Enzyme
4CL
Enzyme
4-coumarate:CoA ligase
Enzyme name
EC:6.2.1.12
Entry
Ligases;Forming carbon-sulfur bonds;Acid-thiol ligases
Class
4-coumarate:CoA ligase (AMP-forming)
Sysname
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction
AMP [CPD:C00020];diphosphate [CPD:C00013];4-coumaroyl-CoA [CPD:C00223]
Product
Species information
Sorghum bicolor
Species name
Sorghum (Sorghum bicolor) is a species of monocot in the family Poaceae (grass family).
Species info
Gene sequence info
Sorghum_bicolor.4CL.fa
Download
>rna-XM_021448240.1
MARTTAPAAGYGADGVYRSPRPAVRIESDPGLSLNDLLFRRADACPSALALVDSATGQSLTFAAFRSAVLTTAVALSSRAGVRRGDVVLFFAPNCFLYPVCFFAVTALGAVATTANPLYTPREVAKQATDSRAKLAITVSELLPKIVDLRLPTILLDVDGGAASVTASKPQGASVTLYSDLISGVRETEYRRPPTKQSDTAALLYSSGTTGASKGVILTHRNFISAAAMMTADQDELGEGPNVFLCFLPMFHIFGLSVLTFAQMQRGNSVVVMSRFDMDSVMAAVQRHRVTHLFCVPPVMIALAKLGSVGKYDLSSLRFIGSGAAPLGKDVMEGVAKNFPEAVIAQGYGMTETCGIISLEYPEKGQVRQFGSTGALVSGVEAKIVDVETLKCLPPNQLGEICVRGLNIMQGYFNNVQATEFTIKQGWLHTGDIGYFDEGGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSPVSSLTEVDVQKFIEKQVAYYKKLRRVTFVDSVPKSASGKILRRELIAKVRSSKL
>rna-XM_021452058.1
MAGTASPAAGYGSDGVYRSPRAAAQIASDPGLSLADLVLRRAAACPSAPALVDAATGRALTFGSLRSAVLVAAAALSSRAGVRRGDAVLLLAPNCVLYPVCFLAVTSLGAVATTANPRYTPREIAKQAADARAKLVVTVSDLLPKIAGLRLPTVLLDGDGGGAPVPSSDCPSRSSNVTLYSDLVAGVQEAEYRRPPAVGQGDTAALFYSSGTTGESKGVVLTHRNFIAAATMVTSDQDELGEGGRNVFLCFLPMFHIFGMAVVTLGQLQRGNAVVVMARFDVDAVLAAVERHRVTYIFGAPPAMIALAKHGGGRRYDLSSLRCIGSGAAPLGKDVMVAMADRFPGADIVQGYGMTETCGIISLEYVQKGRARQFGSTGALVIGVEAKIVDTKTMKHLPPNQLGEICVRGPNIMEGYFNNVQATEFTIKQGWLHTGDLGYFDERGQLHVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAAVIPYPDPEAGEVPIAYVVRSPKSSLAEVDVQKFIEKQVAHYKRLRKVKFVDSVPKSAAGKILRRELIAQVRSSKL
>rna-XM_002454832.2
MTQPNLTCTPPVLTPRKNCVAAANMASPSSRGHSLPMPRPLVISSNANAAPFLLLPTNNQQQQQQLRRMGDAAIATVHLHDAEEEQEQEHIFRSRFPPVAVPDDVTVPEFVLAGAEAYADKTALVEAAPGGQSYTYGEVVRDVARFARALRSVGIRKGHVVVVALPNLAVYPVVSLGIMSAGAVFSGVNPRAVAGEIKKQVEDSEARLVVADAVAYDKVKDAGVPVIGIGDAARLPGAISWDELLAAADRTGAPAVALDPAQQSDLCALPYSSGTTGVSKGVMLSHRNLVSSLCSSMFAVGPEMVGