDLCYIDEDGFVFVVDRLKELIKYKGYQVAPAELEALLLTHPEIIDAAVIPFPDKEVGQVPMAYVVRKTGSFLSEKSIMEFVAKQVAPYKRIRKAAFISSIPKNPSGKLLRKDLIKLATTNSKL
>Spe00244.t1
MTEAGPVLAMSLGFAKEPFPTKSGARGTVVRNAEMKIVDPNTGDSLSRNQPGEICIRGHRIMKGYLNNPAATTDTIDKESWLHTGDVGLIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHHDITDVAVVAMKDEAAGEVPVAFVVRSKVSKLSEDKVKQFVSNQVVFYKRINKVFFVDSIPKATSGKILRKDLRAKLANGSMK
>Spe08572.t1
MAATHLHQNTPFWFSPETGIYTSKYPSVNLPVDPNLDAVSALFSHIHDGDNASTSAAAALVDSLTGFSISHGELRAMVQSMAAGIHYELGVKQGDVVSLVLPNSVYFPLIFLSLVSLGAIVTTMNPSSSLGEIKKQVSECSVGLAFTSRENVEKLNSLGVIVIRVPESYDFDSIRIENPKFYSVMRGGFGSVLPPKPLIKQDDIAAIMYSSGTTGATKGVLLTHRNLISSMELFVRFEASLYEYPGSSNVYLAALPLCHIYGLSLFVLGLLSLGSTIVVMRRFDVSDVVNVIERFRITHFPVVPPMLMALTKKAKGVNEKLFRSLKQVSCGAAPLSRKFIEDFLGTLPHVDLIQGYGMTESTAVGTRGFNSEKLRRYSSVGLLAPNMQAKVVDWSSGSFLPPGNRGELWIQGPGVMKGYLNNPEATQMTIVEDSWLRTGDIAYFDDDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTAAPSEECGEIPVAFVVRKQGATLSEQDVISYVAAQVAPYRKVRKVVMVSFIPKSPAGKILRKELKRILTCSVSSRL
>Spe13230.t1
MAPQEEVMQKQSKSDVIFRSKLPDIYIPNHLPLHDYIFQNISDFASKPCLINGPTGQVYTYSDVHVISRRIAAGFHKLGVNQHDVVMILLPNCPEFVLTFLAASFRGATATAANPFFTPAEIAKQAKASNSKLIVTESRYVDKIKDLQNDGVLIVCIDESAPIPEGCLRFTELTQSTESDVVSSVEISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSKNNPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPHITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDEVKQFVSKQVVFYKRINKVFFADSIPKAPSGKILRKDLRAKLANGF
>Spe15368.t1
MTESGTVAKSLAFAKNPFKTKSGSCGTVIRNAEMKVVDTITGISLPRNESGEICVRGNQLMKGYLNDPEATARTIDKEGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPSIEDAAVVGMKDEVADEVPVAFIVRSEGSQLTEDDVKSYVNKQVVHYKRIKMVFFIEAIPKAVSGKILRKELRAKLETEYLK
>Spe21564.t1
MERSGYGRDGIYRSLRPPLVLPKDPNASLVSHLFRNSSSYPTKPALVDSDSGVSLSFSQLKSAVARLAHGFLRLGIRKNDVVLIFAPNSYQFPLCFLAVSAIGGIVTTANPLYTVNEISKQIKDSNPKIIVSVRELFDKINGFDLPVVLLGSAQIQNSNSKILSFNDVMDLASSSEDLDLPSVEIKQSDTAALLYSSGTTGVSKGVELTHGNFIAASLMVTMDQDLMEEFHGVFLCVLPMFHVFGLTVVVYSQLQRGNAVISMAKFELEKLLKNVEKYRVTHLWIVPPVFLALSKQSIVKNFDLSSLKYIGSGAAPLGKDLMEECGRNIPNVVLMQGYGMTETCGIVSVEDPRLGKRNSGSAGMLAPGIEAQVVSVETGKSQAPNQLGEIWVRGPNMMKGYLNNPQATKETIDRKGWVHTGDLGYFNEDGNLFVVDRLKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDEEAGEVPIAYVVRSPNSSITEEDIQKFIAKQVAPYKRLRKVSFITSVPKSAAGKILRRELIQQVRSKM
>Spe21948.t1