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRGFLGALLTHKVMFAPVVPPIMLAMVKSPVADEFDLSGLALRSVMTAAAPLAPELLAAFERKFPGVQVEEAYGLTEHSCITLTHAGGDDPQQGPVQIAKKKSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVRSQAVMQGYYRRKEETESTIDAAGWLHTGDVGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEVPASCVVRRRGAPESEADMMAYVAERVASYKKLRLLRFVDAIPKSVSGKILRRQLRDDFIKTAAA
>rna-XM_002452659.2
MITVAAPEAQPQVAAPAAPEETVFRSKLPDIDIASHLPLHEYCFARAAEVADAPCLIAAATGRTYTYAETRLLCRKAAASLHGLGVGHGDRVMILLQNSVEFVLTFLGASFLGAVTTAANPFCTPLEIHKQFRASGAKLIVTQSAYVDKLRHEAFPRIGGEDKDNALTVLTIDDVADTPEGCLAFWELVTPADDAALPEVSISPDDPVALPFSSGTTGLPKGVVLTHGGQVSNVAQQVDGANPNLYMREGDVALCVLPLFHIFSLNSVLLCALRAGAAVMLMPKFEMGAMLEGIQRWRVTVAAVVPPLVLALAKNPALEKYDLSSIRIVLSGAAPLGKELVDALRARVPQAVFGQGYGMTEAGPVLSMCPAFAKEPTPAKPGSCGTVVRNAELKVVDPDTGLSLGRNLPGEICIRGPQIMKGYLNDPEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVPQKDDAAGEVPVAFVVRAADSDIAEDAIKEFISKQVVFYKRLHKVYFTPSIPKSASGKILRRELRAKLAAAAST
>rna-XM_002451602.2
MGSVDTAVAVPVPVPEPEAEEKAAVVFRSKLPDIEINNSQSLQTYCFGKMSEVADRACLIDGQTGASYTYAEVESLSRRAASGLRAMGVGKGDVVMNLLRNCPEFAFTFLGAARLGAATTTANPFYTPHEIHRQAEAAGAKVIVTEACAVEKVREFAAGRGVPVVTVDGRFDGCVEFAEVIAAEELDADADVHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKDDVVLCLLPLFHIYSLNSVLLAGLRAGSTIVIMRKFDLGALVDLVRKHGITIAPFVPPIVVEIAKSPRVTADDLASIRMVMSGAAPMGKELQDAFMTKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFQVKSGSCGTVVRNAELKVVDPDTGAALGRNQPGEICIRGEQIMKGYLNDLESTKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDDLAGEIPVAFIVRTEGSEVTEDEIKQFVAKEVVFYKKIHKVFFTESIPKNPSGKILRKDLRARLAAGVH
>rna-XM_002444062.2
MGSTEEQQQPVPVVAAAVEEEEASPEIIFRSKLPDIAITNFLPLHRYCFERLPEVADRPCLIDGATGAVRTYAEVDRLTRRLAAALRRAPLGLGRGAVVMNLMLNSAEFVLSFFAASRVGAAVTTANPMSTPHEIANQIAASGATVVFTESMAVDKLPAVQDDGGGLTVVLIDAHRDGCLHFWDDVMASVPDDEDREAEEAAAAAGFDPDDVVALPYSSGTTGLPKGVMLTHRSLSTSVAQQVDGDNPNIGFTADDVILCSLPMFHIYSLNTIMMCGLRVGAAIVVMRRFDLARMMELVERHRITIAPLVPPIVVAVAKSDEAASHDLSSVRMVLSGAAPMGKDIEDAFMAKLPGAVLGQGYGMTEAGPVLSMCLAFAKEPFKVKSGACGTVVRNAELKIVDPDTGKSLARNLPGEICIRGQQIMKGYLNNPDATKNSIDADGWLHTGDVGFVDDDDEIFIVDRLKEIIKYKGLQVAPAEIEALLITHPSIADAAVVGKQVEPEIGEIPVAFVAKAKGSELSEDDVKQFVAKEVIYYKKVREVIFIDKIPKAPSGKILRKELRKQLQQQVA