MNMKMKLSSSLYMIPSSVTQISYSNFQTKKMENQKQDNEYIFRSLYPSVPIPDNLTLPEFVLQGVEQFTEKVAFVEAVTGKAVTYGDVVRDTKRLAKALTSLGLRKGHVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALISEIKKQVQASGARGIITDSTNYEKVKTLGLPVIVLGEEKIEGAVNWKELLEAGDRAGDNDKVEILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSTLFSVRSEMIGQIVTLGLIPFFHIYGIVGICCATMRNKGKVVAMSRFDLRLFLNALIAHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMSAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGLSLPKNTSGELCVRSQCVMEGYFKNKEETEKTIDEQGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVP
>Spe24326.t1
MITAALHEPLIHKPADTSPTVVSSGDALLPPTPRIFHSKLPDIDIPNDLPLHTYCFDKLPSVSDKPCLIVGSTGKSYTYGETHLICRKVAAGLYKMGIRKGDVIMILLQNSPEFVFSFMGASMIGAVSTTANPFYTSQEVYKQLRCSGAKLIITHPHYVDKLRNLELKIGEDLTVITTTADPPPENCLPFSVLTEHENTIEESVDVVGGDDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKPNDVVLCVLPLFHIYSLNSVLLNSIRSGVTVLLMHKFEIESLLELIERHKVTVAALVPPLVIALAKNPAVSSYDLSSVRLVLSGAAPLGKDLQDSLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPIPTKSGSCGTVVRNAELKVIHPETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDEEGWLHTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHNSIVDAAVVPQNDEVAGEVPVAFVVRSNGNEITEEDIKEYIAKQVVFYKRLHKVFFVTSIPKSPSGKILRKELKAKLC
MASMVDPRSGFCNLNSTFYSTRTPIPLPPNPSLDVTTFISSQAHRGRIAFIDASTGQNLTFQQLWRAVESVGDCLYDMGIRKGHVVLLLSPNSILFPVVCLSVMSLGAIITTTNPLNTSGEISKQIKDSNPILAFTTSQLLPKIAAAASGSIPIVLMDEDRVDSVSQVRRLSEMMKREPSRTRVMERVDQDDTATLLYSSGTTGMSKGVISSHRNLIAMVQTIVNRFGTDDGSQGEQRFICTVPMFHIYGLAAFATGLLAYGSTIIVLSKFEMGEMMSAIGKYKATFLPLVPPILVAMINGADQIKAKYDLSSLHTVLCGGAPLSKEVTEGFAEKYPTVKILQGYGLTESTGIGASTDTVEEGRKYGTAGKISASMEGRIVDPVTGRVLGPNQTGELWLKGPSIMKGNVIDAQESSLLLSILSSFGCCCLLFLAGYFSNEEATSSTLDSEGWLRTGDLCYIDEDGFVFVVDRLKELIKYKGYQVAPAELEALLLTHPEIIDAAVIPFPDKEVGQVPMAYVVRKTGSFLSEKSIMEFVAKQVAPYKRIRKAAFISSIPKNPSGKLLRKDLIKLATTNSKL
>Spe00244.t1
MTEAGPVLAMSLGFAKEPFPTKSGARGTVVRNAEMKIVDPNTGDSLSRNQPGEICIRGHRIMKGYLNNPAATTDTIDKESWLHTGDVGLIDDDDELFIVDRLKELIKYKGFQVAPAELEAMLISHHDITDVAVVAMKDEAAGEVPVAFVVRSKVSKLSEDKVKQFVSNQVVFYKRINKVFFVDSIPKATSGKILRKDLRAKLANGSMK
>Spe08572.t1
MAATHLHQNTPFWFSPETGIYTSKYPSVNLPVDPNLDAVSALFSHIHDGDNASTSAAAALVDSLTGFSISHGELRAMVQSMAAGIHYELGVKQGDVVSLVLPNSVYFPLIFLSLVSLGAIVTTMNPSSSLGEIKKQVSECSVGLAFTSRENVEKLNSLGVIVIRVPESYDFDSIRIENPKFYSVMRGGFGSVLPPKPLIKQDDIAAIMYSSGTTGATKGVLLTHRNLISSMELFVRFEASLYEYPGSSNVYLAALPLCHIYGLSLFVLGLLSLGSTIVVMRRFDVSDVVNVIERFRITHFPVVPPMLMALTKKAKGVNEKLFRSLKQVSCGAAPLSRKFIEDFLGTLPHVDLIQGYGMTESTAVGTRGFNSEKLRRYSSVGLLAPNMQAKVVDWSSGSFLPPGNRGELWIQGPGVMKGYLNNPEATQMTIVEDSWLRTGDIAYFDDDGYLFIVDRIKEIIKYKGFQIAPADLEAVLVSHPLIIDAAVTAAPSEECGEIPVAFVVRKQGATLSEQDVISYVAAQVAPYRKVRKVVMVSFIPKSPAGKILRKELKRILTCSVSSRL
>Spe13230.t1