>rna-XM_002445545.2
MVSPTTAEPKAETTTVFRSTLPDIAIPDHLPLHDYVLERLAERRDRACLIDGATGETLTFGDVDRVSRRVAAGMRAALGVRSGGTVMLLLPNCVEFALAFLACSRLGAAATTANPLHTPPEIAKQAAASGATVVITEPAFVGKVRGLAGVAVVATGDGAEGCVSFSELTDAADDDDGSALPPIDVANDVVALPYSSGTTGLPKGVMLSHRGLVTSVAQLVDGDNPNLHLREDDVVLCVLPMFHVYSLHSILLCGMRAGAALVIMKRFDTLRMFELVKRHGITVVPLVLPIAVEMAKSDAMDRHDLSSVRMVISGAAPMGRELQDLLRAKLPGAVLGQGYGMTEAGPVLSMCMAFAKEPLPVKSGACGTVVRNAELKIVDPDTGLSLRRNQPGEICIRGKQLMKGYLNNPEATAKTIDDEGWLHTGDIGYVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPSIADAAVVPMKDDSCGEIPVAFVVTSGGYEMTEDEIKQYVAKQVVFYKRLHKVFFVEAIPKAPSGKILRKDLRAKLASGFSNGSSC
>rna-XM_002438738.2
MGSVAEDSAAPAAASVVFRSKLPDIEIPRHLSLQAYCFERLPEVSSRPCLIDGQTGAVHTYADVERLSRTAAAALRGLGVGKGDVVMNLLRNCPEFAFVFLGAARLGAATTTANPFYTPHEIHRQAAAAGAKVIVTEACAVEKVRGFAAERGVPVATVDGGAFDGCLELGALMDAAEPLADDEEVDPDDVVALPYSSGTTGMPKGVMLTHRSLVTSVAQQVDGENPNLHFSSDDVVLCVLPLFHIYSLNSVLLAGLRAGCAIVIMRKFEIGALVELVRAHGVTVAPFVPPIVVEIAKSPRVGAADLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFEVKSGSCGTVVRNAELKIVDPDTSESLGRNQPGEICIRGEQIMKGYLNDPEATKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDELAGEVPVAFIIRSEGSEISENEIKQFVAKEVVFYKRINRVFFTDSIPKNPSGKILRKDLRARLAAGIPSSDNTQSKS
MARTTAPAAGYGADGVYRSPRPAVRIESDPGLSLNDLLFRRADACPSALALVDSATGQSLTFAAFRSAVLTTAVALSSRAGVRRGDVVLFFAPNCFLYPVCFFAVTALGAVATTANPLYTPREVAKQATDSRAKLAITVSELLPKIVDLRLPTILLDVDGGAASVTASKPQGASVTLYSDLISGVRETEYRRPPTKQSDTAALLYSSGTTGASKGVILTHRNFISAAAMMTADQDELGEGPNVFLCFLPMFHIFGLSVLTFAQMQRGNSVVVMSRFDMDSVMAAVQRHRVTHLFCVPPVMIALAKLGSVGKYDLSSLRFIGSGAAPLGKDVMEGVAKNFPEAVIAQGYGMTETCGIISLEYPEKGQVRQFGSTGALVSGVEAKIVDVETLKCLPPNQLGEICVRGLNIMQGYFNNVQATEFTIKQGWLHTGDIGYFDEGGQLFVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAVVIPFPDAEAGEVPIAYVVRSPVSSLTEVDVQKFIEKQVAYYKKLRRVTFVDSVPKSASGKILRRELIAKVRSSKL
>rna-XM_021452058.1
MAGTASPAAGYGSDGVYRSPRAAAQIASDPGLSLADLVLRRAAACPSAPALVDAATGRALTFGSLRSAVLVAAAALSSRAGVRRGDAVLLLAPNCVLYPVCFLAVTSLGAVATTANPRYTPREIAKQAADARAKLVVTVSDLLPKIAGLRLPTVLLDGDGGGAPVPSSDCPSRSSNVTLYSDLVAGVQEAEYRRPPAVGQGDTAALFYSSGTTGESKGVVLTHRNFIAAATMVTSDQDELGEGGRNVFLCFLPMFHIFGMAVVTLGQLQRGNAVVVMARFDVDAVLAAVERHRVTYIFGAPPAMIALAKHGGGRRYDLSSLRCIGSGAAPLGKDVMVAMADRFPGADIVQGYGMTETCGIISLEYVQKGRARQFGSTGALVIGVEAKIVDTKTMKHLPPNQLGEICVRGPNIMEGYFNNVQATEFTIKQGWLHTGDLGYFDERGQLHVVDRLKELIKYKGFQIAPAELEGLLLSHPEILDAAVIPYPDPEAGEVPIAYVVRSPKSSLAEVDVQKFIEKQVAHYKRLRKVKFVDSVPKSAAGKILRRELIAQVRSSKL
>rna-XM_002454832.2
MTQPNLTCTPPVLTPRKNCVAAANMASPSSRGHSLPMPRPLVISSNANAAPFLLLPTNNQQQQQQLRRMGDAAIATVHLHDAEEEQEQEHIFRSRFPPVAVPDDVTVPEFVLAGAEAYADKTALVEAAPGGQSYTYGEVVRDVARFARALRSVGIRKGHVVVVALPNLAVYPVVSLGIMSAGAVFSGVNPRAVAGEIKKQVEDSEARLVVADAVAYDKVKDAGVPVIGIGDAARLPGAISWDELLAAADRTGAPAVALDPAQQSDLCALPYSSGTTGVSKGVMLSHRNLVSSLCSSMFAVGPEMVGQVVTLGLMPFFHIYGITGICCATLRHKGTVVVMDRFDLRGFLGALLTHKVMFAPVVPPIMLAMVKSPVADEFDLSGLALRSVMTAAAPLAPELLAAFERKFPGVQVEEAYGLTEHSCITLTHAGGDDPQQGPVQIAKKKSVGFILPNLEVKFVDPDTGRSLPKNTPGEICVRSQAVMQGYYRRKEETESTIDAAGWLHTGDVGYIDDDGDVFIVDRIKELIKYKGFQVAPAELEAILLSHPSVEDAAVFGLPDEEAGEVPASCVVRRRGAPESEADMMAYVAERVASYKKLRLLRFVDAIPKSVSGKILRRQLRDDFIKTAAA
>rna-XM_002452659.2
MITVAAPEAQPQVAAPAAPEETVFRSKLPDIDIASHLPLHEYCFARAAEVADAPCLIAAATGRTYTYAETRLLCRKAAASLHGLGVGHGDRVMILLQNSVEFVLTFLGASFLGAVTTAANPFCTPLEIHKQFRASGAKLIVTQSAYVDKLRHEAFPRIGGEDKDNALTVLTIDDVADTPEGCLAFWELVTPADDAALPEVSISPDDPVALPFSSGTTGLPKGVVLTHGGQVSNVAQQVDGANPNLYMREGDVALCVLPLFHIFSLNSVLLCALRAGAAVMLMPKFEMGAMLEGIQRWRVTVAAVVPPLVLALAKNPALEKYDLSSIRIVLSGAAPLGKELVDALRARVPQAVFGQGYGMTEAGPVLSMCPAFAKEPTPAKPGSCGTVVRNAELKVVDPDTGLSLGRNLPGEICIRGPQIMKGYLNDPEATARTIDVDGWLHTGDIGYVDDDDEVFIVDRVKELIKFKGFQVPPAELEALLIAHPSIADAAVVPQKDDAAGEVPVAFVVRAADSDIAEDAIKEFISKQVVFYKRLHKVYFTPSIPKSASGKILRRELRAKLAAAAST
>rna-XM_002451602.2
MGSVDTAVAVPVPVPEPEAEEKAAVVFRSKLPDIEINNSQSLQTYCFGKMSEVADRACLIDGQTGASYTYAEVESLSRRAASGLRAMGVGKGDVVMNLLRNCPEFAFTFLGAARLGAATTTANPFYTPHEIHRQAEAAGAKVIVTEACAVEKVREFAAGRGVPVVTVDGRFDGCVEFAEVIAAEELDADADVHPDDVVALPYSSGTTGLPKGVMLTHRSLITSVAQQVDGENPNLYFSKDDVVLCLLPLFHIYSLNSVLLAGLRAGSTIVIMRKFDLGALVDLVRKHGITIAPFVPPIVVEIAKSPRVTADDLASIRMVMSGAAPMGKELQDAFMTKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFQVKSGSCGTVVRNAELKVVDPDTGAALGRNQPGEICIRGEQIMKGYLNDLESTKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDDLAGEIPVAFIVRTEGSEVTEDEIKQFVAKEVVFYKKIHKVFFTESIPKNPSGKILRKDLRARLAAGVH