MAPQEEVMQKQSKSDVIFRSKLPDIYIPNHLPLHDYIFQNISDFASKPCLINGPTGQVYTYSDVHVISRRIAAGFHKLGVNQHDVVMILLPNCPEFVLTFLAASFRGATATAANPFFTPAEIAKQAKASNSKLIVTESRYVDKIKDLQNDGVLIVCIDESAPIPEGCLRFTELTQSTESDVVSSVEISPEDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGDNPNLYFHSEDVILCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSPETEKYDLSSIRVVKSGAAPLGKELEDAVSAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSKNNPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPHITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDEVKQFVSKQVVFYKRINKVFFADSIPKAPSGKILRKDLRAKLANGF
>Spe15368.t1
MTESGTVAKSLAFAKNPFKTKSGSCGTVIRNAEMKVVDTITGISLPRNESGEICVRGNQLMKGYLNDPEATARTIDKEGWLHTGDIGFVDDDDEIFIVDRLKELIKFKGYQVAPAELEALLISHPSIEDAAVVGMKDEVADEVPVAFIVRSEGSQLTEDDVKSYVNKQVVHYKRIKMVFFIEAIPKAVSGKILRKELRAKLETEYLK
>Spe21564.t1
MERSGYGRDGIYRSLRPPLVLPKDPNASLVSHLFRNSSSYPTKPALVDSDSGVSLSFSQLKSAVARLAHGFLRLGIRKNDVVLIFAPNSYQFPLCFLAVSAIGGIVTTANPLYTVNEISKQIKDSNPKIIVSVRELFDKINGFDLPVVLLGSAQIQNSNSKILSFNDVMDLASSSEDLDLPSVEIKQSDTAALLYSSGTTGVSKGVELTHGNFIAASLMVTMDQDLMEEFHGVFLCVLPMFHVFGLTVVVYSQLQRGNAVISMAKFELEKLLKNVEKYRVTHLWIVPPVFLALSKQSIVKNFDLSSLKYIGSGAAPLGKDLMEECGRNIPNVVLMQGYGMTETCGIVSVEDPRLGKRNSGSAGMLAPGIEAQVVSVETGKSQAPNQLGEIWVRGPNMMKGYLNNPQATKETIDRKGWVHTGDLGYFNEDGNLFVVDRLKELIKYKGFQVAPAELEGLLVSHPEILDAVVIPFPDEEAGEVPIAYVVRSPNSSITEEDIQKFIAKQVAPYKRLRKVSFITSVPKSAAGKILRRELIQQVRSKM
>Spe21948.t1
MNMKMKLSSSLYMIPSSVTQISYSNFQTKKMENQKQDNEYIFRSLYPSVPIPDNLTLPEFVLQGVEQFTEKVAFVEAVTGKAVTYGDVVRDTKRLAKALTSLGLRKGHVMVVVLPNVAEYGIIALGIMSAGGVFSGANPTALISEIKKQVQASGARGIITDSTNYEKVKTLGLPVIVLGEEKIEGAVNWKELLEAGDRAGDNDKVEILQTDLCALPFSSGTTGLQKGVMLTHRNLIANLCSTLFSVRSEMIGQIVTLGLIPFFHIYGIVGICCATMRNKGKVVAMSRFDLRLFLNALIAHEVSFAPIVPPIILNLVKNPIVDEFDLSKLKLRSVMSAAAPLAPELLTAFEAKFPNVQVQEAYGLTEHSCITLTHGDPEKGQGIAKRNSVGFILPNLEVKFIDPDTGLSLPKNTSGELCVRSQCVMEGYFKNKEETEKTIDEQGWLHTGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDVAVVP
>Spe24326.t1
MITAALHEPLIHKPADTSPTVVSSGDALLPPTPRIFHSKLPDIDIPNDLPLHTYCFDKLPSVSDKPCLIVGSTGKSYTYGETHLICRKVAAGLYKMGIRKGDVIMILLQNSPEFVFSFMGASMIGAVSTTANPFYTSQEVYKQLRCSGAKLIITHPHYVDKLRNLELKIGEDLTVITTTADPPPENCLPFSVLTEHENTIEESVDVVGGDDAAALPFSSGTTGLPKGVVLTHKSLITSVAQQVDGENPNLYLKPNDVVLCVLPLFHIYSLNSVLLNSIRSGVTVLLMHKFEIESLLELIERHKVTVAALVPPLVIALAKNPAVSSYDLSSVRLVLSGAAPLGKDLQDSLRRRLPQAVLGQGYGMTEAGPVLSMSLGFAKEPIPTKSGSCGTVVRNAELKVIHPETRLSLGYNQPGEICIRGQQIMKEYLNDPEATSATIDEEGWLHTGDIGYVDEDDEIFIVDRLKEVIKFKGFQVPPAELEALLINHNSIVDAAVVPQNDEVAGEVPVAFVVRSNGNEITEEDIKEYIAKQVVFYKRLHKVFFVTSIPKSPSGKILRKELKAKLC
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University