>rna-XM_002444062.2
MGSTEEQQQPVPVVAAAVEEEEASPEIIFRSKLPDIAITNFLPLHRYCFERLPEVADRPCLIDGATGAVRTYAEVDRLTRRLAAALRRAPLGLGRGAVVMNLMLNSAEFVLSFFAASRVGAAVTTANPMSTPHEIANQIAASGATVVFTESMAVDKLPAVQDDGGGLTVVLIDAHRDGCLHFWDDVMASVPDDEDREAEEAAAAAGFDPDDVVALPYSSGTTGLPKGVMLTHRSLSTSVAQQVDGDNPNIGFTADDVILCSLPMFHIYSLNTIMMCGLRVGAAIVVMRRFDLARMMELVERHRITIAPLVPPIVVAVAKSDEAASHDLSSVRMVLSGAAPMGKDIEDAFMAKLPGAVLGQGYGMTEAGPVLSMCLAFAKEPFKVKSGACGTVVRNAELKIVDPDTGKSLARNLPGEICIRGQQIMKGYLNNPDATKNSIDADGWLHTGDVGFVDDDDEIFIVDRLKEIIKYKGLQVAPAEIEALLITHPSIADAAVVGKQVEPEIGEIPVAFVAKAKGSELSEDDVKQFVAKEVIYYKKVREVIFIDKIPKAPSGKILRKELRKQLQQQVA
>rna-XM_002445545.2
MVSPTTAEPKAETTTVFRSTLPDIAIPDHLPLHDYVLERLAERRDRACLIDGATGETLTFGDVDRVSRRVAAGMRAALGVRSGGTVMLLLPNCVEFALAFLACSRLGAAATTANPLHTPPEIAKQAAASGATVVITEPAFVGKVRGLAGVAVVATGDGAEGCVSFSELTDAADDDDGSALPPIDVANDVVALPYSSGTTGLPKGVMLSHRGLVTSVAQLVDGDNPNLHLREDDVVLCVLPMFHVYSLHSILLCGMRAGAALVIMKRFDTLRMFELVKRHGITVVPLVLPIAVEMAKSDAMDRHDLSSVRMVISGAAPMGRELQDLLRAKLPGAVLGQGYGMTEAGPVLSMCMAFAKEPLPVKSGACGTVVRNAELKIVDPDTGLSLRRNQPGEICIRGKQLMKGYLNNPEATAKTIDDEGWLHTGDIGYVDDDDEIFIVDRLKELIKYKGFQVAPAELEAMLIAHPSIADAAVVPMKDDSCGEIPVAFVVTSGGYEMTEDEIKQYVAKQVVFYKRLHKVFFVEAIPKAPSGKILRKDLRAKLASGFSNGSSC
>rna-XM_002438738.2
MGSVAEDSAAPAAASVVFRSKLPDIEIPRHLSLQAYCFERLPEVSSRPCLIDGQTGAVHTYADVERLSRTAAAALRGLGVGKGDVVMNLLRNCPEFAFVFLGAARLGAATTTANPFYTPHEIHRQAAAAGAKVIVTEACAVEKVRGFAAERGVPVATVDGGAFDGCLELGALMDAAEPLADDEEVDPDDVVALPYSSGTTGMPKGVMLTHRSLVTSVAQQVDGENPNLHFSSDDVVLCVLPLFHIYSLNSVLLAGLRAGCAIVIMRKFEIGALVELVRAHGVTVAPFVPPIVVEIAKSPRVGAADLASIRMVMSGAAPMGKDLQDAFMAKIPNAVLGQGYGMTEAGPVLAMCLAFAKEPFEVKSGSCGTVVRNAELKIVDPDTSESLGRNQPGEICIRGEQIMKGYLNDPEATKNTIDKDGWLHTGDIGYVDDDDEIFIVDRLKEIIKYKGFQVPPAELEALLITHPEIKDAAVVSMKDELAGEVPVAFIIRSEGSEISENEIKQFVAKEVVFYKRINRVFFTDSIPKNPSGKILRKDLRARLAAGIPSSDNTQSKS
Gene tree
Gene tree
Sheng jun & Dong yang Teams, Yunnan agriculture University